The Impact of Cigarette Smoking on the Oral Mucosa
DOI:
https://doi.org/10.12775/JEHS.2026.90.70552Keywords
smoking, tobacco, oral mucosaAbstract
Introduction. Tobacco smoking is the most common addiction worldwide. It is estimated that there are currently around 1.2 billion people addicted to this product globally (Reibel, 2005). The situation in Poland is not more optimistic - approximately 27–28% of adult Poles declare this habit (TNS Polska, n.d.). Each year, tobacco is responsible for the deaths of over 7 million people worldwide (World Health Organization, n.d.). Tobacco smoke contains approximately 4,000 chemical compounds, many of which are carcinogenic substances (Piekoszowski & Florek, 2001; Rudzinski & Banach, 2008). Aim. The aim of this study is to present the harmful effects of tobacco smoke on the condition of the oral mucosa and to discuss the most common pathological changes associated with exposure to tobacco smoke. Material and methods. The research material consisted of scientific publications concerning the impact of cigarette smoking on the oral mucosa. The literature review was conducted based on the PubMed and Google Scholar databases. Publications in both Polish and English, published between 1987 and 2023, were included.
References
Reibel, J. (2005). Tobacco or oral health. Bulletin of the World Health Organization, 83, 643–644.
TNS Polska. (05.02.2026). Report from a nationwide survey on attitudes toward tobacco smoking conducted for the Chief Sanitary Inspectorate (Poland).
World Health Organization. (05.02.2026). Tobacco. https://www.who.int/news-room/fact-sheets/detail/tobacco
Piekoszowski, W., & Florek, E. (2001). Markery narażenia na dym tytoniowy. Poznań: Katedra i Zakład Toksykologii Akademii Medycznej w Poznaniu.
Rudzinski, R., & Banach, J. (2008). Wpływ nawyku palenia tytoniu na stan przyzębia oraz toksyczne oddziaływanie nikotyny i jej metabolitów na tkanki przyzębia. Czasopismo Stomatologiczne, 61, 635–643.
Tutka, P., Mosiewicz, J., & Wielosz, M. (2005). Pharmacokinetics and metabolism of nicotine. Pharmacological Reports, 57, 143–153.
Fontes, P. C., Correa, G. H., Issa, J. C., Brandao, A. A., & Almeida, J. D. (2008). Comparison of exfoliative pap stain and AgNOR counts of the tongue in smokers and non-smokers. Head and Neck Pathology, 2, 157–162.
Chandra, P., & Govinadraju, P. (2012). Prevalence of oral changes among tobacco users. Oral Health & Preventive Dentistry, 10, 149–153.
Aljabab, M. A., Aljabab, A. A., & Patil, S. R. (2015). Evaluation of oral changes among tobacco users of Aljouf Province, Saudi Arabia. Journal of Clinical and Diagnostic Research, 9, 58–61.
Taybos, G. (2003). Oral changes associated with tobacco use. American Journal of the Medical Sciences, 326, 179–182.
Górska, R. (2023). Choroby błony śluzowej jamy ustnej. Podręcznik dla studentów i do LDEK (pp. 102–104). Wrocław: Edra Urban & Partner.
Kaliakatsou, F., Hodgson, T. A., Lewsey, J. D., Hegarty, A. M., Murphy, A. G., & Porter, S. R. (2002). Management of recalcitrant ulcerative oral lichen planus with topical tacrolimus. Journal of the American Academy of Dermatology, 46(1), 35–41.
Patil, S., Khandelwal, S., Sinha, N., Kaswan, S., Rahman, F., & Tipu, S. (2012). Treatment modalities of oral lichen planus: An update. Journal of Oral Diagnosis, 1(2), 47–52.
Petkowicz, B., Skiba, M., Tomaszewski, T., & Wysokinska-Miszczuk, J. (2004). Leukoplakia błony śluzowej jamy ustnej w aspekcie klinicznym i epidemiologicznym – analiza przypadków. Dental and Medical Problems, 41(4), 635–641.
Axell, T. (1987). Occurrence of leukoplakia and some other oral white lesions among 20,333 adult Swedish people. Community Dentistry and Oral Epidemiology, 15, 46–51.
Waśkowska, J., & Koszowski, R. (2006). Ocena wyników leczenia kriochirurgicznego leukoplakii błony śluzowej jamy ustnej w materiale Katedry i Zakładu Chirurgii Stomatologicznej ŚAM. Czasopismo Stomatologiczne, 59(6), 438–445.
Banoczy, J., Gintner, Z., & Dombi, C. (2001). Tobacco use and oral leukoplakia. Journal of Dental Education, 65, 322–327.
Lima, J. S., Pinto, D. dos S., Jr., Sousa, S. O., & Correa, L. (2012). Oral leukoplakia manifests differently in smokers and non-smokers. Brazilian Oral Research, 26, 543–549.
Sarkar, R., & Rathod, G. P. (2014). Clinicopathologic assessment of Candida colonization of oral leukoplakia. Indian Journal of Dermatology, Venereology and Leprology, 80, 413–418.
Yu, C. H., Lin, H. P., Cheng, S. J., Sun, A., & Chen, H. M. (2014). Cryotherapy for oral precancers and cancers. Journal of the Formosan Medical Association, 113, 272–277.
Nagao, T., Warnakulasuriya, S., Nakamura, T., et al. (2015). Treatment of oral leukoplakia with a low-dose of beta-carotene and vitamin C supplements: A randomized controlled trial. International Journal of Cancer, 136, 1708–1717.
Warnakulasuriya, S., Johnson, N. W., & van der Waal, I. (2007). Nomenclature and classification of potentially malignant disorders of the oral mucosa. Journal of Oral Pathology & Medicine, 36(10), 575–580.
Mortazavi, H., Baharvand, M., & Mehdipour, M. (2014). Oral potentially malignant disorders: An overview of more than 20 entities. Journal of Dental Research, Dental Clinics, Dental Prospects, 8(1), 6–14.
Vedtofte, P., Holmstrup, P., Hjørting-Hansen, E., & Pindborg, J. J. (1987). Surgical treatment of premalignant lesions of the oral mucosa. International Journal of Oral and Maxillofacial Surgery, 16(6), 656–664.
EU-Working Group on Tobacco and Oral Health. (1999). Tobacco and oral diseases: Report of EU Working Group. Journal of the Irish Dental Association, 46, 12–23.
Bharath, T. S., Kumar, N. G., Nagaraja, A., Saraswathi, T. R., Babu, G. S., & Raju, P. R. (2015). Palatal changes of reverse smokers in a rural coastal Andhra population with review of literature. Journal of Oral and Maxillofacial Pathology, 19, 182–187.
Behura, S. S., Masthan, K. M. K., & Narayanasamy, A. B. (2015). Oral mucosal lesions associated with smokers and chewers – A case-control study in Chennai population. Journal of Clinical and Diagnostic Research, 9, 17–22.
Piątkowska, A., & Szymańska, J. (2004). Przykry zapach z ust – halitosis. Zdrowie Publiczne, 114(3), 383–387.
Kamińska, K., Emeryk, B., & Kamińska, K. (2005). Halitosis – przykry zapach z ust – problem pacjenta i lekarza. Nowa Stomatologia, 4, 220–221.
Górska, R. (2023). Choroby błony śluzowej jamy ustnej. Podręcznik dla studentów i do LDEK (pp. 49–51). Wrocław: Edra Urban & Partner.
Słowińska, S. M., Pierzynowska, E., & Foik, T. (2000). Występowanie grzybów z rodzaju Candida w jamie ustnej u pacjentów z zapaleniem dziąseł i zapaleniem przyzębia. Nowa Stomatologia, 3, 51–54.
Łabuś, M., Sekuła, B., Kubicka-Musiał, M., et al. (2018). Kandydoza jamy ustnej – diagnostyka i leczenie. Twój Przegląd Stomatologiczny, 3, 22–26.
Górska, R. (2023). Choroby błony śluzowej jamy ustnej. Podręcznik dla studentów i do LDEK (pp. 123–127). Wrocław: Edra Urban & Partner.
Mielnik-Błaszczak, M., Kosek, K., Hoehne, D., Ciurysek, M., & Schabowski, J. (2009). Kserostomia – problem dotykający coraz większą populację. Medycyna Ogólna, 15(3), 445.
Jańczuk, Z., & Banach, J. (1998). Choroby błony śluzowej jamy ustnej i przyzębia. Warszawa: Wydawnictwo Lekarskie PZWL.
Maciąg, W., & Bachanek, T. (2006). Wpływ alkoholu i nikotyny na stan zdrowia jamy ustnej. Magazyn Stomatologiczny, 11, 28–29.
Gurvits, G. E., & Tan, A. (2014). Black hairy tongue syndrome. World Journal of Gastroenterology, 20, 10845–10850.
Stewart, B. W., & Kleihues, P. (2003). World cancer report. Lyon: WHO International Agency for Research on Cancer.
Mirbod, S. M., & Ahing, S. I. (2000). Tobacco-associated lesions of the oral cavity: Part II. Malignant lesions. Journal of the Canadian Dental Association, 66, 308–311.
Kolokythas, A., Schwartz, J. L., Pytynia, K. B., Panda, S., Yao, M., et al. (2011). Analysis of RNA from brush cytology detects changes in B2M, CYP1B1 and KRT17 levels with OSCC in tobacco users. Oral Oncology, 47, 532–536.
Ho, M. W., Risk, J. M., Woolgar, J. A., Field, E. A., Field, J. K., et al. (2012). The clinical determinants of malignant transformation in oral epithelial dysplasia. Oral Oncology, 48, 969–976.
Brzeziński, P. (2010). Nikotynowe zapalenie jamy ustnej u żołnierzy. Forum Medycyny Rodzinnej, 4(5), 319–322.
Jaworska-Zaremba, M., Domagała, J., Łomżyński, Ł., & Trębacki, J. (2007). Wpływ palenia tytoniu na proces osteointegracji wszczepów stomatologicznych. Nowa Stomatologia, 2/3, 91–94.
Szpak, P., Szymańska, J., & Koszuta, A. (2012). Niepowodzenia w leczeniu implantoprotetycznym związane z paleniem tytoniu. Zdrowie Publiczne, 122(3), 310–315.
Koszuta, A., Szymańska, J., & Szpak, P. (2012). Leczenie protetyczne z zastosowaniem implantów zębowych. Zdrowie Publiczne, 122(2), 217–221.
Moś, D., & Ogłodek, E. (2009). Ocena wskaźnika wypływu płynu dziąsłowego u kobiet palących nikotynę. Nowa Stomatologia, 4, 128–131.
Kowalski, J., & Dragan, M. (2006). Wpływ czynników miejscowych i ogólnoustrojowych na stan kliniczny tkanek przyzębia. Opis dwóch przypadków. Nowa Stomatologia, 1, 42–46.
Barczewska, E., & Nowak, A. (2000). Zaburzenia smakowe – dysgeusia. Nowa Stomatologia, 1–2, 3–8.
Górska, R. (2007). Choroby błony śluzowej jamy ustnej. Med. Tour Press International.
Gonul, M., Gul, U., Kaya, I., Kocak, O., Cakmak, S. K., Kilic, A., et al. (2011). Smoking, alcohol consumption and denture use in patients with oral mucosal lesions. Journal of Dermatology Case Reports, 4, 64–68.
National Cancer Institute & Centers for Disease Control and Prevention. (2014). Smokeless tobacco and public health: A global perspective (NIH Publication No. 14-7983). U.S. Department of Health and Human Services, Centers for Disease Control and Prevention and National Institutes of Health, National Cancer Institute.
Kallischnigg, G., Weitkunat, R., & Lee, P. N. (2008). Systematic review of the relation between smokeless tobacco and non-neoplastic oral diseases in Europe and United States. BMC Oral Health, 8, 13.
Underner, M., Perriot, J., & Peiffer, G. (2012). Smokeless tobacco. Presse Médicale, 41(3), 3–9.
Avon, S. L. (2004). Oral mucosal lesions associated with use of quid. Journal of the Canadian Dental Association, 70, 244–248.
Auluck, A., Rosin, M. P., Zhang, L., & Sumanth, K. N. (2008). Oral submucous fibrosis, a clinically benign but potentially malignant disease: Report of 3 cases and review of the literature. Journal of the Canadian Dental Association, 74, 735–740.
Sabharwal, R., Gupta, S., Kapoor, K., Puri, A., & Rajpal, K. (2013). Oral submucous fibrosis: A review. Journal of Advanced Medical and Dental Sciences Research, 1, 29–37.
Arakeri, G., Rai, K. K., Boraks, G., Patil, S. G., Aljabab, A. S., Merkx, M. A. W., et al. (2017). Current protocols in the management of oral submucous fibrosis: An update. Journal of Oral Pathology & Medicine, 46(6), 418–423.
Gopinath, D., Lai, M. H., Veettil, S. K., Balakrishnan Nair, A., & Maharajan, M. K. (2022). Comparative efficacy of interventions for the management of oral submucous fibrosis: A systematic review and network meta-analysis. Journal of Personalized Medicine, 12(8), 1272.
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Copyright (c) 2026 Adrianna Adamczyk, Maja Gałuszka, Aleksandra Gałuszka, Kamila Krycia, Karolina Mazur, Karolina Różycka, Magdalena Mulawa, Emilia Piaszczyńska, Dominika Matacz, Sandra Drabik
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