Testicular cancer: The Most Common Malignancy in Young Men – A Review of Current Knowledge on Diagnosis and Treatment

Authors

DOI:

https://doi.org/10.12775/JEHS.2026.90.70440

Keywords

testicular cancer, epidemiology, diagnostics, cancer markers, treatment

Abstract

Background. Testicular cancer is a rare malignancy that primarily affects young men and requires early diagnosis. The diagnosis is based on clinical tests, imaging tests and measurement of tumor markers. Treatment consists mainly of surgery, and further therapeutic management is adapted to the tumor type and stage.
Aim. The aim of this study was to review the literature on testicular cancer, including risk factors, prevention, diagnosis, and treatment.
Method and Materials. The literature review was conducted based on publications retrieved from the PubMed, Google Scholar, and Web of Science databases, using the keywords: testicular cancer, epidemiology, diagnostics, cancer markers, and treatment.
Results. Regular monitoring of risk factors, testicular self-examination and attention to symptoms increase the likelihood of early detection of  testicular cancer by patients. Prompt initiation of appropriate therapy allows effective disease control and improves survival outcomes
Conclusion. Testicular cancer requires special diagnostic vigilance, and early therapeutic intervention is crucial for effective treatment.

References

[1]. Nuñez-Corona D, Contreras-Sanzón E, Puente-Rivera J, et al. Epigenetic Factors and ncRNAs in Testicular Cancer. Int J Mol Sci. 2023;24(15):12194. Published 2023 Jul 30. doi:10.3390/ijms241512194

[2]. Rosenvilde JJ, Wagner T, Lauritsen J, et al. Testicular cancer [Testicular cancer]. Ugeskr Laeger. 2023;185(14):V10220664.

[3]. Pandit K, Morgan K, Riviere P, et al. Incidence of benign prostatic hyperplasia in testicular cancer survivors in the Veteran's affairs health system. World J Urol. 2025;43(1):249. Published 2025 Apr 25. doi:10.1007/s00345-025-05631-3

[4]. Tateo V, Thompson ZJ, Gilbert SM, et al. Epidemiology and Risk Factors for Testicular Cancer: A Systematic Review. Eur Urol. 2025;87(4):427-441. doi:10.1016/j.eururo.2024.10.023

[5]. Stritt K, Bohner P, Lucca I, Crettenand F. Cancer testiculaire : épidémiologie, diagnostic et prise en charge [Testicular cancer : epidemiology, diagnosis, and management]. Rev Med Suisse. 2024;20(897):2229-2233. doi:10.53738/REVMED.2024.20.897.2229

[6]. McHugh DJ, Gleeson JP, Feldman DR. Testicular cancer in 2023: Current status and recent progress. CA Cancer J Clin. 2024;74(2):167-186. doi:10.3322/caac.21819

[7]. Oldenburg J, Berney DM, Bokemeyer C, et al. Testicular seminoma and non-seminoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol. 2022;33(4):362-375. doi:10.1016/j.annonc.2022.01.002

[8]. Giona S. The Epidemiology of Testicular Cancer. In: Barber N, Ali A, eds. Urologic Cancers. Brisbane (AU): Exon Publications; September 12, 2022.

[9]. Pullen RL Jr, Canada KN. Managing testicular cancer. Nursing. 2025;55(6):17-26. doi:10.1097/NSG.0000000000000200.

[10]. Travis LB, Feldman DR, Fung C, Poynter JN, Lockley M, Frazier AL. Adolescent and Young Adult Germ Cell Tumors: Epidemiology, Genomics, Treatment, and Survivorship. J Clin Oncol. 2024;42(6):696-706. doi:10.1200/JCO.23.01099

[11]. Cayuela L, Cabrera Fernández S, Pereyra-Rodríguez JJ, Hernández-Rodríguez JC, Cayuela A. Rising testicular cancer incidence in Spain despite declining mortality: an age-period-cohort analysis. Actas Urol Esp (Engl Ed). 2024;48(8):596-602. doi:10.1016/j.acuroe.2024.05.003

[12]. Singla N, Bagrodia A, Baraban E, Fankhauser CD, Ged YMA. Testicular Germ Cell Tumors: A Review. JAMA. 2025;333(9):793-803. doi:10.1001/jama.2024.27122.

[13]. Chavarriaga J, Nappi L, Papachristofilou A, Conduit C, Hamilton RJ. Testicular cancer. Lancet. 2025;406(10498):76-90. doi:10.1016/S0140-6736(25)00455-6.

[14]. Yazici S, Del Biondo D, Napodano G, et al. Risk Factors for Testicular Cancer: Environment, Genes and Infections-Is It All?. Medicina (Kaunas). 2023;59(4):724. Published 2023 Apr 7. doi:10.3390/medicina59040724

[15]. Maiolino G, Fernández-Pascual E, Ochoa Arvizo MA, Vishwakarma R, Martínez-Salamanca JI. Male Infertility and the Risk of Developing Testicular Cancer: A Critical Contemporary Literature Review. Medicina (Kaunas). 2023;59(7):1305. Published 2023 Jul 14. doi:10.3390/medicina59071305

[16]. RAZIK, Michał, BATOR, Piotr, ROZWADOWSKA, Patrycja, RAMIAN, Jan, RYBAK, Jakub, MAGIERA, Barbara, MAGIERA, Karol and RAZIK, Wiktor. Fertility Preservation Strategies in Cancer Patients: A Comprehensive Review. Journal of Education, Health and Sport. Online. 19 February 2024. Vol. 61, pp. 129-139. [Accessed 25 March 2026]. DOI 10.12775/JEHS.2024.61.008.

[17]. Demirci A, Başar H. Effects of epidemiological risk factors on prognosis in testicular cancer. Int Urol Nephrol. 2023;55(1):51-59. doi:10.1007/s11255-022-03359-2

[18]. Chong RIH, Leow JJ, Choo ZW, Salada R, Yong DZP, Chong YL. Testicular self-examination for early detection of testicular cancer. World J Urol. 2023;41(4):941-951. doi:10.1007/s00345-023-04381-4

[19]. PIETRASZEK, Agata, BRZOZOWSKA, Joanna, CHARZYŃSKA-GULA, Marianna, ŁUCZYK, Marta, STANISŁAWEK, Andrzej and ŁUCZYK, Robert. Zapotrzebowanie na edukację z zakresu profilaktyki nowotworu jądra w grupie młodych mężczyzn - badania wstępne. Journal of Education, Health and Sport. Online. 29 July 2015. Vol. 5, no. 7, pp. 521-532.

[20]. Boisselier Q, Pinar U, Durand X, et al. Patients and general practitioner knowledge and perception of testicular self-examination for cancer. World J Urol. 2024;42(1):58. Published 2024 Jan 27. doi:10.1007/s00345-023-04707-2

[21]. Cieślikowski WA, Kasperczak M, Milecki T, Antczak A. Reasons behind the Delayed Diagnosis of Testicular Cancer: A Retrospective Analysis. Int J Environ Res Public Health. 2023;20(6):4752. Published 2023 Mar 8. doi:10.3390/ijerph20064752

[22]. Rovito MJ, Adams WB, Craycraft M, et al. The Association Between Testicular Self-Examination and Stages of Testicular Cancer Diagnosis: A Cross-Sectional Analysis. J Adolesc Young Adult Oncol. 2022;11(1):41-47. doi:10.1089/jayao.2021.0020

[23]. Lee S, Oh YT, Jung DC. 음낭 종양의 영상 소견 [Imaging of Scrotal Tumors]. Taehan Yongsang Uihakhoe Chi. 2021;82(5):1053-1065. doi:10.3348/jksr.2021.0110

[24]. Gilligan T, Lin DW, Adra N, et al. NCCN Guidelines® Insights: Testicular Cancer, Version 2.2025. J Natl Compr Canc Netw. 2025;23(4):e250018. doi:10.6004/jnccn.2025.0018

[25]. ROŚ, Bartosz, KOWALEWSKI, Wojciech, SIEKANIEC, Katarzyna, JAKUBOWICZ, Magdalena, KUCHENBEKER, Natalia, DOJS, Adriana and MIERZWIŃSKA-MUCHA, Julia. Clinical Relevance of Tumor Markers in Genitourinary Cancer Diagnosis and Treatment - a Literature Review. Journal of Education, Health and Sport. Online. 5 July 2025. Vol. 83, p. 61788. [Accessed 25 March 2026]. DOI 10.12775/JEHS.2025.83.61788.

[26]. Saidian A, Bagrodia A. Imaging Techniques to Differentiate Benign Testicular Masses from Germ Cell Tumors. Curr Urol Rep. 2023;24(9):451-454. doi:10.1007/s11934-023-01172-7

[27]. Martin FC, Conduit C, Loveland KL, Thomas B, Lewin J, Tran B. Genetics of testicular cancer: a review. Curr Opin Urol. 2022;32(5):481-487. doi:10.1097/MOU.0000000000001017

[28]. Patrikidou A, Cazzaniga W, Berney D, et al. European Association of Urology Guidelines on Testicular Cancer: 2023 Update. Eur Urol. 2023;84(3):289-301. doi:10.1016/j.eururo.2023.04.010

[29]. Schoch J, Schmelz H, Dieckmann KP, Nestler T. Neue Tumormarker bei Hodentumoren – im hier und jetzt und in der Zukunft [New tumor markers for testicular cancer - in the here and now and in the future]. Aktuelle Urol. 2024;55(6):520-527. doi:10.1055/a-2422-0354

[30]. Singla N, Lafin JT, Bagrodia A. MicroRNAs: Turning the Tide in Testicular Cancer. Eur Urol. 2019;76(5):541-542. doi:10.1016/j.eururo.2019.06.010

[31]. Ditonno F, Franco A, Manfredi C, et al. The Role of miRNA in Testicular Cancer: Current Insights and Future Perspectives. Medicina (Kaunas). 2023;59(11):2033. Published 2023 Nov 17. doi:10.3390/medicina59112033

[32]. Baird DC, Meyers GJ, Hu JS. Testicular Cancer: Diagnosis and Treatment. Am Fam Physician. 2018;97(4):261-268.

[33]. Stephenson A, Bass EB, Bixler BR, et al. Diagnosis and Treatment of Early-Stage Testicular Cancer: AUA Guideline Amendment 2023. J Urol. 2024;211(1):20-25. doi:10.1097/JU.0000000000003694

[34]. Passarelli R, Pfail JL, Jang TL. Contemporary surgical management of testicular seminoma. Transl Cancer Res. 2024;13(11):6463-6472. doi:10.21037/tcr-24-241

[35]. Krege S, Oing C, Bokemeyer C. Testicular Tumors. Dtsch Arztebl Int. 2023;120(49):843-854. doi:10.3238/arztebl.m2023.0143

Journal of Education, Health and Sport

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2026-04-18

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1.
KRYCIA, Kamila, MAZUR , Karolina, RÓŻYCKA , Karolina, MULAWA, Magdalena, GAŁUSZKA, Aleksandra, PIASZCZYŃSKA , Emilia, MATACZ , Dominika, DRABIK, Sandra, GAŁUSZKA , Maja and ADAMCZYK , Adrianna. Testicular cancer: The Most Common Malignancy in Young Men – A Review of Current Knowledge on Diagnosis and Treatment. Journal of Education, Health and Sport. Online. 18 April 2026. Vol. 90, p. 70440. [Accessed 19 April 2026]. DOI 10.12775/JEHS.2026.90.70440.

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Vol. 90 (2026)

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Medical Sciences

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Copyright (c) 2026 Kamila Krycia, Karolina Mazur , Karolina Różycka , Magdalena Mulawa, Aleksandra Gałuszka, Emilia Piaszczyńska , Dominika Matacz , Sandra Drabik, Maja Gałuszka , Adrianna Adamczyk

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