Eat, sleep and feel better - the impact of intermittent fasting on sleep and general well-being
DOI:
https://doi.org/10.12775/JEHS.2026.89.69909Keywords
intermittent fasting, circadian rhythm, sleep, quality of life, metabolic diseases, inflammationAbstract
Background
Intermittent fasting (IF) is a dietary pattern based on alternating fasting and feeding periods.
It is gaining attention for its potential effects on sleep, health, and well-being. Current evidence on these links remains limited and inconsistent.
Objective
To analyze and synthesize existing studies on intermittent fasting and evaluate its potential impact on sleep outcomes and overall well-being, including possible underlying mechanisms.
Methods
A systematic literature search was conducted using PubMed and Google Scholar. Articles published between 2015 and 2025 were reviewed. Keywords included: circadian rhythm, intermittent fasting, sleep, quality of life.
Results
Intermittent fasting shows small but noticeable improvements in perceived well-being, including better mood, reduced inflammation, and enhanced cognitive functioning. Its effects on sleep remain modest and inconsistent: some studies report slight improvements in subjective sleep quality, while objective measures reveal minimal or no change, with occasional worsening of sleep efficiency. In terms of health, IF supports metabolic regulation by improving insulin sensitivity, glucose control, and lipid profile.
Conclusions
Intermittent fasting appears to exert variable effects on sleep and well-being and also supports metabolic health and weight control. Current research is not yet sufficient to define clear clinical guidance. IF may benefit some individuals, although its safety and effectiveness vary. More long-term, well-designed studies are needed to identify protocols that provide meaningful benefits with minimal risk.
References
1. Vasim I, Majeed CN, DeBoer MD. Intermittent Fasting and Metabolic Health. Nutrients. 2022;14(3):631. doi:10.3390/nu14030631
2. Conde-Pipó J, Mora-Fernandez A, Martinez-Bebia M, et al. Intermittent Fasting: Does It Affect Sports Performance? A Systematic Review. Nutrients. 2024;16(1):168. doi:10.3390/nu16010168
3. Wojtczak M, Michał Pniak, Paweł Miklis, et al. Intermittent Fasting: Weighing the Benefits and Drawbacks for Health and Longevity – A Comprehensive Literature Review. Qual Sport. 2025;37:57195. doi:10.12775/QS.2025.37.57195
4. Dias GP, Murphy T, Stangl D, et al. Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho. Mol Psychiatry. 2021;26(11):6365-6379. doi:10.1038/s41380-021-01102-4
5. Murta L, Seixas D, Harada L, Damiano RF, Zanetti M. Intermittent Fasting as a Potential Therapeutic Instrument for Major Depression Disorder: A Systematic Review of Clinical and Preclinical Studies. Int J Mol Sci. 2023;24(21):15551. doi:10.3390/ijms242115551
6. Chaput JP, McHill AW, Cox RC, et al. The role of insufficient sleep and circadian misalignment in obesity. Nat Rev Endocrinol. 2023;19(2):82-97. doi:10.1038/s41574-022-00747-7
7. Sejbuk M, Mirończuk-Chodakowska I, Witkowska AM. Sleep Quality: A Narrative Review on Nutrition, Stimulants, and Physical Activity as Important Factors. Nutrients. 2022;14(9):1912. doi:10.3390/nu14091912
8. Ross DA, Hinton R, Melles-Brewer M, et al. Adolescent Well-Being: A Definition and Conceptual Framework. J Adolesc Health. 2020;67(4):472-476. doi:10.1016/j.jadohealth.2020.06.042
9. Wren-Lewis S, Alexandrova A. Mental Health Without Well-being. J Med Philos Forum Bioeth Philos Med. 2021;46(6):684-703. doi:10.1093/jmp/jhab032
10. Hepsomali P, Groeger JA. Diet, Sleep, and Mental Health: Insights from the UK Biobank Study. Nutrients. 2021;13(8):2573. doi:10.3390/nu13082573
11. Hastings MH, Maywood ES, Brancaccio M. Generation of circadian rhythms in the suprachiasmatic nucleus. Nat Rev Neurosci. 2018;19(8):453-469. doi:10.1038/s41583-018-0026-z
12. Patterson RE, Sears DD. Metabolic Effects of Intermittent Fasting. Annu Rev Nutr. 2017;37(1):371-393. doi:10.1146/annurev-nutr-071816-064634
13. Mukherji A, Kobiita A, Damara M, et al. Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome. Proc Natl Acad Sci. 2015;112(48). doi:10.1073/pnas.1519807112
14. Hu D, Xie Z, Ye Y, Bahijri S, Chen M. The beneficial effects of intermittent fasting: an update on mechanism, and the role of circadian rhythm and gut microbiota. Hepatobiliary Surg Nutr. 2020;9(5):597-602. doi:10.21037/hbsn-20-317
15. Deota S, Lin T, Chaix A, et al. Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals. Cell Metab. 2023;35(1):150-165.e4. doi:10.1016/j.cmet.2022.12.006
16. Elias A, Padinjakara N, Lautenschlager NT. Effects of intermittent fasting on cognitive health and Alzheimer’s disease. Nutr Rev. 2023;81(9):1225-1233. doi:10.1093/nutrit/nuad021
17. Lee JH, Verma N, Thakkar N, Yeung C, Sung HK. Intermittent Fasting: Physiological Implications on Outcomes in Mice and Men. Physiology. 2020;35(3):185-195. doi:10.1152/physiol.00030.2019
18. Oliveira LDC, Morais GP, Ropelle ER, et al. Using Intermittent Fasting as a Non-pharmacological Strategy to Alleviate Obesity-Induced Hypothalamic Molecular Pathway Disruption. Front Nutr. 2022;9:858320. doi:10.3389/fnut.2022.858320
19. Liu H, Javaheri A, Godar RJ, et al. Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway. Autophagy. 2017;13(11):1952-1968. doi:10.1080/15548627.2017.1368596
20. Stolarczyk SP, Romańczuk KB, Wójcik ZM, et al. The Impact of Time-Restricted Eating and Intermittent Fasting on Glycemia, Body Weight, and Overall Well-Being in Patients with Type 2 Diabetes – A Review of Studies. Qual Sport. 2025;38:58230. doi:10.12775/QS.2025.38.58230
21. McStay M, Gabel K, Cienfuegos S, Ezpeleta M, Lin S, Varady KA. Intermittent Fasting and Sleep: A Review of Human Trials. Nutrients. 2021;13(10):3489. doi:10.3390/nu13103489
22. Kim BH, Joo Y, Kim MS, Choe HK, Tong Q, Kwon O. Effects of Intermittent Fasting on the Circulating Levels and Circadian Rhythms of Hormones. Endocrinol Metab. 2021;36(4):745-756. doi:10.3803/EnM.2021.405
23. Martin CK, Bhapkar M, Pittas AG, et al. Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Trial. JAMA Intern Med. 2016;176(6):743. doi:10.1001/jamainternmed.2016.1189
24. Hudson JL, Zhou J, Campbell WW. Adults Who Are Overweight or Obese and Consuming an Energy-Restricted Healthy US-Style Eating Pattern at Either the Recommended or a Higher Protein Quantity Perceive a Shift from “Poor” to “Good” Sleep: A Randomized Controlled Trial. J Nutr. 2020;150(12):3216-3223. doi:10.1093/jn/nxaa302
25. Kalam F, Gabel K, Cienfuegos S, Ezpeleta M, Wiseman E, Varady KA. Alternate Day Fasting Combined with a Low Carbohydrate Diet: Effect on Sleep Quality, Duration, Insomnia Severity and Risk of Obstructive Sleep Apnea in Adults with Obesity. Nutrients. 2021;13(1):211. doi:10.3390/nu13010211
26. Manoogian ENC, Wei-Shatzel J, Panda S. Assessing temporal eating pattern in free living humans through the myCircadianClock app. Int J Obes. 2022;46(4):696-706. doi:10.1038/s41366-021-01038-3
27. Zhou J, Kim JE, Armstrong CL, Chen N, Campbell WW. Higher-protein diets improve indexes of sleep in energy-restricted overweight and obese adults: results from 2 randomized controlled trials. Am J Clin Nutr. 2016;103(3):766-774. doi:10.3945/ajcn.115.124669
28. Gill S, Panda S. A Smartphone App Reveals Erratic Diurnal Eating Patterns in Humans that Can Be Modulated for Health Benefits. Cell Metab. 2015;22(5):789-798. doi:10.1016/j.cmet.2015.09.005
29. Lim KG, Morgenthaler TI, Katzka DA. Sleep and Nocturnal Gastroesophageal Reflux. Chest. 2018;154(4):963-971. doi:10.1016/j.chest.2018.05.030
30. Surdea-Blaga T, Negrutiu DE, Palage M, Dumitrascu DL. Food and Gastroesophageal Reflux Disease. Curr Med Chem. 2019;26(19):3497-3511. doi:10.2174/0929867324666170515123807
31. Cienfuegos S, Gabel K, Kalam F, et al. The effect of 4-h versus 6-h time restricted feeding on sleep quality, duration, insomnia severity and obstructive sleep apnea in adults with obesity. Nutr Health. 2022;28(1):5-11. doi:10.1177/02601060211002347
32. Gabel K, Hoddy KK, Burgess HJ, Varady KA. Effect of 8-h time-restricted feeding on sleep quality and duration in adults with obesity. Appl Physiol Nutr Metab. 2019;44(8):903-906. doi:10.1139/apnm-2019-0032
33. Lessan N, Ali T. Energy Metabolism and Intermittent Fasting: The Ramadan Perspective. Nutrients. 2019;11(5):1192. doi:10.3390/nu11051192
34. Yamada RG, Ueda HR. Molecular Mechanisms of REM Sleep. Front Neurosci. 2020;13:1402. doi:10.3389/fnins.2019.01402
35. Almeneessier AS, BaHammam AS. How does diurnal intermittent fasting impact sleep, daytime sleepiness, and markers of the biological clock? Current insights. Nat Sci Sleep. 2018;Volume 10:439-452. doi:10.2147/NSS.S165637
36. Fernández-Rodríguez R, Martínez-Vizcaíno V, Mesas AE, Notario-Pacheco B, Medrano M, Heilbronn LK. Does intermittent fasting impact mental disorders? A systematic review with meta-analysis. Crit Rev Food Sci Nutr. 2023;63(32):11169-11184. doi:10.1080/10408398.2022.2088687
37. Pereira M, Liang J, Edwards-Hicks J, et al. Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting. Cell Rep. 2024;43(2):113700. doi:10.1016/j.celrep.2024.113700
38. Beveridge J, Montgomery A, Grossberg G. Intermittent fasting and neurocognitive disorders: What the evidence shows. J Nutr Health Aging. 2025;29(4):100480. doi:10.1016/j.jnha.2025.100480
39. Stencel NJ, Szczot J, Krala-Szkaradowska M, Skrzypczak KO, Stuczyński SK. Impact of Intermittent Fasting on Alzheimer’s Disease Risk: A Literature Review. Qual Sport. 2024;23:55272. doi:10.12775/QS.2024.23.55272
40. Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017;39:46-58. doi:10.1016/j.arr.2016.10.005
41. Kaźmierczak A, Perkowska K, Kiełb A, et al. Effects of Intermittent Fasting on Weight Loss and Metabolic Health. Qual Sport. 2024;22:54618. doi:10.12775/QS.2024.22.54618
42. Lv R, Liu B, Jiang Z, et al. Intermittent fasting and neurodegenerative diseases: Molecular mechanisms and therapeutic potential. Metabolism. 2025;164:156104. doi:10.1016/j.metabol.2024.156104
43. Wang Y, Wu R. The Effect of Fasting on Human Metabolism and Psychological Health. Xu Y, ed. Dis Markers. 2022;2022:1-7. doi:10.1155/2022/5653739
44. Rabiei S. The Association of Different Types of Intermittent Fasting with Mental Health: A Protocol for Systematic Review. Int J Prev Med. 2025;16. doi:10.4103/ijpvm.ijpvm_312_24
45. Kowalczuk M, Lipińska J, Lipiński Ł, Kopeć I. Intermittent fasting and its influence on health and sports results. J Educ Health Sport. 2024;57:11-25. doi:10.12775/JEHS.2024.57.001
46. Zang BY, He LX, Xue L. Intermittent Fasting: Potential Bridge of Obesity and Diabetes to Health? Nutrients. 2022;14(5):981. doi:10.3390/nu14050981
47. Minciuna I, Gallage S, Heikenwalder M, Zelber-Sagi S, Dufour JF. Intermittent fasting—the future treatment in NASH patients? Hepatology. 2023;78(4):1290-1305. doi:10.1097/HEP.0000000000000330
48. Mazurek J, Stachowicz H, Adamczyk M, et al. Intermittent fasting - a diet to fight type 2 diabetes and obesity - current state of knowledge. J Educ Health Sport. 2024;67:55044. doi:10.12775/JEHS.2024.67.55044
49. Diab R, Dimachkie L, Zein O, Dakroub A, Eid AH. Intermittent Fasting Regulates Metabolic Homeostasis and Improves Cardiovascular Health. Cell Biochem Biophys. 2024;82(3):1583-1597. doi:10.1007/s12013-024-01314-9
50. Dyńka D, Rodzeń Ł, Rodzeń M, et al. Intermittent fasting in the treatment of type 2 diabetes. Front Nutr. 2025;12:1629154. doi:10.3389/fnut.2025.1629154
51. Guo L, Xi Y, Jin W, et al. A 5:2 Intermittent Fasting Meal Replacement Diet and Glycemic Control for Adults With Diabetes: The EARLY Randomized Clinical Trial. JAMA Netw Open. 2024;7(6):e2416786. doi:10.1001/jamanetworkopen.2024.16786
52. Obermayer A, Tripolt NJ, Pferschy PN, et al. Efficacy and Safety of Intermittent Fasting in People With Insulin-Treated Type 2 Diabetes (INTERFAST-2)—A Randomized Controlled Trial. Diabetes Care. 2023;46(2):463-468. doi:10.2337/dc22-1622
53. Couto S, Cenit MC, Montero J, Iguacel I. The impact of intermittent fasting and Mediterranean diet on older adults’ physical health and quality of life: A randomized clinical trial. Nutr Metab Cardiovasc Dis. 2025;35(10):104132. doi:10.1016/j.numecd.2025.104132
54. Bohlman C, McLaren C, Ezzati A, Vial P, Ibrahim D, Anton SD. The effects of time-restricted eating on sleep in adults: a systematic review of randomized controlled trials. Front Nutr. 2024;11:1419811. doi:10.3389/fnut.2024.1419811
55. Kesztyüs D, Fuchs M, Cermak P, Kesztyüs T. Associations of time-restricted eating with health-related quality of life and sleep in adults: a secondary analysis of two pre-post pilot studies. BMC Nutr. 2020;6(1):76. doi:10.1186/s40795-020-00402-2
56. Duan D, Pham LV, Jun JC, et al. Effects of time-restricted eating on actigraphy-derived sleep parameters: post hoc analysis of a randomized, isocaloric feeding study. SLEEP. 2025;48(9):zsaf089. doi:10.1093/sleep/zsaf089
57. Lubczyńska Z, Popravko Y, Lewandowski MM, et al. Intermittent fasting – a novel approach to treating overweight and obesity? – meta-analysis and literature review. J Educ Health Sport. 2023;38(1):64-80. doi:10.12775/JEHS.2023.38.01.005
58. Manoogian ENC, Chow LS, Taub PR, Laferrère B, Panda S. Time-restricted Eating for the Prevention and Management of Metabolic Diseases. Endocr Rev. 2022;43(2):405-436. doi:10.1210/endrev/bnab027
59. Chawla S, Beretoulis S, Deere A, Radenkovic D. The Window Matters: A Systematic Review of Time Restricted Eating Strategies in Relation to Cortisol and Melatonin Secretion. Nutrients. 2021;13(8):2525. doi:10.3390/nu13082525
60. Hooshiar SH, Yazdani A, Jafarnejad S. Comparison of the effect of modified intermittent fasting and daily calorie restriction on sleep quality, anthropometric data, and body composition in women with obesity or overweight: study protocol of a randomized controlled trial. Trials. 2023;24(1):30. doi:10.1186/s13063-023-07070-0
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Patrycja Chudzik, Martyna Zdych, Zuzanna Cisowska, Maksym Bodziony, Andrzej Terebus, Julia Sobala, dr Dagmara Gaweł-Dąbrowska

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 128
Number of citations: 0