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Journal of Education, Health and Sport

Gut Microbiota Dysbiosis and Probiotic Supplementation in IBD: A Narrative Review
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Gut Microbiota Dysbiosis and Probiotic Supplementation in IBD: A Narrative Review

Authors

  • Małgorzata Wandzel Medical University of Silesia, Poniatowskiego 15, 40-055 Katowice https://orcid.org/0009-0003-1151-3346
  • Daria Twardowska Medical University of Silesia, Poniatowskiego 15, 40-055 Katowice https://orcid.org/0009-0004-5807-4915
  • Wiktoria Tłoczek Medical University of Silesia, Poniatowskiego 15, 40-055 Katowice https://orcid.org/0009-0004-7722-5037
  • Barbara Tomczak Medical University of Silesia, Poniatowskiego 15, 40-055 Katowice https://orcid.org/0009-0004-3113-4922
  • Kamil Topolski Medical University of Silesia, Poniatowskiego 15, 40-055 Katowice https://orcid.org/0009-0002-8552-8332
  • Dominika Żukowiecka-Sęga Medical University of Silesia, Poniatowskiego 15, 40-055 Katowice https://orcid.org/0009-0000-3426-7393
  • Wiktoria Śliwa Medical University of Silesia, Poniatowskiego 15, 40-055 Katowice https://orcid.org/0009-0009-2406-853X
  • Barbara Jelonek Medical University of Silesia, Poniatowskiego 15, 40-055 Katowice https://orcid.org/0009-0007-5238-0710
  • Karolina Klubikowska Medical University of Silesia, Poniatowskiego 15, 40-055 Katowice https://orcid.org/0009-0002-7893-3081
  • Dagmara Porada Medical University of Silesia, Poniatowskiego 15, 40-055 Katowice https://orcid.org/0009-0000-5326-3996

DOI:

https://doi.org/10.12775/QS.2026.88.69386

Keywords

Inflammatory Bowel Disease, IBD, Crohn's disease, Ulcerative colitis, Probiotics, Microbiota

Abstract

Inflammatory bowel diseases (IBD) are chronic, multifactorial disorders with yet unclear etiopathogenesis. The incidence of this illness continues to rise. Growing amounts of evidence suggest environmental factors, particularly diet, as important for the onset and progression of IBD. Diet affects the function and composition of the gut microbiota which has been implicated in its pathophysiology. Therefore, interest is growing in the therapeutic potential of microbiota-modulating therapies, including probiotics. Although the latter one is considered adjunct therapy in managing IBD, evidence regarding their effectiveness are inconsistent.

 

References

Bai, J., Bouwknegt, D. G., Weersma, R. K., Dijkstra, G., van der Sloot, K. W. J., & Festen, E. A. M. (2025). Gene-Environment Interactions in Inflammatory Bowel Disease: A Systematic Review of Human Epidemiologic Studies. Journal of Crohn’s and Colitis, 19(6), jjaf061. https://doi.org/10.1093/ecco-jcc/jjaf061

Bertin, B., Foligne, B., Ley, D., Lesage, J., Beghin, L., Morcel, J., Gottrand, F., & Hermann, E. (2023). An Overview of the Influence of Breastfeeding on the Development of Inflammatory Bowel Disease. Nutrients, 15(24), 5103. https://doi.org/10.3390/nu15245103

Chiba, M., Nakane, K., & Komatsu, M. (2019). Westernized Diet is the Most Ubiquitous Environmental Factor in Inflammatory Bowel Disease. The Permanente Journal, 23(1), 18–107. https://doi.org/10.7812/TPP/18-107

Dar, S. H., Maniya, M. T., Merza, N., Musheer, A., Zahid, M., Ahmed, F., Shurjeel, Q., Qazi, S., Ahmed, A., Shah, H., Zafar, A., Iqbal, A. Z., Khan, S. F., Rizwan, T., & Ligresti, R. (2023). The association of antibiotic exposure with new-onset inflammatory bowel disease: A systematic review and meta-analysis. Clinics and Research in Hepatology and Gastroenterology, 47(6), 102129. https://doi.org/10.1016/j.clinre.2023.102129

Estevinho, M. M., Yuan, Y., Rodríguez-Lago, I., Sousa-Pimenta, M., Dias, C. C., Barreiro-de Acosta, M., Jairath, V., & Magro, F. (2024). Efficacy and safety of probiotics in IBD: An overview of systematic reviews and updated meta-analysis of randomized controlled trials. United European Gastroenterology Journal, 12(7), 960–981. https://doi.org/10.1002/ueg2.12636

Heydari, K., Rahnavard, M., Ghahramani, S., Hoseini, A., Alizadeh-Navaei, R., Rafati, S., Raei, M., Vahidipour, M., Salehi, F., Motafeghi, F., Neshat, S., Moosazadeh, M., Yousefi, M., Pourali, F., Rasouli, K., Shokrirad, S., Lotfi, P., Beladi, S.-A., Neisanghalb, M. H., … Moghadam, S. (2025). Global prevalence and incidence of inflammatory bowel disease: A systematic review and meta-analysis of population-based studies. Gastroenterology and Hepatology from Bed to Bench, 18(2). https://doi.org/10.22037/ghfbb.v18i2.3105

Hijová, E. (2025). Probiotics in IBD: Evidence and Perspectives on Patient Health and Disease Management. International Journal of Molecular Sciences, 26(18), 9065. https://doi.org/10.3390/ijms26189065

Huang, Z., Liu, B., Xiao, L., Liao, M., Huang, L., Zhao, X., Ma, K., Wang, R., Ji, F., Li, W., Huang, L., & Xie, L. (2024). Effects of breast-fed infants-derived Limosilactobacillus reuteri and Bifidobacterium breve ameliorate DSS-induced colitis in mice. iScience, 27(10). https://doi.org/10.1016/j.isci.2024.110902

Iyer, N., & Corr, S. C. (2021). Gut Microbial Metabolite-Mediated Regulation of the Intestinal Barrier in the Pathogenesis of Inflammatory Bowel Disease. Nutrients, 13(12), 4259. https://doi.org/10.3390/nu13124259

Jans, D., & Cleynen, I. (2023). The genetics of non-monogenic IBD. Human Genetics, 142(5), 669–682. https://doi.org/10.1007/s00439-023-02521-9

Juhl, A. E., Westfall, M., Hebbelstrup Jensen, B., & Mirsepasi-Lauridsen, H. C. (2025). Gut Microbiota in IBD: The Beneficial and Adverse Effects of Diet and Medication. Nutrients, 18(1), 9. https://doi.org/10.3390/nu18010009

Kaur, L., Gordon, M., Baines, P. A., Iheozor-Ejiofor, Z., Sinopoulou, V., & Akobeng, A. K. (2020). Probiotics for induction of remission in ulcerative colitis. Cochrane Database of Systematic Reviews, (3). https://doi.org/10.1002/14651858.CD005573.pub3

Khan, I., Ullah, N., Zha, L., Bai, Y., Khan, A., Zhao, T., Che, T., & Zhang, C. (2019). Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome. Pathogens, 8(3), 126. https://doi.org/10.3390/pathogens8030126

Limketkai, B. N., Akobeng, A. K., Gordon, M., & Adepoju, A. A. (2020). Probiotics for induction of remission in Crohn’s disease. Cochrane Database of Systematic Reviews, (7). https://doi.org/10.1002/14651858.CD006634.pub3

Ma, T., Gan, G., Cheng, J., Shen, Z., Zhang, G., Liu, S., & Hu, J. (2025). Engineered Probiotics Enable Targeted Gut Delivery of Dual Gasotransmitters for Inflammatory Bowel Disease Therapy. Angewandte Chemie International Edition, 64(22), e202502588. https://doi.org/10.1002/anie.202502588

Ma, Y., Yang, D., Huang, J., Liu, K., Liu, H., Wu, H., & Bao, C. (2024). Probiotics for inflammatory bowel disease: Is there sufficient evidence? Open Life Sciences, 19(1). https://doi.org/10.1515/biol-2022-0821

Ng, S. C., Shi, H. Y., Hamidi, N., Underwood, F. E., Tang, W., Benchimol, E. I., Panaccione, R., Ghosh, S., Wu, J. C. Y., Chan, F. K. L., Sung, J. J. Y., & Kaplan, G. G. (2017). Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies. The Lancet, 390(10114), 2769–2778. https://doi.org/10.1016/S0140-6736(17)32448-0

Rubin, D. T., Ananthakrishnan, A. N., Siegel, C. A., Barnes, E. L., & Long, M. D. (2025). ACG Clinical Guideline Update: Ulcerative Colitis in Adults. Official Journal of the American College of Gastroenterology | ACG, 120(6), 1187. https://doi.org/10.14309/ajg.0000000000003463

Sabino, J., Tarassishin, L., Eisele, C., Hawkins, K., Barré, A., Nair, N., Rendon, A., Debebe, A., Picker, M., Agrawal, M., Stone, J., George, J., Legnani, P., Maser, E., Chen, C.-L., Thjømøe, A., Mørk, E., Dubinsky, M., Hu, J., … Torres, J. (2023). Influence of Early Life Factors, including breast milk Composition, on the Microbiome of Infants Born to Mothers with and without Inflammatory Bowel Disease. Journal of Crohn’s and Colitis, 17(11), 1723–1732. https://doi.org/10.1093/ecco-jcc/jjad096

Shivashankar, R., & Lewis, J. D. (2017). The Role of Diet in Inflammatory Bowel Disease. Current Gastroenterology Reports, 19(5), 22. https://doi.org/10.1007/s12664-019-00976-1

Størdal, K., Andersen, S., Mårild, K., Larsson, V., & Imberg, H. (2026). Systematic review and meta-analysis of childhood exposure to antibiotics and the subsequent risk of IBD. Inflammatory Bowel Diseases, izaf324. https://doi.org/10.1093/ibd/izaf324

Vaghela, P., Dave, B., Dabhade, A., Deshmukh, R., Prajapati, B., Alsaidan, O. A., Patel, S., Mehta, A., Singh, A., & Dudhat, K. (2026). Redrawing the gut map: Evolving probiotic approaches to microbiota modulation in inflammatory bowel disease. Antonie van Leeuwenhoek, 119(3), 51. https://doi.org/10.1007/s10482-026-02254-5

Vakadaris, G., Stefanis, C., Giorgi, E., Brouvalis, M., Voidarou, C. (Chrysa), Kourkoutas, Y., Tsigalou, C., & Bezirtzoglou, E. (2023). The Role of Probiotics in Inducing and Maintaining Remission in Crohn’s Disease and Ulcerative Colitis: A Systematic Review of the Literature. Biomedicines, 11(2), 494. https://doi.org/10.3390/biomedicines11020494

Weingarden, A. R., & Ko, C. W. (2024). Non-prescription Therapeutics. Official Journal of the American College of Gastroenterology | ACG, 119(1S), S7. https://doi.org/10.14309/ajg.0000000000002578

Yang, Q.-H., & Zhang, C.-N. (2025). Comparative study on the pathogenesis of Crohn’s disease and ulcerative colitis. World Journal of Gastroenterology, 31(19). https://doi.org/10.3748/wjg.v31.i19.106406

Zakerska-Banaszak, O., Zuraszek-Szymanska, J., Eder, P., Ladziak, K., Slomski, R., & Skrzypczak-Zielinska, M. (2024). The Role of Host Genetics and Intestinal Microbiota and Metabolome as a New Insight into IBD Pathogenesis. International Journal of Molecular Sciences, 25(17), 9589. https://doi.org/10.3390/ijms25179589

Zheng, M., Han, R., Yuan, Y., Xing, Y., Zhang, W., Sun, Z., Liu, Y., Li, J., & Mao, T. (2023). The role of Akkermansia muciniphila in inflammatory bowel disease: Current knowledge and perspectives. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.1089600

Zhou, J., Li, M., Chen, Q., Li, X., Chen, L., Dong, Z., Zhu, W., Yang, Y., Liu, Z., & Chen, Q. (2022). Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery. Nature Communications, 13(1), 3432. https://doi.org/10.1038/s41467-022-31171-0

Journal of Education, Health and Sport

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Published

2026-03-15

How to Cite

1.
WANDZEL, Małgorzata, TWARDOWSKA, Daria, TŁOCZEK, Wiktoria, TOMCZAK, Barbara, TOPOLSKI, Kamil, ŻUKOWIECKA-SĘGA, Dominika, ŚLIWA, Wiktoria, JELONEK, Barbara, KLUBIKOWSKA, Karolina and PORADA, Dagmara. Gut Microbiota Dysbiosis and Probiotic Supplementation in IBD: A Narrative Review. Journal of Education, Health and Sport. Online. 15 March 2026. Vol. 88, p. 69386. [Accessed 26 March 2026]. DOI 10.12775/QS.2026.88.69386.
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Vol. 88 (2026)

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Copyright (c) 2026 Małgorzata Wandzel, Daria Twardowska, Wiktoria Tłoczek, Barbara Tomczak, Kamil Topolski, Dominika Żukowiecka-Sęga, Wiktoria Śliwa, Barbara Jelonek, Karolina Klubikowska, Dagmara Porada

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