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Journal of Education, Health and Sport

Cefiderocol - a promising new antibiotic for the antibiotic-resistant pathogens of the highest epidemiological priority
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  • Cefiderocol - a promising new antibiotic for the antibiotic-resistant pathogens of the highest epidemiological priority
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Cefiderocol - a promising new antibiotic for the antibiotic-resistant pathogens of the highest epidemiological priority

Authors

  • Karol Lorenc Lorenc Student Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin
  • Magdalena Kozioł Student Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin
  • Alicja Sobek Student Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin
  • Mateusz Pawlicki Student Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin
  • Anna Łopuszyńska Student Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin
  • Zofia Misztal Student Scientific Association at Department of Family Medicine, Medical University of Lodz
  • Marcin Lewicki Department of Epidemiology and Clinical Research Methodology of the Medical University of Lublin
  • Agata Smoleń Department of Epidemiology and Clinical Research Methodology of the Medical University of Lublin

Keywords

Cefiderocol, cephalosporin, antibiotic resistance

Abstract

Increase in the incidence of multidrug-resistant Gram-negative bacterial strains pose a significant threat to healthcare system worldwide. New antibiotics are necessary to combat particularly resitant pathogens. WHO’s global priority pathogens list was published in 2017 to promote research and development of new antibiotics, as part of WHO’s efforts to address growing global resistance to antimicrobial agents. Acinetobacter baumannii, Pseudomonas aeruginosa and carbapenem-resistant, third-generation cephalosporin-resistant Enterobacteriaceae were classified as highest priority pathogens requiring a new antibiotic treatment options. Cefiderocol is a novel parenteral siderophore cephalosporin that shows efficacy against listed Gram-negative bacteria. The results of the presented studies showed that cefiderocol has a strong antimicrobial effect against problematic strains that produce carbapenemases, such as KPC (K. pneumoniae carbapenemase) and B-class metallo-β-lactamases, including NDM-1 (New Delhi metallo-β-lactamase), as well as the ESBL-producing strains. In addition, it does not require the use of the β-lactamase inhibitor. The new agent demonstrates a favorable side effect profile. There is an urgent need to develop new antibiotics. Cefiderocol is a new antibiotic that has a potential to effectively combat particularly resistant bacteries such as carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, as well as carbapenem and 3rd generation cephalosporin-resistant Enterobacteriaceae.

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Published

2019-05-04

How to Cite

1.
LORENC, Karol Lorenc, KOZIOŁ, Magdalena, SOBEK, Alicja, PAWLICKI, Mateusz, ŁOPUSZYŃSKA, Anna, MISZTAL, Zofia, LEWICKI, Marcin and SMOLEŃ, Agata. Cefiderocol - a promising new antibiotic for the antibiotic-resistant pathogens of the highest epidemiological priority. Journal of Education, Health and Sport. Online. 4 May 2019. Vol. 9, no. 5, pp. 81-88. [Accessed 24 May 2025].
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Issue

Vol. 9 No. 5 (2019)

Section

Review Articles

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The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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