Rosacea and Anxiety Disorders - Psychosocial Impact, Quality of Life and Integrated Management
DOI:
https://doi.org/10.12775/JEHS.2026.88.68382Keywords
rosacea, anxiety disorders, quality of life, mental health, psychodermatology, stressAbstract
Introduction and purpose: Rosacea is a chronic inflammatory facial skin disease that may be associated with significant psychosocial burden. Studies indicate that affected individuals may experience anxiety, reduced self-esteem and lower quality of life compared with the general population. This review aims to summarize current evidence on the epidemiology, pathophysiology, psychosocial impact and integrated management of rosacea with coexisting anxiety disorders.
Materials and methods: A literature review was performed using PubMed and Google Scholar, focusing on English-language publications. Priority was given to systematic reviews, meta-analyses, randomized controlled trials and observational studies.
State of knowledge: Rosacea is a common chronic inflammatory skin disease in adults, more frequently reported in women and individuals with fair skin. Its etiopathogenesis is thought to involve immune dysregulation, neurovascular abnormalities and skin-brain axis dysfunction. Facial manifestations are associated with an increased risk of social anxiety, internalized stigma and reduced quality of life. Studies indicate that patients with rosacea may have an over twofold increased risk of anxiety disorders compared with the general population. Evidence suggests that dermatological treatment, combined with cognitive-behavioral therapy and stress management, can improve skin symptoms and psychological well-being.
Conclusions: The bidirectional link between rosacea and anxiety disorders highlights the need for holistic management. Combining dermatological treatment with mental health assessment and psychological support may improve quality of life, reduce psychosocial burden and help interrupt the cycle of stress and disease exacerbation.
References
1. van Zuuren EJ, Arents BWM, van der Linden MMD, Vermeulen S, Fedorowicz Z, Tan J. Rosacea: New Concepts in Classification and Treatment. Am J Clin Dermatol. 2021;22(4):457-465. https://doi.org/10.1007/s40257-021-00595-7
2. Fisher GW, Travers JB, Rohan CA. Rosacea pathogenesis and therapeutics: current treatments and a look at future targets. Front Med (Lausanne). 2023;10:1292722. https://doi.org/10.3389/fmed.2023.1292722
3. Geng RSQ, Bourkas AN, Mufti A, Sibbald RG. Rosacea: Pathogenesis and Therapeutic Correlates. J Cutan Med Surg. 2024;28(2):178-189. https://doi.org/10.1177/12034754241229365
4. Mar K, Rivers JK. The Mind Body Connection in Dermatologic Conditions: A Literature Review. J Cutan Med Surg. 2023;27(6):628-640. https://doi.org/10.1177/12034754231204295
5. Gether L, Overgaard LK, Egeberg A, Thyssen JP. Incidence and prevalence of rosacea: a systematic review and meta-analysis. Br J Dermatol. 2018;179(2):282-289. https://doi.org/10.1111/bjd.16481
6. Bandelow B, Michaelis S. Epidemiology of anxiety disorders in the 21st century. Dialogues Clin Neurosci. 2015;17(3):327-335. https://doi.org/10.31887/DCNS.2015.17.3/bbandelow
7. O'Leary KB, Khan JS. Pharmacotherapy for Anxiety Disorders. Psychiatr Clin North Am. 2024;47(4):689-709. https://doi.org/10.1016/j.psc.2024.04.012
8. Heisig M, Reich A. Psychosocial aspects of rosacea with a focus on anxiety and depression. Clin Cosmet Investig Dermatol. 2018;11:103-107. https://doi.org/10.2147/CCID.S126850
9. Kikas K, Werner-Seidler A, Upton E, Newby J. Illness Anxiety Disorder: A Review of the Current Research and Future Directions. Curr Psychiatry Rep. 2024;26(7):331-339. https://doi.org/10.1007/s11920-024-01507-2
10. Sinikumpu SP, Jokelainen J, Tasanen K, Timonen M, Huilaja L. Association of Rosacea with Depressive and Anxiety Symptoms: A General Population Study. Dermatology. 2024;240(2):189-194. https://doi.org/10.1159/000535034
11. Egeberg A, Hansen PR, Gislason GH, Thyssen JP. Patients with Rosacea Have Increased Risk of Depression and Anxiety Disorders: A Danish Nationwide Cohort Study. Dermatology. 2016;232(2):208-213. https://doi.org/10.1159/000444082
12. Chang HC, Huang YC, Lien YJ, Chang YS. Association of rosacea with depression and anxiety: A systematic review and meta-analysis. J Affect Disord. 2022;299:239-245. https://doi.org/10.1016/j.jad.2021.12.008
13. Dai R, Lin B, Zhang X, Lou Y, Xu S. Depression and Anxiety in Rosacea Patients: A Systematic Review and Meta-Analysis. Dermatol Ther (Heidelb). 2021;11(6):2089-2105. https://doi.org/10.1007/s13555-021-00613-w
14. Yang X, Cai M. New Insights into the Mutual Promotion of Rosacea, Anxiety, and Depression from Neuroendocrine Immune Aspects. Clin Cosmet Investig Dermatol. 2023;16:1363-1371. https://doi.org/10.2147/CCID.S413237
15. Tu KY, Jung CJ, Shih YH, Chang ALS. Therapeutic strategies focusing on immune dysregulation and neuroinflammation in rosacea. Front Immunol. 2024;15:1403798. https://doi.org/10.3389/fimmu.2024.1403798
16. Yang X, Feng Z, Cai M. Elevated Specific Pro-Inflammatory Cytokines in Peripheral Circulation Indicate an Increased Risk of Anxiety and Depression in Rosacea. J Inflamm Res. 2024;17:4443-4452. https://doi.org/10.2147/JIR.S468773
17. Kıratlı Nalbant E, İmren IG, Tas Dolek G. Internalized Stigma and Its Relationship With Quality of Life and Perceived Health Status in Rosacea and Acne Vulgaris: A Comparative Cross-Sectional Study. Cureus. 2024;16(5):e60731. https://doi.org/10.7759/cureus.60731
18. Seetan K, Gablan M, Alnaimi M, et al. Assessment of Depressive and Anxiety Symptoms and Health-Related Quality of Life in Rosacea Patients: A Case-Control Study. Dermatol Res Pract. 2024;2024:5532532. https://doi.org/10.1155/drp/5532532
19. Chiu CW, Tsai J, Huang YC. Health-related Quality of Life of Patients with Rosacea: A Systematic Review and Meta-analysis of Real-world Data. Acta Derm Venereol. 2024;104:adv40053. https://doi.org/10.2340/actadv.v104.40053
20. Su D, Drummond PD. Blushing propensity and psychological distress in people with rosacea. Clin Psychol Psychother. 2012;19(6):488-495. https://doi.org/10.1002/cpp.763
21. Albukhari F, Alotaibi K, Almajed E, et al. Psychosocial aspects of rosacea: patient-reported coping strategies in Saudi Arabia. Front Med (Lausanne). 2025;12:1634437. https://doi.org/10.3389/fmed.2025.1634437
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