The place of the endothelial component in the pathogenesis of influenza A
Keywordsinfluenza A, endothelial dysfunction, desquamated endotheliocytes
AbstractInfluenza A viruses are genetically diverse and the most unpredictable variable pathogens. It is a dangerous and poorly managed infection, able to reassort, with a high probability of developing urgent conditions, complications and death at any age. The objective: to determine the diagnostic value of CEC in influenza A. Materials and methods: There were 158 influenza A patients included in the survey presented. Observation period - 2015-2018. The 1st group included 32 patients with a mild flu course, the 2nd group - 62 patients with moderate flu, and the 3rd group - 64 patients with a severe flu and mild pneumonia. The severity was determined by clinical manifestations and the presence of complications. Exclusion criteria from the study: age under 18 and over 45 y.o., pregnancy and severe somatic pathology. The control group consisted of healthy volunteers - 30 persons, similar in sex and age with a patient’s group. Conclusions. It was established that endothelium damage occurs even at mild course of influenza A. Severe influenza infection is accompanied by a massive endothelial damage with the development of endothelial dysfunction. Determination of circulating endothelial cells in blood is a simple and reliable indicator of the disease severity and its complications development.
How to Cite
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Number of views and downloads: 96
Number of citations: 0