Obstructive sleep apnoea in children – clinical presentation, diagnosis, treatment
DOI:
https://doi.org/10.12775/JEHS.2025.81.66650Keywords
obstructive sleep apnea, children, diagnosis, treatment, snoring, polysomnography, adenotonsillectomyAbstract
Introduction and purpose
The diagnosis of OSA in children is based on clinical symptoms and polysomnography (Apnea-Hypopnea Index ≥1 or hypoventilation). The ICSD-3 (International Classification of Sleep Disorders - Third Edition) guidelines are also utilized. Diagnostics are supported by pulse oximetry, lateral nasopharyngeal X-ray, cephalometry, fiberoptic endoscopy, and magnetic resonance imaging of the upper respiratory tract. OSA is associated with serious complications, including behavioral disorders, cardiovascular complications, metabolic disorders, and growth disturbances. Children with OSA also experience learning difficulties and lower school performance. Treatment includes adenotonsillectomy, CPAP/BiPAP therapy, surgical procedures, weight reduction, and pharmacotherapy. The effectiveness of treatment may be limited, particularly in obese children. Post-treatment monitoring of patients is necessary due to the risk of residual symptoms.
Material and methods
The literature available in Pubmed and Google Scholar databases was conducted using the key words.
Results
Data indicate that OSA occurs in approx. 5% of children, especially during the preschool years and adolescence. Symptoms include loud snoring, respiratory pauses, behavioral disorders, school difficulties, and daytime sleepiness. Polysomnography remains the cornerstone of diagnosis, supported by the PSQ and modified STOP-BANG questionnaires. Untreated OSA leads to metabolic, cardiovascular, and neurobehavioral complications. Treatment includes adenotonsillectomy, PAP therapy, weight reduction, pharmacotherapy, and orthodontic management.
Conclusions
Obstructive sleep apnea in children is a disorder with significant health consequences, requiring prompt diagnosis and tailored treatment. Adenotonsillectomy is the primary treatment method, with additional therapies applied to patients with persistent symptoms or contraindications to surgery.
References
1. Marcus, C. L., Brooks, L. J., Draper, K. A., Gozal, D., Halbower, A. C., Jones, J., Lehmann, C., Schechter, M. S., Ward, S. D., Sheldon, S., Shiffman, R. N., & Lehmann, C. (2012). Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics, 130(3), e714–e755. https://doi.org/10.1542/peds.2012-1672
2. Leung, T. N., Cheng, J. W., & Chan, A. K. (2021). Pediatrics: How to manage obstructive sleep apnea syndrome. Drugs in Context, 10, 2020-12-5. https://doi.org/10.7573/dic.2020-12-5
3. Goodwin, J. L., Kaemingk, K. L., Mulvaney, S. A., Morgan, W. J., O’Connor, T., Witmans, M., & Quan, S. F. (2005). Clinical screening of school children for polysomnography to detect sleep-disordered breathing: The Tucson Children’s Assessment of Sleep Apnea study (TuCASA). Journal of Clinical Sleep Medicine, 1(3), 247–254.
4. Solano-Pérez, E., Coso, C., Castillo-García, M., Aragón, A., García-Sánchez, A., Martínez-Martínez, A., & Navarrete, P. (2023). Diagnosis and treatment of sleep apnea in children: A future perspective is needed. Biomedicines, 11(6), 1708. https://doi.org/10.3390/biomedicines11061708
5. Magnusdottir, S., & Hill, E. A. (2024). Prevalence of obstructive sleep apnea among preschool-aged children in the general population: A systematic review. Sleep Medicine Reviews, 73, 101871. https://doi.org/10.1016/j.smrv.2023.101871
6. Yang, Q., Huang, X., Lin, Y., Chen, K., Lu, Q., Lin, W., Wang, X., Teng, Y., Jiang, P., Patil, S., & Zheng, Y. (2024). Exploring the multifaceted landscape of pediatric obstructive sleep apnea: Insights into prevalence, severity, and coexisting conditions. Nature and Science of Sleep, 16, 359–368. https://doi.org/10.2147/NSS.S452221
7. Manivannan, P. C., Silla, S. S., & Penmetcha, S. (2021). Obstructive sleep apnea in children – A review. International Journal of Dentistry and Oral Science, 8(2), 1447–1452. https://doi.org/10.19070/2377-8075-21000319
8. Alonso-Álvarez, M. L., Canet, T., Cubell-Alarcó, M., Martínez-Costa, C., Gozal, D., Martínez-García, M. Á., … SEPAR. (2011). Consensus document on sleep apnea–hypopnea syndrome in children (full version) [Translated title]. Archivos de Bronconeumología, 47(Suppl. 5), 0–18. https://doi.org/10.1016/S0300-2896(11)70026-6
9. Gulotta, G., Iannella, G., Vicini, C., Meccariello, G., Cammaroto, G., Pelucchi, S., … de Vito, A. (2019). Risk factors for obstructive sleep apnea syndrome in children: State of the art. International Journal of Environmental Research and Public Health, 16(18), 3235. https://doi.org/10.3390/ijerph16183235
10. Mussi, N., Forestiero, R., Zambelli, G., Laurino, S., Vanni, A., Doria, E., & Mezzanotte, D. (2023). The first-line approach in children with obstructive sleep apnea syndrome (OSA). Journal of Clinical Medicine, 12(22), 7092. https://doi.org/10.3390/jcm12227092
11. Thomas, S., Patel, S., Gummalla, P., Sabharwal, S., & Yalamanchili, S. (2022). You cannot hit snooze on OSA: Sequelae of pediatric obstructive sleep apnea. Children, 9(2), 261. https://doi.org/10.3390/children9020261
12. Mazurkiewicz, H., & Grygalewicz, J. (2008). Obstructive sleep apnea (and hypoventilation) syndrome in children [Translated title]. Postępy Nauk Medycznych, 21(9), 618–622.
13. Chervin, R. D., Hedger, K., Dillon, J. E., & Pituch, K. J. (2000). Pediatric Sleep Questionnaire (PSQ): Validity and reliability of scales for sleep-disordered breathing, snoring, sleepiness, and behavioral problems. Sleep Medicine, 1(1), 21–32. https://doi.org/10.1016/S1389-9457(99)00009-X
14. Krzeski, A., & Burghard, M. (2018). Obstructive sleep-disordered breathing in children – An important problem in light of current European guidelines [Translated title]. Otolaryngologia Polska, 72(5), 9–16. https://doi.org/10.5604/01.3001.0012.1570
15. Combs, D., Goodwin, J. L., Quan, S. F., Morgan, W. J., & Parthasarathy, S. (2015). Modified STOP-Bang tool for stratifying obstructive sleep apnea risk in adolescent children. PLOS ONE, 10(11), e0142242. https://doi.org/10.1371/journal.pone.0142242
16. Włodarska, A., & Doboszyńska, A. (2016). Obstructive sleep apnea syndrome in children [Translated title]. Pediatria i Medycyna Rodzinna, 12(3), 242–248. https://doi.org/10.15557/PiMR.2016.0024
17. Kaditis, A. G., Alonso Alvarez, M. L., Boudewyns, A., Alexopoulos, E. I., Ersu, R., Joosten, K., … Verhulst, S. L. (2016). Obstructive sleep-disordered breathing in 2–18-year-old children: Diagnosis and management. European Respiratory Journal, 47(1), 69–94. https://doi.org/10.1183/13993003.00385-2015
18. Sateia, M. J. (2014). International Classification of Sleep Disorders—Third Edition: Highlights and modifications. Chest, 146(5), 1387–1394. https://doi.org/10.1378/chest.14-0970
19. Dehlink, E., & Tan, H. L. (2016). Update on pediatric obstructive sleep apnea. Journal of Thoracic Disease, 8(2), 224–235. https://doi.org/10.3978/j.issn.2072-1439.2015.12.04
20. Kennedy, J. D., & Waters, K. A. (2005). Investigation and treatment of upper-airway obstruction: Childhood sleep disorders I. Medical Journal of Australia, 182(8), 419–423. https://doi.org/10.5694/j.1326-5377.2005.tb06763.x
21. Brockmann, P. E., & Gozal, D. (2022). Neurocognitive consequences in children with sleep-disordered breathing: Who is at risk? Children, 9(9), 1278. https://doi.org/10.3390/children9091278
22. Chan, K. C.-C., Au, C. T., Hui, L. L., Wing, Y. K., & Li, A. M. (2020). Childhood OSA is an independent determinant of blood pressure in adulthood: Long-term observational study. Thorax, 75(5), 422–431. https://doi.org/10.1136/thoraxjnl-2019-213692
23. Kulus, M., Krauze, A., & Bartosiewicz, W. (2007). Obstructive sleep apnea in children [Translated title]. Advances in Respiratory Medicine, 75(1), 23–27. https://doi.org/10.5603/ARM.27938
24. Fernandez-Mendoza, J., He, F., Calhoun, S. L., et al. (2021). Association of pediatric obstructive sleep apnea with elevated blood pressure and orthostatic hypertension in adolescence. JAMA Cardiology, 6(10), 1144–1151. https://doi.org/10.1001/jamacardio.2021.2003
25. Maloney, M. A., Ward, S. L. D., Su, J. A., et al. (2022). Prevalence of pulmonary hypertension on echocardiogram in children with severe obstructive sleep apnea. Journal of Clinical Sleep Medicine, 18(6), 1629–1637. https://doi.org/10.5664/jcsm.9944
26. Blechner, M., & Williamson, A. A. (2016). Consequences of obstructive sleep apnea in children. Current Problems in Pediatric and Adolescent Health Care, 46(1), 19–26. https://doi.org/10.1016/j.cppeds.2015.10.007
27. Gozal, D. (1998). Sleep-disordered breathing and school performance in children. Pediatrics, 102(3), 616–620. https://doi.org/10.1542/peds.102.3.616
28. Huang, Y. S., & Guilleminault, C. (2017). Pediatric obstructive sleep apnea: Where do we stand? Advances in Otorhinolaryngology, 80, 136–144. https://doi.org/10.1159/000470885
29. Lee, S. Y., Guilleminault, C., Chiu, H. Y., et al. (2015). Mouth breathing, “nasal disuse,” and pediatric sleep-disordered breathing. Sleep and Breathing, 19(4), 1257–1264. https://doi.org/10.1007/s11325-015-1154-6
30. Parmar, A., Baker, A., & Narang, I. (2019). Positive airway pressure in pediatric obstructive sleep apnea. Paediatric Respiratory Reviews, 31, 43–51. https://doi.org/10.1016/j.prrv.2019.04.006
31. Uong, E. C., Epperson, M., Bathon, S. A., & Jeffe, D. B. (2007). Adherence to nasal positive airway pressure therapy among school-aged children and adolescents with obstructive sleep apnea syndrome. Pediatrics, 120(5), e1203. https://doi.org/10.1542/peds.2007-0184
32. Bitners, A. C., & Arens, R. (2020). Evaluation and management of children with obstructive sleep apnea syndrome. Lung, 198(2), 257–270. https://doi.org/10.1007/s00408-020-00342-5
33. Alexopoulos, E. I., Kaditis, A. G., Kalampouka, E., et al. (2004). Nasal corticosteroids for children with snoring. Pediatric Pulmonology, 38(2), 161–167. https://doi.org/10.1002/ppul.20150
34. Berlucchi, M., Salsi, D., Valetti, L., Parrinello, G., & Nicolai, P. (2007). The role of mometasone furoate aqueous nasal spray in the treatment of adenoidal hypertrophy in the pediatric age group: Preliminary results of a prospective, randomized study. Pediatrics, 119(6), e1392. https://doi.org/10.1542/peds.2006-2015
35. Goldbart, A. D., Goldman, J. L., Veling, M. C., & Gozal, D. (2005). Leukotriene modifier therapy for mild sleep-disordered breathing in children. American Journal of Respiratory and Critical Care Medicine, 172(3), 364–370. https://doi.org/10.1164/rccm.200412-1734OC
36. Kheirandish, L., Goldbart, A. D., & Gozal, D. (2006). Intranasal steroids and oral leukotriene modifier therapy in residual sleep-disordered breathing after tonsillectomy and adenoidectomy in children. Pediatrics, 117(1), e61. https://doi.org/10.1542/peds.2005-0798
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Copyright (c) 2025 Maria Ochwat, Oliwia Osiak, Anna Piecha, Jagoda Pawlak, Sara Orłowska, Łukasz Bednarczyk, Maja Pękala, Katarzyna Niedziółka, Michał Oborski

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