The Role of Physical Activity in the Prevention and Management of Mental Health Disorders: A Review
DOI:
https://doi.org/10.12775/JEHS.2025.81.66622Keywords
physical activity, mental health, depression, anxiety, prevention, exercise therapyAbstract
Introduction and Purpose:
Mental health disorders such as depression, anxiety, and stress-related conditions are major contributors to global disability. Growing evidence indicates that physical activity is an effective non-pharmacological strategy for preventing and managing these conditions. This review aims to summarize current knowledge on the impact of physical activity on mental health and the mechanisms through which it exerts its effects.
Material and Method:
A narrative review was conducted using PubMed, Scopus, and Google Scholar to identify studies from 2010-2025 examining physical activity and mental health outcomes in adults. Priority was given to randomized trials, systematic reviews, and meta-analyses exploring exercise-based interventions and their psychological or physiological effects.
Results:
The analyzed literature shows that regular physical activity - particularly aerobic and moderate-intensity exercise - supports mood regulation, enhances cognitive functioning, and increases resilience to stress. Reported mechanisms include neurobiological changes such as improved neurotransmitter balance, reduced inflammation, and enhanced neuroplasticity, alongside psychological benefits such as increased self-efficacy and reduced rumination. Structured exercise programs also demonstrate efficacy as adjuncts to psychotherapy and pharmacotherapy.
Conclusions:
Physical activity represents a valuable and evidence-based component of mental health promotion and treatment. Incorporating tailored exercise interventions into prevention strategies and clinical care may significantly improve psychological well-being and reduce the burden of mental health disorders
References
1. Abdin, S., Welch, R. K., Byron-Daniel, J., & Meyrick, J. (2018). The effectiveness of physical activity interventions in improving well-being across office-based workplace settings: A systematic review. Public Health, 160, 70–76. https://doi.org/10.1016/j.puhe.2018.03.029
2. Agbangla, N. F., Séba, M.-P., Bunlon, F., Toulotte, C., & Fraser, S. A. (2023). Effects of Physical Activity on Physical and Mental Health of Older Adults Living in Care Settings: A Systematic Review of Meta-Analyses. International Journal of Environmental Research and Public Health, 20(13), 6226. https://doi.org/10.3390/ijerph20136226
3. Ahn, J., & Kim, M. (2023). Effects of exercise therapy on global cognitive function and, depression in older adults with mild cognitive impairment: A systematic review and meta-analysis. Archives of Gerontology and Geriatrics, 106, 104855. https://doi.org/10.1016/j.archger.2022.104855
4. Belcher, B. R., Zink, J., Azad, A., Campbell, C. E., Chakravartti, S. P., & Herting, M. M. (2021). The Roles of Physical Activity, Exercise, and Fitness in Promoting Resilience During Adolescence: Effects on Mental Well-Being and Brain Development. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging, 6(2), 225–237. https://doi.org/10.1016/j.bpsc.2020.08.005
5. Beserra, A., Kameda, P., Deslandes, A., Schuch, F., Laks, J., & Moraes, H. (2018). Can physical exercise modulate cortisol level in subjects with depression? A systematic review and meta-analysis. Trends in Psychiatry and Psychotherapy, 40, 360–368. https://doi.org/10.1590/2237-6089-2017-0155
6. Budde, H., Dolz, N., Mueller-Alcazar, A., Schacht, F., Velasques, B., Ribeiro, P., Machado, S., & Wegner, M. (2025). A 10 years update of effects of exercise on depression disorders—in otherwise healthy adults: A systematic review of meta-analyses and neurobiological mechanisms. PLOS One, 20(5), e0317610. https://doi.org/10.1371/journal.pone.0317610
7. Cadore, E. L., Casas-Herrero, A., Zambom-Ferraresi, F., Idoate, F., Millor, N., Gómez, M., Rodriguez-Mañas, L., & Izquierdo, M. (2014). Multicomponent exercises including muscle power training enhance muscle mass, power output, and functional outcomes in institutionalized frail nonagenarians. Age, 36(2), 773–785. https://doi.org/10.1007/s11357-013-9586-z
8. Carvalho Silva, R., Meattini, M., Perusi, G., Carletto, S., Bortolomasi, M., Gennarelli, M., Baune, B. T., & Minelli, A. (2025). Disentangling the biological mechanisms underlying the effects of physical exercise in major depressive disorder: A comprehensive systematic review of randomized controlled trials. Psychological Medicine, 55, e197. https://doi.org/10.1017/S0033291725100743
9. Crichton, M., & Fenesi, B. (2025). Physical Activity in Mental Health Treatment: Clinician Perspectives and Practices. Clinics and Practice, 15(7), 129. https://doi.org/10.3390/clinpract15070129
10. Cui, Z., Li, Z., Wang, T., Li, K., Zheng, H., & Yang, C. (2025). The mediating effect of resilience and self-efficacy between physical activity and wellbeing: A meta-analytic structural equation modeling. Frontiers in Psychology, 16, 1621100. https://doi.org/10.3389/fpsyg.2025.1621100
11. da Cunha, L. L., Feter, N., Alt, R., & Rombaldi, A. J. (2023). Effects of exercise training on inflammatory, neurotrophic and immunological markers and neurotransmitters in people with depression: A systematic review and meta-analysis. Journal of Affective Disorders, 326, 73–82. https://doi.org/10.1016/j.jad.2023.01.086
12. Da Silva, J. L., Agbangla, N. F., Le Page, C., Ghernout, W., & Andrieu, B. (2022). Effects of Chronic Physical Exercise or Multicomponent Exercise Programs on the Mental Health and Cognition of Older Adults Living in a Nursing Home: A Systematic Review of Studies From the Past 10 Years. Frontiers in Psychology, 13, 888851. https://doi.org/10.3389/fpsyg.2022.888851
13. Dinoff, A., Herrmann, N., Swardfager, W., Liu, C. S., Sherman, C., Chan, S., & Lanctôt, K. L. (2016). The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis. PloS One, 11(9), e0163037. https://doi.org/10.1371/journal.pone.0163037
14. Escobar-Roldan, I. D., Babyak, M. A., & Blumenthal, J. A. (2021). Exercise Prescription Practices to Improve Mental Health. Journal of Psychiatric Practice, 27(4), 273–282. https://doi.org/10.1097/PRA.0000000000000554
15. Firth, J., Carney, R., French, P., Elliott, R., Cotter, J., & Yung, A. R. (2018). Long-term maintenance and effects of exercise in early psychosis. Early Intervention in Psychiatry, 12(4), 578–585. https://doi.org/10.1111/eip.12365
16. Fu, Q., Li, L., Li, Q., & Wang, J. (2025). The effects of physical activity on the mental health of typically developing children and adolescents: A systematic review and meta-analysis. BMC Public Health, 25(1), 1514. https://doi.org/10.1186/s12889-025-22690-8
17. Gasana, J., O’Keeffe, T., Withers, T. M., & Greaves, C. J. (2023). A systematic review and meta-analysis of the long-term effects of physical activity interventions on objectively measured outcomes. BMC Public Health, 23(1), 1697. https://doi.org/10.1186/s12889-023-16541-7
18. Gerber, M., Imboden, C., Beck, J., Brand, S., Colledge, F., Eckert, A., Holsboer-Trachsler, E., Pühse, U., & Hatzinger, M. (2020). Effects of Aerobic Exercise on Cortisol Stress Reactivity in Response to the Trier Social Stress Test in Inpatients with Major Depressive Disorders: A Randomized Controlled Trial. Journal of Clinical Medicine, 9(5), 1419. https://doi.org/10.3390/jcm9051419
19. Gunawan, Y. A., Suen, M.-W., Denny, H. M., & Restya, W. P. (2025). Alleviating work stress with physical activity: A comprehensive review. Work (Reading, Mass.), 82(1), 35–45. https://doi.org/10.1177/10519815251337040
20. Heissel, A., Heinen, D., Brokmeier, L. L., Skarabis, N., Kangas, M., Vancampfort, D., Stubbs, B., Firth, J., Ward, P. B., Rosenbaum, S., Hallgren, M., & Schuch, F. (2023). Exercise as medicine for depressive symptoms? A systematic review and meta-analysis with meta-regression. British Journal of Sports Medicine, 57(16), 1049–1057. https://doi.org/10.1136/bjsports-2022-106282
21. Hossain, M. N., Lee, J., Choi, H., Kwak, Y.-S., & Kim, J. (2024). The impact of exercise on depression: How moving makes your brain and body feel better. Physical Activity and Nutrition, 28(2), 43–51. https://doi.org/10.20463/pan.2024.0015
22. Hurley, M., Dickson, K., Hallett, R., Grant, R., Hauari, H., Walsh, N., Stansfield, C., & Oliver, S. (2018). Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: A mixed methods review. The Cochrane Database of Systematic Reviews, 4(4), CD010842. https://doi.org/10.1002/14651858.CD010842.pub2
23. Kvam, S., Kleppe, C. L., Nordhus, I. H., & Hovland, A. (2016). Exercise as a treatment for depression: A meta-analysis. Journal of Affective Disorders, 202, 67–86. https://doi.org/10.1016/j.jad.2016.03.063
24. Leaviss, J., Davis, S., Ren, S., Hamilton, J., Scope, A., Booth, A., Sutton, A., Parry, G., Buszewicz, M., Moss-Morris, R., & White, P. (2020). Behavioural modification interventions for medically unexplained symptoms in primary care: Systematic reviews and economic evaluation. Health Technology Assessment (Winchester, England), 24(46), 1–490. https://doi.org/10.3310/hta24460
25. Li, H., & Hao, F. (2025). The influence of physical activity on the mental health of high school students: The chain mediating effects of social support and self-esteem. Scientific Reports, 15(1), 27537. https://doi.org/10.1038/s41598-025-11952-5
26. Mahindru, A., Patil, P., & Agrawal, V. (b.d.). Role of Physical Activity on Mental Health and Well-Being: A Review. Cureus, 15(1), e33475. https://doi.org/10.7759/cureus.33475
27. Menke, A. (2024). The HPA Axis as Target for Depression. Current Neuropharmacology, 22(5), 904–915. https://doi.org/10.2174/1570159X21666230811141557
28. Mental disorders. (b.d.). Pobrano 13 listopada 2025, z https://www.who.int/news-room/fact-sheets/detail/mental-disorders
29. Moyers, S. A., & Hagger, M. S. (2023). Physical activity and cortisol regulation: A meta-analysis. Biological Psychology, 179, 108548. https://doi.org/10.1016/j.biopsycho.2023.108548
30. Muth, A.-K., Losecaat Vermeer, A., Terenzi, D., & Park, S. Q. (2022). The impact of diet and lifestyle on wellbeing in adults during COVID-19 lockdown. Frontiers in Nutrition, 9, 993180. https://doi.org/10.3389/fnut.2022.993180
31. Noetel, M., Sanders, T., Gallardo-Gómez, D., Taylor, P., Cruz, B. del P., Hoek, D. van den, Smith, J. J., Mahoney, J., Spathis, J., Moresi, M., Pagano, R., Pagano, L., Vasconcellos, R., Arnott, H., Varley, B., Parker, P., Biddle, S., & Lonsdale, C. (2024). Effect of exercise for depression: Systematic review and network meta-analysis of randomised controlled trials. BMJ, 384, e075847. https://doi.org/10.1136/bmj-2023-075847
32. Pearce, M., Garcia, L., Abbas, A., Strain, T., Schuch, F. B., Golubic, R., Kelly, P., Khan, S., Utukuri, M., Laird, Y., Mok, A., Smith, A., Tainio, M., Brage, S., & Woodcock, J. (2022). Association Between Physical Activity and Risk of Depression: A Systematic Review and Meta-analysis. JAMA Psychiatry, 79(6), 550–559. https://doi.org/10.1001/jamapsychiatry.2022.0609
33. Phillips, C., & Fahimi, A. (2018). Immune and Neuroprotective Effects of Physical Activity on the Brain in Depression. Frontiers in Neuroscience, 12, 498. https://doi.org/10.3389/fnins.2018.00498
34. Rahmati, M., Lee, S., Yon, D. K., Lee, S. W., Udeh, R., McEvoy, M., Oh, H., Butler, L., Keyes, H., Barnett, Y., Koyanagi, A., Shin, J. I., & Smith, L. (2024). Physical activity and prevention of mental health complications: An umbrella review. Neuroscience and Biobehavioral Reviews, 160, 105641. https://doi.org/10.1016/j.neubiorev.2024.105641
35. Recchia, F., Leung, C. K., Chin, E. C., Fong, D. Y., Montero, D., Cheng, C. P., Yau, S. Y., & Siu, P. M. (2022). Comparative effectiveness of exercise, antidepressants and their combination in treating non-severe depression: A systematic review and network meta-analysis of randomised controlled trials. British Journal of Sports Medicine, 56(23), 1375–1380. https://doi.org/10.1136/bjsports-2022-105964
36. Rhodes, R., & Sui, W. (2021). Physical Activity Maintenance: A Critical Narrative Review and Directions for Future Research. Frontiers in Psychology, 12. https://doi.org/10.3389/fpsyg.2021.725671
37. Schuch, F. B., Vancampfort, D., Firth, J., Rosenbaum, S., Ward, P. B., Silva, E. S., Hallgren, M., Ponce De Leon, A., Dunn, A. L., Deslandes, A. C., Fleck, M. P., Carvalho, A. F., & Stubbs, B. (2018). Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies. The American Journal of Psychiatry, 175(7), 631–648. https://doi.org/10.1176/appi.ajp.2018.17111194
38. Shannon, A., McGuire, D., Brown, E., & O’Donoghue, B. (2020). A systematic review of the effectiveness of group-based exercise interventions for individuals with first episode psychosis. Psychiatry Research, 293, 113402. https://doi.org/10.1016/j.psychres.2020.113402
39. Simpson, A., Teague, S., Kramer, B., Lin, A., Thornton, A. L., Budden, T., Furzer, B., Jeftic, I., Dimmock, J., Rosenberg, M., & Jackson, B. (2024). Physical activity interventions for the promotion of mental health outcomes in at-risk children and adolescents: A systematic review. Health Psychology Review, 18(4), 899–933. https://doi.org/10.1080/17437199.2024.2391787
40. Singh, B., Olds, T., Curtis, R., Dumuid, D., Virgara, R., Watson, A., Szeto, K., O’Connor, E., Ferguson, T., Eglitis, E., Miatke, A., Simpson, C. E., & Maher, C. (2023a). Effectiveness of physical activity interventions for improving depression, anxiety and distress: An overview of systematic reviews. British Journal of Sports Medicine, 57(18), 1203–1209. https://doi.org/10.1136/bjsports-2022-106195
41. Singh, B., Olds, T., Curtis, R., Dumuid, D., Virgara, R., Watson, A., Szeto, K., O’Connor, E., Ferguson, T., Eglitis, E., Miatke, A., Simpson, C. E., & Maher, C. (2023b). Effectiveness of physical activity interventions for improving depression, anxiety and distress: An overview of systematic reviews. British Journal of Sports Medicine, 57(18), 1203–1209. https://doi.org/10.1136/bjsports-2022-106195
42. Stubbs, B., Vancampfort, D., Rosenbaum, S., Ward, P. B., Richards, J., Ussher, M., & Schuch, F. B. (2016). Challenges Establishing the Efficacy of Exercise as an Antidepressant Treatment: A Systematic Review and Meta-Analysis of Control Group Responses in Exercise Randomised Controlled Trials. Sports Medicine (Auckland, N.Z.), 46(5), 699–713. https://doi.org/10.1007/s40279-015-0441-5
43. Vendrik, K. E. W., Terveer, E. M., Kuijper, E. J., Nooij, S., Boeije-Koppenol, E., Sanders, I. M. J. G., van Lingen, E., Verspaget, H. W., Berssenbrugge, E. K. L., Keller, J. J., van Prehn, J., & Netherlands Donor Faeces Bank Study Group. (2021). Periodic screening of donor faeces with a quarantine period to prevent transmission of multidrug-resistant organisms during faecal microbiota transplantation: A retrospective cohort study. The Lancet. Infectious Diseases, 21(5), 711–721. https://doi.org/10.1016/S1473-3099(20)30473-4
44. White, R. L., Vella, S., Biddle, S., Sutcliffe, J., Guagliano, J. M., Uddin, R., Burgin, A., Apostolopoulos, M., Nguyen, T., Young, C., Taylor, N., Lilley, S., & Teychenne, M. (2024). Physical activity and mental health: A systematic review and best-evidence synthesis of mediation and moderation studies. International Journal of Behavioral Nutrition and Physical Activity, 21(1), 134. https://doi.org/10.1186/s12966-024-01676-6
45. WHO guidelines on physical activity and sedentary behaviour. (b.d.). https://www.who.int/publications/i/item/978924001512
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Sergiusz Romaniuk, Aleksandra Jurczuk, Paulina Bałdyga, Kinga Marciniak, Aleksandra Wilczyńska

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 142
Number of citations: 0