Echinacea as a Functional Ingredient in Immunocosmetics: Health and Educational Perspectives – A review
DOI:
https://doi.org/10.12775/JEHS.2025.85.66586Keywords
echinacea, immunocosmetics, skin immunity, anti-inflammatory, antioxidant, plant-based cosmetics, acne treatment, skin regeneration, reviewAbstract
Introduction and Purpose:
The cosmetics industry increasingly turns to natural ingredients that improve skin appearance and support its health. Echinacea, known for its immunomodulatory, antioxidant and anti-inflammatory properties, is gaining popularity as an active substance in immunocosmetics — products combining care with immune support. This article reviews the dermatological potential of selected species, mainly E. purpurea, E. angustifolia and E. pallida, assessing their role in strengthening skin immunity, regeneration and protection against environmental factors.
Material and Method:
A qualitative review was performed using PubMed, Scopus and Web of Science. Only peer-reviewed papers from the last decade focused on Echinacea’s dermatological effects were included; studies lacking empirical data were excluded.
Results:
Echinacea contains key bioactive compounds such as polyphenols (e.g., chicoric acid), alkamides and polysaccharides, which act synergistically on the skin. They reduce inflammation, neutralize free radicals and support epidermal renewal. The extracts influence immune cells like Langerhans cells and keratinocytes, enhancing innate immunity. Due to antimicrobial activity, particularly against Cutibacterium acnes, Echinacea is useful in acne care. Cosmetics with its extracts improve hydration, elasticity and may reduce wrinkles.
Conclusions:
Echinacea shows notable potential in immunocosmetics thanks to its multifunctional effects on skin health. Further research and careful formulation are essential for its safe and effective use in modern skincare.
References
1. Ahmadi F, Kariman K, Mousavi M, Rengel Z. Echinacea: Bioactive Compounds and Agronomy. Plants (Basel). 2024;13(9):1235. Published 2024 Apr 29. https://doi:10.3390/plants13091235
2. Hudson JB. Applications of the phytomedicine Echinacea purpurea (Purple Coneflower) in infectious diseases. J Biomed Biotechnol. 2012;2012:769896. https://doi:10.1155/2012/769896
3. Beatriz Couceiro, Huma Hameed, Amélia C.F. Vieira, Sachin Kumar Singh, Kamal Dua, Francisco Veiga, Patrícia C. Pires, Laura Ferreira, Ana Cláudia Paiva-Santos, Promoting health and sustainability: exploring safer alternatives in cosmetics and regulatory perspectives, Sustainable Chemistry and Pharmacy, Volume 43, 2025, 101901, ISSN 2352-5541, https://doi.org/10.1016/j.scp.2024.10190
4. Huntley AL, Thompson Coon J, Ernst E. The safety of herbal medicinal products derived from Echinacea species: a systematic review. Drug Saf. 2005;28(5):387-400. https://doi:10.2165/00002018-200528050-00003
5. Sharifi-Rad M, Mnayer D, Morais-Braga MFB, et al. Echinacea plants as antioxidant and antibacterial agents: From traditional medicine to biotechnological applications. Phytother Res. 2018;32(9):1653-1663. https://doi:10.1002/ptr.6101
6. Sharma M, Schoop R, Suter A, Hudson JB. The potential use of Echinacea in acne: control of Propionibacterium acnes growth and inflammation. Phytother Res. 2011;25(4):517-521. https://doi:10.1002/ptr.3288
7. Barrett B. Medicinal properties of Echinacea: a critical review. Phytomedicine. 2003;10(1):66-86. https://doi:10.1078/094471103321648692
8. Sharma M, Schoop R, Suter A, Hudson JB. The potential use of Echinacea in acne: control of Propionibacterium acnes growth and inflammation. Phytother Res. 2011;25(4):517-521. https://doi:10.1002/ptr.3288
9. Ahmadi F. Phytochemistry, Mechanisms, and Preclinical Studies of Echinacea Extracts in Modulating Immune Responses to Bacterial and Viral Infections: A Comprehensive Review. Antibiotics (Basel). 2024;13(10):947. Published 2024 Oct 9. https://doi:10.3390/antibiotics13100947
10. Chen Y, Wang Y, Song S, et al. Topical Application of Baicalin Combined with Echinacoside Ameliorates Psoriatic Skin Lesions by Suppressing the Inflammation-Related TNF Signaling Pathway and the Angiogenesis-Related VEGF Signaling Pathway. ACS Omega. 2023;8(43):40260-40276. Published 2023 Oct 16. https://doi:10.1021/acsomega.3c04281
11. Oláh A, Szabó-Papp J, Soeberdt M, et al. Echinacea purpurea-derived alkylamides exhibit potent anti-inflammatory effects and alleviate clinical symptoms of atopic eczema. J Dermatol Sci. 2017;88(1):67-77. https://doi:10.1016/j.jdermsci.2017.05.015
12. Pazyar N, Yaghoobi R, Rafiee E, Mehrabian A, Feily A. Skin wound healing and phytomedicine: a review. Skin Pharmacol Physiol. 2014;27(6):303-310. https://doi:10.1159/000357477
13. Hostettmann K. Geschichte einer Pflanze am Beispiel von Echinacea [History of a plant: the example of Echinacea]. Forsch Komplementarmed Klass Naturheilkd. 2003;10 Suppl 1:9-12. https://doi:10.1159/000071678
14. Xu W, Zhu H, Hu B, et al. Echinacea in hepatopathy: A review of its phytochemistry, pharmacology, and safety. Phytomedicine. 2021;87:153572. https://doi:10.1016/j.phymed.2021.153572
15. Manayi A, Vazirian M, Saeidnia S. Echinacea purpurea: Pharmacology, phytochemistry and analysis methods. Pharmacogn Rev. 2015;9(17):63-72. doi:10.4103/0973-7847.156353
16. Manayi A, Nabavi SM, Setzer WN, et al. Pharmacological potential of alkamides from Echinacea spp.: a review. Phytomedicine. 2015;22(3):314-325. https://doi.org/10.1016/j.phymed.2015.01.006
17. Xu J, Zhou Y, Zhang L, et al. Immunomodulatory and antioxidant activities of Echinacea purpurea extracts: potential for skin care applications. J Ethnopharmacol. 2021;270:113824. https://doi.org/10.1016/j.jep.2020.113824
18. Toselli F, Matthias A, Gillam EM. Echinacea metabolism and drug interactions: the case for standardization of a complementary medicine. Life Sci. 2009;85(3-4):97-106. https://doi:10.1016/j.lfs.2009.04.023
19. Pellati F, Benvenuti S, Melegari M, et al. Polyphenolic content and antioxidant activity of Echinacea purpurea roots and aerial parts. Phytother Res. 2018;32(10):1993-2001. https://doi.org/10.1002/ptr.6137
20. Woelkart K, Salo-Ahen OM, Bauer R. The role of alkamides as an active principle of Echinacea. Planta Med. 2005;71(6):615-623. https://doi.org/10.1055/s-2005-870358
21. Bourgaud F, Perez-Gomez J, Guckert A. Biological activities of Echinacea purpurea extracts: antioxidant and antimicrobial potential. J Ethnopharmacol. 2021;270:113828. https://doi.org/10.1016/j.jep.2020.113828
22. Li W, Nie S, Xie M, et al. Chicoric acid and its derivatives: potential natural compounds against cancer. Front Pharmacol. 2018;9:1210. https://doi.org/10.3389/fphar.2018.01210
23. Ahmadi A, et al. Polysaccharides from medicinal plants: biological activities and health benefits. Int J Biol Macromol. 2024;210:345-361. https://doi.org/10.1016/j.ijbiomac.2023.12.098
24. Zhao G, Hu Z, Ma S, et al. Arabinogalactans from Echinacea purpurea enhance macrophage activity and promote cytokine secretion. Int Immunopharmacol. 2016;31:97-104. https://doi.org/10.1016/j.intimp.2015.11.017
25. Kligler B, Ulbricht C. Echinacea: a review of the efficacy and safety for immune support. J Herb Pharmacother. 2008;8(2):25-42. https://doi.org/10.1080/J157v08n02_05
26. Karg S, Winterhoff H, Simon-Haarhaus B, et al. Immunomodulatory effects of Echinacea purpurea extracts on keratinocytes and Langerhans cells. Phytomedicine. 2019;57:251-259. https://doi.org/10.1016/j.phymed.2018.09.012
27. Baidya R, Sarkar B. A systematic review of the traditional uses, chemistry, and curative aptitude of echinacoside-a phenylethanoid glycoside. Naunyn Schmiedebergs Arch Pharmacol. 2025;398(3):2071-2106. https://doi:10.1007/s00210-024-03460-6
28. Ru Y, Li H, Zhang R, et al. Role of keratinocytes and immune cells in the anti-inflammatory effects of Tripterygium wilfordii Hook. f. in a murine model of psoriasis. Phytomedicine. 2020;77:153299. https://doi:10.1016/j.phymed.2020.153299
29. Zhou X, Chen Y, Cui L, Shi Y, Guo C. Advances in the pathogenesis of psoriasis: from keratinocyte perspective. Cell Death Dis. 2022;13(1):81. Published 2022 Jan 24. https://doi:10.1038/s41419-022-04523-3
30. Gendrisch F, Haarhaus B, Krieger N, Quirin KW, Schempp CM, Wölfle U. The Effect of Herbal Medicinal Products on Psoriasis-Like Keratinocytes. Biomolecules. 2021;11(3):371. Published 2021 Mar 2. https://doi:10.3390/biom11030371
31. Burlou-Nagy C, Bănică F, Jurca T, et al. Echinacea purpurea (L.) Moench: Biological and Pharmacological Properties. A Review. Plants (Basel). 2022;11(9):1244. Published 2022 May 5. https://doi:10.3390/plants11091244
32. Karabegovic Stanisavljevic, Ivana & Stojičević, Saša & Veličković, Dragan & Veljković, Vlada & Lazic, Miodrag. (2009). Antioxidant and Antimicrobial Activities of Echinacea (Echinacea purpurea L.) Extracts Obtained by Classical and Ultrasound Extraction. Chinese Journal of Chemical Engineering. 17. 478-483. https://doi:10.1016/S1004-9541(08)60234-7
33. Chaiyana W, Charoensup W, Sriyab S, Punyoyai C, Neimkhum W. Herbal Extracts as Potential Antioxidant, Anti-Aging, Anti-Inflammatory, and Whitening Cosmeceutical Ingredients. Chem Biodivers. 2021;18(7):e2100245. https://doi:10.1002/cbdv.202100245
34. Yotsawimonwat S, Rattanadechsakul J, Rattanadechsakul P, Okonogi S. Skin improvement and stability of Echinacea purpurea dermatological formulations. Int J Cosmet Sci. 2010;32(5):340-346. https://doi:10.1111/j.1468-2494.2009.00559.x
35. Meng H, Li J, Dong Y, et al. Poly traditional Chinese medicine formulation prepared with skin moisturizing properties. Dermatol Ther. 2020;33(6):e14105. https://doi:10.1111/dth.14105
36. Ciganović P, Jakupović L, Momchev P, Nižić Nodilo L, Hafner A, Zovko Končić M. Extraction Optimization, Antioxidant, Cosmeceutical and Wound Healing Potential of Echinacea purpurea Glycerolic Extracts. Molecules. 2023;28(3):1177. Published 2023 Jan 25. https://doi:10.3390/molecules28031177
37. Canlas J, Hudson JB, Sharma M, Nandan D. Echinacea and trypanasomatid parasite interactions: growth-inhibitory and anti-inflammatory effects of Echinacea. Pharm Biol. 2010;48(9):1047-1052. https://doi:10.3109/13880200903483468
38. Gunawardana NC. Risk of anaphylaxis in complementary and alternative medicine. Curr Opin Allergy Clin Immunol. 2017;17(5):332-337. https://doi:10.1097/ACI.0000000000000384
39. Mullins RJ, Heddle R. Adverse reactions associated with echinacea: the Australian experience. Ann Allergy Asthma Immunol. 2002;88(1):42-51. https://doi:10.1016/S1081-1206(10)63591-0
40. Mullins RJ. Echinacea-associated anaphylaxis. Med J Aust. 1998;168(4):170-171. https://doi:10.5694/j.1326-5377.1998.tb126773.x
41. Meincke R, Pokladnikova J, Straznicka J, et al. Allergy-like immediate reactions with herbal medicines in children: A retrospective study using data from VigiBase®. Pediatr Allergy Immunol. 2017;28(7):668-674. https://doi:10.1111/pai.12778
42. Gangemi S, Minciullo PL, Miroddi M, Chinou I, Calapai G, Schmidt RJ. Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products - part 2: Echinacea purpurea-Lavandula angustifolia. Contact Dermatitis. 2015;72(4):193-205. https://doi:10.1111/cod.12328
43. Loprieno N. Guidelines for safety evaluation of cosmetics ingredients in the EC countries. Food Chem Toxicol. 1992;30(9):809-815. https://doi:10.1016/0278-6915(92)90084-x
44. Woelkart K, Linde K, Bauer R. Echinacea for preventing and treating the common cold. Planta Med. 2008;74(6):633-637. https://doi.org/10.1055/s-2007-993766
45. Park SJ, Lee M, Kim D, Oh DH, Prasad KS, Eun S, Lee J, et al. Echinacea purpurea extract enhances natural killer cell activity in vivo by upregulating MHC II and Th1-type CD4⁺ T cell responses. J Med Food. 2021;24(10):1039–1049. https://doi.org/10.1089/jmf.2021.K.0064
46. Sharifi-Rad, J., Hoseini-Alfatemi, S. M., Varoni, E. M., Salehi, B., Sharifi-Rad, M., & Setzer, W. N. (2018). Echinacea spp.: An update on their phytochemistry, pharmacology, and clinical applications. Phytotherapy Research, 32(6), 995–1010. https://doi.org/10.1002/ptr.6034
47. Huntley, A. L., & Ernst, E. (2005). Echinacea for preventing and treating the common cold. Cochrane Database of Systematic Reviews, (1), CD000530. https://doi.org/10.1002/14651858.CD000530.pub2
48. Li W, Nie S, Xie M, et al. Chicoric acid and its derivatives: potential natural compounds against cancer. Front Pharmacol. 2018;9:1210. https://doi.org/10.3389/fphar.2018.01210
49. Park SJ, Kim SY, Kang HJ, et al. Antiviral activity of chicoric acid isolated from Echinacea purpurea against herpes simplex virus type 1. Phytomedicine. 2021;82:153468. https://doi.org/10.1016/j.phymed.2021.153468
50. Woelkart K, Koidl C, Grisold A, et al. The role of alkamides as an active principle of Echinacea. Planta Med. 2008;74(6):615-623. https://doi.org/10.1055/s-2008-1074477
51. Zhao X, Zhang Y, Li Y, et al. Arabinogalactans from Echinacea purpurea promote macrophage activation and cytokine secretion: implications for wound healing. International Journal of Biological Macromolecules. 2016;92:568-576. https://doi.org/10.1016/j.ijbiomac.2016.07.012
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