Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

SFRP5-leptin ratio as a promising index in post-partum women with gestational diabetes mellitus
  • Home
  • /
  • SFRP5-leptin ratio as a promising index in post-partum women with gestational diabetes mellitus
  1. Home /
  2. Archives /
  3. Vol. 9 No. 3 (2019) /
  4. Research Articles

SFRP5-leptin ratio as a promising index in post-partum women with gestational diabetes mellitus

Authors

  • Żaneta Kimber-Trojnar Chair and Department of Obstetrics and Perinatology, Medical University of Lublin
  • Jolanta Patro-Małysza Chair and Department of Obstetrics and Perinatology, Medical University of Lublin
  • Bożena Leszczyńska-Gorzelak Chair and Department of Obstetrics and Perinatology, Medical University of Lublin

Keywords

adipokines, secreted frizzled-related protein 5, leptin, bioelectrical impedance analysis, gestational diabetes mellitus

Abstract

INTRODUCTION: Gestational diabetes mellitus (GDM) has often been referred to as the “marker” for the development of diabetes, obesity and cardiovascular diseases in future lives of women. In the current literature the adiponectin-leptin ratio is presented as a valuable index to estimate adipose tissue dysfunction. OBJECTIVES: The aim of the study was to investigate the significance of a novel parameter, i.e. the ratio of serum concentration of secreted frizzled-related protein 5 (SFRP5) to that of leptin in the early post-partum period. The associations between SFRP5/leptin ratio and maternal laboratory test results, body composition and hydration status were also assessed. PATIENTS AND METHODS: 26 mothers diagnosed with gestational diabetes mellitus (GDM) and 28 healthy controls were enrolled in the study. Body composition and hydration status of the patients were evaluated with the use of bioelectrical impedance analysis (BIA) method. The serum concentrations of SFRP5, leptin, fatty acid-binding protein 4 (FABP4) and ghrelin were determined via enzyme-linked immunosorbent assay (ELISA). RESULTS: SFRP5/leptin ratio was lower in the GDM mothers in comparison to that of the control group. There were positive correlations between SFRP5/leptin ratio and total cholesterol and low-density lipoprotein cholesterol (LDL) levels. The SFRP5/leptin ratio correlated negatively with total body water (TBW) and extracellular water (ECW). CONCLUSIONS: The SFRP5/leptin ratio appears to be a promising index for evaluating of metabolic disturbances in mothers with a history of GDM.

Author Biographies

Żaneta Kimber-Trojnar, Chair and Department of Obstetrics and Perinatology, Medical University of Lublin

Chair and Department of Obstetrics and Perinatology, Medical University of Lublin

Jolanta Patro-Małysza, Chair and Department of Obstetrics and Perinatology, Medical University of Lublin

Chair and Department of Obstetrics and Perinatology, Medical University of Lublin

Bożena Leszczyńska-Gorzelak, Chair and Department of Obstetrics and Perinatology, Medical University of Lublin

Chair and Department of Obstetrics and Perinatology, Medical University of Lublin

Downloads

  • PDF

Published

2019-03-05

How to Cite

1.
KIMBER-TROJNAR, Żaneta, PATRO-MAŁYSZA, Jolanta and LESZCZYŃSKA-GORZELAK, Bożena. SFRP5-leptin ratio as a promising index in post-partum women with gestational diabetes mellitus. Journal of Education, Health and Sport. Online. 5 March 2019. Vol. 9, no. 3, pp. 40-47. [Accessed 18 May 2025].
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 9 No. 3 (2019)

Section

Research Articles

License

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 594
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

adipokines, secreted frizzled-related protein 5, leptin, bioelectrical impedance analysis, gestational diabetes mellitus
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop