Aesthetic Medicine Procedures in Cancer Survivors – A Literature Review
DOI:
https://doi.org/10.12775/JEHS.2025.81.65415Keywords
cancer survivors, aesthetic medicine, botulinum toxin, dermal fillers, platelet-rich plasma, laser therapyAbstract
Background: Advances in oncology have significantly increased long-term survival rates, creating a growing need to manage persistent physical and psychosocial consequences of treatment in cancer survivors, including scarring, alopecia, pigmentation changes, and tissue damage.
Objective: To systematically review literature on aesthetic medicine procedures in cancer survivors, evaluating therapeutic potential, safety, and clinical implications.
Methods: A systematic search was conducted in PubMed, Embase, and Cochrane Library (January 2000 – March 2025). Keywords included “cancer survivor,” “aesthetic medicine,” “botulinum toxin,” “fillers,” “platelet-rich plasma,” and “laser therapy.” Eligible studies included clinical trials, cohort studies, case series, and reviews reporting outcomes of aesthetic interventions in oncology patients. Two independent reviewers screened 356 records; 34 studies were included. Quality assessment used GRADE and Newcastle-Ottawa Scale.
Results: Interventions included botulinum toxin (n=8), fillers (n=9), platelet-rich plasma (n=6), laser therapy (n=7), and scalp cooling (n=4). Procedures were generally safe, with mild and transient adverse events, and were associated with improvements in quality of life, self-image, and functional recovery.
Conclusions: Aesthetic medicine procedures can be a valuable adjunct in survivorship care. Multidisciplinary collaboration and evidence-based protocols are recommended.
References
1.Firkins, J., Hansen, L., Driessnack, M., & Dieckmann, N. (2020). Quality of life in "chronic" cancer survivors: a meta-analysis. Journal of Cancer Survivorship, 14(4), 504–517. https://doi.org/10.1007/s11764-020-00869-9
2.Hopwood, P., Fletcher, I., Lee, A., & Al Ghazal, S. (2001). A body image scale for use with cancer patients. European Journal of Cancer, 37(2), 189–197. https://doi.org/10.1016/s0959-8049(00)00353-1
3.Rossi, A. M., Hibler, B. P., Navarrete-Dechent, C., & Lacouture, M. E. (2021). Restorative oncodermatology: Diagnosis and management of dermatologic sequelae from cancer therapies. Journal of the American Academy of Dermatology, 85(3), 693–707. https://doi.org/10.1016/j.jaad.2020.08.005
4.Jankovic, J. (2017). Botulinum toxin: State of the art. Movement Disorders, 32(8), 1131–1138. https://doi.org/10.1002/mds.27072
5.Proietti, I., Skroza, N., Mambrin, A., Marraffa, F., Tolino, E., Bernardini, N., ... Potenza, C. (2021). Aesthetic treatments in cancer patients. Clinical, Cosmetic and Investigational Dermatology, 14, 1831–1837. https://doi.org/10.2147/CCID.S342734
6.Nieri, C. A., Benaim, E. H., Zhang, Y. H., Garcia-Godoy, F., Herr, M. J., Zhang, W., ... Gillespie, M. B. (2023). Botox for the prevention of radiation-induced sialadenitis and xerostomia in head and neck cancer patients: A pilot study. Head & Neck, 45(9), 2198–2206. https://doi.org/10.1002/hed.27449
7.Falcón González, A., Gallegos Sancho, M. I., González Flores, E., et al. (2024). Beyond cancer treatment: Dermo-aesthetic and other wellness recommendations for breast cancer patients. Clinical and Translational Oncology. https://doi.org/10.1007/s12094-024-03636-9
8.Labadie, J. G., Kosche, C., Kyllo, R., Johnson, T., Shumaker, P. R., Alam, M., & Choi, J. N. (2020). Fractional CO₂ laser for the treatment of sclerodermatous cGVHD. Journal of Cosmetic and Laser Therapy, 22(1), 49–51. https://doi.org/10.1080/14764172.2019.1710537
9.Tejero, P., & Pinto, H. (Eds.). (2020). Aesthetic treatments for the oncology patient (1st ed.). CRC Press. https://doi.org/10.1201/9780203728888
10.Kassir, M., Gupta, M., Galadari, H., et al. (2020). Complications of botulinum toxin and fillers: A narrative review. Journal of Cosmetic Dermatology, 19(3), 570–573. https://doi.org/10.1111/jocd.13266
11.Struik, G. M., Godart, J., Verduijn, G. M., et al. (2018). A randomized controlled trial testing a hyaluronic acid spacer injection for skin toxicity reduction of brachytherapy accelerated partial breast irradiation (APBI): A study protocol. Trials, 19(1), 689. https://doi.org/10.1186/s13063-018-3035-3
12.Shachar, E., Hasson, E., Arzi, O., Levy, B., Pantanowitz Mabjeesh, L., Adar, L., Shani, O., & Safra, T. (2024). Aesthetics treatment with injectable fillers in patients with cancer: Safety and quality of life during active antineoplastic therapy. Journal of Clinical Oncology. https://doi.org/10.1200/JCO.2024.42.16_suppl.e23245
13.Freites-Martinez, A., et al. (2019). Hair disorders in cancer survivors. Journal of the American Academy of Dermatology, 80(5), 1199–1213. https://doi.org/10.1016/j.jaad.2018.03.056
14.van den Hurk, C. J. (2013). Safety and effectiveness of scalp cooling in cancer patients undergoing cytotoxic treatment [Doctoral dissertation, Leiden University]. Gildeprint Drukkerijen. https://hdl.handle.net/1887/21761
15.Massey, C. S. (2004). A multicentre study to determine the efficacy and patient acceptability of the Paxman Scalp Cooler to prevent hair loss in patients receiving chemotherapy. European Journal of Oncology Nursing, 8(2), 121–130. https://doi.org/10.1016/j.ejon.2003.10.006
16.Lemieux, J., Desbiens, C., & Hogue, J. C. (2011). Breast cancer scalp metastasis as first metastatic site after scalp cooling: Two cases of occurrence after 7- and 9-year follow-up. Breast Cancer Research and Treatment, 128(2), 563–566. https://doi.org/10.1007/s10549-011-1453-y
17.van de Sande, M. A., van den Hurk, C. J., Breed, W. P., & Nortier, J. W. (2010). Allow scalp cooling during adjuvant chemotherapy in patients with breast cancer; scalp metastases rarely occur. Nederlands Tijdschrift voor Geneeskunde, 154, A2134.
18.Lemieux, J., Amireault, C., Provencher, L., & Maunsell, E. (2009). Incidence of scalp metastases in breast cancer: A retrospective cohort study in women who were offered scalp cooling. Breast Cancer Research and Treatment, 118(3), 547–552. https://doi.org/10.1007/s10549-009-0342-0
19.Christodoulou, C., Tsakalos, G., Galani, E., & Skarlos, D. V. (2006). Scalp metastases and scalp cooling for chemotherapy-induced alopecia prevention. Annals of Oncology, 17(2), 350. https://doi.org/10.1093/annonc/mdj008
20.Nangia, J., Wang, T., Osborne, C., et al. (2017). Effect of a scalp cooling device on alopecia in women undergoing chemotherapy for breast cancer: The SCALP randomized clinical trial. JAMA, 317(6), 596–605. https://doi.org/10.1001/jama.2016.20939
21.Sundaresan, P., Sullivan, L., Pendlebury, S., Kirby, A., Rodger, A., Joseph, D., & Stockler, M. R. (2015). Patients' perceptions of health-related quality of life during and after adjuvant radiotherapy for T1N0M0 breast cancer. Clinical Oncology, 27(1), 9–15. https://doi.org/10.1016/j.clon.2014.09.007
22.Montazeri, A. (2008). Health-related quality of life in breast cancer patients: A bibliographic review of the literature from 1974 to 2007. Journal of Experimental and Clinical Cancer Research, 27(1), 32. https://doi.org/10.1186/1756-9966-27-32
23.Gibbons, E., Casanas i Comabella, C., & Fitzpatrick, R. (2013). A structured review of patient-reported outcome measures for patients with skin cancer. British Journal of Dermatology, 168, 1176–1186.
24.Andersen, B. L., Rowland, J. H., & Somerfield, M. R. (2015). Screening, assessment, and care of anxiety and depressive symptoms in adults with cancer: An American Society of Clinical Oncology guideline adaptation. Journal of Oncology Practice, 11, 133–134.
25.Cury-Martins, J., Eris, A. P. M., Abdalla, C. M. Z., Silva, G. B., de Moura, V. P. T., & Sanches, J. A. (2020). Management of dermatologic adverse events from cancer therapies: Recommendations of an expert panel. Anais Brasileiros de Dermatologia, 95, 221–237. https://doi.org/10.1016/j.abd.2020.01.001
26.Kelm, R. C., & Ibrahim, O. (2022). Utility of platelet-rich plasma in aesthetics. Clinical Dermatology, 40, 19–28. https://doi.org/10.1016/j.clindermatol.2021.08.007
27.Plachouri, K.-M., & Georgiou, S. (2019). Mesotherapy: Safety profile and management of complications. Journal of Cosmetic Dermatology, 18, 1601–1605. https://doi.org/10.1111/jocd.13115
28.Sundaram, H., Signorini, M., Liew, S., et al. (2016). Global aesthetics consensus: Botulinum toxin type A–evidence-based review, emerging concepts, and consensus recommendations for aesthetic use, including updates on complications. Plastic and Reconstructive Surgery, 137(3), 518e–529e. https://doi.org/10.1097/01.prs.0000475758.63709.23
29.Kroumpouzos, G., Kassir, M., Gupta, M., Patil, A., & Goldust, M. (2021). Complications of botulinum toxin A: An update review. Journal of Cosmetic Dermatology, 20(6), 1585–1590. https://doi.org/10.1111/jocd.14160
30.Teymoortash, A., Pfestroff, A., Wittig, A., et al. (2016). Safety and efficacy of botulinum toxin to preserve gland function after radiotherapy in patients with head and neck cancer: A prospective, randomized, placebo-controlled, double-blinded phase I clinical trial. PLoS ONE, 11(3), e0151316. https://doi.org/10.1371/journal.pone.0151316
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