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Journal of Education, Health and Sport

Netosis as a bridge between inflammation and liver cell injury
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Netosis as a bridge between inflammation and liver cell injury

Authors

  • Anna Rycyk Medical University of Lublin
  • Beata Kasztelan-Szczerbinska Medical University of Lublin
  • Halina Cichoz-Lach Medical University of Lublin

Keywords

netosis, alcohol liver disease (ALD), neutrophils, neutrophil netosis, NET

Abstract

One of programmed cell death types, netosis, discovered in ’96, was first described by Zychlinsky et al. and has gained elevating popularity among many researchers. It is a process occurring in order to catch pathogens into a trap and kill them. This trap is a scaffold somewhat consisting of chromatin and particles with antimicrobial properties such as histones. Extracellular histones are capable of proinflammatory cytokines production and platelets aggregation what accounts for inflammatory response. Unfortunately, these proteins have also a toxic potential which leads to cell injury through Toll like receptors presented by neutrophils. Mentioned neutrophils participate in an oxidative burst which yields to production reactive oxygen species performing a crucial role in the development of hepatocytes injury. Thus, alcohol abuse appears to result in a rapid development of liver cell injury through progression of inflammation induced by netosis. However, controlled NETs forming can be a future therapeutic option.

Author Biographies

Anna Rycyk, Medical University of Lublin

Chair and Department of Gastroenterology with Endoscopic Unit

Beata Kasztelan-Szczerbinska, Medical University of Lublin

Department of Gastroenterology with Endoscopy Unit

Halina Cichoz-Lach, Medical University of Lublin

Department of Gastroenterology with Endoscopy Unit

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Published

2019-01-27

How to Cite

1.
RYCYK, Anna, KASZTELAN-SZCZERBINSKA, Beata and CICHOZ-LACH, Halina. Netosis as a bridge between inflammation and liver cell injury. Journal of Education, Health and Sport. Online. 27 January 2019. Vol. 9, no. 1, pp. 234-240. [Accessed 1 July 2025].
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Issue

Vol. 9 No. 1 (2019)

Section

Review Articles

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The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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