Paraoxonase 1 as an important antiatherogenic agent

Authors

  • Ewa Lidia Krzewicka-Romaniuk Department of Pathophysiology, Medical University of Lublin
  • Dagna Agnieszka Siedlecka Department of Pathophysiology, Medical University of Lublin
  • Anna Warpas Department of Pathophysiology, Medical University of Lublin
  • Grażyna Wójcicka Department of Pathophysiology, Medical University of Lublin

Keywords

paraoxonase, PON1, lipoproteins, HDL, antiatherogenic

Abstract

The inverse relationship between High Density Lipoproteins (HDL) level and risk of ischaemic heart disease was proved by many epidemiological studies. Although the main mechanism of antiatherogenic activity of HDL is a reverse transport of cholesterol from peripheral tissues to the liver, HDL additionally carries some antioxidative enzymes like Paraoxonase 1 (PON1) which protects LDL and HDL lipoproteins from oxidative modification. A lot of antiatherogenic activities of HDL depends on PON1 activity.

Author Biographies

Ewa Lidia Krzewicka-Romaniuk, Department of Pathophysiology, Medical University of Lublin

M.D.

Dagna Agnieszka Siedlecka, Department of Pathophysiology, Medical University of Lublin

M.D.

Grażyna Wójcicka, Department of Pathophysiology, Medical University of Lublin

PhD

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Published

2019-01-17

How to Cite

1.
KRZEWICKA-ROMANIUK, Ewa Lidia, SIEDLECKA, Dagna Agnieszka, WARPAS, Anna and WÓJCICKA, Grażyna. Paraoxonase 1 as an important antiatherogenic agent. Journal of Education, Health and Sport. Online. 17 January 2019. Vol. 9, no. 1, pp. 133-143. [Accessed 18 May 2025].

Issue

Vol. 9 No. 1 (2019)

Section

Review Articles

License

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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