Pathophysiological mechanisms of integrated regulation of water-sodium homeostasis: from cellular dysfunction of Na-K-ATPase to dysregulation of systemic volume control: a systematic review
DOI:
https://doi.org/10.12775/JEHS.2025.84.64716Keywords
water-sodium homeostasis, Na-K-ATPase, digitalis-like compounds, natriuretic peptides, dual regulation, pathophysiology, cardiovascular diseases, arterial hypertension, heart failureAbstract
Background: Water-sodium homeostasis regulation is a fundamental physiological process that ensures cellular function maintenance, extracellular fluid volume, and arterial pressure. Despite decades of research, the integrated understanding of the dual sodium regulatory system remains incomplete, limiting the development of effective therapeutic approaches for cardiovascular and renal diseases.
Objective: To conduct a systematic review and meta-analysis of evidence regarding integrated dual regulation of water-sodium homeostasis, including cellular mechanisms (digitalis-like compounds and Na-K-ATPase) and systemic mechanisms (natriuretic peptides and neurohormonal volume regulation), with assessment of their pathophysiological interactions and clinical implications.
Methods: A systematic search was conducted in PubMed/MEDLINE, Embase, Cochrane Library, Web of Science, and Scopus databases (1957-2025) according to PRISMA 2020 guidelines. Experimental studies, clinical trials, and observational studies investigating sodium regulation mechanisms at cellular and systemic levels were included. Study quality was assessed using RoB 2.0, ROBINS-I, and Newcastle-Ottawa Scale. Meta-analysis was performed using random-effects model (DerSimonian-Laird).
Results: We identified 1,847 records, of which 89 studies met inclusion criteria (n=34,156 participants). Meta-analysis of 24 studies showed significant natriuretic increase under digitalis-like compounds influence (SMD = 1.67, 95% CI: 1.52-1.82, p<0.001, I²=68%). Endogenous digitalis-like compound levels were progressively elevated in hypertension (1.87±0.64 vs 0.52±0.18 nmol/L in healthy individuals, p<0.001), heart failure (2.34±0.89 nmol/L), and chronic kidney disease (2.78±1.12 nmol/L). Natriuretic peptides demonstrated coordinated responses with cellular mechanisms: correlation between ANP and Na-K-ATPase activity (r=0.58, p<0.01), BNP and endogenous ouabain levels (r=0.42, p<0.05).
Conclusions: The dual regulatory system of water-sodium homeostasis represents an integrated network of mechanisms that coordinate cellular activity and systemic fluid balance through complex pathophysiological interactions. The cellular subsystem (digitalis-like compounds/Na-K-ATPase) is functionally integrated with the systemic subsystem (natriuretic peptides/neurohormonal regulation) to maintain homeostasis. Disruption of this integration underlies the pathogenesis of arterial hypertension, heart failure, and chronic kidney disease. These findings have critical significance for understanding pathophysiology and developing new personalized therapeutic strategies.
References
Aizman, O., & Aperia, A. (2003). Na,K-ATPase as a signal transducer. Annals of the New York Academy of Sciences, 986(1), 489–496. https://doi.org/10.1111/j.1749-6632.2003.tb07233.x
Alqahtani, S., Seoane-Vazquez, E., Rodríguez-Monguió, R., & Eguale, T. (2015). Priority review drugs approved by the FDA and the EMA: Time for international regulatory harmonization of pharmaceuticals? Pharmacoepidemiology and Drug Safety, 24(7), 709–715. https://doi.org/10.1002/pds.3793
Aperia, A., Akkuratov, E. E., Fontana, J. M., & Brismar, H. (2016). Na⁺-K⁺-ATPase, a new class of plasma membrane receptors. American Journal of Physiology-Cell Physiology, 310(7), C491–C495. https://doi.org/10.1152/ajpcell.00359.2015
Aryal, D., & Jackson, K. (2020). Association of acid-base balance in the renal proximal tubule and blood pressure alterations: Potential role of local mediators. Journal of Biosciences and Medicines, 8(4), 26–44. https://doi.org/10.4236/jbm.2020.84003
Bagrov, A. Y., Shapiro, J. I., & Fedorova, O. V. (2009). Endogenous cardiotonic steroids: Physiology, pharmacology, and novel therapeutic targets. Pharmacological Reviews, 61(1), 9–38. https://doi.org/10.1124/pr.108.000711
Blaustein, M. P. (1993). Physiological effects of endogenous ouabain: Control of intracellular Ca²⁺ stores and cell responsiveness. American Journal of Physiology-Cell Physiology, 264(6), C1367–C1387. https://doi.org/10.1152/ajpcell.1993.264.6.C1367
Blaustein, M. P. (2018). The pump, the exchanger, and the holy spirit: Origins and 40-year evolution of ideas about the ouabain-Na+ pump endocrine system. American Journal of Physiology-Cell Physiology, 314(1), C3–C26. https://doi.org/10.1152/ajpcell.00196.2017
Blaustein, M. P., Chen, L., Hamlyn, J. M., Leenen, F. H. H., Lingrel, J. B., Wier, W. G., & Zhang, J. (2016). Pivotal role of α2 Na+ pumps and their high affinity ouabain binding site in cardiovascular health and disease. The Journal of Physiology, 594(21), 6079–6103. https://doi.org/10.1113/JP272419
Blaustein, M. P., Leenen, F. H. H., Chen, L., Golovina, V. A., Hamlyn, J. M., Pallone, T. L., Van Huysse, J. W., Zhang, J., & Wier, W. G. (2012). How NaCl raises blood pressure: A new paradigm for the pathogenesis of salt-dependent hypertension. American Journal of Physiology-Heart and Circulatory Physiology, 302(5), H1031–H1049. https://doi.org/10.1152/ajpheart.00899.2011
Blaustein, M. P., Zhang, J., Chen, L., Song, H., Raina, H., Kinsey, S. P., Izuka, M., Iwamoto, T., Kotlikoff, M. I., Lingrel, J. B., Philipson, K. D., Wier, W. G., & Hamlyn, J. M. (2009). The pump, the exchanger, and endogenous ouabain: Signaling mechanisms that link salt retention to hypertension. Hypertension, 53(2), 291–298. https://doi.org/10.1161/HYPERTENSIONAHA.108.119974
Broniuk, A. (2022). Functional state of kidneys in patients with acute myocardial infarction. Bukovinian Medical Herald, 26(4), 3–8. https://doi.org/10.24061/2413-0737.XXVI.4.104.2022.1
Chen, D., Song, M., Mohamad, O., & Yu, S. (2014). Inhibition of Na+/K+-ATPase induces hybrid cell death and enhanced sensitivity to chemotherapy in human glioblastoma cells. BMC Cancer, 14(1), Article 716. https://doi.org/10.1186/1471-2407-14-716
Chen, H. H., & Burnett, J. C. (2017). The natriuretic peptides in heart failure: Diagnostic and therapeutic potentials. Proceedings of the Association of American Physicians, 110(5), 406–416. https://doi.org/10.1111/paa.1999.111.5.406
Citarella, M., Choi, M., Gironacci, M., Medici, C., Correa, A., & Fernández, B. (2009). Urodilatin and dopamine: A new interaction in the kidney. Regulatory Peptides, 153(1–3), 19–24. https://doi.org/10.1016/j.regpep.2008.11.009
Crambert, G., & Geering, K. (2003). FXYD proteins: New tissue-specific regulators of the ubiquitous Na,K-ATPase. Science's STKE, 2003(166), re1. https://doi.org/10.1126/stke.2003.166.re1
de Bold, A. J., Borenstein, H. B., Veress, A. T., & Sonnenberg, H. (1981). A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sciences, 28(1), 89–94. https://doi.org/10.1016/0024-3205(81)90370-2
Domnich, A., Manini, I., Panatto, D., Calabrò, G., & Montomoli, E. (2020). Immunogenicity measures of influenza vaccines: A study of 1164 registered clinical trials. Vaccines, 8(2), Article 325. https://doi.org/10.3390/vaccines8020325
Duarte, J., Zineh, I., Burkley, B., Gong, Y., Langaee, T., Turner, S., ... & Johnson, J. (2012). Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide. Journal of Translational Medicine, 10(1), Article 56. https://doi.org/10.1186/1479-5876-10-56
Duval, S., & Tweedie, R. (2000). Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics, 56(2), 455–463. https://doi.org/10.1111/j.0006-341X.2000.00455.x
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315(7109), 629–634. https://doi.org/10.1136/bmj.315.7109.629
Eid, S., & Brändli, A. (2001). Xenopus Na,K-ATPase: Primary sequence of the β2 subunit and in situ localization of α1, β1, and γ expression during pronephric kidney development. Differentiation, 68(2–3), 115–125. https://doi.org/10.1046/j.1432-0436.2001.680205.x
Fan, X., Xie, J., & Tian, J. (2017). Reducing cardiac fibrosis: Na/K-ATPase signaling complex as a novel target. Cardiovascular Pharmacology: Open Access, 6(1), Article 204. https://doi.org/10.4172/2329-6607.1000204
Fedorova, O. V., & Bagrov, A. Y. (1997). Inhibition of Na/K ATPase from rat aorta by two Na/K pump inhibitors, ouabain and marinobufagenin: Evidence of interaction with different alpha-subunit isoforms. American Journal of Hypertension, 10(9, Pt. 1), 929–935. https://doi.org/10.1016/S0895-7061(97)00096-4
Fedorova, O. V., Doris, P. A., & Bagrov, A. Y. (1998). Endogenous marinobufagenin-like factor in acute plasma volume expansion. Clinical and Experimental Hypertension, 20(5–6), 581–591. https://doi.org/10.3109/10641969809053236
Fedorova, O. V., Kashkin, V. A., Zakharova, I. O., Lakatta, E. G., & Bagrov, A. Y. (2012). Age-associated increase in salt sensitivity is accompanied by a shift in the atrial natriuretic peptide modulation of the effect of marinobufagenin on renal and vascular sodium pump. Journal of Hypertension, 30(9), 1817–1826. https://doi.org/10.1097/HJH.0b013e328356399b
Fedorova, O. V., Simbirtsev, A. S., Kolodkin, N. I., Kotov, A. Y., Agalakova, N. I., Kashkin, V. A., ... & Bagrov, A. Y. (2008). Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension. Journal of Hypertension, 26(12), 2414–2425. https://doi.org/10.1097/HJH.0b013e328312c86a
Fedorova, O. V., Talan, M. I., Agalakova, N. I., Lakatta, E. G., & Bagrov, A. Y. (2002). Endogenous ligand of α1 sodium pump, marinobufagenin, is a novel mediator of sodium chloride–dependent hypertension. Circulation, 105(9), 1122–1127. https://doi.org/10.1161/hc0902.104710
Fridman, A. I., Matveev, S. A., Agalakova, N. I., Fedorova, O. V., Lakatta, E. G., & Bagrov, A. Y. (2002). Marinobufagenin, an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity. Journal of Hypertension, 20(6), 1189–1194. https://doi.org/10.1097/00004872-200206000-00032
Gabiyatu, B., Li, W., Tian, Y., Baasandorj, L., Li, S., Tsagaankhuu, S., ... & Boldbaatar, D. (2023). Expression of Notch1 in ameloblastoma and correlation with CBCT imaging subtypes. Central Asian Journal of Medical Sciences, 9(4), 182–188. https://doi.org/10.24079/cajms.2023.12.004
Geering, K., Béguin, P., Garty, H., Karlish, S., Füzesi, M., Horisberger, J.-D., & Crambert, G. (2003). FXYD proteins: New tissue- and isoform-specific regulators of Na,K-ATPase. Annals of the New York Academy of Sciences, 986(1), 388–394. https://doi.org/10.1111/j.1749-6632.2003.tb07219.x
Goetze, J. P. (2004). Biochemistry of pro-B-type natriuretic peptide-derived peptides: The endocrine heart revisited. Clinical Chemistry, 50(9), 1503–1510. https://doi.org/10.1373/clinchem.2004.034272
Goetze, J. P. (2009). Biosynthesis of cardiac natriuretic peptides. In Cellular Peptide Hormone Synthesis and Secretory Pathways (pp. 21–44). Springer. https://doi.org/10.1007/400_2009_25
Goetze, J. P., Hansen, L. H., Terzic, D., Zois, N. E., Albrethsen, J., Timm, A., ... & Hunter, I. (2015). Atrial natriuretic peptides in plasma. Clinica Chimica Acta, 443, 25–28. https://doi.org/10.1016/j.cca.2014.08.017
Gottlieb, S. S., Rogowski, A. C., Weinberg, M., Krichten, C. M., Hamilton, B. P., & Hamlyn, J. M. (1992). Elevated concentrations of endogenous ouabain in patients with congestive heart failure. Circulation, 86(2), 420–425. https://doi.org/10.1161/01.CIR.86.2.420
Gozhenko, A. I. (1974). Activity of succinate dehydrogenase and content of pyridine nucleotides in the cortical substance of the kidneys in nephritis in rats. In Mater. IV konf. po vodno-solevomu obmenu i funktsii pochek (pp. 45–47). Chernovtsy.
Gozhenko, A. I. (1974). Distribution of electrolytes in tissues in rats with nephritis. In Mater. IV konf. po vodno-solevomu obmenu i funktsii pochek (p. 54). Chernovtsy.
Gozhenko, A. I. (1974). Oxidative phosphorylation in the kidneys of rats and rabbits with nephritis. In Mater. IV konf. po vodno-solevomu obmenu i funktsii pochek (pp. 51–52). Chernovtsy.
Gozhenko, A. I. (1976). Influence of metabolic acidosis on oxidative phosphorylation and carbonic anhydrase activity in comparison with excretory kidney activity. In Funktsional'noe sostoyanie pochek pri ekstremal'nykh usloviyakh: Mater. Vsesoyuzn. simpoziuma (p. 34). Leningrad.
Gozhenko, A. I. (1976). Some pathogenetic mechanisms of the formation of chronic renal failure. In Funktsional'noe sostoyanie pochek pri ekstremal'nykh usloviyakh: Mater. Vsesoyuzn. simpoziuma (pp. 47–48). Leningrad.
Gozhenko, A. I. (1976). Water-salt metabolism and kidney activity in glomerulonephritis. In Tez. dokl. II s"ezda patofiziologov (Vol. 2, pp. 76–77). Tashkent.
Gozhenko, A. I. (1978). Features of osmoregulatory function of the kidneys in rats with experimental nephritis. In Tez. dokl. V Vsesoyuzn. konf. po fiziologii pochek i vodno-solevogo obmena (p. 56). Leningrad.
Gozhenko, A. I. (1978). On the role of volume regulation disorders in the pathogenesis of disorders in glomerulonephritis. In Tez. dokl. konf. patofiziologov (p. 87). Poltava.
Gozhenko, A. I. (1979). Adaptive-compensatory changes in energy metabolism and renal processes in nephritis. In Ref. dokl. XIII s"ezda Vsesoyuzn. fiziologicheskogo obshchestva im. I. I. Pavlova (Vol. 1, pp. 32–33). Alma-Ata.
Gozhenko, A. I. (1979). Influence of sodium ration on the development of acute renal failure in rats after sublimate administration. In Tez. dokl. Vsesoyuzn. konf. nefrologov (p. 46). M.
Gozhenko, A. I. (1983). Kidney function in pregnant women with severe forms of toxicosis. In Klinicheskaya patofiziologiya pochek i vodno-solevogo obmena: Tez. dokl. nauch. konf. (p. 51). Irkutsk.
Gozhenko, A. I. (1984). Osmoregulatory function of the kidneys in chronic nephritis. Patofiziologiya i Eksperimental'naya Terapiya, 4, 56–60.
Gozhenko, A. I. (1985). Mechanisms of influence of indomethacin on kidney function under hyper- and hyponatremic ration. In Farmakologiya pochek (pp. 45–47). Kuybyshev.
Gozhenko, A. I. (1985). Renal and systemic effects of metabolic acidosis. In Nervnye i gumorral'nye mekhanizmy kompensatsii v usloviyakh deystviya patogennykh faktorov (pp. 27–29). Zaporozh'e.
Gozhenko, A. I. (1987). Mechanisms of influence of antidiuretic hormone and renin-aldosterone system on kidney function depending on sodium content in the body. In Tez. dokl. XV s"ezda Vsesoyuzn. fiziologicheskogo obshchestva im. I. I. Pavlova (Vol. 2, p. 69). Leningrad.
Gozhenko, A. I. (1987). Organization of renal functions depending on the state of sodium balance in the body. In Tez. dokl. XV s"ezda Vsesoyuzn. fiziologicheskogo obshchestva im. I. I. Pavlova (Vol. 2, p. 67). Leningrad.
Gozhenko, A. I. (1988). Renal mechanisms of organism adaptation to sharp changes in ionic homeostasis. In Ekologo-fiziologicheskie problemy adaptatsii: Mater. V Vsesoyuzn. simpoziuma (pp. 100–102). M.
Gozhenko, A. I. (1989). Acid-excretory function of the kidneys in experimental nephrotoxic hypoxia of different genesis. In Kompensatorno-prisposobitel'nye reaktsii organizma pri gipoksii: Mater. nauch. konf. (pp. 81–83). Kuybyshev.
Gozhenko, A. I. (1989). Pathogenetic significance of lipid peroxidation in damage to the proximal nephron in acute Lindemann-Masugi nephritis. Fiziologicheskiy Zhurnal, 35(5), 123–128.
Gozhenko, A. I. (1990). Mechanisms of kidney adaptation to various water-salt exchange regimes. In Funktsional'nye rezervy i adaptatsiya: Mater. Vsesoyuzn. nauch. konf. (pp. 116–117). Kiev.
Gozhenko, A. I. (1994). Mechanisms of kidney adaptation to disturbances in water-electrolyte exchange in metabolic acidosis. Patologicheskaya Fiziologiya i Eksperimental'naya Terapiya, 3, 42–44.
Gozhenko, A. I., Zaporozhan, V. N., Moskalenko, T. Ya., Dolomatov, S. I., Yakimenko, L. V., & Ambrosiychuk, E. V. (2002). Antipyrine clearance in pregnant smokers [Клиренс антипирина у курящих беременных]. Problemy Reproduktsii, 8(4), 34–36.
Gozhenko, A. I., Fedoruk, A. S., Dolomatov, S. I., & Pogorelaya, I. V. (2003). The influence of arginine, preductal, and sorbilact on kidney function in rats with sublimate nephropathy [Влияние аргинина, предуктала и сорбилакта на функцию почек крыс при сулемовой нефропатии]. Nephrology, 7(1), 98–101.
Gozhenko, A. I., Avramenko, A. O., Sadovnik, E. V., & Chebotarev, O. P. (2003). The role of arterial hypertension in the formation of bleeding from erosive lesions of the duodenal bulb mucosa in patients with chronic gastritis type B [Роль артериальной гипертензии у формуванні кровотеч з ерозивних уражень слизової цибулини дванадцятипалої кишки у хворих на хронічний гастрит типу В]. Halytskyi Likarskyi Visnyk, 10(1), 48–49.
Gozhenko, A. I., Dolomatov, S. I., Shumilova, P. A., Topor, E. A., Pyatenko, V. A., & Badyin, I. Yu. (2004). The influence of osmotic loads on the functional state of kidneys in healthy individuals [Влияние осматических нагрузок на функциональное состояние почек здоровых людей]. Nephrology, 8(2), 44–48.
Gozhenko, A. I., Karchauskas, S. I., Dolomatov, S. I., Dolomatova, E. A., & Pykhteev, D. M. (2004). Kidney function in rats under water and salt loading with cadmium dichloride exposure [Функция почек крыс в условиях водной и солевой нагрузки при воздействии дихлора кадмия]. Occupational Medicine and Industrial Ecology, 8, 45–48.
Gozhenko, A. I., Dolomatov, S. I., Larina, I. M., Buravkova, L. B., & Dolomatova, E. A. (2004). The influence of thyroxine on renal excretion of endogenous nitrites and nitrates in white rats [Влияние тироксина на почечную экскрецию эндогенных нитритов и нитратов у белых крыс]. Nephrology, 8(4), 73–76.
Gozhenko, A. I., & Topor, E. A. (2004). Renal mechanisms of "exaggerated" natriuresis [Ренальные механизмы «преувеличенного» натрийуреза]. Bukovinian Medical Herald, 8(3–4), 343.
Gozhenko, A. I., & Trusova, M. V. (2007). The influence of glutargine and arginine on the course of ifosfamide-induced experimental renal failure in white rats [Влияние глютаргина и аргинина на течение индуцированной йофосфамидом экспериментальной почечной недостаточности у белых крыс]. Nephrology, 11(3), 82–85.
Gozhenko, A. I., Koliev, V. I., Gozhenko, E. A., & Lebedeva, T. L. (2008). Aquaporins and their role in water transport in kidneys and intestines [Аквапорины и их роль в транспорте воды в почках и кишечнике]. Clinical and Experimental Pathology, 7(3), 134–141.
Gozhenko, A. I., & Zaritskaya, L. P. (2009). Old and new problems of railway medicine: A literature review [Старые и новые проблемы железнодорожной медицины (обзор литературы)]. Current Problems of Transport Medicine, 2, 9–18.
Gozhenko, A. I., & Shafran, L. M. (2009). Occupationally induced metal nephropathies in transport: Etiopathogenesis, diagnosis, prevention [Профессионально обусловленные металлонефропатии на транспорте: этиопатогенез, диагностика, профилактика]. Bulletin of East Siberian Scientific Center SB RAMS, 1, 141–146.
Gozhenko, A. I., Khaminich, A. V., & Gozhenko, E. A. (2009). Functional renal reserve: Mechanisms, methods of determination, and diagnostic significance [Функциональный почечный резерв: механизмы, методики определения и диагностическое значение]. Nephrology, 13(3), 149.
Gozhenko, A. I., Golovenko, M., & Sachura, V. (2010). Xenon - prospects for use in neurological and psychiatric practice [Ксенон - перспективы применения в неврологической и психиатрической практике]. Herald of Pharmacology and Pharmacy, 9, 2–9.
Gozhenko, A. I., Mokienko, A. V., & Petrenko, N. F. (2011). Halogen-containing compounds (HCCs) as products of water chlorination. First report. Brief history of the issue and general state of the problem (Part 1) [Галогенсодержащие соединения (ГСС) как продукты хлорирования воды. Сообщение первое. Краткая история вопроса и общее состояние проблемы (Часть 1)]. Current Problems of Transport Medicine, 4(26), 36–49.
Gozhenko, A. I. (2012). Current problems of modern disease theory [Актуальные проблемы современной теории болезни]. Taurian Medical and Biological Herald, 15(3, Pt. 2), 319.
Gozhenko, A. I., & Zhigalina-Gritsenyuk, M. S. (2013). Preventive mechanisms of human water-salt metabolism regulation [Превентивные механизмы регуляции водно-солевого обмена человека]. Water: Hygiene and Ecology, 1(2), 6–13.
Gozhenko, A. I., Levitsky, A. P., & Levchenko, E. M. (2013). The influence of quertulin on lipid content in the liver and blood serum of rats with endotoxemia [Влияние квертулина на содержание липидов в печени и в сыворотке крови крыс с эндотоксинемией]. Current Problems of Transport Medicine, 1(31), 139–143.
Gozhenko, A. I. (1974). Succinate dehydrogenase activity and pyridine nucleotide content in renal cortex of rats with nephritis [Активность сукцинатдегидрогеназы и содержание пиридиннуклеотидов в корковом веществе почек при нефрите у крыс]. In Proceedings of the IV Conference on Water-Salt Metabolism and Kidney Function (pp. 45–47). Chernivtsi University Press.
Gozhenko, A. I., & Koloskova, R. P. (1974). Oxidative phosphorylation in kidneys of rats and rabbits with nephritis [Окислительное фосфорилирование в почках у крыс и кроликов при нефрите]. In Proceedings of the IV Conference on Water-Salt Metabolism and Kidney Function (pp. 51–52). Chernivtsi University Press.
Gozhenko, A. I., Kokoshchuk, G. I., Lobach, A. D., & Koloskova, R. P. (1976). On the interaction between kidneys and the cardiovascular system [К вопросу о взаимодействии почек и сердечно-сосудистой системы]. In Functional State of Kidneys Under Extreme Conditions: Proceedings of the All-Union Symposium (pp. 23–24). Leningrad Medical Institute Press.
Gozhenko, A. I., Krishtal, N. V., & Kukharchuk, A. L. (1986). Mechanisms of the influence of metabolic acidosis on water and sodium transport [Механизмы влияния метаболического ацидоза на транспорт воды и натрия]. In Abstracts of the XII Congress of the Ukrainian Physiological Society named after I.I. Pavlov (pp. 76–78). Lviv Medical Press.
Gozhenko, A. I., Svirsky, A. A., Zelinsky, A. A., & Biletsky, S. V. (1994). The role of atrial natriuretic hormone in the development of gestosis in the second half of pregnancy [Роль предсердного натрийуретического гормона в развитии гестоза второй половины беременности]. In New Approaches in Prevention, Diagnosis and Treatment of Major Internal Organ Diseases: Collection of Scientific Papers (pp. 375–381). Kharkiv Medical Press.
Gozhenko, A. I., & Savitsky, I. V. (2001). The influence of nitric oxide on the development of male rat gonads in antenatal and early prepubertal age [Влияние оксида азота на развитие половых желез крыс-самцов антенатального и раннего препубертатного возраста]. In Current Issues of Pharmaceutical and Medical Science and Practice (Vol. 6, pp. 93–97). Zaporizhzhia Medical Press.
Gozhenko, A. I. (2007). Sanogenesis – the theoretical basis of medical rehabilitation [Саногенез – теоретическая основа медицинской реабилитации]. In Current Problems of Biophysical Medicine: Proceedings of the V International Symposium (pp. 46–47). Kiev Medical Press.
Gozhenko, A. I., Aleksandrov, B. G., Aleksenko, T. L., Andreev, V. I., Andronati, S. A., et al. (2011). Science in the Southern region of Ukraine (1971-2011) [Наука в Южном регионе Украины (1971-2011)]. Feniks.
Gozhenko, A. I., Divocha, V. A., & Mikhalchuk, V. N. (2011). Biological justification for antiproteinase therapy for influenza [Биологическое обоснование антипротеиназной терапии гриппа]. Ivanets.
Gozhenko, A. I., Ivanov, D. D., Nikitenko, O. P., Stepanov, Y. M., Yakovenko, L. F., Yeliseyeva, O. P., Gozhenko, E. A., Badiuk, N. S., & Bilas, V. R. (2019). Functional renal reserve: Physiology, pathophysiology and diagnosis. Application in practice [Функциональный почечный резерв: физиология, патофизиология и диагностика. Применение в практике]. Vydavets Zaslavsky A. Yu.
Guan, Y., Zhao, B., Song, C., Hou, Q., Tong, T., & Xu, S. (2025). Development and evaluation of a nomogram for predicting pulmonary embolism in children with severe Mycoplasma pneumoniae pneumonia. Pediatric Pulmonology, 60(3). https://doi.org/10.1002/ppul.71046
Gutkowska, J., Jankowski, M., Mukaddam-Daher, S., & McCann, S. M. (2000). Oxytocin is a cardiovascular hormone. Brazilian Journal of Medical and Biological Research, 33(6), 625–633. https://doi.org/10.1590/S0100-879X2000000600003
Hamlyn, J. M. (2014). Natriuretic hormones, endogenous ouabain, and related cardiovascular disorders. Frontiers in Endocrinology, 5, Article 199. https://doi.org/10.3389/fendo.2014.00199
Hamlyn, J. M., & Blaustein, M. P. (2013). Salt sensitivity, endogenous ouabain and hypertension. Current Opinion in Nephrology and Hypertension, 22(1), 51–58. https://doi.org/10.1097/MNH.0b013e32835b36ec
Hamlyn, J. M., & Blaustein, M. P. (2016). Endogenous ouabain: Recent advances and controversies. Hypertension, 68(3), 526–532. https://doi.org/10.1161/HYPERTENSIONAHA.116.06599
Hamlyn, J. M., & Manunta, P. (2015). Endogenous cardiotonic steroids in kidney failure: A review and an hypothesis. Advances in Chronic Kidney Disease, 22(3), 232–244. https://doi.org/10.1053/j.ackd.2014.12.005
Hamlyn, J. M., Ringel, R., Schaeffer, J., Levinson, P. D., Hamilton, B. P., Kowarski, A. A., & Blaustein, M. P. (1982). A circulating inhibitor of (Na⁺ + K⁺)-ATPase associated with essential hypertension. Nature, 300(5890), 650–652. https://doi.org/10.1038/300650a0
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003). Measuring inconsistency in meta-analyses. BMJ, 327(7414), 557–560. https://doi.org/10.1136/bmj.327.7414.557
Hnizdyukh, R., & Shmanko, V. (2021). Specificity of blood pressure numbers in Holter monitoring depending on gene polymorphism among residents of Ternopil region afflicted with essential arterial hypertension. Journal of Education, Health and Sport, 11(7), 124–134. https://doi.org/10.12775/34806
Hooijmans, C. R., Rovers, M. M., de Vries, R. B. M., Leenaars, M., Ritskes-Hoitinga, M., & Langendam, M. W. (2014). SYRCLE’s risk of bias tool for animal studies. BMC Medical Research Methodology, 14, Article 43. https://doi.org/10.1186/1471-2288-14-43
Hung, K., Yeung, A., Bornstein, M. M., & Schwendicke, F. (2023). Personalized dental medicine, artificial intelligence, and their relevance for dentomaxillofacial imaging. Dentomaxillofacial Radiology, 52(1), Article 20220335. https://doi.org/10.1259/dmfr.20220335
Jablonski, K. L., Fedorova, O. V., Racine, M. L., Geolfos, C. J., Gates, P. E., Chonchol, M., ... & Seals, D. R. (2013). Dietary sodium restriction and association with urinary marinobufagenin, blood pressure, and aortic stiffness. Clinical Journal of the American Society of Nephrology, 8(11), 1952–1959. https://doi.org/10.2215/CJN.00900113
Jung, J., Ryu, S., Ki, I.-A., Woo, H.-A., & Lee, K. (2018). Some biological consequences of the inhibition of Na,K-ATPase by translationally controlled tumor protein (TCTP). International Journal of Molecular Sciences, 19(6), Article 1657. https://doi.org/10.3390/ijms19061657
Kapoun, A. M., Liang, F., O’Young, G., Damm, D. L., Quon, D., White, R. T., ... & Protter, A. A. (2004). B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts: Fibrosis, myofibroblast conversion, proliferation, and inflammation. Circulation Research, 94(4), 453–461. https://doi.org/10.1161/01.RES.0000117070.86556.9F
Kawatani, Y., Hoshi, K., Yamada, H., & Hori, T. (2023). Torsade de pointes during an oral surgery caused by a combination of herbal medicine-induced pseudoaldosteronism and trigeminocardiac reflex. Oxford Medical Case Reports, 2023(9). https://doi.org/10.1093/omcr/omad098
Kolmakova, E. V., Haller, S. T., Kennedy, D. J., Isachkina, A. N., Budny, G. V., Frolova, E. V., ... & Bagrov, A. Y. (2011). Endogenous cardiotonic steroids in chronic renal failure. Nephrology Dialysis Transplantation, 26(9), 2912–2919. https://doi.org/10.1093/ndt/gfq772
Kuhn, M. (2016). Molecular physiology of membrane guanylyl cyclase receptors. Physiological Reviews, 96(2), 751–804. https://doi.org/10.1152/physrev.00022.2015
Lamichhane, S., Mohammed, C., Haller, S. T., Kennedy, D. J., & Isailović, D. (2022). Quantification of cardiotonic steroids potentially regulated by paraoxonase 3 in a rat model of chronic kidney disease using UHPLC-Orbitrap-MS. International Journal of Molecular Sciences, 23(21), Article 13565. https://doi.org/10.3390/ijms232113565
Lanzani, C., Citterio, L., Glorioso, N., Manunta, P., Tripodi, G., Salvi, E., ... & Bianchi, G. (2010). Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: Clinical studies. Science Translational Medicine, 2(59), Article 59ra87. https://doi.org/10.1126/scitranslmed.3001814
Lastra-González, G., Manrique-Acevedo, C., & Sowers, J. R. (2008). The role of aldosterone in cardiovascular disease in people with diabetes and hypertension: An update. Current Diabetes Reports, 8(3), 203–207. https://doi.org/10.1007/s11892-008-0035-9
Levin, E. R., Gardner, D. G., & Samson, W. K. (1998). Natriuretic peptides. New England Journal of Medicine, 339(5), 321–328. https://doi.org/10.1056/NEJM199807303390507
Li, X., Swaggerty, C. L., Kogut, M. H., Chiang, H.-I., Wang, Y., Genovese, K. J., ... & Zhou, H. (2010). Gene expression profiling of the local cecal response of genetic chicken lines that differ in their susceptibility to Campylobacter jejuni colonization. PLoS ONE, 5(7), Article e11827. https://doi.org/10.1371/journal.pone.0011827
Lingrel, J. B. (2010). The physiological significance of the cardiotonic steroid/ouabain-binding site of the Na,K-ATPase. Annual Review of Physiology, 72, 395–412. https://doi.org/10.1146/annurev-physiol-021909-135725
Liu, J., & Xie, Z.-J. (2010). The sodium pump and cardiotonic steroids-induced signal transduction protein kinases and calcium-signaling microdomain in regulation of transporter trafficking. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1802(12), 1237–1245. https://doi.org/10.1016/j.bbadis.2010.01.013
Mahmmoud, Y. A. (2005). Curcumin modulation of Na,K-ATPase: Phosphoenzyme accumulation, decreased K+ occlusion, and inhibition of hydrolytic activity. British Journal of Pharmacology, 145(2), 236–245. https://doi.org/10.1038/sj.bjp.0706185
Maisel, A. S., Krishnaswamy, P., Nowak, R. M., McCord, J., Hollander, J. E., Duc, P., ... & Breathing Not Properly Multinational Study Investigators. (2002). Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. New England Journal of Medicine, 347(3), 161–167. https://doi.org/10.1056/NEJMoa020233
Mandal, A., Shahidullah, M., & Delamere, N. A. (2015). Calcium entry via connexin hemichannels in lens epithelium. Experimental Eye Research, 132, 52–58. https://doi.org/10.1016/j.exer.2015.01.012
Manhart, I., DeClementi, C., & Guenther, C. (2013). Mountain laurel toxicosis in a dog. Journal of Veterinary Emergency and Critical Care, 23(1), 77–81. https://doi.org/10.1111/vec.12009
Manunta, P., Hamilton, B. P., & Hamlyn, J. M. (2006). Salt intake and depletion stimulate circulating levels of endogenous ouabain in normal men. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 290(3), R553–R559. https://doi.org/10.1152/ajpregu.00648.2005
Manunta, P., Messaggio, E., Ballabeni, C., Sciarrone, M. T., Lanzani, C., Ferrandi, M., ... & Bianchi, G. (2001). Plasma ouabain-like factor during acute and chronic changes in sodium balance in essential hypertension. Hypertension, 38(2), 198–203. https://doi.org/10.1161/01.HYP.38.2.198
McMurray, J. J. V., Packer, M., Desai, A. S., Gong, J., Lefkowitz, M. P., Rizkala, A. R., ... & PARADIGM-HF Investigators and Committees. (2014). Angiotensin-neprilysin inhibition versus enalapril in heart failure. New England Journal of Medicine, 371(11), 993–1004. https://doi.org/10.1056/NEJMoa1409077
Mesquita, E. C., Jorge, A. J. L., Souza, C. V., & Cassino, J. P. (2014). Systems biology applied to heart failure with normal ejection fraction. Arquivos Brasileiros de Cardiologia, 102(5), e21. https://doi.org/10.5935/abc.20140062
Nandi, J., Das, P. K., Levine, R. A., & Ray, T. K. (1988). Half of the (Na+ + K+)-transporting-ATPase-associated K+-stimulated p-nitrophenyl phosphatase activity of gastric epithelial cells is exposed to the surface exterior. Biochemical Journal, 252(1), 29–34. https://doi.org/10.1042/bj2520029
Nesher, M., Shpolansky, U., Rosen, H., & Lichtstein, D. (2007). The digitalis-like steroid hormones: New mechanisms of action and biological significance. Life Sciences, 80(23), 2093–2107. https://doi.org/10.1016/j.lfs.2007.03.013
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., ... & Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, Article n71. https://doi.org/10.1136/bmj.n71
Pedersen, C. J., Axelsen, K. B., Harper, J. F., & Palmgren, M. G. (2012). Evolution of plant P-type ATPases. Frontiers in Plant Science, 3, Article 31. https://doi.org/10.3389/fpls.2012.00031
Péret, B., Middleton, A. M., French, A. P., Larrieu, A., Bishopp, A., Njo, M., ... & Bennett, M. J. (2013). Sequential induction of auxin efflux and influx carriers regulates lateral root emergence. Molecular Systems Biology, 9(1), Article 699. https://doi.org/10.1038/msb.2013.43
Pierre, S. V., & Xie, Z. (2006). The Na,K-ATPase receptor complex: Its organization and membership. Cell Biochemistry and Biophysics, 46(3), 303–316. https://doi.org/10.1385/CBB:46:3:303
Polka, N. S., Savina, R. V., Rudnytska, O. P., Korkach, V. I., Melchenko, Y. V., Leikykh, S. V., ... & Martyshchenko, N. V. (2023). Theoretical and practical significance of scientific research by the Institute of Public Health of the NAMS of Ukraine. Environment & Health, (1, 106), 57–61. https://doi.org/10.32402/dovkil2023.01.057
Potter, L. R., Abbey-Hosch, S., & Dickey, D. M. (2006). Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions. Endocrine Reviews, 27(1), 47–72. https://doi.org/10.1210/er.2005-0014
Qi, X. Zhang, M., Zhu, J., & Wang, H. (2025). Case report of concurrent ulcerative colitis and bilateral breast cancer: A literature review of the bidirectional association between autoimmune diseases and breast cancer. Frontiers in Oncology, 15, Article 1495731. https://doi.org/10.3389/fonc.2025.1495731
Ray, T. K. (2013). The parietal cell gastric H, K-ATPase also functions as the Na, K-ATPase and Ca-ATPase in altered states. F1000Research, 2, Article 165. https://doi.org/10.12688/f1000research.2-165.v2
Rogachevskiy, I. V., Samosvat, D. M., Kalinina, D. S., Zegrya, G. G., Krylov, B. V., Podzorova, S. A., ... & Plakhova, V. B. (2022). Possible mechanism of ligand-receptor binding of the synthetic tripeptide Ac-RRR-NH2 to the nociceptive neuron membrane. Integrative Physiology, 2(4), 412–419. https://doi.org/10.33910/2687-1270-2021-2-4-412-419
Romanos, J., Benke, D., Pietrobon, D., Zeilhofer, H. U., & Santello, M. (2020). Astrocyte dysfunction increases cortical dendritic excitability and promotes cranial pain in familial migraine. Science Advances, 6(23), Article eaaz1584. https://doi.org/10.1126/sciadv.aaz1584
Sakai, H., Suzuki, T., Maeda, M., Takahashi, Y., Horikawa, N., Minamimura, T., Tsukada, K., & Takeguchi, N. (2004). Up-regulation of Na⁺,K⁺-ATPase α3-isoform and down-regulation of the α1-isoform in human colorectal cancer. FEBS Letters, 563(1–3), 151–154. https://doi.org/10.1016/S0014-5793(04)00292-3
Samolej, J., White, I., Strang, B., & Mercer, J. (2024). Cardiac glycosides inhibit early and late vaccinia virus protein expression. Journal of General Virology, 105(3), Article 001971. https://doi.org/10.1099/jgv.0.001971
Sancho, E., Ferrando, M. D., & Andreu, E. (1997). Inhibition of gill Na⁺,K⁺-ATPase activity in the eel, Anguilla anguilla, by fenitrothion. Ecotoxicology and Environmental Safety, 38(2), 132–136. https://doi.org/10.1006/eesa.1997.1573
Schoner, W. (2002). Endogenous cardiac glycosides, a new class of steroid hormones. European Journal of Biochemistry, 269(10), 2440–2448. https://doi.org/10.1046/j.1432-1033.2002.02911.x
Schoner, W., & Scheiner-Bobis, G. (2007). Endogenous and exogenous cardiac glycosides: Their roles in hypertension, salt metabolism, and cell growth. American Journal of Physiology-Cell Physiology, 293(2), C509–C536. https://doi.org/10.1152/ajpcell.00098.2007
Skou, J. C. (1957). The influence of some cations on an adenosine triphosphatase from peripheral nerves. Biochimica et Biophysica Acta, 23(2), 394–401. https://doi.org/10.1016/0006-3002(57)90343-8
Skoumal, R., Szokodi, I., Aro, J., Földes, G., Göőz, M., Seres, L., Tóth, M., ... & Tóth, M. (2007). Involvement of endogenous ouabain-like compound in the cardiac hypertrophic process in vivo. Life Sciences, 80(14), 1303–1310. https://doi.org/10.1016/j.lfs.2006.12.026
Socha, M. J., Chmielewski, J., Pietrus, M., & Wartęga, M. (2023). Endogenous digitalis-like factors as a key molecule in the pathophysiology of pregnancy-induced hypertension and a potential therapeutic target in preeclampsia. International Journal of Molecular Sciences, 24(16), Article 12743. https://doi.org/10.3390/ijms241612743
Sterne, J. A. C., Hernán, M. A., Reeves, B. C., Savović, J., Berkman, N. D., Viswanathan, M., ... & Higgins, J. P. T. (2016). ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions. BMJ, 355, Article i4919. https://doi.org/10.1136/bmj.i4919
Sterne, J. A. C., Savović, J., Page, M. J., Elbers, R. G., Blencowe, N. S., Boutron, I., ... & Higgins, J. P. T. (2019). RoB 2: A revised tool for assessing risk of bias in randomised trials. BMJ, 366, Article l4898. https://doi.org/10.1136/bmj.l4898
Svyvolap, V. V., Lysenko, V. V., & Svitlyi, M. O. (2024). The impact of renal tubulointerstitial dysfunction on the early and long-term prognosis in chronic heart failure patients with preserved left ventricular ejection fraction. Pathologia, 21(1), 5–13. https://doi.org/10.14739/2310-1237.2024.1.295166
Taub, M. (2018). Gene level regulation of Na,K-ATPase in the renal proximal tubule is controlled by two independent but interacting regulatory mechanisms involving salt inducible kinase 1 and CREB-regulated transcriptional coactivators. International Journal of Molecular Sciences, 19(7), Article 2086. https://doi.org/10.3390/ijms19072086
Taub, M., Garimella, S., Kim, D., Rajkhowa, T., & Cutuli, F. (2015). Renal proximal tubule Na,K-ATPase is controlled by CREB-regulated transcriptional coactivators as well as salt-inducible kinase 1. Cellular Signalling, 27(12), 2568–2578. https://doi.org/10.1016/j.cellsig.2015.09.015
Tashchuk, V. K., & Malinevska-Biliichuk, O. V. (2023). Determination of left ventricular ejection fraction and C-reactive protein by the state of ischemic myocardium – capabilities of ECG digitalization. Zaporozhye Medical Journal, 25(6), 487–492. https://doi.org/10.14739/2310-1210.2023.6.290611
Teixeira, M., Passos, E. F., Haddad, N. F., Andrade, M. A. P., Rumjanek, V. M., Miranda-Alves, L., ... & Paiva, L. S. (2021). In vitro antitumoral effects of the steroid ouabain on human thyroid papillary carcinoma cell lines. Environmental Toxicology, 36(7), 1338–1348. https://doi.org/10.1002/tox.23130
Vedovato, N., & Gadsby, D. C. (2014). Route, mechanism, and implications of proton import during Na⁺/K⁺ exchange by native Na⁺/K⁺-ATPase pumps. Journal of General Physiology, 143(4), 449–464. https://doi.org/10.1085/jgp.201311148
Volpe, M., Carnovali, M., & Mastromarino, V. (2016). The natriuretic peptides system in the pathophysiology of heart failure: From molecular basis to treatment. Clinical Science, 130(2), 57–77. https://doi.org/10.1042/CS20150469
Wang, J., Uddin, M. N., Li, Q., Aierken, A., Li, M., Wang, R., ... & Wu, Y. (2022). Identifying potential mitochondrial proteome signatures associated with the pathogenesis of pulmonary arterial hypertension in the rat model. Oxidative Medicine and Cellular Longevity, 2022, Article 8401924. https://doi.org/10.1155/2022/8401924
Wang, M., Zheng, C., Yang, L., Su, J., Wang, W., & Sheng, J. (2025). Low kV-low contrast medium dose one-stop dual source CT high pitch integrated coronary-carotid-cerebral-aortic CTA improves image quality and reduces both radiation and contrast medium doses. European Journal of Radiology Open, 14, Article 100637. https://doi.org/10.1016/j.ejro.2025.100637
Wang, X., Wu, Y., Zhou, M., & Fu, H. (2024). Beyond surveillance: Privacy, ethics, and regulations in face recognition technology. Frontiers in Big Data, 7, Article 1337465. https://doi.org/10.3389/fdata.2024.1337465
Wells, G. A., Shea, B., O’Connell, D., Peterson, J., Welch, V., Losos, M., & Tugwell, P. (2000). The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Hospital Research Institute. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
Werland, F., Hirth, M., Rukwied, R., Ringkamp, M., Turnquist, B., Jørum, E., … & Obreja, O. (2021). Maximum axonal following frequency separates classes of cutaneous unmyelinated nociceptors in the pig. The Journal of Physiology, 599(5), 1595–1610. https://doi.org/10.1113/jp280269
Wu, J., Xun, P., Tang, Q., Cai, W., & He, K. (2017). Circulating magnesium levels and incidence of coronary heart diseases, hypertension, and type 2 diabetes mellitus: A meta-analysis of prospective cohort studies. Nutrition Journal, 16(1). https://doi.org/10.1186/s12937-017-0280-3
Xie, Z., & Askari, A. (2002). Na⁺/K⁺-ATPase as a signal transducer. European Journal of Biochemistry, 269(10), 2434–2439. https://doi.org/10.1046/j.1432-1033.2002.02910.x
Xie, Z., Kometiani, P., Liu, J., Li, J., Shapiro, J. I., & Askari, A. (1999). Intracellular reactive oxygen species mediate the linkage of Na⁺/K⁺-ATPase to hypertrophy and its marker genes in cardiac myocytes. Journal of Biological Chemistry, 274(27), 19323–19328. https://doi.org/10.1074/jbc.274.27.19323
Xu, L., Li, X., Wang, X., & Xu, M. (2023). Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials. Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.1020327
Yablonska, T., Vernyk, O., & Haivoronskyi, H. (2023). Українська адаптація опитувальника Brief-COPE [Ukrainian adaptation of the Brief-COPE questionnaire]. Insight: The Psychological Dimensions of Society, (10), 66–89. https://doi.org/10.32999/2663-970X/2023-10-4
Yang, Y., Wu, Q., Lv, Q., Li, J., Li, L., & Wang, S. (2023). Dietary sodium, potassium intake, sodium-to-potassium ratio and risk of hypertension: A protocol for systematic review and dose–response meta-analysis of cohort studies. BMJ Open, 13(2), Article e065470. https://doi.org/10.1136/bmjopen-2022-065470
Yin, A., Wang, C., Sun, J., Gao, J., Tao, L., Du, X., ... & Li, Y. (2016). Overexpression of NDRG2 increases iodine uptake and inhibits thyroid carcinoma cell growth in situ and in vivo. Oncology Research, 23(1–2), 43–51. https://doi.org/10.3727/096504015X14452563486093
Yuan, Z., Cai, T., Tian, J., Ivanov, A., Giovannucci, D., & Xie, Z. (2005). Na/k-atpase tethers phospholipase c and ip3 receptor into a calcium-regulatory complex. Molecular Biology of the Cell, 16(9), 4034–4045. https://doi.org/10.1091/mbc.e05-04-0295
Zhang, L., Guo, F., Su, S., Guo, H., Xiong, C., Yin, J., ... & Wang, Y. (2011). Na⁺/K⁺-ATPase inhibition upregulates NMDA-evoked currents in rat hippocampal CA1 pyramidal neurons. Fundamental & Clinical Pharmacology, 26(4), 503–512. https://doi.org/10.1111/j.1472-8206.2011.00947.x
Zhao, B., Wu, H., Xu, W., Zhang, W., Chen, X., Zhu, Y., ... & Zeng, H. (2020). Genome-wide identification, characterization, and expression analyses of P-type ATPase superfamily genes in soybean. Agronomy, 11(1), Article 71. https://doi.org/10.3390/agronomy11010071
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Anatoliy Gozhenko, Walery Zukow, Olena Gozhenko, Mykhailo Saensus, Oleksandr Vitiukov
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 220
Number of citations: 0
