Lipopolisacharid disrupts the function of the liver in dysbiosis

Abstract

The paper presents the results of a study of the effect of lincomycin and lipopolysaccharide on the degree of dysbiosis in the intestinal mucosa and indicators of the functional activity of the liver of laboratory rats. It is established, that the introduction of lincomycin and lipopolysaccharide increases the degree of dysbiosis in the mucosa of the colon, increases the activity of alkaline phosphatase and elastase in the liver, and also increases the level of bilirubin, the activity of alkaline phosphatase and alanine aminotransferase in the blood serum of animals. Based on the data obtained, it is assumed that the cause of functional disorders of the liver is lipopolysaccharide, which produces opportunistic bacteria in dysbiosis.