Features of circulating in the blood desquamated endotheliocytes at the patients with hypertonic disease accompanied by alcoholism
DOI:
https://doi.org/10.12775/JEHS.2025.83.63633Keywords
desquamated plasma endothelial cells, stage II hypertension, alcoholismAbstract
Introduction and aim. Previously, we found the characteristics of desquamated endothelial cells circulating in the blood (CECs) in patients with diabetic angiopathy as well as stage II hypertension accompanied by ischemic heart disease. The literature on the effects of alcohol consumption on the cardiovascular system is mixed. Therefore, the aim of this study was to determine the characteristics of CECs in patients with hypertonic disease accompanied by alcoholism.
Material and methods. The object of clinical observation was 38 patients of both sexes with stage II hypertension, which in 20 of them was accompanied by chronic alcoholism. The control group consisted of 21 healthy volunteers. The main subject of the study was the levels of blood pressure and CECs. In addition, routine general blood analysis performed and determined metabolic parameters in serum.
Results. It was found that alcoholism is accompanied by minimal for the sample subnormal levels of markedly and terminally altered circulating endothelial cells (ACEC), LDLP cholesterol, triglycerides, prothrombin, Klimov’s and Dobiasova’s&Frolich’s atherogenity indices, ankle-brachial index of blood pressure (as atherogenity marker) as well as glucose, platelets and leukocytes. Instead, such patients have the maximum for the sample levels of HDLP cholesterol, erythrocytes sedimentation rate, body mass index, urea and creatinine. At the same time, the levels of hemoglobin, erythrocytes and cholesterol total as well as negentropy of endotheliocytogram and lipidogram did not differ from the controls, despite the presence of AH II. At the same time, both diastolic and systolic hypertension are less pronounced than in sober patients. Canonical correlation analysis showed that the absolute levels of the three fractions of CECs are determined by a constellation of 11 factors by 66,7%. Instead, the percentage and negetropy of CECs correlate with the registered factors much weaker (R2=0,390). The U-shape relationship between duration of alcohol consumption and number body parameters detected.
Conclusion. Alcohol consumption by patients with arterial hypertension has a significant impact on a number of body parameters, the severity of which depends nonlinearly on the duration of alcoholism.
References
Babelyuk, V. Y., Dubkowa, G. I., Korolyshyn, T. A., Holubinka, S. M., Dobrovol's'kyi, Y. G., Zukow, W., & Popovych, I. L. (2017). Operator of Kyokushin Karate via Kates increases synaptic efficacy in the rat Hippocampus, decreases C3-θ-rhythm SPD and HRV Vagal markers, increases virtual Chakras Energy in the healthy humans as well as luminosity of distilled water in vitro. Preliminary communication. Journal of Physical Education and Sport, 17(1), 383-393. https://doi.org/10.7752/jpes.2017.01057
Chiva-Blanch, G., & Badimon, L. (2019). Benefits and risks of moderate alcohol consumption on cardiovascular disease: Current findings and controversies. Nutrients, 12(1), Article 108. https://doi.org/10.3390/nu12010108
Dobiásová, M. (2006). AIP - aterogenní index plazmy jako významný prediktor kardiovaskulárního rizika: od výzkumu do praxe [AIP - atherogenic index of plasma as a significant predictor of cardiovascular risk: from research to practice]. Vnitřní Lékařství, 52(1), 64-71. https://doi.org/10.1194/jlr.P011668
Dobiásová, M., & Frohlich, J. (2001). The plasma parameter log(TG/HDL-C) as an atherogenic index: Correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)). Clinical Biochemistry, 34(7), 583-588. https://doi.org/10.1016/s0009-9120(01)00263-6
Dobiásová, M., Frohlich, J., Sedová, M., Cheung, M. C., & Brown, B. G. (2011). Cholesterol esterification and atherogenic index of plasma correlate with lipoprotein size and findings on coronary angiography. Journal of Lipid Research, 52(3), 566-571. https://doi.org/10.1194/jlr.P011668
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, 18(6), 499-502. PMID: 4337382.
Gao, Y., Liu, C., Zhang, X., Gao, J., & Yang, C. (2008). Circulating endothelial cells as potential markers of atherosclerosis. Canadian Journal of Neurological Sciences, 35(5), 638-642. https://doi.org/10.1017/S0317167100009446
Goryachkovskiy, A. M. (1998). Clinical biochemistry [in Russian]. Astroprint. 608.
Gozhenko, A., Kuznetsova, H., Kuznetsova, K., Stroi, D., & Kuznetsov, S. (2019). Dynamics of endothelial desquamation in patients with diabetic kidney disease. IOSR Journal of Dental and Medical Sciences, 18(8), 16-20. https://doi.org/10.9790/0853-1808061620
Gozhenko, A. I., Kuznetsova, H. S., Kuznetsov, S. H., Kuznetsova, K. S., & Byts, T. M. (2017a). The number of circulating endotheliocytes in the blood plasma of the patients with diabetes mellitus increases. Pharmacologyonline, 3, 23-26.
Gozhenko, A. I., Kuznetsova, H. S., Kuznetsova, K. S., Byts, T. M., Gozhenko, E. A., & Shevchenko, N. O. (2018). Circulating in the blood desquamated endotheliocytes at the diabetic nephropathy. Fiziolohichnyy Zhurnal, 64(2), 34-39. https://doi.org/10.15407/fz64.02.034
Gozhenko, A. I., Kuznetsova, H. S., Kuznetsova, K. S., Kuznetsova, O. M., Byts, T. M., & Zukow, W. (2017b). Morpho-functional basis of endothelial dysfunction in diabetes mellitus. Journal of Education, Health and Sport, 7(6), 516-524. https://doi.org/10.5281/zenodo.822050
Gozhenko, A. I., Korda, M. M., Popadynets, O. O., & Popovych, I. L. (2021). Entropy, harmony, synchronization and their neuro-endocrine-immune correlates [in Ukrainian]. Feniks. 232.
Gozhenko, A., Pavlega, H., Badiuk, N., & Zukow, W. (2024). Circulating in the blood desquamated endotheliocytes at the cardiovascular diseases. Preliminary communication. Quality in Sport, 19, Article 51571. https://doi.org/10.12775/QS.2024.19.51571
Hiller, G. (1987). Test for the quantitative determination of HDL cholesterol in EDTA plasma with Reflotron®. Klinische Chemie, 33, 895-898.
Hladovec, J., Prerovsky, I., Stanek, V., & Fabian, J. (1978). Circulating endothelial cells in acute myocardial infarction and angina pectoris. Klinische Wochenschrift, 56(20), 1033-1036.
Klecka, W. R. (1989). Discriminant analysis [trans. from English in Russian] (Seventh Printing, 1986). In Factor, discriminant and cluster analysis (pp. 78-138). Finansy i Statistika.
Klimov, A. N., & Nikulcheva, N. G. (1995). Lipids, lipoproteides and atherosclerosis [in Russian]. Piter Press. 304.
Kuznetsova, H. S., Gozhenko, A. I., Kuznetsova, K. S., Shukhtin, V. V., Kuznetsova, E. N., & Kuznetsov, S. H. (2018a). Endothelium. Physiology and pathology: Monograph. Feniks. 284.
Kuznetsova, H. S., Kuznetsova, K. S., Byts, T. M., Bobryk, L. M., Kuznetsova, O. M., & Gozhenko, A. I. (2018b). Mechanisms of regeneration of the endothelium at diabetes mellitus. Endokrynologia, 23(4), 384-390. https://doi.org/10.31793/1680-1466.2018.23-4.384
Kuznetsova, H. S., Kuznetsova, K. S., Olenovych, O. A., Gozhenko, O. A., Kuznetsov, S. H., & Gozhenko, A. I. (2018c). The desquamation of the endothelium due to normalization of glycemia decreases in patients with diabetes mellitus. Pharmacologyonline, 2, 74-81.
Popadynets, O., Gozhenko, A., Badyuk, N., Popovych, I., Skaliy, A., Hagner-Derengowska, M., Napierata, M., Muszkieta, R., Sokołowski, D., Zukow, W., & Rybałko, L. (2020). Interpersonal differences caused by adaptogen changes in entropies of EEG, HRV, immunocytogram, and leukocytogram. Journal of Physical Education and Sport, 20(Suppl. 2), 982-999. https://doi.org/10.7752/jpes.2020.s2139
Popovych, I. L., Gozhenko, A. I., Korda, M. M., Klishch, I. M., Popovych, D. V., & Zukow, W. (Eds.). (2022). Mineral waters, metabolism, neuro-endocrine-immune complex. Feniks. 252.
Shannon, C. E. (1948). A mathematical theory of information. Bell System Technical Journal, 27, 379-423.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Anatoliy Gozhenko, Hanna Pavlega, Nataliya Badiuk, Walery Zukow
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 233
Number of citations: 0
