Skin clinical and morphological changes in patients with seborrheic keratosis
DOI:
https://doi.org/10.12775/JEHS.2025.78.60770Keywords
seborrheic keratosis, clinic, morphology, inflammation, diagnosis, treatmentAbstract
The clinical characteristics and morphological features of seborrheic keratosis in 30 patients are presented. In 26 (86.7%) cases, the process was localized only on the covered areas of the skin (back, chest, shoulders), and in 4 (13.3%) cases, it affected the face and neck. The average number of lesions per patient was 6.5±2.1, with an average size of the largest diameter measuring 1.7±0.6 cm. Morphologically, seborrheic keratosis was manifested in various histological variants (hyperkeratotic, acanthotic, "irritated", mixed), acanthosis, epidermal cell proliferation, primarily of basal cells, as well as the presence of keratin cysts, circulatory disturbances, and immune cell reactions of varying intensity.
References
1. Carnero L, Soloeta R, Arbide N, Gonzбlez-Pйrez R. Squamous cell carcinoma on seborrheic keratosis. Actas Dermosifiliogr. 2009; 100(7): 621-622.
2. Laing ME, O'Keane C, Murphy GM. Basal cell carcinoma arising in a seborrhoeic keratosis. Clin Exp Dermatol. 2009; 34(7): 371-372.
3. Duperret EK, Oh SJ, McNeal A, Prouty SM, Ridky TW. Activating FGFR3 mutations cause mild hyperplasia in human skin, but are insufficient to drive benign or malignant skin tumors. Cell Cycle. 2014; 13(10): 1551-1559. doi: 10.4161/cc.28492
4. Fernandez-Flores A.Irritated seborrheic keratosis with coarse keratohyalin granules. Rom J Morphol Embryol. 2009; 50(4): 583-587.
5. Hafner C, Vogt T. Seborrheic keratosis. J Dtsch Dermatol Ges. 2008; 6: 664.
6. Jee H, Lee NR, Ahn SK. Case of seborrheic keratosis with underlying basal cell carcinoma suggesting a collision tumor. J Dermatol. 2013; 40: 837.
7. Longo C, Moscarella E, Piana S, Lallas A, Carrera C, Pellacani G. et al. Not all lesions with a verrucous surface are seborrheic keratoses. J Am Acad Dermatol. 2014; 70(6): 121-123. doi: 10.1016/j.jaad.2013.10.042
8. Meulener MC, Ayli EE, Elenitsas R, Seykora JT. Decreased Srcasm expression in hyperproliferative cutaneous lesions. J Cutan Pathol. 2009; 36(3): 291-295.
9. Rybin AI, Vastyanov RS, Zapolska DM. Dermatoscopic and morphological features of different forms of actinic keratosis depending on localization. Bulletin of Marine Medicine. 2025; 1(106): 160-166. [In Ukrainian] doi: http://dx.doi.org/10.5281/zenodo.15127160
10. Moroz VM, Shandra OA, Vastyanov RS, Yoltukhivsky MV, Omelchenko OD. Physiology. Vinnytsia: Nova Knyha. 2016. 722.
11. Vastyanov RS, Stoyanov OM, Babienko VV, Hruzevskiy OA, Talalayev KO, Kirchev VV. et al. Plasma rich platelets anti-inflammatory effect in conditions of carrageenan-induced paw edema in rats. World of Medicine and Biology. 2024; 4(90): 170-175. doi: 10.26724/2079-8334-2024-4-90-170-175
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