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Journal of Education, Health and Sport

Bronchial Thermoplasty in the Treatment of Asthma A Literature Review
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  • Bronchial Thermoplasty in the Treatment of Asthma A Literature Review
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Bronchial Thermoplasty in the Treatment of Asthma A Literature Review

Authors

  • Katarzyna Torbacka 5 Military Clinical Hospital with Polyclinic SPZOZ, Wrocławska 1/3, 30-901 Kraków https://orcid.org/0009-0002-7208-3725
  • Zuzanna Wróbel The West Hospital in Grodzisk Mazowiecki, Daleka 11, 05-825 Grodzisk Mazowiecki https://orcid.org/0009-0005-7529-0641
  • Katarzyna Rozkosz Independent Public Health Care Center of the Ministry of the Interior and Administration in Katowice named after sergeant Grzegorz Załoga, Wita Stwosza 39-41, 40-042 Katowice https://orcid.org/0009-0000-3610-1901
  • Maja Torbacka Jagiellonian University Collegium Medicum, Świętej Anny 12, 31-008 Kraków https://orcid.org/0009-0000-7139-2134
  • Joanna Kaczor Independent Public Healthcare Institution in Myślenice, Szpitalna 2, 32-400 Myślenice https://orcid.org/0009-0002-1714-2630
  • Natalia Wróbel 5 Military Clinical Hospital with Polyclinic SPZOZ, Wrocławska 1/3, 30-901 Kraków https://orcid.org/0009-0005-9236-9802
  • Aleksandra Sosin Jagiellonian University Collegium Medicum, Świętej Anny 12, 31-008 Kraków https://orcid.org/0009-0008-0440-5431
  • Wojciech Bednarz Independent Public Healthcare Institution of the Ministry of the Interior and Administration in Kraków, Kronikarza Galla 25, 30-053 Kraków https://orcid.org/0009-0003-9522-6298
  • Olga Jakubik Praski Hospital, Sp. z o.o., al. "Solidarności" 67, 03-401 Warszawa https://orcid.org/0009-0006-4378-7087
  • Patrycja Podlejska Independent Public Health Care Center of the Ministry of the Interior and Administration in Katowice named after sergeant Grzegorz Załoga, Wita Stwosza 39-41, 40-042 Katowice https://orcid.org/0009-0002-0074-9778

DOI:

https://doi.org/10.12775/JEHS.2025.80.60137

Keywords

bronchial thermoplasty, asthma, treatment

Abstract

Introduction and purpose                                                                                       

Asthma is a chronic inflammatory disorder affecting people worldwide. Although standard pharmacological management is adequate for most asthma patients, bronchial thermoplasty may serve as a therapeutic alternative in individuals with severe, uncontrolled asthma. The aim of this review is to summarize the knowledge of the effects of bronchial thermoplasty on symptom control, quality of life, and airway remodeling, as well as the use and effectiveness of this procedure in treating asthma.

Description of the state of knowledge

Bronchial thermoplasty (BT) is an endoscopic treatment method that can be used in patients with severe asthma, whose condition has not been adequately controlled with recommended pharmacological treatment. This procedure involves the application of radiofrequency energy to modify the airways’ structure and decrease airway smooth muscle mass. It is regarded as a safe and effective treatment option for long-term asthma management.

 Conclusion

After bronchial thermoplasty, improved symptom control and a reduction in the frequency of exacerbations were observed, resulting from a decrease in airway smooth muscle mass and an expansion of airway volume. However, this therapeutic strategy is recommended for individuals for whom other treatments have proven ineffective.

References

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2. Astma (Asthma). Medycyna Praktyczna (Practical Medicine). https://www.mp.pl/interna/chapter/B16.II.3.7 (accessed January 3, 2025)

3. Ichikawa T, Panariti A, Audusseau S, et al. Effect of bronchial thermoplasty on structural changes and inflammatory mediators in the airways of subjects with severe asthma. Respir Med. 2019;150:165-172. doi:10.1016/j.rmed.2019.03.005

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7. Donovan GM, Noble PB, Langton D. Therapeutic response to bronchial thermoplasty: toward feasibility of patient selection based on modeling predictions. J Appl Physiol (1985). 2022;133(6):1341-1348. doi:10.1152/japplphysiol.00493.2022

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15. Goorsenberg AWM, d'Hooghe JNS, Slats AM, van den Aardweg JG, Annema JT, Bonta PI. Resistance of the respiratory system measured with forced oscillation technique (FOT) correlates with bronchial thermoplasty response. Respir Res. 2020;21(1):52. Published 2020 Feb 12. doi:10.1186/s12931-020-1313-6

16. Langton D, Ing A, Bennetts K, et al. Bronchial thermoplasty reduces gas trapping in severe asthma. BMC Pulm Med. 2018;18(1):155. Published 2018 Sep 24. doi:10.1186/s12890-018-0721-6

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20. Denner DR, Doeing DC, Hogarth DK, Dugan K, Naureckas ET, White SR. Airway Inflammation after Bronchial Thermoplasty for Severe Asthma. Ann Am Thorac Soc. 2015;12(9):1302-1309. doi:10.1513/AnnalsATS.201502-082OC

21. Goorsenberg AWM, d'Hooghe JNS, Srikanthan K, et al. Bronchial Thermoplasty Induced Airway Smooth Muscle Reduction and Clinical Response in Severe Asthma. The TASMA Randomized Trial. Am J Respir Crit Care Med. 2021;203(2):175-184. doi:10.1164/rccm.201911-2298OC

22. Wijsman PC, Goorsenberg AWM, d'Hooghe JNS, et al. Airway smooth muscle and long-term clinical efficacy following bronchial thermoplasty in severe asthma. Thorax. 2024;79(4):359-362. Published 2024 Mar 15. doi:10.1136/thorax-2023-220967

23. Chakir J, Haj-Salem I, Gras D, et al. Effects of Bronchial Thermoplasty on Airway Smooth Muscle and Collagen Deposition in Asthma. Ann Am Thorac Soc. 2015;12(11):1612-1618. doi:10.1513/AnnalsATS.201504-208OC

24. Facciolongo N, Di Stefano A, Pietrini V, et al. Nerve ablation after bronchial thermoplasty and sustained improvement in severe asthma. BMC Pulm Med. 2018;18(1):29. Published 2018 Feb 8. doi:10.1186/s12890-017-0554-8

25. Langton D, Sloan G, Banks C, Bennetts K, Plummer V, Thien F. Bronchial thermoplasty increases airway volume measured by functional respiratory imaging. Respir Res. 2019;20(1):157. Published 2019 Jul 16. doi:10.1186/s12931-019-1132-9

26. Langton D, Bennetts K, Thien F, Plummer V, Noble PB. Bronchial thermoplasty reduces ventilation heterogeneity measured by multiple breath nitrogen washout. Respir Res. 2020;21(1):308. Published 2020 Nov 23. doi:10.1186/s12931-020-01575-x

27. Langton D, Bennetts K, Noble P, Plummer V, Thien F. Bronchial thermoplasty reduces airway resistance. Respir Res. 2020;21(1):76. Published 2020 Mar 30. doi:10.1186/s12931-020-1330-5

28. Langton D, Banks C, Noble PB, Plummer V, Thien F, Donovan GM. The effect of bronchial thermoplasty on airway volume measured 12 months post-procedure. ERJ Open Res. 2020;6(4):00300-2020. Published 2020 Nov 2. doi:10.1183/23120541.00300-2020

29. Dokuni R, Kobayashi K, Ohno Y, et al. Effect of Bronchial Thermoplasty on Air Trapping Assessed by Xenon Ventilation Computed Tomography. Intern Med. 2021;60(13):2027-2032. doi:10.2169/internalmedicine.6493-20

30. Langton D, Sha J, Guo S, et al. Bronchial thermoplasty versus mepolizumab: Comparison of outcomes in a severe asthma clinic. Respirology. 2020;25(12):1243-1249. doi:10.1111/resp.13830

31. Niven RM, Simmonds MR, Cangelosi MJ, Tilden DP, Cottrell S, Shargill NS. Indirect comparison of bronchial thermoplasty versus omalizumab for uncontrolled severe asthma. J Asthma. 2018;55(4):443-451. doi:10.1080/02770903.2017.1337789

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Published

2025-05-10

How to Cite

1.
TORBACKA, Katarzyna, WRÓBEL, Zuzanna, ROZKOSZ, Katarzyna, TORBACKA, Maja, KACZOR, Joanna, WRÓBEL, Natalia, SOSIN, Aleksandra, BEDNARZ, Wojciech, JAKUBIK, Olga and PODLEJSKA, Patrycja. Bronchial Thermoplasty in the Treatment of Asthma A Literature Review. Journal of Education, Health and Sport. Online. 10 May 2025. Vol. 80, p. 60137. [Accessed 17 June 2025]. DOI 10.12775/JEHS.2025.80.60137.
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Issue

Vol. 80 (2025)

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Medical Sciences

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Copyright (c) 2025 Katarzyna Torbacka, Zuzanna Wróbel, Katarzyna Rozkosz, Maja Torbacka, Joanna Kaczor, Natalia Wróbel, Aleksandra Sosin, Wojciech Bednarz, Olga Jakubik, Patrycja Podlejska

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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