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Journal of Education, Health and Sport

Treatment strategies of unruptured intracranial aneurysms: A Literature Review
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  • Treatment strategies of unruptured intracranial aneurysms: A Literature Review
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  3. Vol. 80 (2025) /
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Treatment strategies of unruptured intracranial aneurysms: A Literature Review

Authors

  • Agnieszka Szema University Clinical Hospital no. 2 PMU in Szczecin, Powstańców Wielkopolskich 72 St 70-111 Szczecin https://orcid.org/0009-0000-5017-3426
  • Mikołaj Łabuda Independent Public Voivodeship Integrated Hospital in Szczecin, ul. Arkońska 4 71-455 Szczecin https://orcid.org/0009-0002-4137-4319
  • Karolina Knychalska University Clinical Hospital no. 2 PMU in Szczecin, Powstańców Wielkopolskich 72 St 70-111 Szczecin https://orcid.org/0009-0003-3736-0579
  • Teresa Sowińska University Clinical Hospital no. 2 PMU in Szczecin, Powstańców Wielkopolskich 72 St 70-111 Szczecin https://orcid.org/0009-0003-0061-212X
  • Adrianna Bogucka Independent Public Voivodeship Integrated Hospital in Szczecin, ul. Arkońska 4 71-455 Szczecin https://orcid.org/0009-0001-8870-0495
  • Jakub Sikora Profi-Med Medical Center Goleniów Marii Konopnickiej 10A 72-100 Goleniów https://orcid.org/0009-0007-9637-0709
  • Agata Kotkowiak Family Medicine Clinic "Podgórna", Podgórna 22 St. 70-205 Szczecin Poland https://orcid.org/0009-0004-4797-6980
  • Klaudia Królikowska University Clinical Hospital no. 2 PMU in Szczecin, Powstańców Wielkopolskich 72 St 70-111 Szczecin https://orcid.org/0009-0007-7984-4642
  • Aleksandra Słojewska Independent Public Voivodeship Integrated Hospital in Szczecin, ul. Arkońska 4 71-455 Szczecin https://orcid.org/0009-0007-7532-0948
  • Oliwia Mentel University Clinical Hospital no. 2 PMU in Szczecin, Powstańców Wielkopolskich 72 St 70-111 Szczecin https://orcid.org/0009-0004-4739-0621

DOI:

https://doi.org/10.12775/JEHS.2025.80.60131

Keywords

unruptured intracranial aneurysm, aneurysm management, endovascular treatment, surgical clipping, PHASES score, ELAPSS score

Abstract

Introduction and purpose
 Unruptured intracranial aneurysms (UIAs) are often diagnosed incidentally and become a complex clinical dilemma. The main challenge is to choose between invasive treatment and conservative management, considering the low but difficult to predict risk of rupture. The aim of this review is to present current knowledge and approaches regarding UIA management, highlighting both traditional and emerging strategies.

Description of state of knowledge
 Management of UIAs depends on various factors, including aneurysm size, location, morphology, and patient-specific risks. Surgical clipping remains a reasonable method for long-term durability, but more perioperative complications, while endovascular approaches have an advantage due to their less invasive nature, but lower adequate occlusion rate. In selected low-risk patients, conservative monitoring with regular imaging may be appropriate. Advances in computational modeling, artificial intelligence, and hemodynamic analysis are improving our ability to assess rupture risk and tailor treatment plans. However, the lack of universally accepted guidelines continues to complicate decision-making.

Conclusion
 UIA management should be individualized, weighing the risks and benefits of each treatment option. Despite technological progress and improved diagnostic tools, further research and international consensus are needed to establish standardized protocols for clinical practice.

References

[1] Thompson BG, Brown RD, Amin-Hanjani S, et al. Guidelines for the Management of Patients With Unruptured Intracranial Aneurysms. Stroke. 2015;46(8):2368-2400. doi:https://doi.org/10.1161/str.0000000000000070

[2] Tawk RG, Hasan TF, D’Souza CE, Peel JB, Freeman WD. Diagnosis and Treatment of Unruptured Intracranial Aneurysms and Aneurysmal Subarachnoid Hemorrhage. Mayo Clinic Proceedings. 2021;96(7):1970-2000. doi:https://doi.org/10.1016/j.mayocp.2021.01.005

[3] Schievink WI, Wijdicks EFM, Piepgras DG, Chu CP, O’Fallon WM, Whisnant JP. The poor prognosis of ruptured intracranial aneurysms of the posterior circulation. Journal of Neurosurgery. 1995;82(5):791-795. doi:https://doi.org/10.3171/jns.1995.82.5.0791

[4] Georges Versyck, Loon J van, Lemmens R, et al. An overview of decision-making in cerebrovascular treatment strategies: part I - unruptured aneurysms. Brain and Spine. 2024;4:103331-103331. doi:https://doi.org/10.1016/j.bas.2024.103331

[5] Bijlenga P, Gondar R, Schilling S, et al. PHASES Score for the Management of Intracranial Aneurysm. Stroke. 2017;48(8):2105-2112. doi:https://doi.org/10.1161/strokeaha.117.017391

[6] Sánchez van Kammen M, Greving JP, Kuroda S, et al. External Validation of the ELAPSS Score for Prediction of Unruptured Intracranial Aneurysm Growth Risk. J Stroke. 2019;21(3):340-346. doi:10.5853/jos.2019.01277

[7] Backes D, Rinkel GJE, Greving JP, et al. ELAPSS score for prediction of risk of growth of unruptured intracranial aneurysms. Neurology. 2017;88(17):1600-1606. doi:10.1212/WNL.0000000000003865

[8] Staartjes VE, Sebök M, Blum PG, et al. Development of machine learning-based preoperative predictive analytics for unruptured intracranial aneurysm surgery: a pilot study. Acta Neurochir (Wien). 2020;162(11):2759-2765. doi:10.1007/s00701-020-04355-0

[9] Marasini A, Shrestha A, Phuyal S, Zaidat OO, Kalia JS. Role of Artificial Intelligence in Unruptured Intracranial Aneurysm: An Overview. Front Neurol. 2022;13:784326. Published 2022 Feb 23. doi:10.3389/fneur.2022.784326

[10] Greving JP, Wermer MJ, Brown RD Jr, et al. Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies. Lancet Neurol. 2014;13(1):59-66. doi:10.1016/S1474-4422(13)70263-1

[11] Algra AM, Lindgren A, Vergouwen MDI, et al. Procedural Clinical Complications, Case-Fatality Risks, and Risk Factors in Endovascular and Neurosurgical Treatment of Unruptured Intracranial Aneurysms: A Systematic Review and Meta-analysis. JAMA Neurol. 2019;76(3):282-293. doi:10.1001/jamaneurol.2018.4165

[12] Tjoumakaris SI, Hanel R, Mocco J, et al. ARISE I Consensus Review on the Management of Intracranial Aneurysms. Stroke. 2024;55(5):1428-1437. doi:10.1161/STROKEAHA.123.046208

[13] Malhotra A, Wu X, Forman HP, Matouk CC, Gandhi D, Sanelli P. Management of Tiny Unruptured Intracranial Aneurysms: A Comparative Effectiveness Analysis. JAMA Neurol. 2018;75(1):27-34. doi:10.1001/jamaneurol.2017.3232

[14] Burns JD, Huston J 3rd, Layton KF, Piepgras DG, Brown RD Jr. Intracranial aneurysm enlargement on serial magnetic resonance angiography: frequency and risk factors. Stroke. 2009;40(2):406-411. doi:10.1161/STROKEAHA.108.519165

[15] Chien A, Liang F, Sayre J, Salamon N, Villablanca P, Viñuela F. Enlargement of small, asymptomatic, unruptured intracranial aneurysms in patients with no history of subarachnoid hemorrhage: the different factors related to the growth of single and multiple aneurysms. J Neurosurg. 2013;119(1):190-197. doi:10.3171/2013.3.JNS121469

[16] Flemming KD, Lanzino G. Management of Unruptured Intracranial Aneurysms and Cerebrovascular Malformations. Continuum (Minneap Minn). 2017;23(1, Cerebrovascular Disease):181-210. doi:10.1212/CON.0000000000000418

[17] Vázquez Sufuentes S, Esteban Estallo L, Moles Herbera J, González Martínez LM, van Popta JS, Casado Pellejero J. Microsurgical clipping of unruptured intracranial aneurysms: Clinical and radiological outcomes. Neurocirugia (Astur : Engl Ed). 2024;35(6):289-298. doi:10.1016/j.neucie.2024.07.007

[18] Perrini P, Montemurro N, Caniglia M, Lazzarotti G, Benedetto N. Wrapping of intracranial aneurysms: Single-center series and systematic review of the literature. Br J Neurosurg. 2015;29(6):785-791. doi:10.3109/02688697.2015.1071320

[19] Choudhari KA. Wrapping and coating of cerebral aneurysms: history, evolution and surgical management after a re-bleed. Br J Neurosurg. 2004;18(3):259-267. doi:10.1080/026886690410001732706

[20] Jang EW, Kim YB, Chung J, Suh SH, Hong CK, Joo JY. Clinical Risk Factors Affecting Procedure-Related Major Neurological Complications in Unruptured Intracranial Aneurysms. Yonsei Med J. 2015;56(4):987-992. doi:10.3349/ymj.2015.56.4.987

[21] Tong FC, Cloft HJ, Dion JE. Endovascular treatment of intracranial aneurysms with Guglielmi Detachable Coils: emphasis on new techniques. J Clin Neurosci. 2000;7(3):244-253. doi:10.1054/jocn.1999.0211

[22] Briganti F, Leone G, Marseglia M, et al. Endovascular treatment of cerebral aneurysms using flow-diverter devices: A systematic review. Neuroradiol J. 2015;28(4):365-375. doi:10.1177/1971400915602803

[23] Chalouhi N, Jabbour P, Singhal S, et al. Stent-assisted coiling of intracranial aneurysms: predictors of complications, recanalization, and outcome in 508 cases. Stroke. 2013;44(5):1348-1353. doi:10.1161/STROKEAHA.111.000641

[24] Hong Y, Wang YJ, Deng Z, Wu Q, Zhang JM. Stent-assisted coiling versus coiling in treatment of intracranial aneurysm: a systematic review and meta-analysis. PLoS One. 2014;9(1):e82311. Published 2014 Jan 15. doi:10.1371/journal.pone.0082311

[25] Akiba Y, Murayama Y, Viñuela F, Lefkowitz MA, Duckwiler GR, Gobin YP. Balloon-assisted Guglielmi detachable coiling of wide-necked aneurysms: Part I--experimental evaluation. Neurosurgery. 1999;45(3):519-530. doi:10.1097/00006123-199909000-00022

[26] Hecker C, Broussalis E, Griessenauer CJ, Killer-Oberpfalzer M. A mini-review of intrasaccular flow diverters. J Neurointerv Surg. 2023;15(1):70-74. doi:10.1136/neurintsurg-2021-018426

[27] Bruneau M, Amin-Hanjani S, Koroknay-Pal P, et al. Surgical Clipping of Very Small Unruptured Intracranial Aneurysms: A Multicenter International Study. Neurosurgery. 2016;78(1):47-52. doi:10.1227/NEU.0000000000000991

[28] Yamaki VN, Brinjikji W, Murad MH, Lanzino G. Endovascular Treatment of Very Small Intracranial Aneurysms: Meta-Analysis. AJNR Am J Neuroradiol. 2016;37(5):862-867. doi:10.3174/ajnr.A4651

[29] Burkhardt JK, Benet A, Lawton MT. Management of Small Incidental Intracranial Aneurysms. Neurosurg Clin N Am. 2017;28(3):389-396. doi:10.1016/j.nec.2017.02.006

[30] Dengler J, Maldaner N, Gläsker S, et al. Outcome of Surgical or Endovascular Treatment of Giant Intracranial Aneurysms, with Emphasis on Age, Aneurysm Location, and Unruptured Aneuryms--A Systematic Review and Meta-Analysis. Cerebrovasc Dis. 2016;41(3-4):187-198. doi:10.1159/000443485

[31] Sughrue ME, Saloner D, Rayz VL, Lawton MT. Giant intracranial aneurysms: evolution of management in a contemporary surgical series. Neurosurgery. 2011;69(6):1261-1271. doi:10.1227/NEU.0b013e31822bb8a6

[32] Göttsche J, Piffko A, Pantel TF, et al. Aneurysm Location Affects Clinical Course and Mortality in Patients With Subarachnoid Hemorrhage. Front Neurol. 2022;13:846066. Published 2022 Mar 14. doi:10.3389/fneur.2022.846066

[33] Rinaldo L, Nesvick CL, Rabinstein AA, Lanzino G. Differences in Size Between Unruptured and Ruptured Saccular Intracranial Aneurysms by Location. World Neurosurg. 2020;133:e828-e834. doi:10.1016/j.wneu.2019.10.027

[34] Medani K, Hussain A, Quispe Espíritu JC, et al. Basilar apex aneurysm systematic review: Microsurgical versus endovascular treatment. Neurochirurgie. 2022;68(6):661-673. doi:10.1016/j.neuchi.2022.07.007

[35] Essibayi MA, Oushy SH, Keser Z, Lanzino G. Natural history and management of posterior cerebral artery aneurysms: a systematic review and meta-analysis of individual patient data. Neurosurg Rev. 2022;45(6):3595-3608. doi:10.1007/s10143-022-01867-4

[36] Ali AMS, Hannan CJ, Islim AI, Mascitelli JR, Javadpour M. Surgical and Endovascular Treatment of Saccular Posterior Inferior Cerebellar Artery Aneurysms: Systematic Review and Meta-Analysis. World Neurosurg. 2022;162:e168-e177. doi:10.1016/j.wneu.2022.02.103

[37] Petr O, Sejkorová A, Bradáč O, Brinjikji W, Lanzino G. Safety and efficacy of treatment strategies for posterior inferior cerebellar artery aneurysms: a systematic review and meta-analysis. Acta Neurochir (Wien). 2016;158(12):2415-2428. doi:10.1007/s00701-016-2965-3

[38] Toccaceli G, Diana F, Cagnazzo F, et al. Microsurgical Clipping Compared with New and Most Advanced Endovascular Techniques in the Treatment of Unruptured Middle Cerebral Artery Aneurysms: A Meta-Analysis in the Modern Era. World Neurosurg. 2020;137:451-464.e1.

[39] Darsaut TE, Keough MB, Boisseau W, et al. Middle Cerebral Artery Aneurysm Trial (MCAAT): A Randomized Care Trial Comparing Surgical and Endovascular Management of MCA Aneurysm Patients. World Neurosurg. 2022;160:e49-e54. doi:10.1016/j.wneu.2021.12.083

[40] Asaid M, O'Neill AH, Bervini D, Chandra RV, Lai LT. Unruptured Paraclinoid Aneurysm Treatment Effects on Visual Function: Systematic Review and Meta-analysis. World Neurosurg. 2017;106:322-330. doi:10.1016/j.wneu.2017.06.135

[41] Konczalla J, Platz J, Brawanski N, et al. Endovascular and surgical treatment of internal carotid bifurcation aneurysms: comparison of results, outcome, and mid-term follow-up. Neurosurgery. 2015;76(5):540-551. doi:10.1227/NEU.0000000000000672

[42] You Z, Xiang Y, Dai J, Huang X, Wu Q, Zhang X. Surgery Versus Endovascular Treatment for Proximal Anterior Cerebral Artery Aneurysms: A Meta-Analysis. Neurol India. 2024;72(2):242-247. doi:10.4103/neuroindia.NI_6_21

[43] Diana F, Pesce A, Toccaceli G, et al. Microsurgical clipping versus newer endovascular techniques in treatment of unruptured anterior communicating artery-complex aneurysms: a meta-analysis and systematic review. Neurosurg Rev. 2022;45(2):1089-1100. doi:10.1007/s10143-021-01647-6

[44] Batista S, Ferreira MY, B Oliveira L, et al. Surgical clipping and endovascular treatments for small or very small anterior communicating artery aneurysms: A comparative pooled analysis. J Clin Neurosci. 2024;127:110766. doi:10.1016/j.jocn.2024.110766

[45] de Sousa AA, Dantas FL, de Cardoso GT, Costa BS. Distal anterior cerebral artery aneurysms. Surg Neurol. 1999;52(2):128-136. doi:10.1016/s0090-3019(99)00066-x

[46] Petr O, Coufalová L, Bradáč O, Rehwald R, Glodny B, Beneš V. Safety and Efficacy of Surgical and Endovascular Treatment for Distal Anterior Cerebral Artery Aneurysms: A Systematic Review and Meta-Analysis. World Neurosurg. 2017;100:557-566. doi:10.1016/j.wneu.2016.11.134

[47] Cagnazzo F, Fanti A, Lefevre PH, et al. Distal anterior cerebral artery aneurysms treated with flow diversion: experience of a large-volume center and systematic review of the literature. J Neurointerv Surg. 2021;13(1):42-48. doi:10.1136/neurintsurg-2020-015980

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Published

2025-05-10

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SZEMA, Agnieszka, ŁABUDA, Mikołaj, KNYCHALSKA, Karolina, SOWIŃSKA, Teresa, BOGUCKA, Adrianna, SIKORA, Jakub, KOTKOWIAK, Agata, KRÓLIKOWSKA, Klaudia, SŁOJEWSKA, Aleksandra and MENTEL, Oliwia. Treatment strategies of unruptured intracranial aneurysms: A Literature Review. Journal of Education, Health and Sport. Online. 10 May 2025. Vol. 80, p. 60131. [Accessed 28 June 2025]. DOI 10.12775/JEHS.2025.80.60131.
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Vol. 80 (2025)

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Copyright (c) 2025 Agnieszka Szema, Mikołaj Łabuda, Karolina Knychalska, Teresa Sowińska, Adrianna Bogucka, Jakub Sikora, Agata Kotkowiak, Klaudia Królikowska, Aleksandra Słojewska, Oliwia Mentel

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