Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

A review of the effectiveness of virtual bronchoscopy in biopsy of lung tumors. Evolution of lung tumor diagnosis
  • Home
  • /
  • A review of the effectiveness of virtual bronchoscopy in biopsy of lung tumors. Evolution of lung tumor diagnosis
  1. Home /
  2. Archives /
  3. Vol. 80 (2025) /
  4. Medical Sciences

A review of the effectiveness of virtual bronchoscopy in biopsy of lung tumors. Evolution of lung tumor diagnosis

Authors

  • Kacper Ziarnik Regional Hospital in Poznań, Juraszów 7-19, 60-479 Poznań https://orcid.org/0009-0006-4676-3232
  • Michał Hofman https://orcid.org/0000-0001-9365-4537
  • Michał Krasowski https://orcid.org/0009-0006-6243-1246

DOI:

https://doi.org/10.12775/JEHS.2025.80.59887

Keywords

lung biopsy, bronchoscopy navigation, lung cancer, bronchoscopic

Abstract

Lung cancer remains the leading cause of cancer-related mortality, emphasizing the need for advanced diagnostic methods. This study reviews modern bronchoscopy navigational techniques, focusing on Virtual Bronchoscopic Navigation (VBN) and Electromagnetic Navigation Bronchoscopy (ENB), assessing their efficacy and safety in biopsying pulmonary lesions. Based on literature from 2000 to 2023, VBN demonstrated superior diagnostic accuracy for smaller nodules, with success rates of 93% vs 89% for ENB, while both methods exhibited low complication rates. Despite higher upfront costs, these technologies may offer long-term savings due to improved outcomes. Further research is warranted to optimize lung cancer diagnostics and enhance patient care.

 

Aim of the study

This study aims to evaluate the effectiveness and safety of VBN and ENB in diagnosing lung nodules. By comparing diagnostic success rates, complication rates, procedure durations, and cost-effectiveness, we seek to identify the safer and more efficient technique for biopsying neoplastic lesions, ultimately improving patient outcomes.

 

Materials and methods

We searched the following databases: PubMed, Web of Science, clinical trial registry platforms, using key terms such as virtual bronchoscopy navigation, navigation system-guided biopsy, bronchoscopic lung biopsy. The results were limited to papers published between 2000 - 2023.

 

Conclusion

Navigational bronchoscopy techniques like VBN and ENB are safe and effective, with minimal adverse events and no hospitalization needed. They reduce procedure times and patient burden, offering long-term cost-effectiveness despite higher initial costs. Further research is necessary to enhance these technologies for better lung cancer diagnostics.

 

Key words: lung biopsy, bronchoscopy navigation, lung cancer, bronchoscopic

Author Biographies

Michał Hofman

Medical Center HCP SP. z O. O.

28 czerwca 1956 r. nr 194, Poznań

Michał Krasowski

Poznan University of Medical Sciences

41 Jackowskiego St., 60-512 Poznań

References

Asano, F., Matsuno, Y., Ibuka, T., Takeichi, N., & Oya, H. (2004). A barium marking method using an ultrathin bronchoscope with virtual bronchoscopic navigation. Respirology (Carlton, Vic.), 9(3), 409–413. https://doi.org/10.1111/j.1440-1843.2004.00587.x

Asano, F., Matsuno, Y., Shinagawa, N., Yamazaki, K., Suzuki, T., Ishida, T., & Moriya, H. (2006). A Virtual Bronchoscopic Navigation System for Pulmonary Peripheral Lesions. CHEST, 130(2), 559–566. https://doi.org/10.1378/chest.130.2.559

Asano, F., Shindoh, J., Shigemitsu, K., Miya, K., Abe, T., Horiba, M., & Ishihara, Y. (2004). Ultrathin bronchoscopic barium marking with virtual bronchoscopic navigation for fluoroscopy-assisted thoracoscopic surgery. Chest, 126(5), 1687–1693. https://doi.org/10.1378/chest.126.5.1687

Bade, B. C., & Dela Cruz, C. S. (2020). Lung Cancer 2020: Epidemiology, Etiology, and Prevention. Clinics in Chest Medicine, 41(1), 1–24. https://doi.org/10.1016/j.ccm.2019.10.001

Broncus Medical. (b.d.). Pobrano 11 maj 2024, z https://www.broncus.com/dist/#/goodsdetails?id=68

Cone beam CT-guided navigation bronchoscopy: a cost-effective alternative to CT-guided transthoracic biopsy for diagnosis of peripheral pulmonary nodules | BMJ Open Respiratory Research. (b.d.). Pobrano 13 maj 2024, z https://bmjopenrespres.bmj.com/content/9/1/e001280.abstract

DiBardino, D. M., Yarmus, L. B., & Semaan, R. W. (2015). Transthoracic needle biopsy of the lung. Journal of Thoracic Disease, 7(Suppl 4), S304-316. https://doi.org/10.3978/j.issn.2072-1439.2015.12.16

Dolina, M. Y., Cornish, D. C., Merritt, S. A., Rai, L., Mahraj, R., Higgins, W. E., & Bascom, R. (2008). Interbronchoscopist variability in endobronchial path selection: a simulation study. Chest, 133(4), 897–905. https://doi.org/10.1378/chest.07-2540

Eberhardt, R., Ernst, A., & Herth, F. J. F. (2009). Ultrasound-guided transbronchial biopsy of solitary pulmonary nodules less than 20 mm. European Respiratory Journal, 34(6), 1284–1287. https://doi.org/10.1183/09031936.00166708

Eberhardt, Ralf, Anantham, D., Ernst, A., Feller-Kopman, D., & Herth, F. (2007). Multimodality bronchoscopic diagnosis of peripheral lung lesions: a randomized controlled trial. American Journal of Respiratory and Critical Care Medicine, 176(1), 36–41. https://doi.org/10.1164/rccm.200612-1866OC

Eberhardt, Ralf, Anantham, D., Herth, F., Feller-Kopman, D., & Ernst, A. (2007). Electromagnetic Navigation Diagnostic Bronchoscopy in Peripheral Lung Lesions. CHEST, 131(6), 1800–1805. https://doi.org/10.1378/chest.06-3016

Eberhardt, Ralf, Kahn, N., Gompelmann, D., Schumann, M., Heussel, C. P., & Herth, F. J. F. (2010). LungPoint--a new approach to peripheral lesions. Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer, 5(10), 1559–1563. https://doi.org/10.1097/JTO.0b013e3181e8b308

Han, Y., Kim, H. J., Kong, K. A., Kim, S. J., Lee, S. H., Ryu, Y. J., Lee, J. H., Kim, Y., Shim, S. S., & Chang, J. H. (2018). Diagnosis of small pulmonary lesions by transbronchial lung biopsy with radial endobronchial ultrasound and virtual bronchoscopic navigation versus CT-guided transthoracic needle biopsy: A systematic review and meta-analysis. PloS One, 13(1), e0191590. https://doi.org/10.1371/journal.pone.0191590

Heerink, W. J., de Bock, G. H., de Jonge, G. J., Groen, H. J. M., Vliegenthart, R., & Oudkerk, M. (2017). Complication rates of CT-guided transthoracic lung biopsy: meta-analysis. European Radiology, 27(1), 138–148. https://doi.org/10.1007/s00330-016-4357-8

Hiddinga, B. I., Slebos, D.-J., David Koster, T., Hijmering-Kappelle, L. B. M., Hiltermann, T. J. N., Kievit, H., van der Wekken, A. J., de Jonge, G., Vliegenthart, R., Van De Wauwer, C., Timens, W., & Bensch, F. (2023). The additional diagnostic value of virtual bronchoscopy navigation in patients with pulmonary nodules - The NAVIGATOR study. Lung Cancer (Amsterdam, Netherlands), 177, 37–43. https://doi.org/10.1016/j.lungcan.2023.01.012

Huo, Y. R., Chan, M. V., Habib, A.-R., Lui, I., & Ridley, L. (2020). Pneumothorax rates in CT-Guided lung biopsies: a comprehensive systematic review and meta-analysis of risk factors. The British Journal of Radiology, 93(1108), 20190866. https://doi.org/10.1259/bjr.20190866

Ishida, T., Asano, F., Yamazaki, K., Shinagawa, N., Oizumi, S., Moriya, H., Munakata, M., Nishimura, M., & Virtual Navigation in Japan Trial Group. (2011). Virtual bronchoscopic navigation combined with endobronchial ultrasound to diagnose small peripheral pulmonary lesions: a randomised trial. Thorax, 66(12), 1072–1077. https://doi.org/10.1136/thx.2010.145490

Kato, A., Yasuo, M., Tokoro, Y., Kobayashi, T., Ichiyama, T., Tateishi, K., Ushiki, A., Urushihata, K., Yamamoto, H., & Hanaoka, M. (2018). Virtual bronchoscopic navigation as an aid to CT‐guided transbronchial biopsy improves the diagnostic yield for small peripheral pulmonary lesions. Respirology, 23(11), 1049–1054. https://doi.org/10.1111/resp.13377

Kawakita, N., Takizawa, H., Toba, H., Sakamoto, S., Miyamoto, N., Matsumoto, D., Takashima, M., Tsuboi, M., Yoshida, M., Kawakami, Y., Kondo, K., & Tangoku, A. (2021). Cone‐beam computed tomography versus computed tomography‐guided ultrathin bronchoscopic diagnosis for peripheral pulmonary lesions: A propensity score‐matched analysis. Respirology, 26(5), 477–484. https://doi.org/10.1111/resp.14016

Kops, S. E. P., Heus, P., Korevaar, D. A., Damen, J. A. A., Idema, D. L., Verhoeven, R. L. J., Annema, J. T., Hooft, L., & Heijden, E. H. F. M. van der. (2023). Diagnostic yield and safety of navigation bronchoscopy: A systematic review and meta-analysis. Lung Cancer, 180. https://doi.org/10.1016/j.lungcan.2023.107196

Lai, R. S., Lee, S. S., Ting, Y. M., Wang, H. C., Lin, C. C., & Lu, J. Y. (1996). Diagnostic value of transbronchial lung biopsy under fluoroscopic guidance in solitary pulmonary nodule in an endemic area of tuberculosis. Respiratory Medicine, 90(3), 139–143. https://doi.org/10.1016/s0954-6111(96)90155-9

OECD (2023), Krajowe profile dotyczące nowotworów: Polska 2023, EU Country Cancer Profiles, OECD Publishing, Paris,. (b.d.). https://doi.org/10.1787/aab579a7-pl.

Rivera, M. P., Mehta, A. C., & American College of Chest Physicians. (2007). Initial diagnosis of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest, 132(3 Suppl), 131S-148S. https://doi.org/10.1378/chest.07-1357

Sun, J., Criner, G. J., Dibardino, D., Li, S., Nader, D., Lam, B., Kopas, L., Wahidi, M. M., Majid, A., Marron, R., Verga, S., & Herth, F. J. F. (2022). Efficacy and safety of virtual bronchoscopic navigation with fused fluoroscopy and vessel mapping for access of pulmonary lesions. Respirology, 27(5), 357–365. https://doi.org/10.1111/resp.14224

Światowy Dzień Raka Płuca - o wyzwaniach związanych z diagnostyką i leczeniem raka płuca. (2023, sierpień 1). Polska Grupa Raka Płuca. https://polgrp.org.pl/swiatowy-dzien-raka-pluca-o-wyzwaniach-zwiazanych-z-diagnostyka-i-leczeniem-raka-pluca/

Tsai, Y.-M., Kuo, Y.-S., Lin, K.-H., Chen, Y.-Y., & Huang, T.-W. (2023). Diagnostic Performance of Electromagnetic Navigation versus Virtual Navigation Bronchoscopy-Guided Biopsy for Pulmonary Lesions in a Single Institution: Potential Role of Artificial Intelligence for Navigation Planning. Diagnostics, 13(6), 1124. https://doi.org/10.3390/diagnostics13061124

van ’t Westeinde, S. C., Horeweg, N., Vernhout, R. M., Groen, H. J. M., Lammers, J.-W. J., Weenink, C., Nackaerts, K., Oudkerk, M., Mali, W., Thunnissen, F. B., de Koning, H. J., & van Klaveren, R. J. (2012). The role of conventional bronchoscopy in the workup of suspicious CT scan screen-detected pulmonary nodules. Chest, 142(2), 377–384. https://doi.org/10.1378/chest.11-2030

Wiener, R. S., Schwartz, L. M., Woloshin, S., & Welch, H. G. (2011). Population-based risk for complications after transthoracic needle lung biopsy of a pulmonary nodule: an analysis of discharge records. Annals of Internal Medicine, 155(3), 137–144. https://doi.org/10.7326/0003-4819-155-3-201108020-00003

Yamamoto, S., Ueno, K., Imamura, F., Matsuoka, H., Nagatomo, I., Omiya, Y., Yoshimura, M., & Kusunoki, Y. (2004). Usefulness of ultrathin bronchoscopy in diagnosis of lung cancer. Lung Cancer, 46(1), 43–48. https://doi.org/10.1016/j.lungcan.2004.03.005

Yang, H., Turgon, E., Pan, Y., Wen, X., Zhang, X., Shen, Y., & Wang, F. (2023). Pilot study of archimedes virtual bronchoscopic navigation system-guided biopsy to diagnose lung nodules in children. Frontiers in Pediatrics, 10, 1053289. https://doi.org/10.3389/fped.2022.1053289

Zhu, J., Qu, Y., Wang, X., Jiang, C., Mo, J., Xi, J., & Wen, Z. (2020). Risk factors associated with pulmonary hemorrhage and hemoptysis following percutaneous CT-guided transthoracic lung core needle biopsy: a retrospective study of 1,090 cases. Quantitative Imaging in Medicine and Surgery, 10(5), 1008–1020. https://doi.org/10.21037/qims-19-1024

Downloads

  • PDF

Published

2025-05-10

How to Cite

1.
ZIARNIK, Kacper, HOFMAN, Michał and KRASOWSKI, Michał. A review of the effectiveness of virtual bronchoscopy in biopsy of lung tumors. Evolution of lung tumor diagnosis. Journal of Education, Health and Sport. Online. 10 May 2025. Vol. 80, p. 59887. [Accessed 17 May 2025]. DOI 10.12775/JEHS.2025.80.59887.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 80 (2025)

Section

Medical Sciences

License

Copyright (c) 2025 Kacper Ziarnik, Michał Hofman, Michał Krasowski

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 18
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

lung biopsy, bronchoscopy navigation, lung cancer, bronchoscopic
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop