Drug-induced rhinitis as a complication of using mucosal decongestants
DOI:
https://doi.org/10.12775/JEHS.2025.80.59787Keywords
rhinitis medicamentosa, nonallergic rhinitis, nasal congestion, decongestantsAbstract
Rhinitis medicamentosa is induced by the overuse of topical nasal decongestants. It is characterized by chronic nasal obstruction, not related to allergy or common cold. This problem often affects young and middle-aged patients who, in order to reduce nasal congestion, exudation and swelling of the nasal mucosa, use drugs that only initially relieve the patient's symptoms. Rhinitis medicamentosa is associated with the risk of many complications, including the development of nasal polyps, otitis and sinusitis. The basis of treatment is discontinuation of decongestants and the use of nasal corticosteroid. In situations where conservative treatment is not sufficient, surgical methods can also be used. It is complicated to cure and the therapy is often long-lasting. Therefore, it seems much easier to prevent the development of rhinitis medicamentosa by avoiding this type of drugs or using nasal decongestant only for short periods and in correct doses.
References
1. Graf P. Rhinitis medicamentosa: a review of causes and treatment. Treat Respir Med. 2005;4(1):21-9. doi: 10.2165/00151829-200504010-00003. PMID: 15725047.
2. Doshi J. Rhinitis medicamentosa: what an otolaryngologist needs to know. Eur Arch Otorhinolaryngol. 2009 May;266(5):623-5. doi: 10.1007/s00405-008-0896-1. Epub 2008 Dec 19. PMID: 19096862.
3. Lockey RF. Rhinitis medicamentosa and the stuffy nose. J Allergy Clin Immunol. 2006 Nov;118(5):1017-8. doi: 10.1016/j.jaci.2006.06.018. Epub 2006 Jul 24. PMID: 17088123.
4. Mortuaire G, de Gabory L, François M, Massé G, Bloch F, Brion N, Jankowski R, Serrano E. Rebound congestion and rhinitis medicamentosa: nasal decongestants in clinical practice. Critical review of the literature by a medical panel. Eur Ann Otorhinolaryngol Head Neck Dis. 2013 Jun;130(3):137-44. doi: 10.1016/j.anorl.2012.09.005. Epub 2013 Feb 1. PMID: 23375990.
5. Elwany S, Abdel-Salaam S. Treatment of rhinitis medicamentosa with fluticasone propionate--an experimental study. Eur Arch Otorhinolaryngol. 2001 Mar;258(3):116-9. doi: 10.1007/s004050000309. PMID: 11374251.
6. Mortuaire G, de Gabory L, François M, Massé G, Bloch F, Brion N, Jankowski R, Serrano E. Rebound congestion and rhinitis medicamentosa: nasal decongestants in clinical practice. Critical review of the literature by a medical panel. Eur Ann Otorhinolaryngol Head Neck Dis. 2013 Jun;130(3):137-44. doi: 10.1016/j.anorl.2012.09.005. Epub 2013 Feb 1. PMID: 23375990.
7. Min YG, Kim HS, Suh SH, Jeon SY, Son YI, Yoon S. Paranasal sinusitis after long-term use of topical nasal decongestants. Acta Otolaryngol. 1996 May;116(3):465-71. doi: 10.3109/00016489609137874. PMID: 8790749.
8. Wahid NWB, Shermetaro C. Rhinitis Medicamentosa. 2023 Sep 4. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30855902.
9. Graf P. Rhinitis medicamentosa: a review of causes and treatment. Treat Respir Med. 2005; 4:21-9.
10. Ramey JT, Bailen E, Lockey RF. Rhinitis medicamentosa. J Investig Allergol Clin Immunol. 2006;16(3):148-55. PMID: 16784007.
11. Lin CY, Cheng PH, Fang SY. Mucosal changes in rhinitis medicamentosa. Ann Otol Rhinol Laryngol. 2004 Feb;113(2):147-51. doi: 10.1177/000348940411300213. PMID: 14994772.
12. Graf P. Rhinitis medicamentosa: aspects of pathophysiology and treatment. Allergy. 1997; 52:28-34.
13. Elwany S, Abdel-Salaam S. Treatment of rhinitis medicamentosa with fluticasone propionate--an experimental study. Eur Arch Otorhinolaryngol. 2001 Mar;258(3):116-9. doi: 10.1007/s004050000309. PMID: 11374251.
14. Graf P. Rhinitis medicamentosa: aspects of pathophysiology and treatment. Allergy. 1997;52(40 Suppl):28-34. doi: 10.1111/j.1398-9995.1997.tb04881.x. PMID: 9353558.
15. Dykewicz MS, Fineman S, Skoner DP, Nicklas R, Lee R, Blessing-Moore J, Li JT, Bernstein IL, Berger W, Spector S, Schuller D. Diagnosis and management of rhinitis: complete guidelines of the Joint Task Force on Practice Parameters in Allergy, Asthma and Immunology. American Academy of Allergy, Asthma, and Immunology. Ann Allergy Asthma Immunol. 1998 Nov;81(5 Pt 2):478-518. doi: 10.1016/s1081-1206(10)63155-9. PMID: 9860027.
16. Gorenberg D. Rhinitis medicamentosa. West J Med. 1979 Oct;131(4):313-4. PMID: 92102; PMCID: PMC1271827.
17. Black MJ, Remsen KA. Rhinitis medicamentosa. Can Med Assoc J. 1980 Apr 19;122(8):881-4. PMID: 6154514; PMCID: PMC1801634.
18. Keyserling HF, Grimme JD, Camacho DL, Castillo M. Nasal septal perforation secondary to rhinitis medicamentosa. Ear Nose Throat J. 2006 Jun;85(6):376, 378-9. PMID: 16866112.
19. Doshi J. Rhinitis medicamentosa: what an otolaryngologist needs to know. Eur Arch Otorhinolaryngol. 2009 May;266(5):623-5. doi: 10.1007/s00405-008-0896-1. Epub 2008 Dec 19. PMID: 19096862.
20. Black MJ, Remsen KA. Rhinitis medicamentosa. Can Med Assoc J. 1980 Apr 19;122(8):881-4. PMID: 6154514; PMCID: PMC1801634.
21. Wahid NWB, Shermetaro C. Rhinitis Medicamentosa. 2023 Sep 4. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30855902.
22. Elwany SS, Stephanos WM. Rhinitis medicamentosa. An experimental histopathological and histochemical study. ORL J Otorhinolaryngol Relat Spec. 1983;45(4):187-94. doi: 10.1159/000275642. PMID: 6192384.
23. Graf P. Rhinitis medicamentosa: a review of causes and treatment. Treat Respir Med. 2005;4(1):21-9. doi: 10.2165/00151829-200504010-00003. PMID: 15725047.
24. Wahid NWB, Shermetaro C. Rhinitis Medicamentosa. 2023 Sep 4. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30855902.
25. Ramey JT, Bailen E, Lockey RF. Rhinitis medicamentosa. J Investig Allergol Clin Immunol. 2006;16(3):148-55. PMID: 16784007.
26. Graf P, Hallén H. One-week use of oxymetazoline nasal spray in patients with rhinitis medicamentosa 1 year after treatment. ORL J Otorhinolaryngol Relat Spec. 1997 Jan-Feb;59(1):39-44. doi: 10.1159/000276903. PMID: 9104748.
27. Wang JQ, Bu GX. Studies of rhinitis medicamentosa. Chin Med J (Engl). 1991 Jan;104(1):60-3. PMID: 1879198.
28. Elwany S, Abdel-Salaam S. Treatment of rhinitis medicamentosa with fluticasone propionate--an experimental study. Eur Arch Otorhinolaryngol. 2001 Mar;258(3):116-9. doi: 10.1007/s004050000309. PMID: 11374251.
29. Graf P, Hallén H, Juto JE. The pathophysiology and treatment of rhinitis medicamentosa. Clin Otolaryngol Allied Sci. 1995 Jun;20(3):224-9. doi: 10.1111/j.1365-2273.1995.tb01853.x. PMID: 7554332.
30. Hallén H, Enerdal J, Graf P. Fluticasone propionate nasal spray is more effective and has a faster onset of action than placebo in treatment of rhinitis medicamentosa. Clin Exp Allergy. 1997 May;27(5):552-8. PMID: 9179430.
31. Zucker SM, Barton BM, McCoul ED. Management of Rhinitis Medicamentosa: A Systematic Review. Otolaryngol Head Neck Surg. 2019 Mar;160(3):429-438. doi: 10.1177/0194599818807891. Epub 2018 Oct 16. PMID: 30325708.
32. Fowler J, Chin CJ, Massoud E. Rhinitis medicamentosa: a nationwide survey of Canadian otolaryngologists. J Otolaryngol Head Neck Surg. 2019 Dec 9;48(1):70. doi: 10.1186/s40463-019-0392-1. PMID: 31818321; PMCID: PMC6902618.
33. https://www.mp.pl/pacjent/otolaryngologia/choroby/choroby-nosa-i-zatok/105992,niezyt-nosa
34. Segboer C, Gevorgyan A, Avdeeva K, Chusakul S, Kanjanaumporn J, Aeumjaturapat S, Reeskamp LF, Snidvongs K, Fokkens W. Intranasal corticosteroids for non-allergic rhinitis. Cochrane Database Syst Rev. 2019 Nov 2;2019(11):CD010592. doi: 10.1002/14651858.CD010592.pub2. PMID: 31677153; PMCID: PMC6824914.
35. Inanli S, Oztürk O, Korkmaz M, Tutkun A, Batman C. The effects of topical agents of fluticasone propionate, oxymetazoline, and 3% and 0.9% sodium chloride solutions on mucociliary clearance in the therapy of acute bacterial rhinosinusitis in vivo. Laryngoscope. 2002 Feb;112(2):320-5. doi: 10.1097/00005537-200202000-00022. PMID: 11889391.
36. King D. What role for saline nasal irrigation? Drug Ther Bull. 2019 Apr;57(4):56-59. doi: 10.1136/dtb.2018.000023. Epub 2019 Mar 11. PMID: 30858292.
37. Tas A, Yagiz R, Yalcin O, Uzun C, Huseyinova G, Adali MK, Karasalihoglu AR. Use of mometasone furoate aqueous nasal spray in the treatment of rhinitis medicamentosa: an experimental study. Otolaryngol Head Neck Surg. 2005 Apr;132(4):608-12. doi: 10.1016/j.otohns.2005.01.010. PMID: 15806055.
38. Casale M, Vella P, Moffa A, Sabatino L, Rinaldi V, Grimaldi V, Salvinelli F. Topical hyaluronic acid in rhinitis medicamentosa: could our perspective be changed? J Biol Regul Homeost Agents. 2017 Dec 27;31(4 Suppl 2):55-62. PMID: 29202563.
39. Li LJ, Wang S, Tsai C, et al. Rhinitis medicamentosa BMJ Case Reports CP 2021;14:e247051.
40. Mahato NB, Regmi D, Bista M. Diode Laser Reduction of Symptomatic Inferior Turbinate Hypertrophy. JNMA J Nepal Med Assoc. 2018 Nov-Dec;56(214):958-962. doi: 10.31729/jnma.4005. PMID: 31065143; PMCID: PMC8827603.
41. Caffier PP, Frieler K, Scherer H, Sedlmaier B, Göktas O. Rhinitis medicamentosa: therapeutic effect of diode laser inferior turbinate reduction on nasal obstruction and decongestant abuse. Am J Rhinol. 2008 Jul-Aug;22(4):433-9. doi: 10.2500/ajr.2008.22.3199. PMID: 18702912.
42. Utley DS, Goode RL, Hakim I. Radiofrequency energy tissue ablation for the treatment of nasal obstruction secondary to turbinate hypertrophy. Laryngoscope. 1999 May;109(5):683-6. doi: 10.1097/00005537-199905000-00001. PMID: 10334213.
43. Carmel Neiderman NN, Caspi I, Eisenberg N, Halevy N, Wengier A, Shpigel I, Ziv Baran T, Ringel B, Warshavsky A, Abergel A. Quality of life after radio frequency ablation turbinate reduction (RFATR) among patients with rhinitis medicamentosa & withdrawal from decongestant topical spray abuse. Am J Otolaryngol. 2023 Jul-Aug;44(4):103842. doi: 10.1016/j.amjoto.2023.103842. Epub 2023 Mar 20. PMID: 36989755.
44. Fowler J, Chin CJ, Massoud E. Rhinitis medicamentosa: a nationwide survey of Canadian otolaryngologists. J Otolaryngol Head Neck Surg. 2019 Dec 9;48(1):70. doi: 10.1186/s40463-019-0392-1. PMID: 31818321; PMCID: PMC6902618.
45. Archontaki M, Symvoulakis EK, Hajiioannou JK, Stamou AK, Kastrinakis S, Bizaki AJ, Kyrmizakis DE. Increased frequency of rhinitis medicamentosa due to media advertising for nasal topical decongestants. B-ENT. 2009;5(3):159-62. PMID: 19902852.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Aleksandra Ratajczak, Olga Snoch, Zuzanna Kalinowska, Weronika Matera

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 2036
Number of citations: 0