Cannabinoid Hyperemesis Syndrome - case report
DOI:
https://doi.org/10.12775/JEHS.2025.81.59574Keywords
Cannabinoid Hyperemesis Syndrome, CHS, Adolescents, Vomiting, Cannabis Use, Diagnosis, Rome IV CriteriaAbstract
In 2018, research conducted by Kantar Polska and the National Bureau for Counteracting Drug Addiction showed that marijuana was the most commonly used drug in Poland among the general population. Its usage rate was 12.1%. The age group most likely to use marijuana was 15-24 years old. Marijuana use was more common among males. Despite promising results regarding the use of medicinal marijuana for certain conditions, easier access to this drug among the young population generates the problem of addiction and the occurrence of negative effects from its use. The suspicion and diagnosis of the effects of cannabinoid intake – including cannabinoid hyperemesis syndrome – should be considered in the differential diagnosis of patients presenting to pediatric emergency departments, especially in cases with unclear etiology of symptoms, their recurrence, and the age group typical for more frequent use of this drug.
References
1. Malczewski A, Jabłoński P. Report on the State of Drug Addiction 2020. National Bureau for Drug Prevention, Warsaw 2020.
2. Chen YC, Klig JE. Cannabis-related emergencies in children and teens. Curr Opin Pediatr. 2019;31(3):291–296.
3. Szczepanek M, Strzeszyński Ł. Functional gastrointestinal disorders – Rome IV criteria. Med Prakt. 2016;27-38.
4. Chen J, McCarron RM. Cannabinoid hyperemesis syndrome: A result of chronic, heavy Cannabis use. Curr Psychiatry. 2013.
5. Desjardins N, Jamoulle O, Taddeo D, Stheneur C. Cannabinoid Hyperemesis Syndrome in a 17-year-old adolescent. J Adolesc Health. 2015;57(5):565-567.
6. Galli JA, Sawaya RA, Friedenberg FK. Cannabinoid Hyperemesis Syndrome. Curr Drug Abuse Rev. 2011;4(4):241-249.
7. Takakuwa KM, Schears RM. The emergency department care of the cannabis and synthetic cannabinoid patient: a narrative review. Int J Emerg Med. 2021 Feb 10;14(1):10.
8. Kichloo A, Albosta M, Aljadah M, et al. Marijuana: A systems-based primer of adverse effects associated with use and an overview of its therapeutic utility. SAGE Open Med. 2021 Mar 9;9:20503121211000909.
9. Valdivielso Cortázar E, Ucha Abal P, Alonso Aguirre P. Cannabinoid hyperemesis syndrome. Rev Esp Enferm Dig. 2018 May;110(5):334-335.
10. Parekh JD, Wozniak SE, Khan K, Dutta SK. Cannabinoid hyperemesis syndrome. BMJ Case Rep. 2016 Jan 20;2016:bcr2015213620.
11. Schmulson MJ, Drossman DA. What Is New in Rome IV. J Neurogastroenterol Motil. 2017 Apr 30;23(2):151-163.
12. Bajgoric S, Samra K, Chandrapalan S, Gautam N. Cannabinoid hyperemesis syndrome: a guide for the practising clinician. BMJ Case Rep. 2015 Dec 23;2015:bcr2015210246.
13. Contreras Narváez C, Mola Gilbert M, Batlle de Santiago E, et al. Cannabinoid hyperemesis syndrome. Adicciones. 2016 Mar 2;28(2):90-8.
14. Lapoint J, Meyer S, Yu CK, et al. Cannabinoid Hyperemesis Syndrome: Public Health Implications and a Novel Model Treatment Guideline. West J Emerg Med. 2018 Mar;19(2):380-386.
15. Burillo-Putze G, Llorens P. Perspectives in the treatment for cannabinoid hyperemesis syndrome. Adicciones. 2017 Jan 12;29(2):134-135.
16. Gregoire P, Tau M, Robertson D. Cannabinoid hyperemesis syndrome and the onset of a manic episode. BMJ Case Rep. 2016 Apr 27;2016:bcr2016215129.
17. Klassen J, Wilson G. Cannabinoid Hyperemesis Syndrome Masquerading as Uremia: An Educational Case Report. Can J Kidney Health Dis. 2018 Aug 24;5:2054358118791146.
18. Jones JL, Abernathy KE. Successful Treatment of Suspected Cannabinoid Hyperemesis Syndrome Using Haloperidol in the Outpatient Setting. Case Rep Psychiatry. 2016;2016:3614053.
19. Moon AM, Buckley SA, Mark NM. Successful Treatment of Cannabinoid Hyperemesis Syndrome with Topical Capsaicin. ACG Case Rep J. 2018 Jan 3;5:e3.
20. Hermes-Laufer J, Del Puppo L, Inan I, et al. Cannabinoid Hyperemesis Syndrome: A Case Report of Cyclic Severe Hyperemesis and Abdominal Pain with Long-Term Cannabis Use. Case Rep Gastrointest Med. 2016;2016:2815901.
21. Inayat F, Virk HU, Ullah W, et al. Is haloperidol the wonder drug for cannabinoid hyperemesis syndrome? BMJ Case Rep. 2017 Jan 4;2017:bcr2016218239.
22. Senderovich H, Patel P, Jimenez Lopez B, et al. A Systematic Review on Cannabis Hyperemesis Syndrome and Its Management Options. Med Princ Pract. 2022;31(1):29-38.
23. DeVuono MV, Parker LA. Cannabinoid Hyperemesis Syndrome: A Review of Potential Mechanisms. Cannabis Cannabinoid Res. 2020 Jun 5;5(2):132-144.
24. Yacoub H, Hassine H, Kchir H, Maamouri N. Cannabinoid Hyperemesis Syndrome: A Case Study in a Tunisian Young Man. Case Rep Med. 2021 Feb 6;2021:6617148.
25. Wightman RS, Perrone J, Collins AB, Lakamana S, Sarker A. An analysis of cannabinoid hyperemesis syndrome Reddit posts and themes. Clin Toxicol (Phila). 2023 Apr;61(4):283-289.
26. Reinert JP, Niyamugabo O, Harmon KS, Fenn NE 3rd. Management of Pediatric Cannabinoid Hyperemesis Syndrome: A Review. J Pediatr Pharmacol Ther. 2021;26(4):339-345.
27. Breijyeh Z, Jubeh B, Bufo SA, Karaman R, Scrano L. Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses. Toxins (Basel). 2021 Feb 5;13(2):117.
28. Kim HS, Anderson JD, Saghafi O, Heard KJ, Monte AA. Cyclic vomiting presentations following marijuana liberalization in Colorado. Acad Emerg Med. 2015 Jun;22(6):694-9.
29. Sorensen CJ, DeSanto K, Borgelt L, Phillips KT, Monte AA. Cannabinoid Hyperemesis Syndrome: Diagnosis, Pathophysiology, and Treatment-a Systematic Review. J Med Toxicol. 2017 Mar;13(1):71-87.
30. Leu N, Routsolias JC. Cannabinoid Hyperemesis Syndrome: A Review of the Presentation and Treatment. J Emerg Nurs. 2021 May;47(3):483-486.
31. Mahmad AI, Jehangir W, Littlefield JM 2nd, John S, Yousif A. Cannabis hyperemesis syndrome: A case report review of treatment. Toxicol Rep. 2015 Jun 9;2:889-890.
32. Lapoint J, Meyer S, Yu CK, et al. Cannabinoid Hyperemesis Syndrome: Public Health Implications and a Novel Model Treatment Guideline. West J Emerg Med. 2018 Mar;19(2):380-386.
33. Habboushe J, Rubin A, Liu H, Hoffman RS. The Prevalence of Cannabinoid Hyperemesis Syndrome Among Regular Marijuana Smokers in an Urban Public Hospital. Basic Clin Pharmacol Toxicol. 2018 Jun;122(6):660-662.
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Copyright (c) 2025 Maria Mazurek-Staroń, Izabela Zgardzińska-Głąb, Magdalena Michalska-Borowiec, Aneta Radwan-Pizoń, Sylwia Sędłak, Barbara Dengler-Orzechowska, Agata Rocka, Justyna Sudoł
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