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Journal of Education, Health and Sport

Improving Reproductive Outcomes in PCOS: The Emerging Role of GLP-1 Receptor Agonists
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  • Improving Reproductive Outcomes in PCOS: The Emerging Role of GLP-1 Receptor Agonists
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  3. Vol. 79 (2025) /
  4. Medical Sciences

Improving Reproductive Outcomes in PCOS: The Emerging Role of GLP-1 Receptor Agonists

Authors

  • Adrianna Tabeau Central Clinical Hospital https://orcid.org/0009-0001-2881-8491
  • Agnieszka Pawlik Bielanski Hospital 80 Cegłowska Street, 01-809 Warsaw https://orcid.org/0009-0008-9043-0405
  • Patryk Dudek Warsaw Southern Hospital Rotmistrza Witolda Pileckiego 99, 02-781 Warsaw https://orcid.org/0009-0004-9103-7905
  • Klaudia Łuczak Central Clinical Hospital Banacha St. 1A, 02-097 Warsaw https://orcid.org/0009-0008-8209-0121
  • Wiktoria Ulicka https://orcid.org/0009-0003-5442-3439
  • Justyna Pięta Bielański Hospital in Warsaw, Cegłowska 80, 01-809 Warszawa, Poland https://orcid.org/0009-0007-2835-5064
  • Hanna Sitarek St John Paul II Independent Public Specialist Western Hospital Daleka 11, 05-825 Grodzisk Mazowiecki, Poland https://orcid.org/0009-0002-4507-3038
  • Joanna Prus Praski Hospital of Lord's Transfiguration, Aleja, Solidarności'' 67, 03-401, Warsaw, Poland https://orcid.org/0009-0002-6274-7436
  • Marcel Chudzikowski Warsaw Southern Hospital Rotmistrza Witolda Pileckiego 99, 02-781 Warsaw https://orcid.org/0009-0003-2268-6154
  • Agata Prokopiuk Regional Specialist Hospital in Biała Podlaska Ul. Terebelska 57-65, 21-500 Biała Podlaska https://orcid.org/0009-0005-3668-6512

DOI:

https://doi.org/10.12775/JEHS.2025.79.59347

Keywords

Polycystic ovary syndrome, PCOS, Glucagon-Like Peptide-1 Receptor Agonists, glp-1, pregnancy, gestation

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder affecting a significant proportion of women of reproductive age. It is associated with infertility, metabolic abnormalities, and hormonal imbalances, including insulin resistance and hyperandrogenism. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), such as exenatide and liraglutide, have shown promise in improving reproductive outcomes in women with PCOS. This review evaluates the potential benefits of GLP-1 RAs in enhancing fertility, with a focus on menstrual regularity, ovulation rates, pregnancy rates, and metabolic outcomes. Studies have indicated that GLP-1 RAs improve insulin sensitivity, reduce BMI, waist circumference, and testosterone levels, and contribute to higher natural pregnancy rates. Despite the promising results, the long-term safety of GLP-1 RAs, particularly during pregnancy, remains uncertain. Patients using GLP-1 RAs are advised to use contraception, as the safety profile during pregnancy is still under investigation. Further research is necessary to establish the long-term effects and safety of these medications in women with PCOS. Overall, GLP-1 RAs offer a potential therapeutic approach for improving fertility and metabolic health in women with PCOS.

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Published

2025-03-25

How to Cite

1.
TABEAU, Adrianna, PAWLIK, Agnieszka, DUDEK, Patryk, ŁUCZAK, Klaudia, ULICKA, Wiktoria, PIĘTA, Justyna, SITAREK, Hanna, PRUS, Joanna, CHUDZIKOWSKI, Marcel and PROKOPIUK, Agata. Improving Reproductive Outcomes in PCOS: The Emerging Role of GLP-1 Receptor Agonists. Journal of Education, Health and Sport. Online. 25 March 2025. Vol. 79, p. 53347. [Accessed 22 May 2025]. DOI 10.12775/JEHS.2025.79.59347.
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Issue

Vol. 79 (2025)

Section

Medical Sciences

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Copyright (c) 2025 Adrianna Tabeau, Agnieszka Pawlik, Patryk Dudek, Klaudia Łuczak, Wiktoria Ulicka, Justyna Pięta, Hanna Sitarek, Joanna Prus, Marcel Chudzikowski, Agata Prokopiuk

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