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Journal of Education, Health and Sport

Eyelid Margin Inflammation: Pathophysiology, Diagnosis and Management Approaches
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Eyelid Margin Inflammation: Pathophysiology, Diagnosis and Management Approaches

Authors

  • Grzegorz Szcześniak Independent Provincial Hospital named after Nicolaus Copernicus in Piotrków Trybunalski https://orcid.org/0009-0008-3726-5164
  • Aleksandra Kiełczewska Polish Mother's Memorial Hospital, ul. Rzgowska 281/289, 93-338 Łódź, Poland https://orcid.org/0009-0002-4283-4487
  • Anna Kiełczewska Medical University of Warsaw, ul Żwirki i Wigury 61, 02-091 Warsaw, Poland https://orcid.org/0009-0009-1690-506X

DOI:

https://doi.org/10.12775/JEHS.2025.79.58742

Keywords

eyelid rim inflammation, Meibomian gland dysfunction, demodex

Abstract

Introduction and Purpose: Eyelid margin inflammation is a commonly reported syndrome of ophthalmic complaints. It is a chronic, multifactorial disorder of the eyelid margins that significantly impacts the visual function and quality of life of patients across all age groups. Establishing the epidemiology is challenging, and the diagnosis relies primarily on a physical examination combined with a thorough ophthalmological assessment, potentially supplemented by additional tests. The condition is recurrent, often necessitating long-term treatment. Successful management requires close collaboration between the specialist and the patient, which demands commitment and patience. Eyelid margin inflammation manifests through various symptoms, such as burning, itching, dryness, or a feeling of sand in the eyes. This condition is characterized by a wide range of symptoms with varying severity, contributing to the complexity of its diagnosis and treatment. This review examines the diagnostic approaches and treatment strategies for eyelid margin inflammation, focusing on the most common underlying factors.

 

Materials and Methods: A comprehensive survey of articles published in scientific journals was conducted via the online research platforms PubMed and Google Scholar. Articles were searched by entering keywords in the appropriate configuration: “eyelid rim inflammation”, “ Meibomian gland dysfunction”, “demodex”.

 

Description of current knowledge: Studies have indicated that the approach to diagnosing and managing eyelid margin inflammation is largely contingent on the underlying cause and the intensity of the patient's symptoms.

 

Keywords: “eyelid rim inflammation”, “ Meibomian gland dysfunction”, “demodex”.

 

References

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[2] “Bowman RW, Dougherty JM, McCulley JP. Chronic blepharitis and dry eyes. Int Ophthalmol Clin. 1987; 27(1): 27-35,”

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[10] “The Definition and Classification of Dry Eye Disease: Report of the Definition and Classification Subcommittee of the InternationalDry Eye Workshop (2007). Ocul Surf. 2007; 5(2): 75-92.,”

[11] “Chamaillard M, Mortemousque B, Boralevi F, et al. Cutaneous and ocular signs of childhood rosacea. Arch Dermatol. 2008;144(2):167-171.,”

[12] “Arici MK, Sümer Z, Toker MI et al. The prevalence of Demodex folliculorum in blepharitis patients and the normal population. Ophthalmic Epidemiol. 2005; 12(4): 287-90.,”

[13] S. Sabeti, A. Kheirkhah, J. Yin, and R. Dana, “Management of meibomian gland dysfunction: a review,” Survey of Ophthalmology, vol. 65, no. 2. Elsevier BV, p. 205, Sep. 05, 2019. doi: 10.1016/j.survophthal.2019.08.007.

[14] F. SR, H. JS, J. K. Patel, and O. DL, “Demodex blepharitis: clinical perspectives,” Jul. 01, 2018. Accessed: Dec. 2024. [Online]. Available: https://doaj.org/article/d58303eaa7ec4e8ea692b548c047d55c

[15] J. Liu, H. Sheha, and S. C. G. Tseng, “Pathogenic role of Demodex mites in blepharitis,” Current Opinion in Allergy and Clinical Immunology, vol. 10, no. 5. Lippincott Williams & Wilkins, p. 505, Aug. 04, 2010. doi: 10.1097/aci.0b013e32833df9f4.

[16] “Kheirkhah A, Blanco G, Casas V et al. Fluorescein dye improves microscopic evaluation and counting of Demodex in blepharitis withcylindrical dandruff. Cornea. 2007; 26(6): 697-700,”

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[18]

“https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/blepharitis,”

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[20] “https://www.webmd.com/eye-health/blepharitis,”

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[22] K. Lindsley, S. Matsumura, E. Hatef, and E. K. Akpek, “Interventions for chronic blepharitis,” Cochrane library. Elsevier BV, May 10, 2012. doi: 10.1002/14651858.cd005556.pub2.

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[25] C. M. Putnam, “Diagnosis and management of blepharitis: an optometrist’s perspective,” Clinical Optometry. Dove Medical Press, p. 71, Aug. 01, 2016. doi: 10.2147/opto.s84795.

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[27] “Perry HD, Doshi-Carnevale S, Donnenfeld ED et al. Efficacy of commercially available topical cyclosporine A 0.05% in the treatmentof meibomian gland dysfunction. Cornea. 2006; 25(2): 171-5. ,”

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Published

2025-03-03

How to Cite

1.
SZCZEŚNIAK, Grzegorz, KIEŁCZEWSKA, Aleksandra and KIEŁCZEWSKA, Anna. Eyelid Margin Inflammation: Pathophysiology, Diagnosis and Management Approaches. Journal of Education, Health and Sport. Online. 3 March 2025. Vol. 79, p. 58742. [Accessed 29 June 2025]. DOI 10.12775/JEHS.2025.79.58742.
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Issue

Vol. 79 (2025)

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Medical Sciences

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Copyright (c) 2025 Grzegorz Szcześniak, Aleksandra Kiełczewska, Anna Kiełczewska

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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