Dry Eye Syndrome: Mechanism, Diagnosis and Treatment Strategies
DOI:
https://doi.org/10.12775/JEHS.2025.79.58739Keywords
dry eye syndrome, management, diagnosisAbstract
Introduction and Purpose: Dry eye syndrome is a set of ophthalmic complaints frequently reported by ophthalmology patients. It is a chronic, multifactorial disorder of the ocular surface that significantly impacts visual function and the quality of life of patients across all age groups. The condition is more prevalent in women and becomes more common with advancing age. Dry eye syndrome presents a wide range of symptoms with varying degrees of severity, contributing to the complexity of its diagnosis and treatment. This review examines the diagnostic approaches and management strategies for dry eye syndrome, with a particular focus on the most common underlying factors.
Materials and Methods: A comprehensive survey of articles published in scientific journals was conducted via the online research platforms PubMed and Google Scholar. Articles were searched by entering keywords in the appropriate configuration: “dry eye syndrome,” “management” and ”diagnosis.”
Description of current knowledge: Studies have indicated that the approach to diagnosing and managing dry eye syndrome is largely contingent on the underlying cause and the intensity of the patient's symptoms.
References
[1] “Lemp M. A.: Surfacing abnormalities in the preocular tear film and dry eye syndromes. Int. Ophthalmol. Clin. 1973; 13: 191-199.,”
[2] “Calonge M.: Dry eye syndrome: Is there any hope for a curative therapy? Arch. Soc. Españ. Oftalmol. 2002; 76: 119-120.,”
[3] “Korb D. R.: Alleviation of computer-induced eye discomfort syndrome and associated lipid layerchanges. Adv Exp Med Biol. 2002; 506 (Pt A): 501-506.,”
[4] “The epidemiology of dry eye disease:report of the Epidemiology Subcommitteeof the International Dry Eye WorkShop(2007). Ocul Surf 2007;5:93-107,”
[5] “Lens A., Nemeth S.C., Bedford J. K. Anatomia i fizjologianarządu wzroku. Misiuk-Hojło M. (red.). Górnicki Wydawnictwo Medyczne, Wrocław 2010,”
[6] “de Souza GA, Godoy LM and Mann M. Identification of 491 proteins in the tear fluid proteome reveals a large number of prote ases and protease inhibitors. Genome Biology2006;7:8 R72.,”
[7] “Rantamäki AH, Seppänen-Laakso T, Oresic M et al. Human tear fluid lipidome: from composition to function. PLoS One 2011;6:5 e19553. ,”
[8] “Mantelli F and Argüeso P. Functions of ocular surface mucins in health and disease. Curr Opin Allergy Clin Immunol 2008;8:5 477-83.,”
[9] “Niżanowska M.H. Okulistyka. Podstawy kliniczne. PZWL, Warszawa 2010. ,”
[10] “ Pieńkowska-Machoy E., Karczewicz D. Zespół suchego oka.Lekarz 2003; 11: 15–17.,”
[11] “Yamada C., King K.E., Ness P.M. Autologous serum eyedrops:literature review and implications for transfusion medicine specialists. Transfusion 2008; 48: 1245–1255,”
[12] “Abelson M, Dartt D and McLaughlin J. Mucins: foundation of a good tear film. Review of Ophthalmology. November 7, 2011.www.reviewofophthalmology.com/content/d/therapeutic_topics/c/30968. Accessed September 2, 2015,”
[13] “Tiffany J.M. The normal tear film. Dev. Ophthalmol. 41:1-20, 2008.,”
[14] “Green-Church KB, Butovich I, Willcox M et al. The International Workshop on Meibomian Gland Dysfunction: Report of the Subcommittee on Tear Film Lipids and Lipid–ProteinInteractions in Health and Disease. Invest Ophthalmol Vis Sci 2011;52:4 1979-93.,”
[15] S. C. Pflugfelder and M. E. Stern, “Biological functions of tear film,” Experimental Eye Research, vol. 197. Elsevier BV, p. 108115, Jun. 16, 2020. doi: 10.1016/j.exer.2020.108115.
[16] D. F. Rabensteiner, H. Aminfar, I. Boldin, G. Schwantzer, and J. Horwath‐Winter, “The prevalence of meibomian gland dysfunction, tear film and ocular surface parameters in an Austrian dry eye clinic population,” Apr. 15, 2018, Wiley. doi: 10.1111/aos.13732.
[17] “Mielczarek M. Zespół suchego oka. Medycyna Rodzinna 2005; 2:51–56.,” Jan. 01, 1AD.
[18] C. M. Bommert, C. N. Grupcheva, M. Radeva, D. Grupchev, and M. R. Boyadzieva, “Sleep apnea and dry eye: how sleep apnea affects the eye surface,” Jun. 30, 2020. doi: 10.24292/01.ot.300620.3.
[19] “Rohit A, Willcox M and Stapleton F. Tear lipid layer and contact lens comfort: a review. Eye Contact Lens 2013;39:3 247-53,”
[20] “Nichols JJ and Sinnott LT. Tear film, contact lens, and patient-related factors associated with contact lens-related dry eye. Invest Ophthalmol Vis Sci 2006;47:1319-28,”
[21] “ D. Kopacz, Ł. Niezgoda, E. Fudalej, A. Nowak, and P. Maciejewicz, “Tear Film – Physiology and Disturbances in Various Diseases and Disorders,” in IntechOpen eBooks, IntechOpen, 2020. doi: 10.5772/intechopen.94142.”
[22] “Stapleton F, Alves M, Bunya VY, Jalbert I, Lekhanont K, Malet F, et al. TFOS DEWS II epidemiology report. Ocul Surf 2017;15:334-65.,”
[23] “Ekong A.S., Foster S.C. Dry eye syndrome. eMedicine. WilsonJ.L. et al. (red.). 2004, Medscape. 2005.,”
[24] “Murube J.: Dacryologia Basica. Ed Royper. Madrid 1981: 510-586.,”
[25] “Findlay Q, Reid K. Dry eye disease: when to treat and when to refer. Aust Prescr 2018;41:160-3.,”
[26] H. J. Davidson and V. J. Kuonen, “The tear film and ocular mucins,” Veterinary Ophthalmology, vol. 7, no. 2. Wiley, p. 71, Feb. 18, 2004. doi: 10.1111/j.1463-5224.2004.00325.x.
[27] J. Weng, M. K. Fink, and A. Sharma, “A Critical Appraisal of the Physicochemical Properties and Biological Effects of Artificial Tear Ingredients and Formulations,” International Journal of Molecular Sciences, vol. 24, no. 3. Multidisciplinary Digital Publishing Institute, p. 2758, Feb. 01, 2023. doi: 10.3390/ijms24032758.
[28] J. Murube, “Triple Classification of Diagnosis of Dry Eyes,” The Ocular Surface, vol. 6, no. 2. Elsevier BV, p. 61, Apr. 01, 2008. doi: 10.1016/s1542-0124(12)70269-0.
[29] “Reddy K., Grad O., Rajagopalan K.: The Economic Burden of Dry Eye. A Conceptual Frameworkand Preliminary Assesment. Cornea 2004; 8(23): 751-759.,”
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