Relapse of indurative tuberculosis of the skin of the lower extremities against the background of undiagnosed spontaneously cured pulmonary tuberculosis
DOI:
https://doi.org/10.12775/JEHS.2025.80.58376Keywords
tuberculosis, indurative tuberculosis of the skinAbstract
Introduction. In recent years, there has been a marked increase in the prevalence of cutaneous tuberculosis in Ukraine. Tuberculous lesions of the skin, as a rule, are secondary.
Case description. Tuberculous lesions of the skin are typically secondary in nature.
Patient N, aged 58 years, presented with a dermatological complaint on the lower extremities, characterised by pruritus, burning and functional impairment. He had been experiencing symptoms for approximately three years prior to seeking medical attention at his place of residence, where a diagnosis was not established. The dermal lesions present as dense, rounded nodules up to 1.0 cm in diameter on the lower limbs. The skin in the vicinity of the nodes displays a reddish hue with a bluish tinge. Irregularly shaped foci of cicatricial atrophy are present on the skin of the ankle-foot joints. An additional rounded formation is identified on the X-ray of the thoracic organs and lungs, taken in both direct and left lateral projections. The pathohistological examination revealed uneven infiltration in the surface layers of the dermis, comprising lymphocytes, plasma cells, and multinucleated Langhans cells, which formed non-caseous granulomas. Additionally, the dermis exhibited focal sclerosis, granulomatous vasculitis with damage to the walls of small and medium-sized vessels, and signs of lobular panniculitis.
Discussion. In consideration of the patient's complaints, anamnesis data, data from objective and special research methods, a diagnosis was formulated. A relapse of indurative tuberculosis of the skin of the lower extremities was observed. The patient presented with residual changes in a previously treated case of pulmonary tuberculosis.
Conclusions. In order to facilitate an early diagnosis of tuberculosis of the skin, it is necessary to perform a mandatory X-ray examination of the organs of the chest cavity and a histological examination of the affected area of the skin at the initial visit.
References
1. Melnyk V, Matusevych V, Nedospasova O, Veselovsky L, Tarasenko O, Bushura I, Prychodko A, Novozhylova I. Dynamics of the incidence of the relapses in patients with pulmonary tuberculosis. IC [Internet]. 2021Sep.24 [cited 2024Dec.11];(3):18-4. Available from :https://infusion-chemotherapy.com/index.php/journal/article/view/290
https://doi.org/10.32902/2663-0338-2021-3-18-24
2. Kuś J . Gruźlica pozapłucna . introduction Postępy Nauk Medycznych 2007; 12: 544–546.
https://www.czytelniamedyczna.pl/2784,gruzlica-pozaplucna-wprowadzenie.html#kod
3. Owczarek W, Targowski T, Kozera-Zywczyk A, Paluchowska E, Patera J. Gruźlica toczniowa skóry jako powikłanie gruźlicy płuc--opis przypadku [Lupus vulgaris as a complication of pulmonary tuberculosis--case report]. Pol Merkur Lekarski. 2009;27(160):326-330.
https://pubmed.ncbi.nlm.nih.gov/19928663/
4. Visser AJ, Heyl T. Skin tuberculosis as seen at Ga-Rankuwa Hospital. Clin Exp Dermatol. 1993;18(6):507-515. doi:10.1111/j.1365-2230.1993.tb01019.x
https://doi.org/10.1111/j.1365-2230.1993.tb01019.x
5. Franco-Paredes C, Marcos LA, Henao-Martínez AF, et al. Cutaneous Mycobacterial Infections. Clin Microbiol Rev. 2018;32(1):e00069-18. Published 2018 Nov 14. doi:10.1128/CMR.00069-18
https://doi.org/10.1128/cmr.00069-18
6. Kołaczkowska M. Is extrapulmonary tuberculosis a real problem in Poland?. Przewodnik Lekarza/Guide for GPs Supplement. 2007:83-88.
https://www.termedia.pl/Czy-w-Polsce-istnieje-problem-gruzlicy-pozaplucnej-,49,7811,1,0.html
7. Mello RB, Vale ECSD, Baeta IGR. Scrofuloderma: a diagnostic challenge. An Bras Dermatol. 2019;94(1):102-104. doi:10.1590/abd1806-4841.20188560.
https://doi.org/10.1590/abd1806-4841.20188560
8. Khan A, Singaraddi R, Shetty D, Rodrigues G. Primary cutaneous 'ulcerative' tuberculosis of the scrotum: a rare occurrence. BMJ Case Rep. 2018;11(1):e227177. Published 2018 Dec 19. doi:10.1136/bcr-2018-227177
https://doi.org/10.1136/bcr-2018-227177
9. van Zyl L, du Plessis J, Viljoen J. Cutaneous tuberculosis overview and current treatment regimens. Tuberculosis (Edinb). 2015;95(6):629-638. doi:10.1016/j.tube.2014.12.006
https://doi.org/10.1016/j.tube.2014.12.006
10. Lake E, Worobec SM, Aronson IK, Panniculitis. In: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, Orringer JS. eds. Fitzpatrick's Dermatology, 9e. McGraw-Hill Education; 2019. Accessed December 11, 2024.
https://accessmedicine.mhmedical.com/content.aspx?bookid=2570§ionid=210418466’
11. Souto A, Maneiro JR, Salgado E, Carmona L, Gomez-Reino JJ. Risk of tuberculosis in patients with chronic immune-mediated inflammatory diseases treated with biologics and tofacitinib: a systematic review and meta-analysis of randomized controlled trials and long-term extension studies. Rheumatology (Oxford). 2014;53(10):1872-1885. doi:10.1093/rheumatology/keu172.
https://doi.org/10.1093/rheumatology/keu172
12. Chen Q, Chen W, Hao F. Cutaneous tuberculosis: A great imitator. Clin Dermatol. 2019;37(3):192-199. doi:10.1016/j.clindermatol.2019.01.008
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Żanna Białoszycka, Monika Białoszycka , Alisa Pachevska

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 38
Number of citations: 0