Advancements in Alzheimer's Disease Therapy: The Role of Anti-Amyloid Monoclonal Antibodies - A Literature Review
DOI:
https://doi.org/10.12775/JEHS.2025.79.58362Keywords
Alzheimer's disease, anti-amyloid monoclonal antibodies, aducanumab, lecanemab, donanemab, ARIAAbstract
Alzheimer's disease is a neurodegenerative disorder characterized by progressive cognitive decline and neuronal damage. Anti-amyloid monoclonal antibodies such as aducanumab, lecanemab, and donanemab, represent the first disease-modifying therapies for Alzheimer’s disease, specifically targeting amyloid-β plaques, a hallmark of the disease. This review examines the pathogenesis of Alzheimer’s disease, the mechanism of action of these anti-amyloid therapies, and their potential benefits and associated risks, particularly amyloid-related imaging abnormalities (ARIA). While these therapies have demonstrated statistically significant efficacy in reducing amyloid plaques and decelerating cognitive decline, further research is required to confirm their long-term clinical benefits and establish a precise safety profile. Nonetheless, the approval of these monoclonal antibodies constitutes a significant advancement and potentially heralds the beginning of a new era in the treatment of Alzheimer’s disease.
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Copyright (c) 2025 Agnieszka Skoczeń, Natalia Rutecka, Błażej Kaczmarek, Agata Kuśnierz-Gibała, Adrian Kruk, Michał Kulesza, Weronika Wawrzynów, Martyna Miłoś, Aleksandra Dorosz, Magdalena Maria Jakubowska
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