The Role of Maternal and Infant Diet in the Management of Infantile Colic: A Comprehensive Review
DOI:
https://doi.org/10.12775/JEHS.2025.80.58338Keywords
maternal diet, infant diet, infantile colic, probiotics, gut microbiome, breastfeedingAbstract
This systematic review aims to determine the effects of maternal and infant diet on the incidence and treatment of infant colic with emphasis on dietary modifications and its potential to reduce the symptoms. The role of maternal and infant diet on psychological health of the mother and breastfeeding practices as risk factors in reducing the frequency of colic episodes has been highlighted. The role of maternal gut microbiota composition especially the bacterial enterotypes has been discussed with relation to colic. Also, the efficacy of probiotics especially the Lactobacillus reuteri strains has been evaluated with variable results depending upon the strain and the dose used.
The review discusses how the definitions and criteria used, for instance Wessel and Rome IV, influence the perception of incidence and nature of colic. It also includes descriptive content analysis of various researches where cultural and socio-economic factors including maternal empowerment in different contexts are discussed in relation to the management plans. The analysis of meta-analysis and risk of bias studies enhances the conclusions and offers practical recommendations on dietary interventions.
The present study reveals that the personalized dietary approaches are effective and at the same time points out the need to fill the research gaps in order to provide better solutions for parents of colicky infants.
References
1. TG Ong et al. “Probiotics to prevent infantile colic”. In: Cochrane Database of Systematic Reviews 2019.3 (Mar. 2019). doi: 10.1002/14651858.CD012473.pub2. url: www.cochranelibrary.com.
2. Aysu Yıldız Karaahmet, Gülümser Dolgun, and Unknown Author. “The Effect of Probiotics Added to Maternal Nutrition on Infantile Colic: A Systematic Review and Meta-analysis”. In: Türkiye Klinikleri Journal of Pediatrics (May 2021). doi: 10.5336/pediatr.2020-78942. url: https://www.researchgate.net/publication/351992568.
3. Tracy Harb et al. “Infant Colic —What works: A Systematic Review of Interventions for Breast- fed Infants”. In: Journal of Pediatric Gastroenterology and Nutrition 62.5 (May 2016). doi: 10. 1097/MPG.0000000000001075.
4. Faiqa Hassan et al. “Occurrence of Colic and Stomach Pain in Infants; An Observational Study”. In: (June 2022). url: https://www.researchgate.net/publication/362223727.
5. M Gordon, J Gohil, and SSC Banks. “Parent training programmes for managing infantile colic”. In: Cochrane Database of Systematic Reviews 2019.12 (Dec. 2019). doi: 10.1002/14651858. CD012459.pub2. url: www.cochranelibrary.com.
6. Huazi Liu, Qiang Fei, and Tianming Yuan. “The effectiveness of Lactobacillus rhamnosus GG in the treatment of infantile colic: a systematic review and meta-analysis”. In: Translational Pediatrics 13.8 (Aug. 2024). doi: 10.21037/tp-24-112. url: https://dx.doi.org/10.21037/ tp-24-112.
7. Samat Kozhakhmetov et al. “Compositional and functional variability of the gut microbiome in children with infantile colic”. In: Scientific Reports 13 (2023). doi: 10.1038/s41598- 023- 36641-z. url: https://doi.org/10.1038/s41598-023-36641-z.
8. Francesco Savino et al. “Lactobacillus rhamnosus GG (ATCC 53103) for the Management of Infantile Colic: A Randomized Controlled Trial”. In: Nutrients 12.6 (June 2020). doi: 10.3390/ nu12061693. url: https://www.mdpi.com/2072-6643/12/6/1693.
9. Robert J. Shulman et al. “Infant behavioral state and stool microbiome in infants receiving Lactocaseibacillus rhamnosus GG in formula: randomized controlled trial”. In: BMC Pediatrics 22.580 (2022). doi: 10.1186/s12887-022-03647-x. url: https://doi.org/10.1186/s12887- 022-03647-x.
10. F. Savino et al. Dietary modifications for infantile colic (Protocol). Mar. 2014. url: http:// www.thecochranelibrary.com.
11. C. Grafton-Clarke et al. Oral probiotics for the treatment of infantile colic (Protocol). May 2022. doi: 10.1002/14651858.CD015262. url: www.cochranelibrary.com.
12. M Gordon et al. “Dietary modifications for infantile colic”. In: Cochrane Database of System- atic Reviews (Oct. 2018), p. CD011029. doi: 10.1002/14651858.CD011029.pub2. url: www. cochranelibrary.com.
13. Julie Ellwood, Jerry Draper-Rodi, and Dawn Carnes. “Comparison of common interventions for the treatment of infantile colic: a systematic review of reviews and guidelines”. In: BMJ Open 10 (Feb. 2020). doi: 10.1136/bmjopen- 2019- 035405. url: http://dx.doi.org/10.1136/ bmjopen-2019-035405.
14. Behnaz Bagherian, Roghayeh Mehdipour-Rabori, and Monirsadat Nematollahi. “How Do Moth- ers Take Care of Their Infants with Colic Pain? A Mixed-Method Study”. In: Ethiop J Health Sci 31.4 (July 2021). doi: 10.4314/ejhs.v31i4.10. url: http://dx.doi.org/10.4314/ejhs. v31i4.10.
15. Karolina Skonieczna-Żydecka et al. “The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta- Regression of Randomized Controlled Trials”. In: Journal of Clinical Medicine 9.4 (Apr. 2020). doi: 10.3390/jcm9040999. url: https://www.mdpi.com/2077-0383/9/4/999.
16. Jean Cowie. “Managing Infant Colic: A Literature Review”. In: Primary Health Care 23.2 (Mar. 2013).
17. Valerie Sung. “Infantile colic”. In: Aust Prescr 41.4 (Aug. 2018). doi: 10.18773/austprescr. 2018.033. url: https://doi.org/10.18773/austprescr.2018.033.
18. Siel Daelemans et al. “Recent advances in understanding and managing infantile colic”. In: F1000Research 7.F1000 Faculty Rev (Sept. 2018). doi: 10 . 12688 / f1000research . 14940 . 1. url: https://doi.org/10.12688/f1000research.14940.1.
19. Radoslaw Dryl and Hanna Szajewska. “Probiotics for management of infantile colic: a systematic review of randomized controlled trials”. In: Arch Med Sci 14.5 (May 2018). doi: 10.5114/aoms. 2017.66055. url: https://doi.org/10.5114/aoms.2017.66055.
20. Rachel Perry et al. “An overview of systematic reviews of complementary and alternative thera- pies for infantile colic”. In: Systematic Reviews 8.271 (2019). doi: 10.1186/s13643-019-1191-5
21. V. E. Garnacho-Garnacho et al. “Maternal Psychological Well-Being as a Protector in Infantile Colic”. In: Nutrients 16.16 (July 2024). doi: 10.3390/nu16142342. url: https://doi.org/10. 3390/nu16142342.
22. Katja Korpela et al. “Microbiome of the first stool after birth and infantile colic”. In: Pediatric Research 88 (Feb. 2020). doi: 10.1038/s41390-020-0804-y. url: https://doi.org/10.1038/ s41390-020-0804-y.
23. J. M. Moreno-Villares et al. “Comparative efficacy of probiotic mixture Bifidobacterium longum KABP042 plus Pediococcus pentosaceus KABP041 vs. Limosilactobacillus reuteri DSM17938 in the management of infant colic: a randomized clinical trial”. In: European Journal of Pediatrics 183 (Oct. 2024). doi: 10 . 1007 / s00431 - 024 - 05806 - x. url: https :// doi . org / 10 . 1007 / s00431-024-05806-x.
24. Meliha Aksoy Okan et al. “Does maternal diet affect infantile colic?” In: The Journal of Maternal- Fetal & Neonatal Medicine (Nov. 2015). doi: 10.3109/14767058.2015.1115011. url: http://dx.doi.org/10.3109/14767058.2015.1115011.
25. Aysu Yıldız Karaahmet, Gülümser Dolgun, and Metehan Özen. “Probiotics added to maternal nutrition affect infantile colic symptoms and fecal microbiota profile: a single-blind randomized controlled study”. In: CEPClin Exp Pediatr 65.11 (Aug. 2022). doi: 10.3345/cep.2022.00766. url: https://doi.org/10.3345/cep.2022.00766.
26. Reza Shirazinia, Ali Akbar Golabchifar, and Mohammad Reza Fazeli. “Efficacy of probiotics for managing infantile colic due to their anti-inflammatory properties: a meta-analysis and system- atic review”. In: CEPClin Exp Pediatr 64.12 (Dec. 2021). doi: 10.3345/cep.2020.01676. url: https://doi.org/10.3345/cep.2020.01676.
27. Sergei Gerasimov et al. “Role of Lactobacillus rhamnosus (FloraActive™) 19070-2 and Lacto- bacillus reuteri (FloraActive™) 12246 in Infant Colic: A Randomized Dietary Study”. In: Nu- trients 10.12 (Dec. 2018). doi: 10 . 3390 / nu10121975. url: https :// www . mdpi . com / 2072 - 6643/10/12/1975
28. Happy Tummy Consortium et al. “Infant feeding practice and gastrointestinal tolerance: a real- world, multi-country, cross-sectional observational study”. In: BMC Pediatrics 22.22 (Oct. 2022). doi: 10.1186/s12887-022-03763-8. url: https://doi.org/10.1186/s12887-022-03763-8.
29. Francesco Savino et al. “Looking for new treatments of Infantile Colic”. In: Italian Journal of Pediatrics 40.1 (May 2014). doi: 10.1186/1824- 7288- 40- 53. url: http://www.ijponline. net/content/40/1/53.
30. Ioannis Xinias et al. “Innovative Dietary Intervention Answers to Baby Colic”. In: Pediatr Gas- troenterol Hepatol Nutr 20.2 (June 2017). doi: 10.5223/pghn.2017.20.2.100. url: https://doi.org/10.5223/pghn.2017.20.2.100.
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Copyright (c) 2025 Marcel Paruzel, Martyna Łęcka, Katarzyna Żak, Adam Załóg, Maria Nowak, Edyta Pietryszak, Wojciech Kulej, Paulina Szołtek, Rafał Pardela, Monika Wojtasik
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