The Effects of short term L-citrulline supplementation in the immediate preparation period on the blood morphotic indicators in the population of amateur runners
DOI:
https://doi.org/10.12775/JEHS.2025.78.58255Keywords
cytruline, blood count, morphological blood parameters, semi-professional runners, post-exercise responseAbstract
Background and Study Aim: The main aim of the study was to asses the effects of short term L-citrulline supplementation in the immediate preparation period on the blood morphotic indicators in the population of amateur runners.
Material and Methods: Population of 24 physically active semi-professional runners preperign for the long distance runn were assigned to two groups to determine the effect of 14-days of 6000 mg per day cytruline supplementation in the immediate preparation period on the blood morphotic indicators in the population of amateur runners. The study was completed by 12 subjects receiving 6 000 mg per cytruline daily (in six 1g gelatin capsules), and 10 subjects receiving placebo gelatin capluses fulfilled with potato flour. The morphological blood parameters were messured from the venous blood collected into 5-ml tubes containing EDTAK2 as the anticoagulant before and after two weeks of supplementation.
Results: There were no significant differences found between the groups with respect to changes in the levels of the studied parameters, except for creatine kinase.
References
1. Bendahan, D., Mattei, J. P., Ghattas, B., Confort-Gouny, S., Le Guern, M. E., & Cozzone, P. J. (2002). Citrulline/malate promotes aerobic energy production in human exercising muscle. British journal of sports medicine, 36(4), 282-289.
2. Bendahan, D., Mattei, J. P., Ghattas, B., Confort-Gouny, S., Le Guern, M. E., & Cozzone, P. J. (2002). Citrulline/malate promotes aerobic energy production in human exercising muscle. British journal of sports medicine, 36(4), 282-289.
3. Cutrufello, P. T., Gadomski, S. J., & Zavorsky, G. S. (2015). The effect of l-citrulline and watermelon juice supplementation on anaerobic and aerobic exercise performance. Journal of sports sciences, 33(14), 1459-1466.
4. Fitts, R. H. (1994). Cellular mechanisms of muscle fatigue. Physiological reviews, 74(1), 49-94.
5. Ghozali, D. A., Rahma, A. A., Hanifa, S. N., & Ilyas, M. F. (2024). Effect of L-Citrulline on Creatine Kinase MM (CK-MM) Isoenzymes in Mice: An In Vivo Study Focusing on Immunohistochemistry Analysis. Folia Medica Indonesiana, 60(3), 192-199.
6. Gonzalez, A. M., & Trexler, E. T. (2020). Effects of citrulline supplementation on exercise performance in humans: A review of the current literature. The Journal of Strength & Conditioning Research, 34(5), 1480-1495.
7. Gonzalez, A. M., Townsend, J. R., Pinzone, A. G., & Hoffman, J. R. (2023). Supplementation with nitric oxide precursors for strength performance: A review of the current literature. Nutrients, 15(3), 660.
8. Moinard C, Nicolis I, Neveux N, et al. Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: The citrudose pharmacokinetic study. Br J Nutr 99: 855–862, 2008.
9. Perez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res. 2010;24(5):1215–22
10. Thompson, C., Jones, A. M., & Bailey, S. J. (2019). Nitric oxide precursors. In Dietary Supplementation in Sport and Exercise (pp. 173-190). Routledge.
11. Trexler, E. T., Persky, A. M., Ryan, E. D., Schwartz, T. A., Stoner, L., & Smith-Ryan, A. E. (2019). Acute effects of citrulline supplementation on high-intensity strength and power performance: A systematic review and meta-analysis. Sports Medicine, 49, 707-718.
12. Vårvik, F. T., Bjørnsen, T., & Gonzalez, A. M. (2021). Acute effect of citrulline malate on repetition performance during strength training: a systematic review and meta-analysis. International journal of sport nutrition and exercise metabolism, 31(4), 350-358.
13. Villareal, M. O., Matsukawa, T., & Isoda, H. (2018). L‐Citrulline supplementation‐increased skeletal muscle PGC‐1α expression is associated with exercise performance and increased skeletal muscle weight. Molecular nutrition & food research, 62(14), 1701043.
14. Viribay, A., Fernández-Landa, J., Castañeda-Babarro, A., Collado, P. S., Fernández-Lázaro, D., & Mielgo-Ayuso, J. (2022). Effects of citrulline supplementation on different aerobic exercise performance outcomes: A systematic review and meta-analysis. Nutrients,
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