Taeniasis: symptoms, diagnosis and treatment – a systematic review
DOI:
https://doi.org/10.12775/JEHS.2025.79.58206Keywords
taeniasis, Taenia saginata, Taenia solium, symptoms of taeniasis, taeniasis treatment, tapeworm infectionAbstract
Human taeniasis is caused by infection with one of three Taenia species: Taenia saginata, Taenia solium, and Taenia asiatica. It is a parasitic disease that remains a public health concern in endemic regions. This systematic review examines the clinical manifestations, diagnostic approaches, and methods of treatment for taeniasis. A comprehensive analysis of available literature highlights the diverse symptomatology, ranging from asymptomatic carriers to individuals with life-threatening complications. Advances in diagnostic techniques, including molecular methods, have improved detection rates, while pharmacological treatments like praziquantel and niclosamide remain the key elements of therapy. This review underscores the importance of integrated control strategies to reduce the burden of taeniasis, including sanitation improvements and public health education.
References
1. Eichenberger RM, Thomas LF, Gabriël S, et al. Epidemiology of Taenia saginata taeniosis/cysticercosis: a systematic review of the distribution in East, Southeast and South Asia. Parasit Vectors. 2020;13(1):234. doi:10.1186/s13071-020-04095-1
2. García HH, Gonzalez AE, Evans CA, Gilman RH. Taenia solium cysticercosis. The Lancet. 2003;362(9383):547-556. doi:10.1016/S0140-6736(03)14117-7
3. Ryan ET, Hill DR, Solomon T, Aronson NE, Endy TP, eds. Hunter’s Tropical Medicine and Emerging Infectious Diseases. Tenth edition. Elsevier; 2020.
4. WHO, FAO, OIE. WHO/FAO/OIE Guidelines for the Surveillance, Prevention and Control of Taeniosis/Cysticercosis. OIE (World Organisation for Animal Health); 2005.
5. World Health Organization. Global Report on Neglected Tropical Diseases 2024. World Health Organization; 2024.
6. Okello A, Thomas L. Human taeniasis: current insights into prevention and management strategies in endemic countries. Risk Manag Healthc Policy. 2017;Volume 10:107-116. doi:10.2147/RMHP.S116545
7. Pawlowski Z, Schultz MG. Taeniasis and Cysticercosis (Taenia saginata). In: Advances in Parasitology. Vol 10. Elsevier; 1972:269-343. doi:10.1016/S0065-308X(08)60176-1
8. Flisser A. Taeniasis and cysticercosis due to Taenia solium. Prog Clin Parasitol. 1994;4:77-116.
9. Merchant MT, Aguilar L, Avila G, Robert L, Flisser A, Willms K. Taenia solium: description of the intestinal implantation sites in experimental hamster infections. J Parasitol. 1998;84(4):681-685.
10. Fan PC, Chung WC, Lin CY, Chan CH. Clinical manifestations of taeniasis in Taiwan aborigines. J Helminthol. 1992;66(2):118-123. doi:10.1017/S0022149X00012694
11. Flisser A, Craig PS, Ito A. Cysticercosis and taeniosis: Taenia solium, Taenia saginata and Taenia asiatica. In: Palmer SR, Soulsby, Lord, Torgerson P, Brown DWG, eds. Oxford Textbook of Zoonoses: Biology, Clinical Practice, and Public Health Control. Oxford University Press; 2011:0. doi:10.1093/med/9780198570028.003.0058
12. Li P, Xu L, Xiang J, et al. Taeniasis Related Frequent Intestinal Obstruction: Case Report and Mini-Review: Li P al. Taeniasis related intestinal obstruction. J Gastroenterol Hepatol Res. 2015;4(1):1455-1458. doi:10.17554/j.issn.2224-3992.2015.04.496
13. Wani AA, Ilyas M, Robbani I, Taley SA. Taenia saginata as a Cause of Bowel Obstruction. ACG Case Rep J. 2018;5:e37. doi:10.14309/crj.2018.37
14. Garcia HH, Nash TE, Del Brutto OH. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol. 2014;13(12):1202-1215. doi:10.1016/S1474-4422(14)70094-8
15. Carabin H, Ndimubanzi PC, Budke CM, et al. Clinical manifestations associated with neurocysticercosis: a systematic review. PLoS Negl Trop Dis. 2011;5(5):e1152. doi:10.1371/journal.pntd.0001152
16. Rath S, Honavar SG, Naik M, et al. Orbital cysticercosis: clinical manifestations, diagnosis, management, and outcome. Ophthalmology. 2010;117(3):600-605, 605.e1. doi:10.1016/j.ophtha.2009.07.030
17. Dhiman R, Devi S, Duraipandi K, et al. Cysticercosis of the eye. Int J Ophthalmol. 2017;10(8):1319-1324. doi:10.18240/ijo.2017.08.21
18. Meena D, Gupta M, Jain VK, Arya RK. Isolated intramuscular cysticercosis: Clinicopathological features, diagnosis and management - A review. J Clin Orthop Trauma. 2016;7(Suppl 2):243-249. doi:10.1016/j.jcot.2016.06.016
19. Ito A, Nakao M, Wandra T. Human Taeniasis and cysticercosis in Asia. Lancet Lond Engl. 2003;362(9399):1918-1920. doi:10.1016/S0140-6736(03)14965-3
20. Galán-Puchades MT, Fuentes MV. Lights and shadows of the Taenia asiatica life cycle and pathogenicity. Trop Parasitol. 2013;3(2):114-119. doi:10.4103/2229-5070.122114
21. Jackson PG, Raiji MT. Evaluation and management of intestinal obstruction. Am Fam Physician. 2011;83(2):159-165.
22. Yu HJ, Ahn CS, Lim S, et al. Biliary Taeniasis with Cholecystitis: An Unusual Case of Taenia solium Infection with a Literature Review. Am J Trop Med Hyg. 2019;100(1):135-139. doi:10.4269/ajtmh.18-0633
23. Hakeem SY, Rashid A, Khuroo S, Bali RS. Taenia saginata : A Rare Cause of Gall Bladder Perforation. Case Rep Surg. 2012;2012:1-3. doi:10.1155/2012/572484
24. Uygur-Bayramiçli O, Ak O, Dabak R, Demirhan G, Ozer S. Taenia saginata a rare cause of acute cholangitis: a case report. Acta Clin Belg. 2012;67(6):436-437. doi:10.2143/ACB.67.6.2062709
25. Chakrabarti I, Gangopadhyay M, Bandopadhyay A, Das NK. A rare case of gangrenous appendicitis by eggs of Taenia species. J Parasit Dis. 2014;38(1):135-137. doi:10.1007/s12639-012-0182-4
26. Tsilman B, Cohen HI, Lejbkowicz F, Abel AB. Taenia infestation in the appendix: a report of two cases. J Med Microbiol. 2002;51(1):90-91. doi:10.1099/0022-1317-51-1-90
27. Del Brutto OH, García HH. Neurocysticercosis in nonendemic countries: time for a reappraisal. Neuroepidemiology. 2012;39(2):145-146. doi:10.1159/000341693
28. Minciullo PL, Cascio A, Isola S, Gangemi S. Different clinical allergological features of Taenia solium infestation. Clin Mol Allergy CMA. 2016;14:18. doi:10.1186/s12948-016-0056-x
29. Prodjinotho UF, Lema J, Lacorcia M, et al. Host immune responses during Taenia solium Neurocysticercosis infection and treatment. PLoS Negl Trop Dis. 2020;14(4):e0008005. doi:10.1371/journal.pntd.0008005
30. Sadlowski H, Schmidt V, Hiss J, et al. Diagnosis of Taenia solium infections based on “mail order” RNA-sequencing of single tapeworm egg isolates from stool samples. Zhou XN, ed. PLoS Negl Trop Dis. 2021;15(12):e0009787. doi:10.1371/journal.pntd.0009787
31. Mayta H, Talley A, Gilman RH, et al. Differentiating Taenia solium and Taenia saginata infections by simple hematoxylin-eosin staining and PCR-restriction enzyme analysis. J Clin Microbiol. 2000;38(1):133-137. doi:10.1128/JCM.38.1.133-137.2000
32. Flisser A. State of the art of Taenia solium as compared to Taenia asiatica. Korean J Parasitol. 2013;51(1):43-49. doi:10.3347/kjp.2013.51.1.43
33. Mayta H, Gilman RH, Prendergast E, et al. Nested PCR for specific diagnosis of Taenia solium taeniasis. J Clin Microbiol. 2008;46(1):286-289. doi:10.1128/JCM.01172-07
34. Nkouawa A, Sako Y, Okamoto M, Ito A. Simple Identification of Human Taenia Species by Multiplex Loop-Mediated Isothermal Amplification in Combination with Dot Enzyme-Linked Immunosorbent Assay. Am Soc Trop Med Hyg. 2016;94(6):1318-1323. doi:10.4269/ajtmh.15-0829
35. Hossain MS, Shabir S, Toye P, Thomas LF, Falcone FH. Insights into the diagnosis, vaccines, and control of Taenia solium, a zoonotic, neglected parasite. Parasit Vectors. 2023;16(1):380. doi:10.1186/s13071-023-05989-6
36. Wilkins PP, Allan JC, Verastegui M, et al. Development of a serologic assay to detect Taenia solium taeniasis. Am J Trop Med Hyg. 1999;60(2):199-204. doi:10.4269/ajtmh.1999.60.199
37. Guezala MC, Rodriguez S, Zamora H, et al. Development of a species-specific coproantigen ELISA for human Taenia solium taeniasis. Am J Trop Med Hyg. 2009;81(3):433-437.
38. Alhassan M, Barghash AI, Al-Saadi H. Expect the Unexpected: Bowel Obstruction Caused by <i>Taenia saginata</i>: A Case Report of Unusual Complications. Case Rep Clin Med. 2021;10(07):191-196. doi:10.4236/crcm.2021.107024
39. Pawlowski Z, Allan J, Sarti E. Control of Taenia solium taeniasis/cysticercosis: From research towards implementation. Int J Parasitol. 2005;35(11-12):1221-1232. doi:10.1016/j.ijpara.2005.07.015
40. Timson DJ. Praziquantel: An Enigmatic, Yet Effective, Drug. In: Timson DJ, ed. Schistosoma Mansoni. Vol 2151. Methods in Molecular Biology. Springer US; 2020:1-8. doi:10.1007/978-1-0716-0635-3_1
41. Garcia HH, Gonzalez AE, Gilman RH. Diagnosis, treatment and control of Taenia solium cysticercosis: Curr Opin Infect Dis. 2003;16(5):411-419. doi:10.1097/00001432-200310000-00007
42. Raso G, N’Goran EK, Toty A, et al. Efficacy and side effects of praziquantel against Schistosoma mansoni in a community of western Côte d’Ivoire. Trans R Soc Trop Med Hyg. 2004;98(1):18-27. doi:10.1016/S0035-9203(03)00003-8
43. Pearson RD. Niclosamide Therapy for Tapeworm Infections. Ann Intern Med. 1985;102(4):550. doi:10.7326/0003-4819-102-4-550
44. Pawlowski ZS. Role of chemotherapy of taeniasis in prevention of neurocysticercosis. Parasitol Int. 2006;55:S105-S109. doi:10.1016/j.parint.2005.11.017
45. Georgiev VS. Infectious Diseases in Immunocompromised Hosts. CRC Press; 1998.
46. Haby MM, Sosa Leon LA, Luciañez A, Nicholls RS, Reveiz L, Donadeu M. Systematic review of the effectiveness of selected drugs for preventive chemotherapy for Taenia solium taeniasis. Taylan Ozkan A, ed. PLoS Negl Trop Dis. 2020;14(1):e0007873. doi:10.1371/journal.pntd.0007873
47. Chung WC, Fan PC, Lin CY, Wu CC. Poor efficacy of albendazole for the treatment of human taeniasis. Int J Parasitol. 1991;21(2):269-270. doi:10.1016/0020-7519(91)90021-X
48. WHO Guidelines on Management of Taenia Solium Neurocysticercosis. World Health Organization; 2021. Accessed December 27, 2024. http://www.ncbi.nlm.nih.gov/books/NBK573853/
49. White AC, Coyle CM, Rajshekhar V, et al. Diagnosis and Treatment of Neurocysticercosis: 2017 Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH). Am J Trop Med Hyg. 2018;98(4):945-966. doi:10.4269/ajtmh.18-88751
50. Lunn PG, Northrop-Clewes CA. The impact of gastrointestinal parasites on protein-energy malnutrition in man. Proc Nutr Soc. 1993;52(1):101-111. doi:10.1079/PNS19930042
51. Hoste H. Adaptive physiological processes in the host during gastrointestinal parasitism. Int J Parasitol. 2001;31(3):231-244. doi:10.1016/S0020-7519(00)00167-3
52. Gilman RH, Gonzalez AE, Llanos-Zavalaga F, Tsang VCW, Garcia HH, Cysticercosis Working Group in Peru. Prevention and control of Taenia solium taeniasis/cysticercosis in Peru. Pathog Glob Health. 2012;106(5):312-318. doi:10.1179/2047773212Y.0000000045
53. Sarti E, Flisser A, Schantz PM, et al. Development and Evaluation of a Health Education Intervention against Taenia solium in a Rural Community in Mexico. Am J Trop Med Hyg. 1997;56(2):127-132. doi:10.4269/ajtmh.1997.56.127
54. Sarti E, Schantz PM, Avila G, Ambrosio J, Medina-Santillán R, Flisser A. Mass treatment against human taeniasis for the control of cysticercosis: a population-based intervention study. Trans R Soc Trop Med Hyg. 2000;94(1):85-89. doi:10.1016/s0035-9203(00)90451-6
55. Vermund SH, MacLeod S, Goldstein RG. Taeniasis unresponsive to a single dose of niclosamide: case report of persistent infection with Taenia saginata and a review of therapy. Rev Infect Dis. 1986;8(3):423-426. doi:10.1093/clinids/8.3.423
56. Madinga J, Polman K, Kanobana K, et al. Epidemiology of polyparasitism with Taenia solium , schistosomes and soil-transmitted helminths in the co-endemic village of Malanga, Democratic Republic of Congo. Acta Trop. 2017;171:186-193. doi:10.1016/j.actatropica.2017.03.019
57. Shin JH, Won EJ, Jung JS, et al. A co-infection case report of Taenia saginata in a patient with subclinical clonorchiasis confirmed by the combination of diagnostic tools. BMC Infect Dis. 2019;19(1):115. doi:10.1186/s12879-019-3758-0
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