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Journal of Education, Health and Sport

Treatment of Fibromyalgia - duloxetine or pregabalin?
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Treatment of Fibromyalgia - duloxetine or pregabalin?

Authors

  • Magdalena Bujak Krakow University Hospital https://orcid.org/0009-0008-9274-3595
  • Natalia Rulewska Provincial Specialist Hospital in Ciechanów https://orcid.org/0009-0008-4515-7403
  • Filip Grabowski Provincial Specialist Hospital in Ciechanów https://orcid.org/0009-0007-0466-2764
  • Jakub Siemko Ludwika Błażka Provincial Multi-Specialist Hospital in Inowrocław https://orcid.org/0009-0009-9318-9458
  • Dagmara Neska Ludwika Błażka Provincial Multi-Specialist Hospital in Inowrocław https://orcid.org/0009-0003-1900-954X
  • Dominika Prystacka-Szar Ludwik Rydygier Memorial Specialized Hospital in Krakow https://orcid.org/0009-0003-6533-4247
  • Justyna Stadler-Szajda Ludwika Błażka Provincial Multi-Specialist Hospital in Inowrocław https://orcid.org/0000-0002-1742-1835
  • Adrianna Czyżnikiewicz Ludwika Błażka Provincial Multi-Specialist Hospital in Inowrocław https://orcid.org/0009-0007-4541-7175
  • Wenancjusz Stołowski Ludwika Błażka Provincial Multi-Specialist Hospital in Inowrocław https://orcid.org/0009-0009-0317-1212
  • Magdalena Waśniowska Stefana Żeromskiego Specialist Hospital in Kraków https://orcid.org/0009-0006-0614-8307

DOI:

https://doi.org/10.12775/JEHS.2025.80.57856

Keywords

Fibromyalgia, treatment, duloxetine, pregabalin

Abstract

Introduction: Fibromyalgia (FM) is a complex and chronic condition characterized by widespread pain, fatigue, and disrupted sleep, often accompanied by mood disturbances and cognitive difficulties. The pathophysiology of FM involves heightened pain sensitivity, altered neurotransmitter levels, and neurochemical imbalances, including elevated substance P and glutamate. Duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI), has demonstrated efficacy in managing FM symptoms, particularly pain, functional impairment, and quality of life. Pregabalin, another widely used FM medication, reduces pain by modulating calcium channels and neurotransmitter release, improving sleep and reducing fatigue. Comparative studies indicate that duloxetine may offer broader benefits, including reduced healthcare utilization, due to its dual role in pain relief and mood stabilization. While pregabalin may be preferred in patients with specific comorbidities like functional dyspepsia, duloxetine’s antidepressant effects make it a compelling option for individuals with depression-related FM symptoms.

Aim of the study: The study aimed to analyze the current treatment of Fibromyalgia and compare two main treatment methods, duloxetine and pregabalin. 

Review method: The following keywords, such as fibromyalgia treatment, duloxetine, and pregabalin, have been included in the search phrases used to thoroughly examine research publications available on Pubmed. 

Conclusion: This review highlights the importance of personalized treatment strategies for FM, integrating pharmacological and non-pharmacological approaches within a biopsychosocial framework. By tailoring therapies to individual needs, clinicians can optimize outcomes and improve patient quality of life.

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Published

2025-04-05

How to Cite

1.
BUJAK, Magdalena, RULEWSKA, Natalia, GRABOWSKI, Filip, SIEMKO, Jakub, NESKA, Dagmara, PRYSTACKA-SZAR, Dominika, STADLER-SZAJDA, Justyna, CZYŻNIKIEWICZ, Adrianna, STOŁOWSKI, Wenancjusz and WAŚNIOWSKA, Magdalena. Treatment of Fibromyalgia - duloxetine or pregabalin?. Journal of Education, Health and Sport. Online. 5 April 2025. Vol. 80, p. 57856. [Accessed 23 May 2025]. DOI 10.12775/JEHS.2025.80.57856.
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Vol. 80 (2025)

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Health Sciences

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Copyright (c) 2025 Magdalena Bujak, Natalia Rulewska, Filip Grabowski, Jakub Siemko, Dagmara Neska, Dominika Prystacka-Szar, Justyna Stadler-Szajda, Adrianna Czyżnikiewicz, Wenancjusz Stołowski, Magdalena Waśniowska

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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