Acute Otitis Media in children – a review of current literature
DOI:
https://doi.org/10.12775/JEHS.2025.79.57781Keywords
Acute Otitis Media, Otalgia, Otorrhea, Middle Ear Effusion, OtoscopyAbstract
Introduction and purpose
Acute otitis media (AOM) is an infection of the middle ear, with acute onset of symptoms and signs, frequently including otalgia, fever, and otorrhea. It affects 80% of children by the age of 5 years, hence the need to collect and share current knowledge on risk factors, pathophysiology, diagnosis, treatment and complications of AOM.
A brief description of the state of knowledge
AOM is an extremely common infection in children, usually bacterial. Numerous risk factors lead to it, with allergies, allergic rhinitis and gastro-esophageal reflux disease being the most frequent. Inflammation within the eustachian tube causes effusion to accumulate inside the middle ear, leading to irritating symptoms. A thorough medical history and careful physical examination are used to assess, whether the patient meets obligatory criteria: acute onset of symptoms, evidence of effusion, and tympanic membrane inflammation. Observation is often sufficient, and symptoms start fading without any antimicrobials. Should this not be the case, systemic antibiotic therapy is recommended. Regardless of antibiotics, pain management is of great importance. Complications are unlikely to occur with proper diagnosis and treatment.
Conclusions
AOM, being a frequent condition in children, requires good knowledge on diagnostics and management to avoid as many complications as possible. Remembering possible risk factors and symptoms, both specific and less common, leads to faster diagnosis, which then decreases the risk for unnecessary pain and possible complications. Understanding the biology behind AOM together with utilization of new methods in physical examination is key to providing better care. Promising research is made on new ways to treat AOM with drug delivery systems.
References
1. El Feghaly RE, Nedved A, Katz SE, Frost HM. New insights into the treatment of acute otitis media. Expert Rev Anti Infect Ther. 2023 May;21(5):523-534. doi: 10.1080/14787210.2023.2206565. Epub 2023 Apr 28. PMID: 37097281; PMCID: PMC10231305.
2. Venekamp RP, Sanders SL, Glasziou PP, Del Mar CB, Rovers MM. Antibiotics for acute otitis media in children. Cochrane Database Syst Rev. 2015 Jun 23;2015(6):CD000219. doi: 10.1002/14651858.CD000219.pub4. Update in: Cochrane Database Syst Rev. 2023 Nov 15;11:CD000219. doi: 10.1002/14651858.CD000219.pub5. PMID: 26099233; PMCID: PMC7043305.
3. Hayashi T, Kitamura K, Hashimoto S, Hotomi M, Kojima H, Kudo F, Maruyama Y, Sawada S, Taiji H, Takahashi G, Takahashi H, Uno Y, Yano H. Clinical practice guidelines for the diagnosis and management of acute otitis media in children-2018 update. Auris Nasus Larynx. 2020 Aug;47(4):493-526. doi: 10.1016/j.anl.2020.05.019. Epub 2020 Jun 20. PMID: 32576390.
4. Holm NH, Rusan M, Ovesen T. Acute otitis media and antibiotics - a systematic review. Dan Med J. 2020 Oct 29;67(11):A04200272. PMID: 33215607.
5. Jamal A, Alsabea A, Tarakmeh M, Safar A. Etiology, Diagnosis, Complications, and Management of Acute Otitis Media in Children. Cureus. 2022 Aug 15;14(8):e28019. doi: 10.7759/cureus.28019. PMID: 36134092; PMCID: PMC9471510.
6. Suzuki HG, Dewez JE, Nijman RG, et al Clinical practice guidelines for acute otitis media in children: a systematic review and appraisal of European national guidelines BMJ Open 2020;10:e035343. doi: 10.1136/bmjopen-2019-035343
7. Frost HM, Bizune D, Gerber JS, Hersh AL, Hicks LA, Tsay SV. Amoxicillin Versus Other Antibiotic Agents for the Treatment of Acute Otitis Media in Children. J Pediatr. 2022 Dec;251:98-104.e5. doi: 10.1016/j.jpeds.2022.07.053. Epub 2022 Aug 6. PMID: 35944719; PMCID: PMC10122571.
8. Fichera P, Bruschini L, Berrettini S, Capobianco S, Fiacchini G. Acute Otitis Media and Facial Paralysis in Children: A Systemic Review and Proposal of an Operative Algorithm. Audiol Res. 2023 Nov 8;13(6):889-897. doi: 10.3390/audiolres13060077. PMID: 37987335; PMCID: PMC10660501.
9. Tsergouli K, Karampatakis N, Karampatakis T. Efficacy of antimicrobials or placebo compared to amoxicillin-clavulanate in children with acute otitis media: a systematic review. Turk J Pediatr. 2023;65(3):351-361. doi: 10.24953/turkjped.2022.893. PMID: 37395955.
10. López Martín D, Piñeiro Pérez R, Martínez Campos L, Ares Álvarez J, de la Calle Cabrera T, Jiménez Huerta I, Khodayar-Pardo P, Lupiani Castellanos P, Baquero-Artigao F; Grupo colaborador del consenso de otitis media aguda y sinusitis en pediatría. Update of the consensus document on the aetiology, diagnosis and treatment of acute otitis media and sinusitis. An Pediatr (Engl Ed). 2023 May;98(5):362-372. doi: 10.1016/j.anpede.2023.03.006. Epub 2023 Apr 29. PMID: 37127475.
11. de Sévaux JLH, Damoiseaux RA, van de Pol AC, Lutje V, Hay AD, Little P, Schilder AG, Venekamp RP. Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. Cochrane Database Syst Rev. 2023 Aug 18;8(8):CD011534. doi: 10.1002/14651858.CD011534.pub3. PMID: 37594020; PMCID: PMC10436353.
12. Castellazzi ML, Torretta S, Pietro GMD, Ciabatta A, Capaccio P, Caschera L, Marchisio P. Acute otitis media-related facial nerve palsy in a child: a case report and a literary review. Ital J Pediatr. 2023 Jan 14;49(1):8. doi: 10.1186/s13052-022-01405-4. PMID: 36641446; PMCID: PMC9840536.
13. Cassano P, Ciprandi G, Passali D. Acute mastoiditis in children. Acta Biomed. 2020 Feb 17;91(1-S):54-59. doi: 10.23750/abm.v91i1-S.9259. PMID: 32073562; PMCID: PMC7947742.
14. Khairkar M, Deshmukh P, Maity H, Deotale V. Chronic Suppurative Otitis Media: A Comprehensive Review of Epidemiology, Pathogenesis, Microbiology, and Complications. Cureus. 2023 Aug 18;15(8):e43729. doi: 10.7759/cureus.43729. PMID: 37727177; PMCID: PMC10505739.
15. Kaya E, Bozan G, Kılıç Ö, Pınarbaşlı MÖ, Gürbüz MK, Kaya F. Acute Otitis Media with Intracranial and Intratemporal Complications: A Case Study. Indian J Otolaryngol Head Neck Surg. 2023 Apr;75(Suppl 1):79-82. doi: 10.1007/s12070-022-03254-3. Epub 2022 Nov 6. PMID: 37206845; PMCID: PMC10188808.
16. Spoială EL, Stârcea IM, Ioniuc IK, Cozma RS, Rusu DC, Bozomitu L, Lupu VV, Iliescu Haliţchi CO, Roşu VE, Roşu ST, Gavrilovici C. Watchful Waiting in Pediatric Acute Otitis Media: A Real Practice Approach or an Intangible Desideratum? Medicina (Kaunas). 2023 Mar 7;59(3):520. doi: 10.3390/medicina59030520. PMID: 36984521; PMCID: PMC10053714.
17. Ahmad Z, Krüger K, Lautermann J, Lippert B, Tenenbaum T, Tigges M, Tisch M. Adenoid hypertrophy-diagnosis and treatment: the new S2k guideline. HNO. 2023 Aug;71(Suppl 1):67-72. doi: 10.1007/s00106-023-01299-6. Epub 2023 Jul 25. PMID: 37491540; PMCID: PMC10409824.
18. Dogan S, Huber AM, Roosli C. Treatment of Acute Otitis Media with Inner Ear Involvement in Adults. J Clin Med. 2023 Dec 9;12(24):7590. doi: 10.3390/jcm12247590. PMID: 38137659; PMCID: PMC10743793.
19. Folino F, Caruso M, Bosi P, Aldè M, Torretta S, Marchisio P. Acute otitis media diagnosis in childhood: still a problem in 2023? Ital J Pediatr. 2024 Jan 25;50(1):19. doi: 10.1186/s13052-024-01588-y. PMID: 38273404; PMCID: PMC10809769.
20. Gavrilovici C, Spoială EL, Miron IC, Stârcea IM, Haliţchi COI, Zetu IN, Lupu VV, Pânzaru C. Acute Otitis Media in Children-Challenges of Antibiotic Resistance in the Post-Vaccination Era. Microorganisms. 2022 Aug 8;10(8):1598. doi: 10.3390/microorganisms10081598. PMID: 36014016; PMCID: PMC9413688.
21. Esposito S, Bianchini S, Argentiero A, Gobbi R, Vicini C, Principi N. New Approaches and Technologies to Improve Accuracy of Acute Otitis Media Diagnosis. Diagnostics (Basel). 2021 Dec 19;11(12):2392. doi: 10.3390/diagnostics11122392. PMID: 34943628; PMCID: PMC8700495.
22. Goldman RD. Acute otitis media in children 6 months to 2 years of age. Can Fam Physician. 2022 Aug;68(8):589-590. doi: 10.46747/cfp.6808589. PMID: 35961722; PMCID: PMC9374071.
23. Cetinkaya EA, Ciftci O, Alan S, Oztanır MN, Basak N. What is the effectiveness of beta-glucan for treatment of acute otitis media? Braz J Otorhinolaryngol. 2021 Nov-Dec;87(6):683-688. doi: 10.1016/j.bjorl.2020.02.004. Epub 2020 Mar 19. PMID: 32273203; PMCID: PMC9422545.
24. Spoială EL, Stanciu GD, Bild V, Ababei DC, Gavrilovici C. From Evidence to Clinical Guidelines in Antibiotic Treatment in Acute Otitis Media in Children. Antibiotics (Basel). 2021 Jan 6;10(1):52. doi: 10.3390/antibiotics10010052. PMID: 33419114; PMCID: PMC7825459.
25. Kono M, Umar NK, Takeda S, Ohtani M, Murakami D, Sakatani H, Kaneko F, Nanushaj D, Hotomi M. Novel Antimicrobial Treatment Strategy Based on Drug Delivery Systems for Acute Otitis Media. Front Pharmacol. 2021 Aug 4;12:640514. doi: 10.3389/fphar.2021.640514. PMID: 34421583; PMCID: PMC8371970.
26. Bajorski P, Fuji N, Kaur R, Pichichero ME. Window of Susceptibility to Acute Otitis Media Infection. Pediatrics. 2023 Feb 1;151(2):e2022058556. doi: 10.1542/peds.2022-058556. PMID: 36618001; PMCID: PMC9890393.
27. Griffiths JL, Goldman RD. Tympanostomy tubes for children with acute otitis media. Can Fam Physician. 2022 May;68(5):345-347. doi: 10.46747/cfp.6805345. PMID: 35552224; PMCID: PMC9097734.
28. Sánchez Arlegui A, Del Arco Rodríguez J, De Velasco Vázquez X, Gallego Rodrigo M, Gangoiti I, Mintegi S. Bacterial pathogens and antimicrobial resistance in acute otitis media. An Pediatr (Engl Ed). 2024 Mar;100(3):173-179. doi: 10.1016/j.anpede.2023.12.013. Epub 2024 Feb 12. PMID: 38350792.
29. Frosolini A, Lovato A. Future Perspectives in the Management of Otitis Media. Medicina (Kaunas). 2023 Aug 26;59(9):1553. doi: 10.3390/medicina59091553. PMID: 37763672; PMCID: PMC10532948.
30. Kharrat G, Ferchichi S, Jouini Z. Pseudomonas Labyrinthitis Complicating Acute Otitis Media: Case Report. Ear Nose Throat J. 2024 Nov 14:1455613241299675. doi: 10.1177/01455613241299675. Epub ahead of print. PMID: 39540706.
31. Frost HM, Monti JD, Andersen LM, Norlin C, Bizune DJ, Fleming-Dutra KE, Czaja CA. Improving Delayed Antibiotic Prescribing for Acute Otitis Media. Pediatrics. 2021 Jun;147(6):e2020026062. doi: 10.1542/peds.2020-026062. Epub 2021 May 12. PMID: 33980695; PMCID: PMC8168601.
32. van Ingen G, le Clercq CMP, Jaddoe VWV, Moll HA, Duijts L, Raat H, Baatenburg de Jong RJ, van der Schroeff MP. Identifying distinct trajectories of acute otitis media in children: A prospective cohort study. Clin Otolaryngol. 2021 Jul;46(4):788-795. doi: 10.1111/coa.13736. Epub 2021 Feb 21. PMID: 33555145; PMCID: PMC8248120.
33. Frost HM, Keith A, Sebastian T, Jenkins TC. Caregiver perspectives and preferences for acute otitis media management. Antimicrob Steward Healthc Epidemiol. 2021;1(1):e69. doi: 10.1017/ash.2021.242. Epub 2021 Dec 22. PMID: 35340401; PMCID: PMC8950091.
34. Smolinski NE, Djabali EJ, Al-Bahou J, Pomputius A, Antonelli PJ, Winterstein AG. Antibiotic treatment to prevent pediatric acute otitis media infectious complications: A meta-analysis. PLoS One. 2024 Jun 17;19(6):e0304742. doi: 10.1371/journal.pone.0304742. PMID: 38885271; PMCID: PMC11182555.
35. Ricci Conesa H, Skröder H, Norton N, Bencina G, Tsoumani E. Clinical and economic burden of acute otitis media caused by Streptococcus pneumoniae in European children, after widespread use of PCVs-A systematic literature review of published evidence. PLoS One. 2024 Apr 2;19(4):e0297098. doi: 10.1371/journal.pone.0297098. PMID: 38564583; PMCID: PMC10986968.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Jan Węgrzyn, Łukasz Fijałkowski, Aleksandra Nosal, Adam Czarnecki, Aleksandra Galanty-Ochyra, Piotr Zając, Karolina Serwońska, Artur Pastuszka, Olga Jabłońska

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 178
Number of citations: 0