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Journal of Education, Health and Sport

The Effects of the Ketogenic Diet on Disorders of Central Nervous System
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The Effects of the Ketogenic Diet on Disorders of Central Nervous System

Authors

  • Patryk Mikołajec https://orcid.org/0009-0001-3300-0061
  • Jolanta Mędyk Independent Researcher  https://orcid.org/0009-0008-3346-0827
  • Michał Rogulski  Independent Public Health Care Center in Garwolin ul. Lubelska 50, Garwolin https://orcid.org/0009-0004-7328-5016
  • Yauheniya Patarocha Independent Public Health Care Center in Garwolin ul. Lubelska 50, Garwolin https://orcid.org/0009-0007-0472-9789
  • Aleksandra Ślusarska  Public Oupatient Medical Center in Strzelin, ul. Mickiewicza 20 Strzelin https://orcid.org/0009-0009-8208-1222
  • Paulina Błasiak  Independent Researcher https://orcid.org/0000-0002-7967-1776
  • Małgorzata Wirkijowska  Formmed Center for Treatment of Congenital Defects and Malformations, ul. Warszawska 197D, Babice Nowe https://orcid.org/0009-0003-5857-965X
  • Ruslan Huk  Independent Public Health Care Center in Garwolin ul. Lubelska 50, Garwolin https://orcid.org/0009-0008-5756-9448
  • Barbara Bilecka  Jan Kochanowski University Collegium Medicum, aleja IX Wieków Kielc 19A, Kielce https://orcid.org/0009-0009-5611-2996

DOI:

https://doi.org/10.12775/JEHS.2025.78.57586

Keywords

diet, schizophrenia, fasting, epilepsy, autism

Abstract

The ketogenic diet (KD) that focuses on forcing body to switch from burning glucose to burning fat for fuel, has recently been a subject of livid investigation in terms of being a viable therapeutic option for various disorders, starting with obesity, through neurological and neurodevelopmental disorders, to mental disorders such as schizophrenia. Emerging evidence suggests that it may be useful in treating these conditions. This article explores the possible role of KD in the treatment of those condition.

Methods: Extensive research was conducted using PubMed and Google Scholar. References from selected articles were included in the analysis.

References

Batch JT, Lamsal SP, Adkins M, Sultan S, Ramirez MN. Advantages and Disadvantages of the Ketogenic Diet: A Review Article. Cureus. 2020;12(8):e9639. doi:10.7759/cureus.9639

2. McGaugh E, Barthel B. A Review of Ketogenic Diet and Lifestyle. Mo Med. 2022;119(1):84-88.

3. van der Louw E, van den Hurk D, Neal E, et al. Ketogenic diet guidelines for infants with refractory epilepsy. Eur J Paediatr Neurol EJPN Off J Eur Paediatr Neurol Soc. 2016;20(6):798-809. doi:10.1016/j.ejpn.2016.07.009

4. Schwantje M, Verhagen LM, van Hasselt PM, Fuchs SA. Glucose transporter type 1 deficiency syndrome and the ketogenic diet. J Inherit Metab Dis. 2020;43(2):216-222. doi:10.1002/jimd.12175

5. Kolb H, Kempf K, Röhling M, Lenzen-Schulte M, Schloot NC, Martin S. Ketone bodies: from enemy to friend and guardian angel. BMC Med. 2021;19(1):313. doi:10.1186/s12916-021-02185-0

6. Newman JC, Verdin E. Ketone bodies as signaling metabolites. Trends Endocrinol Metab TEM. 2014;25(1):42-52. doi:10.1016/j.tem.2013.09.002

7. Dhillon KK, Gupta S. Biochemistry, Ketogenesis. In: StatPearls. StatPearls Publishing; 2024. Accessed January 5, 2025. http://www.ncbi.nlm.nih.gov/books/NBK493179/

8. Silva B, Mantha OL, Schor J, et al. Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation. Nat Metab. 2022;4(2):213-224. doi:10.1038/s42255-022-00528-6

9. Cox PJ, Kirk T, Ashmore T, et al. Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes. Cell Metab. 2016;24(2):256-268. doi:10.1016/j.cmet.2016.07.010

10. García-Rodríguez D, Giménez-Cassina A. Ketone Bodies in the Brain Beyond Fuel Metabolism: From Excitability to Gene Expression and Cell Signaling. Front Mol Neurosci. 2021;14:732120. doi:10.3389/fnmol.2021.732120

11. Cotter DG, Schugar RC, Crawford PA. Ketone body metabolism and cardiovascular disease. Am J Physiol Heart Circ Physiol. 2013;304(8):H1060-1076. doi:10.1152/ajpheart.00646.2012

12. Newman JC, Verdin E. β-Hydroxybutyrate: A Signaling Metabolite. Annu Rev Nutr. 2017;37:51-76. doi:10.1146/annurev-nutr-071816-064916

13. Jensen NJ, Wodschow HZ, Nilsson M, Rungby J. Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases. Int J Mol Sci. 2020;21(22):8767. doi:10.3390/ijms21228767

14. Kovács Z, D’Agostino DP, Diamond D, Kindy MS, Rogers C, Ari C. Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current Literature. Front Psychiatry. 2019;10:363. doi:10.3389/fpsyt.2019.00363

15. Altayyar M, Nasser JA, Thomopoulos D, Bruneau M. The Implication of Physiological Ketosis on The Cognitive Brain: A Narrative Review. Nutrients. 2022;14(3):513. doi:10.3390/nu14030513

16. Jensen NJ, Wodschow HZ, Nilsson M, Rungby J. Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases. Int J Mol Sci. 2020;21(22):8767. doi:10.3390/ijms21228767

17. Yudkoff M, Daikhin Y, Horyn O, Nissim I, Nissim I. Ketosis and brain handling of glutamate, glutamine, and GABA. Epilepsia. 2008;49(s8):73-75. doi:10.1111/j.1528-1167.2008.01841.x

18. Pietrzak D, Kasperek K, Rękawek P, Piątkowska-Chmiel I. The Therapeutic Role of Ketogenic Diet in Neurological Disorders. Nutrients. 2022;14(9):1952. doi:10.3390/nu14091952

19. García-Rodríguez D, Giménez-Cassina A. Ketone Bodies in the Brain Beyond Fuel Metabolism: From Excitability to Gene Expression and Cell Signaling. Front Mol Neurosci. 2021;14:732120. doi:10.3389/fnmol.2021.732120

20. Qiao YN, Li L, Hu SH, et al. Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy. Cell Discov. 2024;10(1):1-20. doi:10.1038/s41421-023-00636-x

21. Veech RL. The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fatty Acids. 2004;70(3):309-319. doi:10.1016/j.plefa.2003.09.007

22. Thijs RD, Surges R, O’Brien TJ, Sander JW. Epilepsy in adults. The Lancet. 2019;393(10172):689-701. doi:10.1016/S0140-6736(18)32596-0

23. Ułamek-Kozioł M, Czuczwar SJ, Januszewski S, Pluta R. Ketogenic Diet and Epilepsy. Nutrients. 2019;11(10):2510. doi:10.3390/nu11102510

24. Martin-McGill KJ, Bresnahan R, Levy RG, Cooper PN. Ketogenic diets for drug-resistant epilepsy. Cochrane Epilepsy Group, ed. Cochrane Database Syst Rev. 2020;2020(6). doi:10.1002/14651858.CD001903.pub5

25. Westover AN, Marangell LB. A cross-national relationship between sugar consumption and major depression? Depress Anxiety. 2002;16(3):118-120. doi:10.1002/da.10054

26. Jacobsen FM, Dreizzen A, Wehr TA. Diurnal mood variation and REM latency in depression. Biol Psychiatry. 1987;22(6):800-801. doi:10.1016/0006-3223(87)90220-4

27. Rahe C, Baune BT, Unrath M, et al. Associations between depression subtypes, depression severity and diet quality: cross-sectional findings from the BiDirect Study. BMC Psychiatry. 2015;15(1):38. doi:10.1186/s12888-015-0426-9

28. Murphy P, Likhodii S, Nylen K, Burnham WM. The antidepressant properties of the ketogenic diet. Biol Psychiatry. 2004;56(12):981-983. doi:10.1016/j.biopsych.2004.09.019

29. Sarnyai Z, Palmer CM. Ketogenic Therapy in Serious Mental Illness: Emerging Evidence. Int J Neuropsychopharmacol. 2020;23(7):434-439. doi:10.1093/ijnp/pyaa036

30. Li Q, Liang J, Fu N, Han Y, Qin J. A Ketogenic Diet and the Treatment of Autism Spectrum Disorder. Front Pediatr. 2021;9:650624. doi:10.3389/fped.2021.650624

31. El-Rashidy O, El-Baz F, El-Gendy Y, Khalaf R, Reda D, Saad K. Ketogenic diet versus gluten free casein free diet in autistic children: a case-control study. Metab Brain Dis. 2017;32(6):1935-1941. doi:10.1007/s11011-017-0088-z

32. Evangeliou A, Vlachonikolis I, Mihailidou H, et al. Application of a Ketogenic Diet in Children With Autistic Behavior: Pilot Study. J Child Neurol. 2003;18(2):113-118. doi:10.1177/08830738030180020501

33. Herbert MR, Buckley JA. Autism and Dietary Therapy: Case Report and Review of the Literature. J Child Neurol. 2013;28(8):975-982. doi:10.1177/0883073813488668

34. El Karkafi R, Gebara T, Salem M, et al. Ketogenic Diet and Inflammation: Implications for Mood and Anxiety Disorders. Adv Exp Med Biol. 2023;1411:537-554. doi:10.1007/978-981-19-7376-5_23

35. Kraeuter AK, Van Den Buuse M, Sarnyai Z. Ketogenic diet prevents impaired prepulse inhibition of startle in an acute NMDA receptor hypofunction model of schizophrenia. Schizophr Res. 2019;206:244-250. doi:10.1016/j.schres.2018.11.011

36. Sethi S, Wakeham D, Ketter T, et al. Ketogenic Diet Intervention on Metabolic and Psychiatric Health in Bipolar and Schizophrenia: A Pilot Trial. Psychiatry Res. 2024;335:115866. doi:10.1016/j.psychres.2024.115866

37. Danan A, Westman EC, Saslow LR, Ede G. The Ketogenic Diet for Refractory Mental Illness: A Retrospective Analysis of 31 Inpatients. Front Psychiatry. 2022;13:951376. doi:10.3389/fpsyt.2022.951376

38. Palmer CM. Ketogenic diet in the treatment of schizoaffective disorder: Two case studies. Schizophr Res. 2017;189:208-209. doi:10.1016/j.schres.2017.01.053

39. Maalouf M, Sullivan PG, Davis L, Kim DY, Rho JM. Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation. Neuroscience. 2007;145(1):256-264. doi:10.1016/j.neuroscience.2006.11.065

40. Neth BJ, Mintz A, Whitlow C, et al. Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer’s disease: a pilot study. Neurobiol Aging. 2020;86:54-63. doi:10.1016/j.neurobiolaging.2019.09.015

41. Soto-Mota A, Norwitz NG, Clarke K. Why a d -β-hydroxybutyrate monoester? Biochem Soc Trans. 2020;48(1):51-59. doi:10.1042/BST20190240

42. Fedorovich SV, Waseem TV. Metabolic regulation of synaptic activity. Rev Neurosci. 2018;29(8):825-835. doi:10.1515/revneuro-2017-0090

43. Chmiel I. Ketogenic diet in therapy of bipolar affective disorder - case report and literature review. Psychiatr Pol. 2022;56(6):1345-1363. doi:10.12740/PP/OnlineFirst/136356

44. Phillips MCL, Deprez LM, Mortimer GMN, et al. Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease. Alzheimers Res Ther. 2021;13(1):51. doi:10.1186/s13195-021-00783-x

45. Bostock ECS, Kirkby KC, Taylor BV, Hawrelak JA. Consumer Reports of “Keto Flu” Associated With the Ketogenic Diet. Front Nutr. 2020;7:20. doi:10.3389/fnut.2020.00020

46. Meng Y, Sun J, Zhang G. Take the bull by the horns and tackle the potential downsides of the ketogenic diet. Nutr Burbank Los Angel Cty Calif. 2024;125:112480. doi:10.1016/j.nut.2024.112480

47. Shilpa J, Mohan V. Ketogenic diets: Boon or bane? Indian J Med Res. 2018;148(3):251-253. doi:10.4103/ijmr.IJMR_1666_18

48. Paoli A, Mancin L, Bianco A, Thomas E, Mota JF, Piccini F. Ketogenic Diet and Microbiota: Friends or Enemies? Genes. 2019;10(7):534. doi:10.3390/genes10070534

49. Muscogiuri G, Barrea L, Laudisio D, et al. The management of very low-calorie ketogenic diet in obesity outpatient clinic: a practical guide. J Transl Med. 2019;17(1):356. doi:10.1186/s12967-019-2104-z

50. Choi JN, Song JE, Shin JI, Kim HD, Kim MJ, Lee JS. Renal Stone Associated with the Ketogenic Diet in a 5-Year Old Girl with Intractable Epilepsy. Yonsei Med J. 2010;51(3):457. doi:10.3349/ymj.2010.51.3.457

51. Ding J, Xu X, Wu X, et al. Bone loss and biomechanical reduction of appendicular and axial bones under ketogenic diet in rats. Exp Ther Med. Published online February 4, 2019. doi:10.3892/etm.2019.7241

52. Simm PJ, Bicknell-Royle J, Lawrie J, et al. The effect of the ketogenic diet on the developing skeleton. Epilepsy Res. 2017;136:62-66. doi:10.1016/j.eplepsyres.2017.07.014

53. Wu X, Ding J, Xu X, et al. Ketogenic diet compromises vertebral microstructure and biomechanical characteristics in mice. J Bone Miner Metab. 2019;37(6):957-966. doi:10.1007/s00774-019-01002-2

54. Kalra S, Mukherjee J, Venkataraman S, et al. Hypoglycemia: The neglected complication. Indian J Endocrinol Metab. 2013;17(5):819. doi:10.4103/2230-8210.117219

55. Kanikarla-Marie P, Jain SK. Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes. Free Radic Biol Med. 2016;95:268-277. doi:10.1016/j.freeradbiomed.2016.03.020

56. Bostock ECS, Kirkby KC, Taylor BVM. The Current Status of the Ketogenic Diet in Psychiatry. Front Psychiatry. 2017;8. doi:10.3389/fpsyt.2017.00043

57. Zupec‐Kania BA, Spellman E. An Overview of the Ketogenic Diet for Pediatric Epilepsy. Nutr Clin Pract. 2008;23(6):589-596. doi:10.1177/0884533608326138

58. Liao YJ, Wang YH, Wu CY, Hsu FY, Chien CY, Lee YC. Ketogenic Diet Enhances the Cholesterol Accumulation in Liver and Augments the Severity of CCl4 and TAA-Induced Liver Fibrosis in Mice. Int J Mol Sci. 2021;22(6):2934. doi:10.3390/ijms22062934

59. Xia H, Guo J, Shen J, Jiang S, Han S, Li L. Ketogenic Diet Exacerbates L-Arginine-Induced Acute Pancreatitis and Reveals the Therapeutic Potential of Butyrate. Nutrients. 2023;15(20):4427. doi:10.3390/nu15204427

60. Batch JT, Lamsal SP, Adkins M, Sultan S, Ramirez MN. Advantages and Disadvantages of the Ketogenic Diet: A Review Article. Cureus. 2020;12(8):e9639. doi:10.7759/cureus.9639

61. Borowicz-Reutt K, Krawczyk M, Czernia J. Ketogenic Diet in the Treatment of Epilepsy. Nutrients. 2024;16(9):1258. doi:10.3390/nu16091258

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Published

2025-02-14

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MIKOŁAJEC, Patryk, JOLANTA MĘDYK, MICHAŁ ROGULSKI , YAUHENIYA PATAROCHA, ALEKSANDRA ŚLUSARSKA , PAULINA BŁASIAK , MAŁGORZATA WIRKIJOWSKA , RUSLAN HUK  and BARBARA BILECKA . The Effects of the Ketogenic Diet on Disorders of Central Nervous System. Journal of Education, Health and Sport. Online. 14 February 2025. Vol. 78, p. 57586. [Accessed 1 July 2025]. DOI 10.12775/JEHS.2025.78.57586.
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Vol. 78 (2025)

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Copyright (c) 2025 Patryk Mikołajec, Jolanta Mędyk, Michał Rogulski , Yauheniya Patarocha, Aleksandra Ślusarska , Paulina Błasiak , Małgorzata Wirkijowska , Ruslan Huk , Barbara Bilecka 

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