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Journal of Education, Health and Sport

The Impact of Excessive Sugar Consumption on Skin Health Analysis of Biological Mechanisms and Dermatological Effects
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  4. Medical Sciences

The Impact of Excessive Sugar Consumption on Skin Health Analysis of Biological Mechanisms and Dermatological Effects

Authors

  • Natalia Dolata Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0009-0003-9564-9231
  • Bartosz Balcer Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0009-0003-2994-3918
  • Paweł Liszka Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0009-0003-5465-3656
  • Mateusz Pakuła Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0009-0001-1792-0378
  • Maja Weimann Internship at Copernicus Hospital, Nowe Ogrody 1/6 , 80-803, Gdansk, Poland https://orcid.org/0009-0004-1375-1337
  • Adrianna Kruczkowska Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0000-0003-0549-0849
  • Aleksandra Stosiek Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0009-0001-9276-3528
  • Agnieszka Cebula Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0009-0002-7966-6333
  • Emil Bulzacki Nicolaus Copernicus Memorial Hospital, Pabianicka 62, 93-513 Łódź, Poland https://orcid.org/0009-0009-4303-7114
  • Wojciech Urbański Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wrocław, Poland https://orcid.org/0009-0008-6559-7510

DOI:

https://doi.org/10.12775/JEHS.2024.76.56626

Keywords

skin health, protein glycation, skin aging, glucose and skin, healthy diet

Abstract

Introduction and purpose: 

Excessive sugar consumption is one of the main dietary problem of the modern Western diet. Numerous studies have shown that a high intake of simple sugars is associated with an increased risk of developing various diseases such as obesity, type 2 diabetes, metabolic syndrome, and cardiovascular diseases. Moreover, the consumption of large amounts of sugar also affects skin condition, accelerating its aging and exacerbating the course of certain dermatological conditions. This study aims to present the underlying mechanisms of these processes and demonstrate the impact of a low-glycemic index diet on skin health. 

Description of the state of knowledge: 

The skin is the largest organ of the body, and its condition is closely linked to diet. Excessive sugar consumption can contribute to biochemical changes such as skin protein glycation, increased production of reactive oxygen species (ROS), and inflammation. The glycation process leads to damage of collagen and elastin fibers, which reduces skin elasticity and contributes to the formation of wrinkles. Elevated levels of MMP-1/MMP-2 and LOX in the skin can affect collagen fragmentation and disrupt its structural integrity. Studies have also shown that a high-glycemic index diet can exacerbate inflammatory conditions such as acne and psoriasis and promote hormonal imbalances. 

Conclusion: 

In summary, excessive consumption of simple sugars significantly affects skin condition through mechanisms such as glycation, inflammation induction, and hormonal disturbances. Therefore, a low-glycemic index diet may be an effective tool in the prevention and treatment of skin diseases. Future studies should focus on gaining a more precise understanding of these relationships and developing dietary recommendations to improve skin health. 

References

Khan S, Waliullah S, Godfrey V, Khan MAW, Ramachandran RA, Cantarel BL, et al. Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice. Sci Trans Med (2020) 12(567):eaay6218. doi: 10.1126/scitranslmed.aay6218

Ma X, Nan F, Liang H, et al. Excessive intake of sugar: An accomplice of inflammation. Front Immunol. 2022;13:988481. Published 2022 Aug 31. doi:10.3389/fimmu.2022.988481

Malik VS, Hu FB. The role of sugar-sweetened beverages in the global epidemics of obesity and chronic diseases. Nat Rev Endocrinol. 2022;18(4):205-218. doi:10.1038/s41574-021-00627-6

Freeman CR, Zehra A, Ramirez V, Wiers CE, Volkow ND, Wang GJ. Impact of sugar on the body, brain, and behavior. Front Biosci (Landmark Ed). 2018;23(12):2255-2266. Published 2018 Jun 1. doi:10.2741/4704

Montonen J, Järvinen R, Knekt P, Heliövaara M, Reunanen A. Consumption of sweetened beverages and intakes of fructose and glucose predict type 2 diabetes occurrence. J Nutr. 2007;137(6):1447-1454. doi:10.1093/jn/137.6.1447

Yoshida Y, Simoes EJ. Sugar-Sweetened Beverage, Obesity, and Type 2 Diabetes in Children and Adolescents: Policies, Taxation, and Programs. Curr Diab Rep. 2018;18(6):31. Published 2018 Apr 18. doi:10.1007/s11892-018-1004-6

Rodríguez LA, Madsen KA, Cotterman C, Lustig RH. Added sugar intake and metabolic syndrome in US adolescents: cross-sectional analysis of the National Health and Nutrition Examination Survey 2005-2012. Public Health Nutr. 2016;19(13):2424-2434. doi:10.1017/S1368980016000057

Huang C, Liang Z, Ma J, Hu D, Yao F, Qin P. Total sugar, added sugar, fructose, and sucrose intake and all-cause, cardiovascular, and cancer mortality: A systematic review and dose-response meta-analysis of prospective cohort studies. Nutrition. 2023;111:112032. doi:10.1016/j.nut.2023.112032

Penso L, Touvier M, Deschasaux M, et al. Association Between Adult Acne and Dietary Behaviors: Findings From the NutriNet-Santé Prospective Cohort Study. JAMA Dermatol. 2020;156(8):854-862. doi:10.1001/jamadermatol.2020.1602

Kanda N, Hoashi T, Saeki H. Nutrition and Psoriasis. Int J Mol Sci. 2020;21(15):5405. Published 2020 Jul 29. doi:10.3390/ijms21155405

Pageon H. Reaction of glycation and human skin: the effects on the skin and its components, reconstructed skin as a model. Pathol Biol (Paris). 2010;58(3):226-231. doi:10.1016/j.patbio.2009.09.009

Boismal F, Serror K, Dobos G, Zuelgaray E, Bensussan A, Michel L. Vieillissement cutané - Physiopathologie et thérapies innovantes [Skin aging: Pathophysiology and innovative therapies]. Med Sci (Paris). 2020;36(12):1163-1172. doi:10.1051/medsci/2020232

Cosgrove MC, Franco OH, Granger SP, Murray PG, Mayes AE. Dietary nutrient intakes and skin-aging appearance among middle-aged American women [published correction appears in Am J Clin Nutr. 2008 Aug;88(2):480]. Am J Clin Nutr. 2007;86(4):1225-1231. doi:10.1093/ajcn/86.4.1225

Argyropoulos AJ, Robichaud P, Balimunkwe RM, Fisher GJ, Hammerberg C, Yan Y, Quan T. Alterations of Dermal Connective Tissue Collagen in Diabetes: Molecular Basis of Aged-Appearing Skin. PLoS One. 2016 Apr 22;11(4):e0153806. doi: 10.1371/journal.pone.0153806. PMID: 27104752; PMCID: PMC4841569.

Li WZ, Liu XX, Shi YJ, et al. Unveiling the mechanism of high sugar diet induced advanced glycosylation end products damage skin structure via extracellular matrix-receptor interaction pathway. J Cosmet Dermatol. 2024;23(7):2496-2508. doi:10.1111/jocd.16295

Nguyen HP, Katta R. Sugar Sag: Glycation and the Role of Diet in Aging Skin. Skin Therapy Lett. 2015;20(6):1-5.

Avery NC, Bailey AJ. The effects of the Maillard reaction on the physical properties and cell interactions of collagen. Pathol Biol (Paris). 2006;54(7):387-395. doi:10.1016/j.patbio.2006.07.005

Muir R, Forbes S, Birch DJS, Vyshemirsky V, Rolinski OJ. Collagen Glycation Detected by Its Intrinsic Fluorescence. J Phys Chem B. 2021;125(39):11058-11066. doi:10.1021/acs.jpcb.1c05001

Kamml J, Acevedo C, Kammer DS. Advanced-Glycation Endproducts: How cross-linking properties affect the collagen fibril behavior. J Mech Behav Biomed Mater. 2023;148:106198. doi:10.1016/j.jmbbm.2023.106198

Gill V, Kumar V, Singh K, Kumar A, Kim JJ. Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health. Biomolecules. 2019;9(12):888. Published 2019 Dec 17. doi:10.3390/biom9120888

Draelos ZD. INDIVIDUAL ARTICLE: Sugar Sag: What Is Skin Glycation and How Do You Combat It?. J Drugs Dermatol. 2024;23(4):SF378083s5-SF378083s10. doi:10.36849/JDD.SF378083

Katta R, Sanchez A, Tantry E. An Anti-Wrinkle Diet: Nutritional Strategies to Combat Oxidation, Inflammation and Glycation. Skin Therapy Lett. 2020;25(2):3-7.

Yang C, Weiss AS, Tarakanova A. Changes in elastin structure and extensibility induced by hypercalcemia and hyperglycemia. Acta Biomater. 2023;163:131-145. doi:10.1016/j.actbio.2022.03.041

Danby FW. Nutrition and aging skin: sugar and glycation. Clin Dermatol. 2010;28(4):409-411. doi:10.1016/j.clindermatol.2010.03.018

Haitoglou CS, Tsilibary EC, Brownlee M, Charonis AS. Altered cellular interactions between endothelial cells and nonenzymatically glucosylated laminin/type IV collagen. J Biol Chem. 1992;267(18):12404-12407.

DeGroot J, Verzijl N, Wenting-Van Wijk MJ, et al. Age-related decrease in susceptibility of human articular cartilage to matrix metalloproteinase-mediated degradation: the role of advanced glycation end products. Arthritis Rheum. 2001;44(11):2562-2571. doi:10.1002/1529-0131(200111)44:11<2562::aid-art437>3.0.co;2-1

Nowotny K, Grune T. Degradation of oxidized and glycoxidized collagen: role of collagen cross-linking. Arch Biochem Biophys. 2014;542:56-64. doi:10.1016/j.abb.2013.12.007

Umbayev B, Askarova S, Almabayeva A, Saliev T, Masoud AR, Bulanin D. Galactose-Induced Skin Aging: The Role of Oxidative Stress. Oxid Med Cell Longev. 2020;2020:7145656. Published 2020 Jun 17. doi:10.1155/2020/7145656

Vasiljević A, Bursać B, Djordjevic A, et al. Hepatic inflammation induced by high-fructose diet is associated with altered 11βHSD1 expression in the liver of Wistar rats. Eur J Nutr. 2014;53(6):1393-1402. doi:10.1007/s00394-013-0641-4

Bodur M, Unal RN. The effects of dietary high fructose and saturated fatty acids on chronic low grade inflammation in the perspective of chronic diseases. Cukurova Med J (2019) 44(2):685–94. doi: 10.17826/cumj.482623

Della Corte KW, Perrar I, Penczynski KJ, Schwingshackl L, Herder C, Buyken AE. Effect of Dietary Sugar Intake on Biomarkers of Subclinical Inflammation: A Systematic Review and Meta-Analysis of Intervention Studies. Nutrients. 2018;10(5):606. Published 2018 May 12. doi:10.3390/nu10050606

Aeberli I, Gerber PA, Hochuli M, et al. Low to moderate sugar-sweetened beverage consumption impairs glucose and lipid metabolism and promotes inflammation in healthy young men: a randomized controlled trial. Am J Clin Nutr. 2011;94(2):479-485. doi:10.3945/ajcn.111.013540

Sørensen LB, Raben A, Stender S, Astrup A. Effect of sucrose on inflammatory markers in overweight humans. Am J Clin Nutr. 2005;82(2):421-427. doi:10.1093/ajcn.82.2.421

Spruss A, Kanuri G, Wagnerberger S, Haub S, Bischoff SC, Bergheim I. Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. Hepatology. 2009;50(4):1094-1104. doi:10.1002/hep.23122

DiNicolantonio JJ, Mehta V, Onkaramurthy N, O'Keefe JH. Fructose-induced inflammation and increased cortisol: A new mechanism for how sugar induces visceral adiposity. Prog Cardiovasc Dis. 2018;61(1):3-9. doi:10.1016/j.pcad.2017.12.001

Shirley SN, Watson AE, Yusuf N. Pathogenesis of Inflammation in Skin Disease: From Molecular Mechanisms to Pathology. Int J Mol Sci. 2024;25(18):10152. Published 2024 Sep 21. doi:10.3390/ijms251810152

Conforti C, Agozzino M, Emendato G, et al. Acne and diet: a review. Int J Dermatol. 2022;61(8):930-934. doi:10.1111/ijd.15862

González-Mondragón EA, Ganoza-Granados LDC, Toledo-Bahena ME, et al. Acne and diet: a review of pathogenic mechanisms. Acné y dieta: una revisión de los mecanismos patogénicos. Bol Med Hosp Infant Mex. 2022;79(2):83-90. doi:10.24875/BMHIM.21000088

Penso L, Touvier M, Deschasaux M, et al. Association Between Adult Acne and Dietary Behaviors: Findings From the NutriNet-Santé Prospective Cohort Study. JAMA Dermatol. 2020;156(8):854-862. doi:10.1001/jamadermatol.2020.1602

Meixiong J, Ricco C, Vasavda C, Ho BK. Diet and acne: A systematic review. JAAD Int. 2022;7:95-112. Published 2022 Mar 29. doi:10.1016/j.jdin.2022.02.012

Ma X, Nan F, Liang H, et al. Excessive intake of sugar: An accomplice of inflammation. Front Immunol. 2022;13:988481. Published 2022 Aug 31. doi:10.3389/fimmu.2022.988481

Shi Z, Wu X, Santos Rocha C, et al. Short-Term Western Diet Intake Promotes IL-23‒Mediated Skin and Joint Inflammation Accompanied by Changes to the Gut Microbiota in Mice. J Invest Dermatol. 2021;141(7):1780-1791. doi:10.1016/j.jid.2020.11.032

Hu S, Anand P, Laughter M, Maymone MBC, Dellavalle RP. Holistic dermatology: An evidence-based review of modifiable lifestyle factor associations with dermatologic disorders. J Am Acad Dermatol. 2022;86(4):868-877. doi:10.1016/j.jaad.2020.04.108

Duchnik E, Kruk J, Tuchowska A, Marchlewicz M. The Impact of Diet and Physical Activity on Psoriasis: A Narrative Review of the Current Evidence. Nutrients. 2023;15(4):840. Published 2023 Feb 7. doi:10.3390/nu15040840

Paglia L. The sweet danger of added sugars. Eur J Paediatr Dent. 2019;20(2):89. doi:10.23804/ejpd.2019.20.02.01

Hewagalamulage SD, Lee TK, Clarke IJ, Henry BA. Stress, cortisol, and obesity: a role for cortisol responsiveness in identifying individuals prone to obesity. Domest Anim Endocrinol. 2016;56 Suppl:S112-S120. doi:10.1016/j.domaniend.2016.03.004

Pondeljak N, Lugović-Mihić L. Stress-induced Interaction of Skin Immune Cells, Hormones, and Neurotransmitters. Clin Ther. 2020;42(5):757-770. doi:10.1016/j.clinthera.2020.03.008

Evers AW, Verhoeven EW, Kraaimaat FW, et al. How stress gets under the skin: cortisol and stress reactivity in psoriasis. Br J Dermatol. 2010;163(5):986-991. doi:10.1111/j.1365-2133.2010.09984.x

Saalbach A. Association of Nutrition, Obesity and Skin. Nutrients. 2023;15(9):2028. Published 2023 Apr 23. doi:10.3390/nu15092028

Pinter A, Schwarz P, Gerdes S, et al. Biologic Treatment in Combination with Lifestyle Intervention in Moderate to Severe Plaque Psoriasis and Concomitant Metabolic Syndrome: Rationale and Methodology of the METABOLyx Randomized Controlled Clinical Trial. Nutrients. 2021;13(9):3015. Published 2021 Aug 29. doi:10.3390/nu13093015

Diotallevi F, Campanati A, Martina E, et al. The Role of Nutrition in Immune-Mediated, Inflammatory Skin Disease: A Narrative Review. Nutrients. 2022;14(3):591. Published 2022 Jan 29. doi:10.3390/nu14030591

Mintoff D, Agius R, Benhadou F, Das A, Frew JW, Pace NP. Obesity and hidradenitis suppurativa: targeting meta-inflammation for therapeutic gain. Clin Exp Dermatol. 2023;48(9):984-990. doi:10.1093/ced/llad182

Dempsey, A.; Butt, M.; Kirby, J.S. Prevalence and Impact of Dietary Avoidance among Individuals with Hidradenitis Suppurativa. Dermatology 2020, 236, 289–295.

Nasimi, M.; Shakoei, S.; Abedini, R.; Ghandi, N.; Faghihi, Z. A cross-sectional study of metabolic syndrome in patients with alope-cia areata. Indian J. Dermatol. Venereol. Leprol. 2021, 87, 427–429.

Sadgrove, Nicholas John. “The ‘bald’ phenotype (androgenetic alopecia) is caused by the high glycaemic, high cholesterol and low mineral ‘western diet’.” Trends in Food Science & Technology (2021) Volume 116, Pages 1170-1178, https://doi.org/10.1016/j.tifs.2021.06.056.

Shi X, Tuan H, Na X, et al. The Association between Sugar-Sweetened Beverages and Male Pattern Hair Loss in Young Men. Nutrients. 2023;15(1):214. Published 2023 Jan 1. doi:10.3390/nu15010214

Johnson RJ, Sánchez-Lozada LG, Andrews P, Lanaspa MA. Perspective: A Historical and Scientific Perspective of Sugar and Its Relation with Obesity and Diabetes. Adv Nutr. 2017;8(3):412-422. Published 2017 May 15. doi:10.3945/an.116.014654

Lyons TJ, Bailie KE, Dyer DG, Dunn JA, Baynes JW. Decrease in skin collagen glycation with improved glycemic control in patients with insulin-dependent diabetes mellitus. J Clin Invest. 1991;87(6):1910-1915. doi:10.1172/JCI115216

Thorpe SR, Baynes JW. Maillard reaction products in tissue proteins: new products and new perspectives. Amino Acids. 2003;25(3-4):275-281. doi:10.1007/s00726-003-0017-9

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Published

2024-12-18

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DOLATA, Natalia, BALCER, Bartosz, LISZKA, Paweł, PAKUŁA, Mateusz, WEIMANN, Maja, KRUCZKOWSKA, Adrianna, STOSIEK, Aleksandra, CEBULA, Agnieszka, BULZACKI, Emil and URBAŃSKI, Wojciech. The Impact of Excessive Sugar Consumption on Skin Health Analysis of Biological Mechanisms and Dermatological Effects. Journal of Education, Health and Sport. Online. 18 December 2024. Vol. 76, p. 56626. [Accessed 28 June 2025]. DOI 10.12775/JEHS.2024.76.56626.
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Vol. 76 (2024)

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Copyright (c) 2024 Natalia Dolata, Bartosz Balcer, Paweł Liszka, Mateusz Pakuła, Maja Weimann, Adrianna Kruczkowska, Aleksandra Stosiek, Agnieszka Cebula, Emil Bulzacki, Wojciech Urbański

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