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Journal of Education, Health and Sport

The effect of a complex of active metabolites of vitamin D3 with vikasol on the periodontal state of rats
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The effect of a complex of active metabolites of vitamin D3 with vikasol on the periodontal state of rats

Authors

  • A. V. Skiba State Establishment “The Institute of Stomatology and Maxillo-Facial Surgery National Academy of Medical Science of Ukraine”
  • N. N. Savelyeva Kharkiv National Medical University
  • S. A. Schnеider State Establishment “The Institute of Stomatology and Maxillo-Facial Surgery National Academy of Medical Science of Ukraine”
  • E. K. Tkachenko State Establishment “The Institute of Stomatology and Maxillo-Facial Surgery National Academy of Medical Science of Ukraine”

Keywords

cholecalciferol, active metabolites of vitamin D3, vikasol, model of periodontitis, rats

Abstract

Purpose of the study. The study of the periodontoprotective properties of the complex of a mixture of active metabolites of cholecalciferol - 1,25 (OH)2D3 and 24,25(OH)2D3 with a synthetic analogue of vitamin K - vikasol in experimental periodontitis in rats. Materials and methods The study was carried out on 18 white male rats for 1.5 months. age, divided into 3 groups. Group 1 (4 individuals) comprised intact rats. In the rats of the 2nd and 3rd groups (7 individuals each), the parodontitis model was reproduced by oral administration of a 10% solution of pelentane, and also by replacing drinking water with a 2% solution of EDTA ad libitum. In group 3, rats were injected daily with a mixture of hormonal forms of vitamin D3 (1,25 (OH)2D3 and 24,25(OH)2D3) against a background of combined effects of pelentane and EDTA. The duration of the experiment was 60 days. Results and conclusions. It is established that the complex of a mixture of two hormonal-active forms of cholecalciferol with vikasol has significant periodontoprotective properties. The obtained data substantiate the inclusion of vitamin D3 in the composition of perioodontoprotective agents in the treatment of periodontitis.

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Published

2018-06-29

How to Cite

1.
SKIBA, A. V., SAVELYEVA, N. N., Schnеider S. A. and TKACHENKO, E. K. The effect of a complex of active metabolites of vitamin D3 with vikasol on the periodontal state of rats. Journal of Education, Health and Sport. Online. 29 June 2018. Vol. 8, no. 6, pp. 336-342. [Accessed 2 July 2025].
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Issue

Vol. 8 No. 6 (2018)

Section

Research Articles

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The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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