Treatment options of human demodicosis
DOI:
https://doi.org/10.12775/JEHS.2024.76.56556Keywords
Demodex brevis, Demodex folliculorum, Demodex mite, human demodicosis treatmentAbstract
Background: Human demodicosis is a parasitic disease caused by two species of mites, Demodex folliculorum and Demodex brevis. Cutaneous and ocular demodicosis most often occurs in a situation of impaired immune response, where the attacked organism is weakened, has reduced immunity or metabolic disorders. The treatment of demodicosis can last up to several months and requires a lot of patience and regularity from the patient.
Objective: The aim of this paper is to review the therapeutic options used in the treatment of the ocular and cutaneous human demodicosis.
Materials and methods: This review was based on available data collected in the PubMed and Google Scholar databases, using the keywords: ‘Demodex brevis’, ‘Demodex folliculorum’, ‘Demodex mite’, ‘human demodicosis treatment’.
Conclusions: Treatment of demodicosis based on the use of a single medicament has the lowest efficiency and effectiveness. In contrast, a combination therapies, in which oral and local applied medication are taken together or several types of local medication are combined have the best effect.
References
Chioveanu, FG, Niculet, E, Torlac, C, Busila, C, & Tatu, AL (2024). Beyond the Surface: Understanding Demodex and Its Link to Blepharitis and Facial Dermatoses. Clinical Ophthalmology, 18, 1801–1810. https://doi.org/10.2147/OPTH.S440199
Chen, W, Plewig G (2014). Human demodicosis: revisit and a proposed classification. British Journal of Dermatology, 170: 1219-1225.
Wei, F, Li, L, Kong, Y, Yan, X, Varghese, KJ, Zhang, S, Jiang, J, Chai, B & Chen, H (2024). Evidence for the clinical association between demodex and rosacea: A review. Dermatology, 240(1), 95-102.
Sędzikowska, A (2014). Demodicosis – pathophysiology, treatment and therapeutic efficacy of metronidazole ointment and mercury oxide ointment. [Demodekoza – patofizjologia, leczenie oraz ocena skuteczności terapii z zastosowaniem maści z metronidazolem oraz maści z tlenkiem rtęci]. Opthatherapy, 1 (2): 108-113.
Raszeja-Kotelba, B, Jenerowicz, D, Izdebska, JN, Bowszyc-Dmochowska, M, Tomczak, M, Dembińska, M (2004). Some aspects of skin infection with Demodex mites. [Niektóre aspekty zakażenia skóry nużeńcem ludzkim]. Wiadomości Parazytologiczne. 50: 41-54.
Lotze, C, Krüger, WH, Kiefer, T, Swensson, O, Herbst, EW, Schüler, F (2006). Facial rash mimicking cutaneous acute graft -versus -host disease after allogeneic stem cell transplantation for osteomyelofibrosis – was Demodex the culprit? Bone Marrow Transplant. 37: 711–712.
Królik, S, Muth, A, Polańska, A, Żaba, R, Adamski, Z, Jenerowicz, D (2020). Demodicosis as a common problem in dermatology and ophthalmology. [Nużyca jako powszechny problem w dermatologii i okulistyce.] Journal of Face Aesthetics. 3 (2): 108-121.
Kazimierczak, A, Wcisło-Dziadecka, D, Grabarek, B, Jasik, K (2017). Demodicosis, or the true face of Demodex mites. [Demodekoza, czyli prawdziwe oblicze nużeńców.] Pol J Cosmetol. 20 (2): 133-137.
Czerwonka, W (2015). Demodex - a troublesome parasite. [Nużeniec - kłopotliwy pasożyt.] „Kosmetologia Estetyczna”, Rzeszów 2015; 4: 325-327.
Jarmuda, S. (2013). Evaluation of the role of Demodex folliculorum mites and Bacillus oleronius rods in the pathogenesis of rosacea. Doctoral dissertation. [Ocena udziału roztoczy Demodex folliculorum i laseczek Bacillus oleronius w patogenezie trądziku różowatego. Rozprawa doktorska.] Katedra i Klinika Dermatologii Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu. 2013.
Kilian-Pięta, E, Kikowska, M (2018). Demodicosis – characteristics and symptoms and care of infected skin with the use of almond acid. [Demodekoza – charakterystyka i objawy oraz pielęgnacja skóry zainfekowanej z zastosowaniem kwasu migdałowego.] Kosmetologia estetyczna, 6 (7): 679-683.
Marcinowska Z, Kosik-Bogacka D, Łanocha-Arendarczyk N, Czepita D, Łanocha A (2015). Demodex folliculorum and Demodex brevis. [Demodex folliculorum i Demodex brevis.] Pom J Life Sci., 61 (1): 108–114.
Yamashita, LS, Cariello, AJ, Geha, NM, Yu, MCZ, Hofling-Lima, AL (2011). Demodex folliculorum on the eyelash follicle of diabetic patients. Arq Bras Oftalmol 74(6), 422–424, doi: 10.1590/s0004-27492011000600008.
Forton, F, Germaux, MA, Brasseur, T, De Liever, A, Laporte, M, Mathys, C, Sass, U, Stene, JJ, Thibaut, S, Tytgat, M, Seys, B (2005). Demodicosis and rosacea: epidemiology and significance in daily dermatologic practice. J Am Acad Dermatol 2005, 52(1), 74–87, doi: 10.1016/j.jaad.2004.05.034.
Czepita, D; Kuźna-Grygiel, W; Czepita, M; Grobielny, A (2007). Demodex folliculorum and Demodex brevis as a cause of chronic marginal blepharitis. Roczniki Pomorskiej Akademii Medycznej w Szczecinie, 53(1), 63-67.
Lacey, N, Russell-Hallinan, A, Powell, FC (2016). Study of Demodex mites: challenges and solutions. J Eur Acad Dermatol Venereol, 30(5): 764-775.
Skonieczna, D, Sławianowska, P, Wesołowski, R, Szewczyk-Golec, K (2018). Demodex mites – characteristics, pathogenicity, diagnostics. [Roztocze z rodzaju Demodex – charakterystyka, chorobotwórczość, diagnostyka.] Diagn Lab. 54(1): 37-44.
Mrukwa-Kominek, E, Porwik, E, Drzyzga, Ł (2011). Meibomian gland dysfunction. Part II: clinical manifestations and treatment. [Dysfunkcja gruczołów Meiboma. Część II: objawy kliniczne i leczenie.] Mag. Okul, 6: 318-323.
Logger, JGM, Peppelman, M, van Erp, PEJ, de Jong, EMGJ, Nguyen, KP, Driessen, RJB (2022). Value of reflectance confocal microscopy for the monitoring of rosacea during treatment with topical ivermectin. J Dermatolog Treat. 33(1):195-203. doi: 10.1080/09546634.2020.1741501.
Gao, YY, Xu, DL, Huang, IJ, Wang, R, Tseng, SC (2012). Treatment of ocular itching associated with ocular demodicosis by 5% tea tree oil ointment. Cornea. 31(1): 14-17. doi: 10.1097/ICO.0b013e31820ce56c.
Salem, DA, El-Shazly, A, Nabih, N, El-Bayoumy, Y, Saleh, S (2013). Evaluation of the efficacy of oral ivermectin in comparison with ivermectin–metronidazole combined therapy in the treatment of ocular and skin lesions of Demodex folliculorum. Int J Infect Dis., 17: 343-347. doi: 10.1016/j.ijid.2012.11.022.
Krajewska, M, Wasyluk, J, Sędzikowska, A, Roman, B, Jaremko, E, Osęka, M (2013). Evaluation of Demoxoft Lipogel and Demoxoft Solution Efficacy and Safety in Patients with Demodex Blepharitis – Preliminary Results. [Ocena skuteczności i bezpieczeństwa preparatów Demoxoft Lipożel i Demoxoft stosowanych u chorych na nużeńcowe zapalenie brzegów powiek – wyniki wstępne]. KWARTALNIK MEDYCZNY OKULISTYKA – WYDANIE SPECJALNE., 9-11.
Anane, S, Mokni, M, Beltaief, O (2011). Rosacea-like demodicidosis and chronic blepharitis. Ann. Dermatol. Venereol. 138(1): 30-34.
Rodriguez, AE, Ferrer, C, Alió, JL (2005), Chronic blepharitis and Demodex. Arch. Soc. Esp. Oftalmol. 80(11): 635-642.
Raszeja-Kotelba, B, Pecold, K, Pecold-Stępniewska, H, Dadej, I (2004). Ocular rosacea – current etiopathogenetic, clinical and therapeutic data and description of three cases. [Oczny trądzik różowaty – aktualne dane etiopatogenetyczne, kliniczne i terapeutyczne oraz opis trzech przypadków.] Postępy Dermatologii i Alergologii XXI. 3: 144-150.
Sędzikowska, A, Osęka, M, Grytner-Zięcina, B, Roman, B, Jaremko, E (2014). Effect of Metronidazol, Mercury Oxide and Essentials Oils on the in vitro survivability of Demodex mites. [Wpływ preparatów zawierających metronidazol, tlenek rtęci i olejki eteryczne na przeżywalność nużeńców w warunkach in vitro.], Okulistyka (4) 64-66.
Persi, A, Rebora, A (1981). Metronidazole and Demodex folliculorum. Acta Derm. Venereol. 61(2): 182–183.
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