The impact of vitamin D supplementation on hypertension: a literature review
DOI:
https://doi.org/10.12775/JEHS.2024.75.56504Keywords
hypertension, vitamin D deficiencyAbstract
Introduction
Hypertension is one of the most common chronic diseases, and its prevalence continues to rise. Among the lesser-known factors contributing to the increased incidence of hypertension is vitamin D deficiency. Vitamin D, primarily known for its role in calcium and phosphate metabolism, has been implicated as one of the factors influencing cardiovascular function.
Aim of the study
The objective of this review is to analyze the current literature regarding the impact of vitamin D supplementation on blood pressure levels.
Materials and Methods
This review incorporates literature from the PubMed database, which was searched using the keywords "hypertension" and "vitamin D." Randomized controlled trials published between 2020 and 2024 were included.
Results
The literature review reveals various aspects of the relationship between vitamin D supplementation and blood pressure regulation. Hypertension remains one of the most prevalent chronic diseases, with its frequency consistently rising. Despite the development of new treatment methods, many patients still fail to achieve effective blood pressure control, posing a significant challenge to healthcare. Increasing evidence suggests that vitamin D may play a role in regulating blood pressure, which is particularly relevant given the widespread deficiency of this vitamin in global populations. Vitamin D deficiency is a common issue affecting a substantial portion of society, making the topic of supplementation and its potential effects even more urgent.
Conclusion
There is evidence to suggest potential benefits of vitamin D supplementation on blood pressure regulation, although the study results are inconclusive and do not yet support definitive clinical recommendations.
References
Arabi A, El Rassi R, El-Hajj Fuleihan G. Hypovitaminosis D in developing countries—prevalence, risk factors, and outcomes. Nat Rev Endocrinol. 2010 Oct;6(10):550-61. doi: 10.1038/nrendo.2010.146. PMID: 20852586. English.
Cakal S, Çakal B, Karaca O. Association of vitamin D deficiency with arterial stiffness in newly diagnosed hypertension. Blood Press Monit. 2021 Apr 1;26(2):113-117. doi: 10.1097/MBP.0000000000000497. PMID: 33234810. English.
Della Nera G, Sabatino L, Gaggini M,et al. Vitamin D Determinants, Status, and Antioxidant/Anti-inflammatory-Related Effects in Cardiovascular Risk and Disease: Not the Last Word in the Controversy. Antioxidants (Basel). 2023 Apr 18;12(4):948. doi: 10.3390/antiox12040948. PMID: 37107323; PMCID: PMC10135791. English.
Rostand SG. Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension. 1997 Aug;30(2 Pt 1):150-6. doi: 10.1161/01.hyp.30.2.150. PMID: 9260973. English.
Mills KT, Bundy JD, Kelly TN, et al. Global Disparities of Hypertension Prevalence and Control: A Systematic Analysis of Population-Based Studies From 90 Countries. Circulation. 2016 Aug 9;134(6):441-50. doi: 10.1161/CIRCULATIONAHA.115.018912. PMID: 27502908; PMCID: PMC4979614. English.
Noubiap JJ, Nansseu JR, Nyaga UF, et al. Global prevalence of resistant hypertension: a meta-analysis of data from 3.2 million patients. Heart. 2019 Jan;105(2):98-105. doi: 10.1136/heartjnl-2018-313599. Epub 2018 Aug 7. PMID: 30087099. English.
Papakonstantinou E, Zacharodimos N, Georgiopoulos G, et al. Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial. Nutrients. 2024 Apr 28;16(9):1331. doi: 10.3390/nu16091331. PMID: 38732578; PMCID: PMC11085203. English.
Theiler-Schwetz V, Trummer C, Grübler MR, et al Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial. Nutrients. 2022 Mar 24;14(7):1360. doi: 10.3390/nu14071360. PMID: 35405973; PMCID: PMC9003372. English.
Subramanian A, Korsiak J, Murphy KE, et al. Effect of vitamin D supplementation during pregnancy on mid-to-late gestational blood pressure in a randomized controlled trial in Bangladesh. J Hypertens. 2021 Jan;39(1):135-142. doi: 10.1097/HJH.0000000000002609. PMID: 32773651; PMCID: PMC7752208. English.
Zelzer S, Meinitzer A, Enko D, et al. Classification of Vitamin D Status Based on Vitamin D Metabolism: A Randomized Controlled Trial in Hypertensive Patients. Nutrients. 2024 Mar 14;16(6):839. doi: 10.3390/nu16060839. PMID: 38542750; PMCID: PMC10975656. English.
Sheikh V, Mozaianimonfared A, Gharakhani M, et al. Effect of vitamin D supplementation versus placebo on essential hypertension in patients with vitamin D deficiency: a double-blind randomized clinical trial. J Clin Hypertens (Greenwich). 2020 Oct;22(10):1867-1873. doi: 10.1111/jch.13926. Epub 2020 Sep 20. PMID: 32951301; PMCID: PMC8030057.
de Paula TP, Moreira JSR, Sperb LF, et al Efficacy of single-dose cholecalciferol in the blood pressure of patients with type 2 diabetes, hypertension, and hypovitaminoses D. Sci Rep. 2020 Nov 12;10(1):19611. doi: 10.1038/s41598-020-76646-6. PMID: 33184328; PMCID: PMC7665034. English.
Abderhalden LA, Meyer S, Dawson-Hughes B, et al Effect of daily 2000 IU versus 800 IU vitamin D on blood pressure among adults age 60 years and older: a randomized clinical trial. Am J Clin Nutr. 2020 Sep 1;112(3):527-537. doi: 10.1093/ajcn/nqaa145. PMID: 32542307.
Asemi Z, Samimi M, Tabassi Z, et al. Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women. J Nutr. 2013;143:1432–1438.
Asemi Z, Samimi M, Siavashani MA, et al. Calcium-vitamin D co-supplementation affects metabolic profiles, but not pregnancy outcomes, in healthy pregnant women. Int J Prev Med. 2016;7:49. English.
Zerofsky MS, Jacoby BN, Pedersen TL, et al. Daily cholecalciferol supplementation during pregnancy alters markers of regulatory immunity, inflammation, and clinical outcomes in a randomized controlled trial. J Nutr. 2016;146:2388–2397. English.
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