The effect of corvitin on the impaired indicators of the proteinase-inhibitory system in the kidneys under the conditions of the development of experimental pneumonia and adrenaline damage to the myocardium
DOI:
https://doi.org/10.12775/JEHS.2024.70.56502Keywords
experimental pneumonia, adrenaline damage to the myocardium, corvitin, proteinase-inhibitory systemAbstract
Ischemic heart disease and pneumonia are the most common diseases among cardiovascular and respiratory diseases, which are constantly increasing.
To date, the effect of corvitin on the indicators of the proteinase-inhibitory system in the kidneys in experimental pneumonia (EP) and adrenaline damage to the myocardium (APM) has not been studied. Therefore, it became the goal of our research.
The EP was reproduced according to the method of V.N. Shlyapnikov. by infecting animals with staphylococcus. APM was modeled by a single intravenous injection of an adrenaline solution.
The work established a gradual increase in the content of azoalbumin, azocasein and azocollagen against the background of a decrease in the level of alpha1-IP and alpha2-M in the kidneys in EP and APM, which prevailed on the 6th and 14th days of comorbid pathology compared to control.
The use of corvitin led to a corrective effect on the impaired indicators of the proteinase-inhibitory system in the kidneys in EP and APM.
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