Pathophysiology, Diagnosis and Treatment of Tinnitus - a literature review
DOI:
https://doi.org/10.12775/JEHS.2024.76.56491Keywords
Tinnitus, Hearing Loss, Hearing Aids, Cognitive Behavioral TherapyAbstract
Introduction and purpose
Primary tinnitus involves the perception of various types of sounds, usually without the presence of an external or internal stimulus (we then speak of primary tinnitus). Secondary tinnitus is rare, but should be ruled out at the beginning of the diagnostic process, as it can result from a serious disease. The issue of ear noise is a widespread problem in primary care. The purpose of our article was to summarize information on tinnitus, its risk factors, pathophysiology, diagnosis and treatment.
Materials and methods
To write this article, databases such as PubMed and Google Scholar were searched using the following terms: tinnitus, tinnitus treatment, tinnitus cognitive behavioral therapy.
Description of the state of knowledge
There are many mechanisms that can lead to tinnitus. Since they often coexist with hearing loss, tinnitus is thought to be a response to sensory deprivation. In diagnosis, it is very important to take a thorough medical history to distinguish primary from secondary tinnitus, which determines further management of the patient. Due to the truncated knowledge of the pathophysiology of tinnitus, there are no clear guidelines for the treatment of tinnitus. There are various therapeutic options available, such as cognitive-behavioral therapy, sound therapy, somatosensory therapy, neuromodulation and hypnosis. They improve patients' quality of life, however, reliable data confirming reductions in tinnitus intensity is often lacking.
Conclusions
Tinnitus is a commonly encountered condition. Although significant research has been conducted, our understanding, particularly of its pathophysiology, remains incomplete. This makes it difficult to develop effective treatment.
References
Dalrymple SN, Lewis SH, Philman S. Tinnitus: Diagnosis and Management. Am Fam Physician. 2021 Jun 1;103(11):663-671. PMID: 34060792.
Mazurek B, Hesse G, Dobel C, Kratzsch V, Lahmann C, Sattel H. Chronic Tinnitus. Dtsch Arztebl Int. 2022 Apr 1;119(13):219–225. doi: 10.3238/arztebl.m2022.0135. PMID: 35197187; PMCID: PMC9342131.
Biswas R, Genitsaridi E, Trpchevska N, et al. Low evidence for tinnitus risk factors: a systematic review and meta-analysis. J Assoc Res Otolaryngol. 2023 Feb;24(1):81-94. doi: 10.1007/s10162-022-00874-y. Epub 2022 Nov 15. PMID: 36380120; PMCID: PMC9971395.
Al-Lahham S, Nazzal Z, Massarweh A, et al. Prevalence and associated risk factors of tinnitus among adult Palestinians: a cross-sectional study. Sci Rep. 2022 Nov 30;12(1):20617. doi: 10.1038/s41598-022-24015-w. PMID: 36450754 PMCID: PMC9712604.
Boniver V. Tinnitus. Rev Med Liege. 2023 May;78(5-6):285-288. French. PMID: 37350203.
Baguley D, McFerran D, Hall D. Tinnitus. Lancet. 2013 Nov 9;382(9904):1600-7. doi: 10.1016/S0140-6736(13)60142-7. Epub 2013 Jul 2. PMID: 23827090.
Kleinjung T, Langguth B. Avenue for Future Tinnitus Treatments. Otolaryngol Clin North Am. 2020 Aug;53(4):667-683. doi: 10.1016/j.otc.2020.03.013. Epub 2020 May 4. PMID: 32381341.
Kleinjung T, Peter N, Schecklmann M, Langguth B. The Current State of Tinnitus Diagnosis and Treatment: a Multidisciplinary Expert Perspective. J Assoc Res Otolaryngol. 2024 Oct;25(5):413-425. doi: 10.1007/s10162-024-00960-3. Epub 2024 Aug 13. PMID: 39138756; PMCID: PMC11528090.
Langguth B, Kreuzer PM, Kleinjung T, De Ridder D. Tinnitus: causes and clinical management. Lancet Neurol. 2013 Sep;12(9):920-930. doi: 10.1016/S1474-4422(13)70160-1. PMID: 23948178.
Tunkel DE, Bauer CA, Sun GH, et al. Clinical practice guideline: tinnitus. Otolaryngol Head Neck Surg. 2014 Oct;151(2 Suppl):S1-S40. doi: 10.1177/0194599814545325. PMID: 25273878.
Wu V, Cooke B, Eitutis S, Simpson MTW, Beyea JA. Approach to tinnitus management. Can Fam Physician. 2018 Jul;64(7):491-495. PMID: 30002023; PMCID: PMC6042678.
Lockwood AH. Tinnitus. Neurol Clin. 2005 Aug;23(3):893-900. doi: 10.1016/j.ncl.2005.01.007. PMID: 16026681.
Esmaili AA, Renton J. A review of tinnitus. Aust J Gen Pract. 2018 Apr;47(4):205-208. doi: 10.31128/AJGP-12-17-4420. PMID: 29621860.
Cunnane MB. Imaging of Tinnitus. Neuroimaging Clin N Am. 2019 Feb;29(1):49-56. doi: 10.1016/j.nic.2018.09.006. Epub 2018 Oct 31. PMID: 30466644.
Adams ME, Huang TC, Nagarajan S, Cheung SW. Tinnitus Neuroimaging.Otolaryngol Clin North Am. 2020 Aug;53(4):583-603. doi: 10.1016/j.otc.2020.04.002. Epub 2020 May 26. PMID: 32471605.
Han BI, Lee HW, Ryu S, Kim JS. Tinnitus Update. J Clin Neurol. 2021 Jan;17(1):1-10. doi: 10.3988/jcn.2021.17.1.1. PMID: 33480192; PMCID: PMC7840320.
Lockwood AH, Salvi RJ, Burkard RF. Tinnitus. N Engl J Med. 2002 Sep 19;347(12):904-10. doi: 10.1056/NEJMra013395. PMID: 12239260.
Kleinjung T, Langguth B. Pharmacotherapy of Tinnitus. Curr Top Behav Neurosci. 2021;51:193-212. doi: 10.1007/7854_2020_169. PMID: 32761509.
Tang D, Li H, Chen L. Advances in Understanding, Diagnosis, and Treatment of Tinnitus. Adv Exp Med Biol. 2019:1130:109-128. doi: 10.1007/978-981-13-6123-4_7. PMID: 30915704.
Woods JW, Theodoroff SM. Cognitive Behavioral Therapy for Tinnitus. Audiol Today. 2019 Nov-Dec;31(6):22-28. Epub 2019 Oct 28.PMID: 36249161; PMCID: PMC9565874.
Fuller T, Cima R, Langguth B, Mazurek B, Vlaeyen JW, Hoare DJ. Cognitive behavioural therapy for tinnitus. Cochrane Database Syst Rev. 2020 Jan 8;1(1):CD012614. doi: 10.1002/14651858.CD012614.pub2. PMID: 31912887; PMCID: PMC6956618.
Han BI, Lee HW, Kim TY, Lim JS, Shin KS. Tinnitus: characteristics, causes, mechanisms, and treatments. J Clin Neurol. 2009 Mar;5(1):11-9. doi: 10.3988/jcn.2009.5.1.11. Epub 2009 Mar 31. PMID: 19513328; PMCID: PMC2686891.
Langguth B. Treatment of tinnitus. Curr Opin Otolaryngol Head Neck Surg. 2015 Oct;23(5):361-8. doi: 10.1097/MOO.0000000000000185. PMID: 26261868.
McFerran DJ, Phillips JS. Tinnitus. J Laryngol Otol. 2007 Mar;121(3):201-8. doi: 10.1017/S0022215106002714. Epub 2006 Sep 25. PMID: 16995967.
Yu HZ, Gong JM, Hong GW, et al. The Effect of Physical Therapy on Somatosensory Tinnitus. J Clin Med. 2024 Jun 14;13(12):3496. doi: 10.3390/jcm13123496. PMID: 38930025; PMCID: PMC11204550.
Michiels S. Somatosensory Tinnitus: Recent Developments in Diagnosis and Treatment. J Assoc Res Otolaryngol. 2023 Oct;24(5):465-472. doi: 10.1007/s10162-023-00912-3. Epub 2023 Oct 4. PMID: 37794291; PMCID: PMC10695899.
Luetzenberg FS, Babu S, Seidman MD. Alternative Treatments of Tinnitus: Alternative Medicine. Otolaryngol Clin North Am. 2020 Aug;53(4):637-650. doi: 10.1016/j.otc.2020.03.011. Epub 2020 Apr 30. PMID: 32362562.
Suvorkina A, Suvorkin O. Hypnotic suggestion for the treatment of tinnitus. Qual Sport. 2023 Feb 5;9(1):83-7. doi: 10.12775/QS.2023.09.01.011.
Langguth B. Non-Invasive Neuromodulation for Tinnitus. J Audiol Otol. 2020 Jul;24(3):113-118. doi: 10.7874/jao.2020.00052. Epub 2020 Jun 25. PMID: 32575951; PMCID: PMC7364190.
Peter N, Kleinjung T. Neuromodulation for tinnitus treatment: an overview of invasive and non-invasive techniques. J Zhejiang Univ Sci B. 2019;20(2):116-130. doi: 10.1631/jzus.B1700117. Epub 2018 Mar 12. PMID: 29770647; PMCID: PMC6380997.
Soleymani T, Pieton D, Pezeshkian P, et al. Surgical approaches to tinnitus treatment: A review and novel approaches. Surg Neurol Int. 2011:2:154. doi: 10.4103/2152-7806.86834. Epub 2011 Oct 29. PMID: 22140639; PMCID: PMC3228384.
Eisenman DJ, Teplitzky TB. Surgical Treatment of Tinnitus. Neuroimaging Clin N Am. 2016 May;26(2):279-88. doi: 10.1016/j.nic.2015.12.010. Epub 2016 Mar 10. PMID: 27154609.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Martyna Piekarska, Katarzyna Dąbek, Michał Ochwat, Maria Sudoł, Gabriela Mierzwa, Aleksandra Kajtel, Anna Skowronek
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 309
Number of citations: 0