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Journal of Education, Health and Sport

The ketogenic diet as a potential therapeutic approach for migraine management: a review of current evidence
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The ketogenic diet as a potential therapeutic approach for migraine management: a review of current evidence

Authors

  • Larysa Bielecka Stefan Żeromski Specialist Hospital in Kraków https://orcid.org/0009-0000-6352-8564

DOI:

https://doi.org/10.12775/JEHS.2024.76.56442

Keywords

migraine, ketogenic diet

Abstract

Introduction

Migraine, a common neurological disorder, significantly reduces quality of life, particularly among women. Despite advancements in treatment, therapeutic options remain limited, and side effects are common. The ketogenic diet (KD), characterized by low carbohydrate and high fat intake, has shown promise in reducing migraine frequency and severity.

Aim of the study

The aim of this study is to review the literature on the effectiveness of of the ketogenic diet on the frequency of migraine attacks and their severity.

Materials

This review analyzed two studies by Di Lorenzo et al. (2018) and Caprio et al. (2023), both demonstrating that KD significantly reduced migraine days compared to non-ketogenic diets. Additional benefits included reduced inflammatory markers and improved body weight.

Results

While findings are promising, limitations such as small sample sizes, focus on overweight individuals, and lack of long-term safety data highlight the need for larger studies.

Conclusions

KD offers potential as an effective alternative for managing migraines, but further research is required to confirm its benefits and safety.

 

References

Stovner LJ, Hagen K. Prevalence, burden, and cost of headache disorders. Curr Opin Neurol. 2006; 19(3):281-5. doi: 10.1097/01.wco.0000227039.16071.92. PMID: 16702836.

Stovner LJ, Hoff JM, Svalheim S, et al. Neurological disorders in the Global Burden of Disease 2010 study. Acta Neurol Scand Suppl. 2014;(198):1-6. doi: 10.1111/ane.12229. PMID: 24588499.

Colombo B, Saraceno L, Comi G. Riboflavin and migraine: the bridge over troubled mitochondria. Neurol Sci. 2014;35 Suppl 1:141-4. doi: 10.1007/s10072-014-1755-z. PMID: 24867851.

Bigal ME, Lipton RB. Modifiable risk factors for migraine progression. Headache. 2006; 46(9):1334-43. doi: 10.1111/j.1526-4610.2006.00577.x. PMID: 17040331.

Sprenger T, Goadsby PJ. Migraine pathogenesis and state of pharmacological treatment options. BMC Med. 2009 Nov 16;7:71. doi: 10.1186/1741-7015-7-71. PMID: 19917094; PMCID: PMC2784479.

Bailey EE, Pfeifer HH, Thiele EA. The use of diet in the treatment of epilepsy. Epilepsy Behav. 2005; 6(1):4-8. doi: 10.1016/j.yebeh.2004.10.006. PMID: 15652725.

https://pl.wikipedia.org/wiki/Dieta_niskowęglowodanowa [access 21.11.2024]

Strahlman RS. Can ketosis help migraine sufferers? A case report. Headache. 2006; 46(1):182. doi: 10.1111/j.1526-4610.2006.00321_5.x. PMID: 16412174.

Maggioni F, Margoni M, Zanchin G. Ketogenic diet in migraine treatment: a brief but ancient history. Cephalalgia. 2011; 31(10):1150-1. doi: 10.1177/0333102411412089. Epub 2011 Jul 4. PMID: 21727144.

Di Lorenzo C, Coppola G, Sirianni G, et al. Migraine improvement during short lasting ketogenesis: a proof-of-concept study. Eur J Neurol. 2015; 22(1):170-7. doi: 10.1111/ene.12550. Epub 2014 Aug 25. PMID: 25156013.

Di Lorenzo C, Pinto A, Ienca R, et al A Randomized Double-Blind, Cross-Over Trial of very Low-Calorie Diet in Overweight Migraine Patients: A Possible Role for Ketones? Nutrients. 2019; 11(8):1742. doi: 10.3390/nu11081742. PMID: 31357685; PMCID: PMC6722531.

Caprio M, Moriconi E, Camajani E, et al. Very-low-calorie ketogenic diet vs hypocaloric balanced diet in the prevention of high-frequency episodic migraine: the EMIKETO randomized, controlled trial. J Transl Med. 2023;21(1):692. doi: 10.1186/s12967-023-04561-1. PMID: 37794395; PMCID: PMC10548576.

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Published

2024-12-15

How to Cite

1.
BIELECKA, Larysa. The ketogenic diet as a potential therapeutic approach for migraine management: a review of current evidence. Journal of Education, Health and Sport. Online. 15 December 2024. Vol. 76, p. 56442. [Accessed 15 May 2025]. DOI 10.12775/JEHS.2024.76.56442.
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Issue

Vol. 76 (2024)

Section

Medical Sciences

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Copyright (c) 2024 Larysa Bielecka

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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