The Role of Dietary Supplementation in the Prevention of Macular Degeneration: An Analysis of the Efficacy of Vitamins and Antioxidants in Inhibiting the Progression of Macular Degeneration
DOI:
https://doi.org/10.12775/JEHS.2024.76.56412Keywords
AMD, Vitamins, antioxidants, diet supplementation, inhibition of progression, lutein, zeaxanthinAbstract
Age-related macular degeneration (AMD), one of the leading causes of vision loss among the elderly, poses a significant global health issue. This is a retinal condition that causes the loss of central vision. The demographic shift towards an aging population contributes to the increasing number of individuals affected by this condition, presenting a challenge to the medical and scientific community in developing effective prevention and treatment methods. In recent years, considerable attention has been given to the role of a proper diet and the supplementation of vitamins and antioxidants in inhibiting the progression of AMD.
References
Deng Y, Qiao L, Du M, Qu C, Wan L, Li J, Huang L. Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy. Genes Dis. 2021 Feb 27;9(1):62-79. doi: 10.1016/j.gendis.2021.02.009. PMID: 35005108; PMCID: PMC8720701.
AREDS2 Research Group; Chew EY, Clemons T, SanGiovanni JP, Danis R, Domalpally A, McBee W, Sperduto R, Ferris FL. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). Ophthalmology. 2012 Nov;119(11):2282-9. doi: 10.1016/j.ophtha.2012.05.027. Epub 2012 Jul 26. PMID: 22840421; PMCID: PMC3485447.
Khandhadia S, Cipriani V, Yates JR, Lotery AJ. Age-related macular degeneration and the complement system. Immunobiology. 2012 Feb;217(2):127-46. doi: 10.1016/j.imbio.2011.07.019. Epub 2011 Jul 23. PMID: 21868123.
Huang P, Wang F, Sah BK, Jiang J, Ni Z, Wang J, Sun X. Homocysteine and the risk of age-related macular degeneration: a systematic review and meta-analysis. Sci Rep. 2015 Jul 21;5:10585. doi: 10.1038/srep10585. PMID: 26194346; PMCID: PMC4508850.
Booij JC, Baas DC, Beisekeeva J, Gorgels TG, Bergen AA. The dynamic nature of Bruch's membrane. Prog Retin Eye Res. 2010 Jan;29(1):1-18. doi: 10.1016/j.preteyeres.2009.08.003. Epub 2009 Sep 10. PMID: 19747980.
Flores R, Carneiro Â, Vieira M, Tenreiro S, Seabra MC. Age-Related Macular Degeneration: Pathophysiology, Management, and Future Perspectives. Ophthalmologica. 2021;244(6):495-511. doi: 10.1159/000517520. Epub 2021 Jun 15. PMID: 34130290.
Huang P, Wang F, Sah BK, Jiang J, Ni Z, Wang J, Sun X. Homocysteine and the risk of age-related macular degeneration: a systematic review and meta-analysis. Sci Rep. 2015 Jul 21;5:10585. doi: 10.1038/srep10585. PMID: 26194346; PMCID: PMC4508850.
Pinna A, Zaccheddu F, Boscia F, Carru C, Solinas G. Homocysteine and risk of age-related macular degeneration: a systematic review and meta-analysis. Acta Ophthalmol. 2018 May;96(3):e269-e276. doi: 10.1111/aos.13343. Epub 2016 Dec 14. PMID: 27966830.
Christen WG, Chasman DI, Cook NR, Chiuve SE, Ridker PM, Buring JE. Homocysteine, B Vitamins, MTHFR Genotype, and Incident Age-related Macular Degeneration. Ophthalmol Retina. 2018 May;2(5):508-510. doi: 10.1016/j.oret.2017.10.001. PMID: 29963648; PMCID: PMC6022858.
Merle BM, Silver RE, Rosner B, Seddon JM. Dietary folate, B vitamins, genetic susceptibility and progression to advanced nonexudative age-related macular degeneration with geographic atrophy: a prospective cohort study. Am J Clin Nutr. 2016 Apr;103(4):1135-44. doi: 10.3945/ajcn.115.117606. PMID: 26961928; PMCID: PMC4807698.
Goldberg J, Flowerdew G, Smith E, Brody JA, Tso MO. Factors associated with age-related macular degeneration. An analysis of data from the first National Health and Nutrition Examination Survey. Am J Epidemiol. 1988 Oct;128(4):700-10. doi: 10.1093/oxfordjournals.aje.a115023. PMID: 3421236.
Seddon JM, Ajani UA, Sperduto RD, Hiller R, Blair N, Burton TC, Farber MD, Gragoudas ES, Haller J, Miller DT, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA. 1994 Nov 9;272(18):1413-20. Erratum in: JAMA 1995 Feb 22;273(8):622. PMID: 7933422.
Broadhead GK, Grigg JR, Chang AA, McCluskey P. Dietary modification and supplementation for the treatment of age-related macular degeneration. Nutr Rev. 2015 Jul;73(7):448-62. doi: 10.1093/nutrit/nuv005. Epub 2015 Apr 28. PMID: 26081455.
Dziedziak J, Kasarełło K, Cudnoch-Jędrzejewska A. Dietary Antioxidants in Age-Related Macular Degeneration and Glaucoma. Antioxidants (Basel). 2021 Oct 30;10(11):1743. doi: 10.3390/antiox10111743. PMID: 34829613; PMCID: PMC8614766.
Christen WG, Cook NR, Manson JE, Buring JE, Chasman DI, Lee IM, Bubes V, Li C, Haubourg M, Schaumberg DA; VITAL Research Group. Effect of Vitamin D and ω-3 Fatty Acid Supplementation on Risk of Age-Related Macular Degeneration: An Ancillary Study of the VITAL Randomized Clinical Trial. JAMA Ophthalmol. 2020 Dec 1;138(12):1280-1289. doi: 10.1001/jamaophthalmol.2020.4409. PMID: 33119047; PMCID: PMC7596682.
Ezzati TM, Massey JT, Waksberg J, Chu A, Maurer KR. Sample design: Third National Health and Nutrition Examination Survey. Vital Health Stat 2. 1992 Sep;(113):1-35. PMID: 1413563.
Parekh N, Chappell RJ, Millen AE, Albert DM, Mares JA. Association between vitamin D and age-related macular degeneration in the Third National Health and Nutrition Examination Survey, 1988 through 1994. Arch Ophthalmol. 2007 May;125(5):661-9. doi: 10.1001/archopht.125.5.661. PMID: 17502506.
Widomska J, Subczynski WK. Why has Nature Chosen Lutein and Zeaxanthin to Protect the Retina? J Clin Exp Ophthalmol. 2014 Feb 21;5(1):326. doi: 10.4172/2155-9570.1000326. PMID: 24883226; PMCID: PMC4038937.
Ma L, Dou HL, Wu YQ, Huang YM, Huang YB, Xu XR, Zou ZY, Lin XM. Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. Br J Nutr. 2012 Feb;107(3):350-9. doi: 10.1017/S0007114511004260. Epub 2011 Sep 8. PMID: 21899805.
Wu J, Cho E, Willett WC, Sastry SM, Schaumberg DA. Intakes of Lutein, Zeaxanthin, and Other Carotenoids and Age-Related Macular Degeneration During 2 Decades of Prospective Follow-up. JAMA Ophthalmol. 2015 Dec;133(12):1415-24. doi: 10.1001/jamaophthalmol.2015.3590. PMID: 26447482; PMCID: PMC5119484.
Prasad AS. Clinical, immunological, anti-inflammatory and antioxidant roles of zinc. Exp Gerontol. 2008 May;43(5):370-7. doi: 10.1016/j.exger.2007.10.013. Epub 2007 Nov 1. PMID: 18054190.
Jarosz M, Olbert M, Wyszogrodzka G, Młyniec K, Librowski T. Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling. Inflammopharmacology. 2017 Feb;25(1):11-24. doi: 10.1007/s10787-017-0309-4. Epub 2017 Jan 12. PMID: 28083748; PMCID: PMC5306179.
Ha KN, Chen Y, Cai J, Sternberg P Jr. Increased glutathione synthesis through an ARE-Nrf2-dependent pathway by zinc in the RPE: implication for protection against oxidative stress. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2709-15. doi: 10.1167/iovs.05-1322. PMID: 16723490.
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Copyright (c) 2024 Sebastian Mrugała, Waldemar Mrugała, Jakub Kawka, Alicja Baranowska, Katarzyna Baranowska, Filip Czyżewski, Kinga Filipek, Michał Muciek, Bartosz Skierkowski, Natalia Zalewska
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