The effectiveness of music therapy for the treatment of Alzheimer's disease
DOI:
https://doi.org/10.12775/JEHS.2024.76.56407Keywords
Alzheimer’s disease, Music Therapy, Non-pharmacological treatment, New TherapyAbstract
Introduction: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most prevalent cause of dementia. It is caused by the degeneration of brain cells due to the accumulation of intracellular hyperphosphorylated tau - containing neurofibrillary tangles and extracellular plaques of amyloid-beta peptide. While pharmacotherapy remains the main form of treatment (including cholinesterase inhibitors and antagonists to NMDA), various non-pharmacological therapy modalities have gained increasing attention as complementary treatment options, such as music therapy.
Purpose of the study: This review examines the role of music therapy as an important complement to baseline therapy for AD patients, focusing on indications, methods, and the prospect of music therapy.
Materials and methods: A comprehensive literature review was conducted, analyzing 48 studies from the PubMed database (English-language, up to November 2024) that assess the efficacy, methods, and prospect of music therapy as an adjunctive therapy in Alzheimer’s disease.
Conclusions: Music therapy is an established and effective supportive treatment for AD patients. It has demonstrated clinical success over many years as a tool for engaging multiple motor and sensory areas, shaping emotions, and evoking memories. This may be due to activating limbic and paralimbic structures, enhancing neuroplasticity, and modulating neurotransmitter systems. Despite the observable benefits of music therapy, the methodological limitations of existing studies highlight the need for further long-term research to standardize treatment approaches.
References
Breijyeh, Z., & Karaman, R. (2020). Comprehensive Review on Alzheimer’s Disease: Causes and Treatment. Molecules, 25(24), 5789. https://doi.org/10.3390/molecules25245789
Twarowski, B., & Herbet, M. (2023). Inflammatory Processes in Alzheimer’s Disease—Pathomechanism, Diagnosis and Treatment: A Review. International Journal of Molecular Sciences, 24(7), 6518. https://doi.org/10.3390/ijms24076518
Zhang, X. X., Tian, Y., Wang, Z. T., Ma, Y. H., Tan, L., & Yu, J. T. (2021). The Epidemiology of Alzheimer's Disease Modifiable Risk Factors and Prevention. The journal of prevention of Alzheimer's disease, 8(3), 313–321. https://doi.org/10.14283/jpad.2021.15
Khan, S., Barve, K. H., & Kumar, M. S. (2020). Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease. Current neuropharmacology, 18(11), 1106–1125. https://doi.org/10.2174/1570159X18666200528142429
Knopman, D. S., Amieva, H., Petersen, R. C., Chételat, G., Holtzman, D. M., Hyman, B. T., Nixon, R. A., & Jones, D. T. (2021). Alzheimer disease. Nature reviews. Disease primers, 7(1), 33. https://doi.org/10.1038/s41572-021-00269-y
Jack, C. R., Jr, Andrews, J. S., Beach, T. G., Buracchio, T., Dunn, B., Graf, A., Hansson, O., Ho, C., Jagust, W., McDade, E., Molinuevo, J. L., Okonkwo, O. C., Pani, L., Rafii, M. S., Scheltens, P., Siemers, E., Snyder, H. M., Sperling, R., Teunissen, C. E., & Carrillo, M. C. (2024). Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup. Alzheimer's & dementia : the journal of the Alzheimer's Association, 20(8), 5143–5169. https://doi.org/10.1002/alz.13859
Bleibel, M., El Cheikh, A., Sadier, N. S., & Abou-Abbas, L. (2023). The effect of music therapy on cognitive functions in patients with Alzheimer's disease: a systematic review of randomized controlled trials. Alzheimer's research & therapy, 15(1), 65. https://doi.org/10.1186/s13195-023-01214-9
Tang, Q., Huang, Z., Zhou, H., & Ye, P. (2020). Effects of music therapy on depression: A meta-analysis of randomized controlled trials. PloS one, 15(11), e0240862. https://doi.org/10.1371/journal.pone.0240862
Matziorinis, A. M., & Koelsch, S. (2022). The promise of music therapy for Alzheimer's disease: A review. Annals of the New York Academy of Sciences, 1516(1), 11–17. https://doi.org/10.1111/nyas.14864
Altenmüller, E., & Schlaug, G. (2015). Apollo's gift: new aspects of neurologic music therapy. Progress in brain research, 217, 237–252. https://doi.org/10.1016/bs.pbr.2014.11.029
Koelsch S. (2014). Brain correlates of music-evoked emotions. Nature reviews. Neuroscience, 15(3), 170–180. https://doi.org/10.1038/nrn3666
Juslin, P. N., & Västfjäll, D. (2008). Emotional responses to music: the need to consider underlying mechanisms. The Behavioral and brain sciences, 31(5), 559–621. https://doi.org/10.1017/S0140525X08005293
Raglio, A., & Oasi, O. (2015). Music and health: what interventions for what results?. Frontiers in psychology, 6, 230. https://doi.org/10.3389/fpsyg.2015.00230
Thompson, R. G., Moulin, C. J., Hayre, S., & Jones, R. W. (2005). Music enhances category fluency in healthy older adults and Alzheimer's disease patients. Experimental aging research, 31(1), 91–99. https://doi.org/10.1080/03610730590882819
Irish, M., Cunningham, C. J., Walsh, J. B., Coakley, D., Lawlor, B. A., Robertson, I. H., & Coen, R. F. (2006). Investigating the enhancing effect of music on autobiographical memory in mild Alzheimer's disease. Dementia and geriatric cognitive disorders, 22(1), 108–120. https://doi.org/10.1159/000093487
Baddeley A. (1992). Working memory. Science (New York, N.Y.), 255(5044), 556–559. https://doi.org/10.1126/science.1736359
Schaefer, A., & Philippot, P. (2005). Selective effects of emotion on the phenomenal characteristics of autobiographical memories. Memory (Hove, England), 13(2), 148–160. https://doi.org/10.1080/09658210344000648
Talarico, J. M., LaBar, K. S., & Rubin, D. C. (2004). Emotional intensity predicts autobiographical memory experience. Memory & cognition, 32(7), 1118–1132. https://doi.org/10.3758/bf03196886
Cuddy, L. L., Sikka, R., & Vanstone, A. (2015). Preservation of musical memory and engagement in healthy aging and Alzheimer's disease. Annals of the New York Academy of Sciences, 1337, 223–231. https://doi.org/10.1111/nyas.12617
Janata, P., Tomic, S. T., & Rakowski, S. K. (2007). Characterization of music-evoked autobiographical memories. Memory (Hove, England), 15(8), 845–860. https://doi.org/10.1080/09658210701734593
El Haj, M., Fasotti, L., & Allain, P. (2012). The involuntary nature of music-evoked autobiographical memories in Alzheimer's disease. Consciousness and cognition, 21(1), 238–246. https://doi.org/10.1016/j.concog.2011.12.005
Reschke-Hernández, A. E., Belfi, A. M., Guzmán-Vélez, E., & Tranel, D. (2020). Hooked on a Feeling: Influence of Brief Exposure to Familiar Music on Feelings of Emotion in Individuals with Alzheimer's Disease. Journal of Alzheimer's disease : JAD, 78(3), 1019–1031. https://doi.org/10.3233/JAD-200889
El Haj, M., Antoine, P., Nandrino, J. L., Gély-Nargeot, M. C., & Raffard, S. (2015). Self-defining memories during exposure to music in Alzheimer's disease. International psychogeriatrics, 27(10), 1719–1730. https://doi.org/10.1017/S1041610215000812
Lyu, J., Zhang, J., Mu, H., Li, W., Champ, M., Xiong, Q., Gao, T., Xie, L., Jin, W., Yang, W., Cui, M., Gao, M., & Li, M. (2018). The Effects of Music Therapy on Cognition, Psychiatric Symptoms, and Activities of Daily Living in Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD, 64(4), 1347–1358. https://doi.org/10.3233/JAD-180183
Koelsch S. (2020). A coordinate-based meta-analysis of music-evoked emotions. NeuroImage, 223, 117350. https://doi.org/10.1016/j.neuroimage.2020.117350
Wang, S. G., Cevasco-Trotter, A. M., Silverman, M. J., & Yuan, S. H. (2023). A narrative review of music therapy for neuropsychiatric symptoms in Alzheimer's disease and rationale for protocolized music teletherapy. Frontiers in medicine, 10, 1248245. https://doi.org/10.3389/fmed.2023.1248245
Fang, R., Ye, S., Huangfu, J., & Calimag, D. P. (2017). Music therapy is a potential intervention for cognition of Alzheimer's Disease: a mini-review. Translational neurodegeneration, 6, 2. https://doi.org/10.1186/s40035-017-0073-9
Li, C. H., Liu, C. K., Yang, Y. H., Chou, M. C., Chen, C. H., & Lai, C. L. (2015). Adjunct effect of music therapy on cognition in Alzheimer's disease in Taiwan: a pilot study. Neuropsychiatric disease and treatment, 11, 291–296. https://doi.org/10.2147/NDT.S73928
Arroyo-Anlló, E. M., Díaz, J. P., & Gil, R. (2013). Familiar music as an enhancer of self-consciousness in patients with Alzheimer's disease. BioMed research international, 2013, 752965. https://doi.org/10.1155/2013/752965
Satoh, M., Yuba, T., Tabei, K., Okubo, Y., Kida, H., Sakuma, H., & Tomimoto, H. (2015). Music Therapy Using Singing Training Improves Psychomotor Speed in Patients with Alzheimer's Disease: A Neuropsychological and fMRI Study. Dementia and geriatric cognitive disorders extra, 5(3), 296–308. https://doi.org/10.1159/000436960
Palisson, J., Roussel-Baclet, C., Maillet, D., Belin, C., Ankri, J., & Narme, P. (2015). Music enhances verbal episodic memory in Alzheimer's disease. Journal of clinical and experimental neuropsychology, 37(5), 503–517. https://doi.org/10.1080/13803395.2015.1026802
Irish, M., Cunningham, C. J., Walsh, J. B., Coakley, D., Lawlor, B. A., Robertson, I. H., & Coen, R. F. (2006). Investigating the enhancing effect of music on autobiographical memory in mild Alzheimer's disease. Dementia and geriatric cognitive disorders, 22(1), 108–120. https://doi.org/10.1159/000093487
Gómez Gallego, M., & Gómez García, J. (2017). Music therapy and Alzheimer's disease: Cognitive, psychological, and behavioural effects. Musicoterapia en la enfermedad de Alzheimer: efectos cognitivos, psicológicos y conductuales. Neurologia (Barcelona, Spain), 32(5), 300–308. https://doi.org/10.1016/j.nrl.2015.12.003
Kim, H. J., Yang, Y., Oh, J. G., Oh, S., Choi, H., Kim, K. H., & Kim, S. H. (2016). Effectiveness of a community-based multidomain cognitive intervention program in patients with Alzheimer's disease. Geriatrics & gerontology international, 16(2), 191–199. https://doi.org/10.1111/ggi.12453
Thaut, M. H., Gardiner, J. C., Holmberg, D., Horwitz, J., Kent, L., Andrews, G., Donelan, B., & McIntosh, G. R. (2009). Neurologic music therapy improves executive function and emotional adjustment in traumatic brain injury rehabilitation. Annals of the New York Academy of Sciences, 1169, 406–416. https://doi.org/10.1111/j.1749-6632.2009.04585.x
Raglio, A., Bellelli, G., Mazzola, P., Bellandi, D., Giovagnoli, A. R., Farina, E., Stramba-Badiale, M., Gentile, S., Gianelli, M. V., Ubezio, M. C., Zanetti, O., & Trabucchi, M. (2012). Music, music therapy and dementia: a review of literature and the recommendations of the Italian Psychogeriatric Association. Maturitas, 72(4), 305–310. https://doi.org/10.1016/j.maturitas.2012.05.016
Spina, E., Barone, P., Mosca, L.L., Forges Davanzati, R., Lombardi, A., Longo, K., Iavarone, A. and Amboni, M. (2016), Music Therapy for Motor and Nonmotor Symptoms of Parkinson's Disease: A Prospective, Randomized, Controlled, Single-Blinded Study. J Am Geriatr Soc, 64: e36-e39. https://doi.org/10.1111/jgs.14295
Soria-Urios, G., Duque, P., & García-Moreno, J. M. (2011). Música y cerebro (II): evidencias cerebrales del entrenamiento musical [Music and brain (II): evidence of musical training in the brain]. Revista de neurologia, 53(12), 739–746.
Gaser, C., & Schlaug, G. (2003). Brain structures differ between musicians and non-musicians. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(27), 9240–9245. https://doi.org/10.1523/JNEUROSCI.23-27-09240.2003
Li, C. H., Liu, C. K., Yang, Y. H., Chou, M. C., Chen, C. H., & Lai, C. L. (2015). Adjunct effect of music therapy on cognition in Alzheimer's disease in Taiwan: a pilot study. Neuropsychiatric disease and treatment, 11, 291–296. https://doi.org/10.2147/NDT.S73928
Gómez Gallego, M., & Gómez García, J. (2017). Music therapy and Alzheimer's disease: Cognitive, psychological, and behavioural effects. Musicoterapia en la enfermedad de Alzheimer: efectos cognitivos, psicológicos y conductuales. Neurologia (Barcelona, Spain), 32(5), 300–308. https://doi.org/10.1016/j.nrl.2015.12.003
Fang, R., Ye, S., Huangfu, J., & Calimag, D. P. (2017). Music therapy is a potential intervention for cognition of Alzheimer's Disease: a mini-review. Translational neurodegeneration, 6, 2. https://doi.org/10.1186/s40035-017-0073-9
Arroyo-Anlló, E. M., Díaz, J. P., & Gil, R. (2013). Familiar music as an enhancer of self-consciousness in patients with Alzheimer's disease. BioMed research international, 2013, 752965. https://doi.org/10.1155/2013/752965
Bleibel, M., El Cheikh, A., Sadier, N. S., & Abou-Abbas, L. (2023). The effect of music therapy on cognitive functions in patients with Alzheimer's disease: a systematic review of randomized controlled trials. Alzheimer's research & therapy, 15(1), 65. https://doi.org/10.1186/s13195-023-01214-9
Matziorinis, A. M., & Koelsch, S. (2022). The promise of music therapy for Alzheimer's disease: A review. Annals of the New York Academy of Sciences, 1516(1), 11–17. https://doi.org/10.1111/nyas.14864
Flo, B. K., Matziorinis, A. M., Skouras, S., Sudmann, T. T., Gold, C., & Koelsch, S. (2022). Study protocol for the Alzheimer and music therapy study: An RCT to compare the efficacy of music therapy and physical activity on brain plasticity, depressive symptoms, and cognitive decline, in a population with and at risk for Alzheimer's disease. PloS one, 17(6), e0270682. https://doi.org/10.1371/journal.pone.0270682
Siracuse, J. J., Gill, H. L., Jones, D. W., Schneider, D. B., Connolly, P. H., Parrack, I., Huang, Z. S., & Meltzer, A. J. (2014). Risk factors for protracted postoperative length of stay after lower extremity bypass for critical limb ischemia. Annals of vascular surgery, 28(6), 1432–1438. https://doi.org/10.1016/j.avsg.2013.12.027
Popa, L. C., Manea, M. C., Velcea, D., Șalapa, I., Manea, M., & Ciobanu, A. M. (2021). Impact of Alzheimer's Dementia on Caregivers and Quality Improvement through Art and Music Therapy. Healthcare (Basel, Switzerland), 9(6), 698. https://doi.org/10.3390/healthcare9060698
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Copyright (c) 2024 Dominka Rehan, Joanna Szydziak, Aleksandra Hrapkowicz, Kinga Janowska, Olga Szeidl, Julia Wołoszczak, Julia Wołoszczak, Agnieszka Mioskowska, Daria Dąbkowska
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