The Air We Breathe: Exploring the multifaceted impacts of Air Pollution on health and disease
DOI:
https://doi.org/10.12775/JEHS.2024.75.56376Keywords
Air pollution, Skin aging, Atopic dermatitis, Cardiovascular health, Oxidative stress, Respiratory disease, Lung cancerAbstract
Background: Air pollution poses a significant global health risk, affecting a wide range of conditions, including skin aging, atopic dermatitis, cardiovascular diseases, respiratory disorders, and cancer. Recent studies reveal its role in accelerating aging and exacerbating chronic conditions through mechanisms like oxidative stress and systemic inflammation. However, gaps remain in understanding pollutant-specific effects and their cumulative impact on health.
Methods: This review synthesizes findings from recent studies examining the effects of air pollution on skin and systemic health. A comprehensive analysis was conducted across multiple health conditions, with a focus on pollutant-specific mechanisms, including oxidative stress, DNA damage, immune dysregulation, and inflammatory responses.
Results: Findings highlight strong correlations between exposure to pollutants, such as PM2.5, SO2, NOx, and VOCs, with adverse health outcomes. Pollutants exacerbate conditions like wrinkles, atopic dermatitis, thrombosis, and lung cancer. Interestingly, some pollutants, like ozone, showed mixed effects on specific skin conditions, emphasizing the need for nuanced analysis.
Conclusion: Understanding the multifaceted impact of air pollution underscores the urgent need for targeted interventions and policies to mitigate health risks. Further research is essential to develop precise strategies to address the pollutant-specific effects and protect vulnerable populations.
References
Alahmad, B., Khraishah, H., Althalji, K., Borchert, W., Al-Mulla, F., & Koutrakis, P. (2023). Connections Between Air Pollution, Climate Change, and Cardiovascular Health. The Canadian journal of cardiology, 39(9), 1182–1190. https://doi.org/10.1016/j.cjca.2023.03.025
Alexeeff, S. E., Liao, N. S., Liu, X., Van Den Eeden, S. K., & Sidney, S. (2021). Long-Term PM2.5 Exposure and Risks of Ischemic Heart Disease and Stroke Events: Review and Meta-Analysis. Journal of the American Heart Association, 10(1), e016890. https://doi.org/10.1161/JAHA.120.016890
Bevan, G. H., Al-Kindi, S. G., Brook, R., & Rajagopalan, S. (2021). Ambient Air Pollution and Atherosclerosis: Recent Updates. Current atherosclerosis reports, 23(10), 63. https://doi.org/10.1007/s11883-021-00958-9
Bikis A. (2023). Urban Air Pollution and Greenness in Relation to Public Health. Journal of environmental and public health, 2023, 8516622. https://doi.org/10.1155/2023/8516622
Błaszczyk, R. T., Gorlo, A., Dukacz, M., Konopka, A., & Głowniak, A. (2023). Association between exposure to air pollution and incidence of atrial fibrillation. Annals of agricultural and environmental medicine : AAEM, 30(1), 15–21. https://doi.org/10.26444/aaem/157189
Gaio, V., Roquette, R., Dias, C. M., & Nunes, B. (2019). Ambient air pollution and lipid profile: Systematic review and meta-analysis. Environmental pollution (Barking, Essex : 1987), 254(Pt B), 113036. https://doi.org/10.1016/j.envpol.2019.113036
González-Ruíz, J., A Baccarelli, A., Cantu-de-Leon, D., & Prada, D. (2023). Air Pollution and Lung Cancer: Contributions of Extracellular Vesicles as Pathogenic Mechanisms and Clinical Utility. Current environmental health reports, 10(4), 478–489. https://doi.org/10.1007/s40572-023-00421-8
Hassan Bhat, T., Jiawen, G., & Farzaneh, H. (2021). Air Pollution Health Risk Assessment (AP-HRA), Principles and Applications. International journal of environmental research and public health, 18(4), 1935. https://doi.org/10.3390/ijerph18041935
Huang, C. H., Chen, S. C., Wang, Y. C., Wang, C. F., Hung, C. H., & Lee, S. S. (2022). Detrimental correlation between air pollution with skin aging in Taiwan population. Medicine, 101(31), e29380. https://doi.org/10.1097/MD.0000000000029380
Kulick, E. R., Kaufman, J. D., & Sack, C. (2023). Ambient Air Pollution and Stroke: An Updated Review. Stroke, 54(3), 882–893. https://doi.org/10.1161/STROKEAHA.122.035498
Lai, A., Owens, K., Patel, S., & Nicholas, M. (2023). The Impact of Air Pollution on Atopic Dermatitis. Current allergy and asthma reports, 23(8), 435–442. https://doi.org/10.1007/s11882-023-01095-w
Lechner, K., von Schacky, C., McKenzie, A. L., Worm, N., Nixdorff, U., Lechner, B., Kränkel, N., Halle, M., Krauss, R. M., & Scherr, J. (2020). Lifestyle factors and high-risk atherosclerosis: Pathways and mechanisms beyond traditional risk factors. European journal of preventive cardiology, 27(4), 394–406. https://doi.org/10.1177/2047487319869400
Madaniyazi, L., & Xerxes, S. (2021). Outdoor air pollution and the onset and exacerbation of asthma. Chronic diseases and translational medicine, 7(2), 100–106. https://doi.org/10.1016/j.cdtm.2021.04.003
Montone, R. A., Rinaldi, R., Bonanni, A., Severino, A., Pedicino, D., Crea, F., & Liuzzo, G. (2023). Impact of air pollution on ischemic heart disease: Evidence, mechanisms, clinical perspectives. Atherosclerosis, 366, 22–31. https://doi.org/10.1016/j.atherosclerosis.2023.01.013
Robertson, S., & Miller, M. R. (2018). Ambient air pollution and thrombosis. Particle and fibre toxicology, 15(1), 1. https://doi.org/10.1186/s12989-017-0237-x
Santos, U. P., Arbex, M. A., Braga, A. L. F., Mizutani, R. F., Cançado, J. E. D., Terra-Filho, M., & Chatkin, J. M. (2021). Environmental air pollution: respiratory effects. Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia, 47(1), e20200267. https://doi.org/10.36416/1806-3756/e20200267
Tang, L., Wang, Q. Y., Cheng, Z. P., Hu, B., Liu, J. D., & Hu, Y. (2016). Air pollution and venous thrombosis: a meta-analysis. Scientific reports, 6, 32794. https://doi.org/10.1038/srep32794
Tiotiu, A. I., Novakova, P., Nedeva, D., Chong-Neto, H. J., Novakova, S., Steiropoulos, P., & Kowal, K. (2020). Impact of Air Pollution on Asthma Outcomes. International journal of environmental research and public health, 17(17), 6212. https://doi.org/10.3390/ijerph17176212
Virani, S. S., Newby, L. K., Arnold, S. V., Bittner, V., Brewer, L. C., Demeter, S. H., Dixon, D. L., Fearon, W. F., Hess, B., Johnson, H. M., Kazi, D. S., Kolte, D., Kumbhani, D. J., LoFaso, J., Mahtta, D., Mark, D. B., Minissian, M., Navar, A. M., Patel, A. R., Piano, M. R., … Peer Review Committee Members (2023). 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation, 148(9), e9–e119. https://doi.org/10.1161/CIR.0000000000001168
Zhang, Y., Shi, J., Ma, Y., Yu, N., Zheng, P., Chen, Z., Wang, T., & Jia, G. (2023). Association between Air Pollution and Lipid Profiles. Toxics, 11(11), 894. https://doi.org/10.3390/toxics11110894
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Mateusz Górski, Mateusz Bychowski, Julia Kwaśna, Adrianna Załęska, Izabela Kaźmierczyk, Kacper Lenart, Michał Homza, Natalia Zakrzewska, Szymon Bednarek, Joanna Kulicka
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 86
Number of citations: 0
