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Journal of Education, Health and Sport

FKBP5 gene - current knowledge, new approach and possible biomarker function: a narrative review
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  • FKBP5 gene - current knowledge, new approach and possible biomarker function: a narrative review
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  3. Vol. 75 (2024) /
  4. Medical Sciences

FKBP5 gene - current knowledge, new approach and possible biomarker function: a narrative review

Authors

  • Sven Solisch University Clinical Hospital in Opole https://orcid.org/0009-0002-4769-6095
  • Agata Boczar https://orcid.org/0009-0002-3754-598X
  • Patryk Dryja https://orcid.org/0009-0009-4276-474X
  • Bianka Solisch https://orcid.org/0009-0006-9508-1545
  • Jakub Jarmołowicz https://orcid.org/0000-0002-7574-1423

DOI:

https://doi.org/10.12775/JEHS.2024.75.56217

Keywords

FKBP5 gene, stress-related disorders, biomarkers, HPA axis, long-term stress

Abstract

Introduction 

Over the past few decades, the level of interest in the use of complex molecular pathways in the course of various diseases has increased significantly. Despite the rapid development of medicine, the potential and role of FKBP5 as a biomarker has not yet been fully characterized, although current studies are promising.

 

Material and methods of research: The literature included in the PubMed databases is searched through the words such as FKBP5 gene, stress-related disorders, biomarkers.

 

Aim of the study 

The aim of this paper is to provide a comprehensive review of the current state of knowledge regarding the characteristics, current use in diagnosis or treatment of various diseases and to determine the possible function of the biomarker for the FKBP5 gene.

 

Description of the state of knowledge

FKBP5 participates in the regulation of the HPA axis and thus in the stress response. This translates into the course of many diseases, but the exact mechanism of action has not been unequivocally confirmed in previous studies on all conditions involving FKBP5.

 

Conclusions

In general, FKBP5 has a huge diagnostic and therapeutic potential in many disease entities. FKBP5 may act as a biomarker. However, further studies are needed to clarify the current observations and to search for further implications in the pathogenesis or diagnostic and therapeutic procedures in the course of various diseases.

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2024-12-05

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SOLISCH, Sven, BOCZAR, Agata, DRYJA, Patryk, SOLISCH, Bianka and JARMOŁOWICZ, Jakub. FKBP5 gene - current knowledge, new approach and possible biomarker function: a narrative review. Journal of Education, Health and Sport. Online. 5 December 2024. Vol. 75, p. 56217. [Accessed 20 June 2025]. DOI 10.12775/JEHS.2024.75.56217.
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Vol. 75 (2024)

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Medical Sciences

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Copyright (c) 2024 Sven Solisch, Agata Boczar, Patryk Dryja, Bianka Solisch, Jakub Jarmołowicz

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