The role of vitamin D in the prevention and treatment of autoimmune diseases – A literature review and analysis of research
DOI:
https://doi.org/10.12775/JEHS.2024.75.56210Keywords
vitamin D, hashimoto’s thyroiditis, rheumatoid arthritis, crohn”s disease, autoimmune diseaseAbstract
Introduction and purpose. Autoimmune diseases are a group of diseases in which the immune system attacks the body's own cells, leading to chronic inflammation and tissue damage. In the pathogenesis of these diseases, dysregulation of the immune response, including excessive activity of T and B lymphocytes and macrophages, play a key role. The aim of this work is to review the role of vitamin D in the prevention and treatment of autoimmune diseases, with particular emphasis on Hashimoto's disease, rheumatoid arthritis and Crohn's disease.
Methods. A literature review was conducted based on the PubMed and Google Scholar databases, using the key words: "vitamin D", "Hashimoto's disease", "rheumatoid arthritis", "Crohn's disease". Articles published within the last five years were prioritized.
Brief description of the state of knowledge. Vitamin D affects the immune system through the presence of vitamin D receptors (VDR) on immune cells, such as T and B lymphocytes and macrophages. The active form of vitamin D (calcitriol) supports the development of regulatory T cells (Treg), which inhibit excessive inflammatory response, and reduces the activity of Th1 and Th17 lymphocytes. Vitamin D deficiency can disrupt this regulation, increasing the risk of developing autoimmune diseases.
Conclusions. Vitamin D plays an important role in the prevention and treatment of autoimmune diseases. It has an immunomodulatory effect, restoring the balance of the inflammatory response, which is crucial in the treatment of diseases such as Hashimoto's, rheumatoid arthritis and Crohn's disease. Vitamin D supplementation can alleviate symptoms, improve organ function and reduce the severity of autoimmune diseases.
References
Gray PE, David C. Inborn Errors of Immunity and Autoimmune Disease. J Allergy Clin Immunol Pract. 2023;11(6):1602-1622. https://doi.org/10.1016/j.jaip.2023.04.018
Wasniewska MG, Bossowski A. Special Issue: Autoimmune Disease Genetics. Genes (Basel). 2021;12(12):1937. Published 2021 Nov 30. https://doi.org/10.3390/genes12121937
Bieber K, Hundt JE, Yu X, et al. Autoimmune pre-disease. Autoimmun Rev. 2023;22(2):103236. https://doi.org/10.1016/j.autrev.2022.103236
Muñoz A, Grant WB. Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms. Nutrients. 2022;14(7):1448. Published 2022 Mar 30. https://doi.org/10.3390/nu14071448
Zhao R, Zhang W, Ma C, et al. Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease. Front Immunol. 2021;12:574967. Published 2021 Feb 19. https://doi.org/10.3389/fimmu.2021.574967
Demay MB, Pittas AG, Bikle DD, et al. Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2024;109(8):1907-1947. https://doi.org/10.1210/clinem/dgae290
Ismailova A, White JH. Vitamin D, infections and immunity. Rev Endocr Metab Disord. 2022;23(2):265-277. https://doi.org/10.1007/s11154-021-09679-5
Probert C. (2020). Commentary: vitamin D supplementation in Crohn's disease. Alimentary pharmacology & therapeutics, 51(1), 201–202. https://doi.org/10.1111/apt.15524
Charoenngam N. Vitamin D and Rheumatic Diseases: A Review of Clinical Evidence. Int J Mol Sci. 2021;22(19):10659. Published 2021 Oct 1. https://doi.org/10.3390/ijms221910659
Harrison SR, Jutley G, Li D, et al. Vitamin D and early rheumatoid arthritis. BMC Rheumatol. 2020;4:38. Published 2020 Jul 27. https://doi.org/10.1186/s41927-020-00134-7
Durá-Travé T, Gallinas-Victoriano F. Autoimmune Thyroiditis and Vitamin D. Int J Mol Sci. 2024;25(6):3154. Published 2024 Mar 9. https://doi.org/10.3390/ijms25063154
Lebiedziński F, Lisowska KA. Impact of Vitamin D on Immunopathology of Hashimoto's Thyroiditis: From Theory to Practice. Nutrients. 2023;15(14):3174. Published 2023 Jul 17. https://doi.org/10.3390/nu15143174
Wimalawansa SJ. Infections and Autoimmunity-The Immune System and Vitamin D: A Systematic Review. Nutrients. 2023;15(17):3842. Published 2023 Sep 2. https://doi.org/10.3390/nu15173842
Sîrbe C, Rednic S, Grama A, Pop TL. An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases. Int J Mol Sci. 2022;23(17):9784. Published 2022 Aug 29.
https://doi.org/10.3390/ijms23179784
Brown G, Marchwicka A, Marcinkowska E. Vitamin D and immune system. Adv Food Nutr Res. 2024;109:1-41. https://doi.org/10.1016/bs.afnr.2023.12.001
Charoenngam N, Holick MF. Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients. 2020;12(7):2097. Published 2020 Jul 15. https://doi.org/10.3390/nu12072097
Ao T, Kikuta J, Ishii M. The Effects of Vitamin D on Immune System and Inflammatory Diseases. Biomolecules. 2021;11(11):1624. Published 2021 Nov 3. https://doi.org/10.3390/biom11111624
Johnson CR, Thacher TD. Vitamin D: immune function, inflammation, infections and auto-immunity. Paediatr Int Child Health. 2023;43(4):29-39. https://doi.org/10.1080/20469047.2023.2171759
Daryabor G, Gholijani N, Kahmini FR. A review of the critical role of vitamin D axis on the immune system. Exp Mol Pathol. 2023;132-133:104866. https://doi.org/10.1016/j.yexmp.2023.104866
Mailhot G, White JH. Vitamin D and Immunity in Infants and Children. Nutrients. 2020;12(5):1233. Published 2020 Apr 27. https://doi.org/10.3390/nu12051233
Yamamoto EA, Jørgensen TN. Relationships Between Vitamin D, Gut Microbiome, and Systemic Autoimmunity. Front Immunol. 2020;10:3141. Published 2020 Jan 21. https://doi.org/10.3389/fimmu.2019.03141
Ismailova A, White JH. Vitamin D, infections and immunity. Rev Endocr Metab Disord. 2022;23(2):265-277. https://doi.org/10.1007/s11154-021-09679-5
Harrison SR, Li D, Jeffery LE, Raza K, Hewison M. Vitamin D, Autoimmune Disease and Rheumatoid Arthritis. Calcif Tissue Int. 2020;106(1):58-75. https://doi.org/10.1007/s00223-019-00577-2
Palmese F, Del Toro R, Di Marzio G, Cataleta P, Sama MG, Domenicali M. Sarcopenia and Vitamin D Deficiency in Patients with Crohn's Disease: Pathological Conditions That Should Be Linked Together. Nutrients. 2021;13(4):1378. Published 2021 Apr 20. https://doi.org/10.3390/nu13041378
Zheng Y, Li ZB, Wu ZY, et al. Vitamin D levels in the assessment of Crohn's disease activity and their relation to nutritional status and inflammation. J Hum Nutr Diet. 2023;36(4):1159-1169. https://doi.org/10.1111/jhn.13139
Yamada A, Komaki Y, Komaki F, et al. The Correlation between Vitamin D Levels and the Risk of Postoperative Recurrence in Crohn's Disease. Digestion. 2021;102(5):767-775. https://doi.org/10.1159/000513589
Verma S, Chaturvedi V, Ganguly NK, Mittal SA. Vitamin D deficiency: concern for rheumatoid arthritis and COVID-19?. Mol Cell Biochem. 2021;476(12):4351-4362. https://doi.org/10.1007/s11010-021-04245-8
Athanassiou L, Kostoglou-Athanassiou I, Koutsilieris M, Shoenfeld Y. Vitamin D and Autoimmune Rheumatic Diseases. Biomolecules. 2023;13(4):709. Published 2023 Apr 21. https://doi.org/10.3390/biom13040709
Zhang J, Chen Y, Li H, Li H. Effects of vitamin D on thyroid autoimmunity markers in Hashimoto's thyroiditis: systematic review and meta-analysis. J Int Med Res. 2021;49(12):3000605211060675. https://doi.org/10.1177/03000605211060675
Tang J, Shan S, Li F, Yun P. Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis. Medicine (Baltimore). 2023;102(52):e36759. https://doi.org/10.1097/MD.0000000000036759
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