The Impact of prolonged antibiotic use on the development of bacterial resistance - a literature review
DOI:
https://doi.org/10.12775/JEHS.2024.71.56137Keywords
antimicrobial resistance (AMR), antibiotic-resistant bacteria, overuse of antibiotics, mechanisms of bacterial resistanceAbstract
Abstract
Introduction and Objective. Antimicrobial resistance (AMR) arises when pathogens no longer respond to antimicrobials, including antibiotics, making infections harder to treat and increasing the risks of severe illness and death. Although AMR is a natural evolutionary process, human activities, especially the misuse of antimicrobials in healthcare, agriculture, and animal care, accelerate its spread. This review examines the impact of prolonged antibiotic use on bacterial resistance and analyzes global trends and strategies to combat AMR.
Methods. A literature review was conducted using PubMed and Google Scholar with search terms like "antimicrobial resistance," "antibiotic-resistant bacteria," and "overuse of antibiotics." Articles from the last five years were prioritized.
State of Knowledge. AMR poses a major global health threat due to excessive and improper antibiotic use, resulting in resistant infections and higher healthcare costs. Addressing AMR requires limiting antibiotic use, implementing rapid diagnostics, and exploring alternatives like bacteriophage therapy.
Conclusions. Innovative treatments, such as bacteriophages, and rapid diagnostics show promise, while public education on responsible antibiotic use is essential. Combating AMR will require coordinated international efforts, research support, and global standards to maintain effective treatments in the future.
References
van Buul LW, van der Steen JT, Veenhuizen RB, et al. Antibiotic use and resistance in long term care facilities. J Am Med Dir Assoc. 2012;13(6):. doi.org/10.1016/j.jamda.2012.04.004
Development of Bacterial Resistance to Antibiotics. JAMA. 2022;328(20):2074. doi.org/10.1001/jama.2021.17225
Mutuku C, Gazdag Z, Melegh S. Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches. World J Microbiol Biotechnol. 2022;38(9):152. Published 2022 Jul 4. doi.org/10.1007/s11274-022-03334-0
Li T, Wang Z, Guo J, et al. Bacterial resistance to antibacterial agents: Mechanisms, control strategies, and implications for global health. Sci Total Environ. 2023;860:160461. doi.org/10.1016/j.scitotenv.2022.160461
Baran A, Kwiatkowska A, Potocki L. Antibiotics and Bacterial Resistance-A Short Story of an Endless Arms Race. Int J Mol Sci. 2023;24(6):5777. Published 2023 Mar 17. doi.org/10.3390/ijms24065777
Islam MM. Bacterial resistance to antibiotics: access, excess, and awareness in Bangladesh. Expert Rev Anti Infect Ther. 2021;19(8):973-981. doi.org/10.1080/14787210.2021.1865804
Uddin TM, Chakraborty AJ, Khusro A, et al. Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects. J Infect Public Health. 2021;14(12):1750-1766. doi.org/10.1016/j.jiph.2021.10.020
Lewis K. The Science of Antibiotic Discovery. Cell. 2020;181(1):29-45. doi.org/10.1016/j.cell.2020.02.056
Duquette E, Bhatti P, Sur S, Felbaum DR, Dowlati E. History and Use of Antibiotic Irrigation for Preventing Surgical Site Infection in Neurosurgery: A Scoping Review. World Neurosurg. 2022;160:76-83. doi.org/10.1016/j.wneu.2022.01.098
Babiker A, Li X, Lai YL, et al. Effectiveness of adjunctive clindamycin in β-lactam antibiotic-treated patients with invasive β-haemolytic streptococcal infections in US hospitals: a retrospective multicentre cohort study [published correction appears in Lancet Infect Dis. 2021 May;21(5):e122. doi: 10.1016/S1473-3099(21)00228-0]. Lancet Infect Dis. 2021;21(5):697-710. doi.org/10.1016/S1473-3099(20)30523-5
Frimodt-Møller N, Bjerrum L. Treating urinary tract infections in the era of antibiotic resistance. Expert Rev Anti Infect Ther. 2023;21(12):1301-1308. doi.org/10.1080/14787210.2023.2279104
Horne M, Woolley I, Lau JSY. The Use of Long-term Antibiotics for Suppression of Bacterial Infections. Clin Infect Dis. 2024;79(4):848-854. doi.org/10.1093/cid/ciae302
Stefan KL, Kim MV, Iwasaki A, Kasper DL. Commensal Microbiota Modulation of Natural Resistance to Virus Infection. Cell. 2020;183(5):1312-1324.e10. Stefan KL, Kim MV, Iwasaki A, Kasper DL. Commensal Microbiota Modulation of Natural Resistance to Virus Infection. Cell. 2020;183(5):1312-1324.e10. doi.org/10.1016/j.cell.2020.10.047
Netea MG, Domínguez-Andrés J, van de Veerdonk FL, van Crevel R, Pulendran B, van der Meer JWM. Natural resistance against infections: focus on COVID-19.TrendsImmunol.2022;43(2):106-116.
doi.org/10.1016/j.it.2021.12.001
Panou V, Røe OD. Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review. Int J Mol Sci. 2020;21(12):4327. Published 2020 Jun 17. doi.org/10.3390/ijms21124327
Lee C, Park SH, Yoon SK. Genetic mutations affecting mitochondrial function in cancer drug resistance. Genes Genomics. 2023;45(3):261-270. doi.org/10.1007/s13258-022-01359-1
Li W, Zhang G. Detection and various environmental factors of antibiotic resistance gene horizontal transfer. Environ Res. 2022;212(Pt B):113267. doi.org/10.1016/j.envres.2022.113267
Jeon JH, Jang KM, Lee JH, Kang LW, Lee SH. Transmission of antibiotic resistance genes through mobile genetic elements in Acinetobacter baumannii and gene-transfer prevention. Sci Total Environ. 2023;857(Pt 2):159497. doi.org/10.1016/j.scitotenv.2022.159497
Jian Z, Zeng L, Xu T, et al. Antibiotic resistance genes in bacteria: Occurrence, spread, and control. J Basic Microbiol. 2021;61(12):1049-1070. doi.org/10.1002/jobm.202100201
Romero JL, Grande Burgos MJ, Pérez-Pulido R, Gálvez A, Lucas R. Resistance to Antibiotics, Biocides, Preservatives and Metals in Bacteria Isolated from Seafoods: Co-Selection of Strains Resistant or Tolerant to Different Classes of Compounds. Front Microbiol. 2017;8:1650. Published 2017 Aug 31. doi.org/10.3389/fmicb.2017.01650
Poletajew S, Pawlik K, Bonder-Nowicka A, Pakuszewski A, Nyk Ł, Kryst P. Multi-Drug Resistant Bacteria as Aetiological Factors of Infections in a Tertiary Multidisciplinary Hospital in Poland. Antibiotics (Basel). 2021;10(10):1232. Published 2021 Oct 10. doi.org/10.3390/antibiotics10101232
Volgenant CMC, Hoogenkamp MA, Dahlén G, Kalfas S, Petti S, De Soet JJ. Low prevalence of multi-resistant bacteria in undergraduate dental students; an observational case-control multi-centre study in Europe. J Oral Microbiol. 2021;13(1):1889898. Published 2021 Feb 21. doi.org/10.1080/20002297.2021.1889898
Cassini A, Högberg LD, Plachouras D, et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. Lancet Infect Dis. 2019;19(1):56-66. doi.org/10.1016/S1473-3099(18)30605-4
Imoto W, Yamada K, Kuwabara G, et al. Impact of coronavirus disease 2019 on infectious disease treatment and infection control at a tertiary hospital in Japan. J Infect Chemother. 2022;28(5):616-622. doi.org/10.1016/j.jiac.2022.01.008
Kandeel M. The impact of the M184V resistance mutation on treatment outcomes in patients with HIV infection: a systematic review and meta-analysis. AIDS Rev. 2023;26(3):136-144. doi.org/10.24875/AIDSRev.23000002
Govindaraj Vaithinathan A, Vanitha A. WHO global priority pathogens list on antibiotic resistance: an urgent need for action to integrate One Health data. Perspect Public Health. 2018;138(2):87-88. doi.org/10.1177/1757913917743881
Yang X, Li X, Qiu S, et al. Global antimicrobial resistance and antibiotic use in COVID-19 patients within health facilities: A systematic review and meta-analysis of aggregated participant data. J Infect. 2024;89(1):106183. doi.org/10.1016/j.jinf.2024.106183
Roth N, Käsbohrer A, Mayrhofer S, Zitz U, Hofacre C, Domig KJ. The application of antibiotics in broiler production and the resulting antibiotic resistance in Escherichia coli: A global overview. Poult Sci. 2019;98(4):1791-1804. doi.org/10.3382/ps/pey539
Aggarwal R, Mahajan P, Pandiya S, et al. Antibiotic resistance: a global crisis, problems and solutions. Crit Rev Microbiol. 2024;50(5):896-921. doi.org/10.1080/1040841X.2024.2313024
Tarín-Pelló A, Suay-García B, Pérez-Gracia MT. Antibiotic resistant bacteria: current situation and treatment options to accelerate the development of a new antimicrobial arsenal. Expert Rev Anti Infect Ther. 2022;20(8):1095-1108. doi.org/10.1080/14787210.2022.2078308
Tang KWK, Millar BC, Moore JE. Antimicrobial Resistance (AMR). Br J Biomed Sci. 2023;80:11387. Published 2023 Jun 28. doi:10.3389/bjbs.2023.11387
Aslam B, Khurshid M, Arshad MI, et al. Antibiotic Resistance: One Health One World Outlook [published correction appears in Front Cell Infect Microbiol. 2024 Sep 25;14:1488430. doi: 10.3389/fcimb.2024.1488430]. Front Cell Infect Microbiol. 2021;11:771510. Published 2021 Nov 25. doi:10.3389/fcimb.2021.771510
Cunha CB. Antimicrobial Stewardship Programs: Principles and Practice. Med Clin North Am. 2018;102(5):797-803. doi:10.1016/j.mcna.2018.04.003
Donà D, Barbieri E, Daverio M, et al. Implementation and impact of pediatric antimicrobial stewardship programs: a systematic scoping review [published correction appears in Antimicrob Resist Infect Control. 2020 May 7;9(1):59. doi: 10.1186/s13756-020-00720-x]. Antimicrob Resist Infect Control. 2020;9(1):3. Published 2020 Jan 3. doi:10.1186/s13756-019-0659-3
Lanckohr C, Bracht H. Antimicrobial stewardship. Curr Opin Crit Care. 2022;28(5):551-556. doi:10.1097/MCC.0000000000000967
Cook MA, Wright GD. The past, present, and future of antibiotics. Sci Transl Med. 2022;14(657):eabo7793. doi:10.1126/scitranslmed.abo7793
Chegini Z, Khoshbayan A, Taati Moghadam M, Farahani I, Jazireian P, Shariati A. Bacteriophage therapy against Pseudomonas aeruginosa biofilms: a review. Ann Clin Microbiol Antimicrob. 2020;19(1):45. Published 2020 Sep 30. doi:10.1186/s12941-020-00389-5
MacNair CR, Rutherford ST, Tan MW. Alternative therapeutic strategies to treat antibiotic-resistant pathogens. Nat Rev Microbiol. 2024;22(5):262-275. doi:10.1038/s41579-023-00993-0
Dai L, Sahin O, Grover M, Zhang Q. New and alternative strategies for the prevention, control, and treatment of antibiotic-resistant Campylobacter. Transl Res. 2020;223:76-88. doi:10.1016/j.trsl.2020.04.009
Aggarwal R, Mahajan P, Pandiya S, et al. Antibiotic resistance: a global crisis, problems and solutions. Crit Rev Microbiol. 2024;50(5):896-921. doi:10.1080/1040841X.2024.2313024
Satterfield J, Miesner AR, Percival KM. The role of education in antimicrobial stewardship. J Hosp Infect. 2020;105(2):130-141. doi:10.1016/j.jhin.2020.03.028
Mallah N, Orsini N, Figueiras A, Takkouche B. Education level and misuse of antibiotics in the general population: a systematic review and dose-response meta-analysis. Antimicrob Resist Infect Control. 2022;11(1):24. Published 2022 Feb 3. doi:10.1186/s13756-022-01063-5
Machowska A, Stålsby Lundborg C. Drivers of Irrational Use of Antibiotics in Europe. Int J Environ Res Public Health. 2018;16(1):27. Published 2018 Dec 23. doi:10.3390/ijerph16010027
Sulis G, Sayood S, Gandra S. How can we tackle the overuse of antibiotics in low- and middle-income countries?. Expert Rev Anti Infect Ther. 2023;21(11):1189-1201. doi:10.1080/14787210.2023.2263643
Moja L, Zanichelli V, Mertz D, et al. WHO's essential medicines and AWaRe: recommendations on first- and second-choice antibiotics for empiric treatment of clinical infections. Clin Microbiol Infect. 2024;30 Suppl 2:S1-S51. doi:10.1016/j.cmi.2024.02.003
Huemer M, Mairpady Shambat S, Brugger SD, Zinkernagel AS. Antibiotic resistance and persistence-Implications for human health and treatment perspectives. EMBO Rep. 2020;21(12):e51034. doi:10.15252/embr.202051034
Bhardwaj S, Mehra P, Dhanjal DS, et al. Antibiotics and Antibiotic Resistance- Flipsides of the Same Coin. Curr Pharm Des. 2022;28(28):2312-2329. doi:10.2174/1381612828666220608120238
Uddin TM, Chakraborty AJ, Khusro A, et al. Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects. J Infect Public Health. 2021;14(12):1750-1766. doi:10.1016/j.jiph.2021.10.020
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