The impact of diet on the inflammatory bowel disease course – a literature review
DOI:
https://doi.org/10.12775/JEHS.2024.71.56049Keywords
inflammatory bowel disease (IBD), Crohn’s disease, ulcerative colitis, diet, IBD treatment, anti-inflammatory foodAbstract
Introduction and Objective. Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic gastrointestinal disorder marked by relapsing symptoms. Current treatments mainly involve immunosuppressive therapies, which are effective but may have significant side effects. Diet as an adjunctive treatment is appealing due to its accessibility, low cost, and minimal adverse effects. This review explores the role of diet in managing IBD, focusing on dietary strategies during both active disease and remission.
Methods. A literature review was conducted using PubMed and Google Scholar with search terms like "inflammatory bowel disease", "Crohn’s disease", "ulcerative colitis", "diet", "IBD treatment", "anti-inflammatory food" and related variations. Articles published within the last five years were prioritized.
Brief description of the state of Knowledge. Ulcerative colitis and Crohn’s disease cause gastrointestinal inflammation. Crohn’s disease symptoms include abdominal pain, fistulas and rectal lesions, while UC is characterized by diarrhea, severe discomfort, and blood in the stool. Certain foods often exacerbate IBD symptoms. Proper nutrition during disease stages can improve patients’ quality of life. Diets high in processed foods, sugar, and red meat may increase IBD risk, while fiber and vitamin D3 are associated with fewer flare-ups. Regular malnutrition screening is essential for all IBD patients.
Conclusions. Understanding the dietary components that influence inflammation in IBD could lead to better treatment outcomes and longer-lasting symptom relief. Integrating nutrition into personalized treatment strategies should become standard practice for managing IBD.
References
Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease. J Med Life. 2019;12(2):113-122. doi:10.25122/jml-2018-0075
Wark G, Samocha-Bonet D, Ghaly S, Danta M. The Role of Diet in the Pathogenesis and Management of Inflammatory Bowel Disease: A Review. Nutrients. 2020;13(1):135. Published 2020 Dec 31. doi:10.3390/nu13010135
Gentschew L, Ferguson LR. Role of nutrition and microbiota in susceptibility to inflammatory bowel diseases. Mol Nutr Food Res. 2012;56(4):524-535. doi:10.1002/mnfr.201100630
Campmans-Kuijpers MJE, Dijkstra G. Food and Food Groups in Inflammatory Bowel Disease (IBD): The Design of the Groningen Anti-Inflammatory Diet (GrAID). Nutrients. 2021;13(4):1067. Published 2021 Mar 25. doi:10.3390/nu13041067
Balestrieri P, Ribolsi M, Guarino MPL, Emerenziani S, Altomare A, Cicala M. Nutritional Aspects in Inflammatory Bowel Diseases. Nutrients. 2020;12(2):372. Published 2020 Jan 31. doi:10.3390/nu12020372
Einav L, Hirsch A, Ron Y, et al. Risk Factors for Malnutrition among IBD Patients. Nutrients. 2021;13(11):4098. Published 2021 Nov 16. doi:10.3390/nu13114098
Bernstein CN. Extraintestinal manifestations of inflammatory bowel disease. Curr Gastroenterol Rep. 2001;3(6):477-483. doi:10.1007/s11894-001-0068-6
Veauthier B, Hornecker JR. Crohn's Disease: Diagnosis and Management. Am Fam Physician. 2018;98(11):661-669.
Burgmann T, Clara I, Graff L, et al. The Manitoba Inflammatory Bowel Disease Cohort Study: prolonged symptoms before diagnosis--how much is irritable bowel syndrome?. Clin Gastroenterol Hepatol. 2006;4(5):614-620. doi:10.1016/j.cgh.2006.03.003
Bischoff SC, Escher J, Hébuterne X, et al. Guía ESPEN: Nutrición clínica en la enfermedad inflamatoria intestinal [ESPEN guideline: Clinical nutrition in inflammatory bowel disease]. Nutr Hosp. 2022;39(3):678-703. doi:10.20960/nh.03857
Guan Q. A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease. J Immunol Res. 2019;2019:7247238. Published 2019 Dec 1. doi:10.1155/2019/7247238
Baumgart DC, Sandborn WJ. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet. 2007;369(9573):1641-1657. doi:10.1016/S0140-6736(07)60751-X
Hugot JP, Alberti C, Berrebi D, Bingen E, Cézard JP. Crohn's disease: the cold chain hypothesis. Lancet. 2003;362(9400):2012-2015. doi:10.1016/S0140-6736(03)15024-6
Hashash JG, Elkins J, Lewis JD, Binion DG. AGA Clinical Practice Update on Diet and Nutritional Therapies in Patients With Inflammatory Bowel Disease: Expert Review. Gastroenterology. 2024;166(3):521-532. doi:10.1053/j.gastro.2023.11.303
Christensen C, Knudsen A, Arnesen EK, Hatlebakk JG, Sletten IS, Fadnes LT. Diet, Food, and Nutritional Exposures and Inflammatory Bowel Disease or Progression of Disease: an Umbrella Review. Adv Nutr. 2024;15(5):100219. doi:10.1016/j.advnut.2024.100219
Chiba M, Abe T, Tsuda H, et al. Lifestyle-related disease in Crohn's disease: relapse prevention by a semi-vegetarian diet. World J Gastroenterol. 2010;16(20):2484-2495. doi:10.3748/wjg.v16.i20.2484
Owczarek D, Rodacki T, Domagała-Rodacka R, Cibor D, Mach T. Diet and nutritional factors in inflammatory bowel diseases. World J Gastroenterol. 2016;22(3):895-905. doi:10.3748/wjg.v22.i3.895
Radziszewska M, Smarkusz-Zarzecka J, Ostrowska L, Pogodziński D. Nutrition and Supplementation in Ulcerative Colitis. Nutrients. 2022;14(12):2469. Published 2022 Jun 14. doi:10.3390/nu14122469
Papada E, Amerikanou C, Forbes A, Kaliora AC. Adherence to Mediterranean diet in Crohn's disease. Eur J Nutr. 2020;59(3):1115-1121. doi:10.1007/s00394-019-01972-z
Chicco F, Magrì S, Cingolani A, et al. Multidimensional Impact of Mediterranean Diet on IBD Patients. Inflamm Bowel Dis. 2021;27(1):1-9. doi:10.1093/ibd/izaa097
Lewis JD, Abreu MT. Diet as a Trigger or Therapy for Inflammatory Bowel Diseases. Gastroenterology. 2017;152(2):398-414.e6. doi:10.1053/j.gastro.2016.10.019
Olendzki BC, Silverstein TD, Persuitte GM, Ma Y, Baldwin KR, Cave D. An anti-inflammatory diet as treatment for inflammatory bowel disease: a case series report. Nutr J. 2014;13:5. Published 2014 Jan 16. doi:10.1186/1475-2891-13-5
Lewis JD, Sandler RS, Brotherton C, et al. A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults With Crohn's Disease [published correction appears in Gastroenterology. 2022 Nov;163(5):1473. doi: 10.1053/j.gastro.2022.07.058]. Gastroenterology. 2021;161(3):837-852.e9. doi:10.1053/j.gastro.2021.05.047
Sigall Boneh R, Westoby C, Oseran I, et al. The Crohn's Disease Exclusion Diet: A Comprehensive Review of Evidence, Implementation Strategies, Practical Guidance, and Future Directions. Inflamm Bowel Dis. 2024;30(10):1888-1902. doi:10.1093/ibd/izad255
Gearry RB, Irving PM, Barrett JS, Nathan DM, Shepherd SJ, Gibson PR. Reduction of dietary poorly absorbed short-chain carbohydrates (FODMAPs) improves abdominal symptoms in patients with inflammatory bowel disease-a pilot study. J Crohns Colitis. 2009;3(1):8-14. doi:10.1016/j.crohns.2008.09.004
Pedersen N, Ankersen DV, Felding M, et al. Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease. World J Gastroenterol. 2017;23(18):3356-3366. doi:10.3748/wjg.v23.i18.3356
Zallot C, Quilliot D, Chevaux JB, et al. Dietary beliefs and behavior among inflammatory bowel disease patients. Inflamm Bowel Dis. 2013;19(1):66-72. doi:10.1002/ibd.22965
Tun GS, Cripps S, Lobo AJ. Crohn's disease: management in adults, children and young people - concise guidance. Clin Med (Lond). 2018;18(3):231-236. doi:10.7861/clinmedicine.18-3-231
Jørgensen SP, Hvas CL, Agnholt J, Christensen LA, Heickendorff L, Dahlerup JF. Active Crohn's disease is associated with low vitamin D levels. J Crohns Colitis. 2013;7(10):e407-e413. doi:10.1016/j.crohns.2013.01.012
Vernia F, Valvano M, Longo S, Cesaro N, Viscido A, Latella G. Vitamin D in Inflammatory Bowel Diseases. Mechanisms of Action and Therapeutic Implications. Nutrients. 2022;14(2):269. Published 2022 Jan 9. doi:10.3390/nu14020269
Wu Z, Liu D, Deng F. The Role of Vitamin D in Immune System and Inflammatory Bowel Disease. J Inflamm Res. 2022;15:3167-3185. Published 2022 May 28. doi:10.2147/JIR.S363840
Murdaca G, Tonacci A, Negrini S, et al. Emerging role of vitamin D in autoimmune diseases: An update on evidence and therapeutic implications. Autoimmun Rev. 2019;18(9):102350. doi:10.1016/j.autrev.2019.102350
Zheng Y, Li ZB, Wu ZY, et al. Vitamin D levels in the assessment of Crohn's disease activity and their relation to nutritional status and inflammation. J Hum Nutr Diet. 2023;36(4):1159-1169. doi:10.1111/jhn.13139
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