Sleep Quality and Immune Function: Implications for Overall Health – A Literature Review
DOI:
https://doi.org/10.12775/JEHS.2024.75.56048Keywords
sleep quality, immune function, inflammation, depressionAbstract
Introduction
Sleep quality is increasingly acknowledged as critical for immune function and overall health. Poor sleep can disrupt immune response, elevating inflammation and susceptibility to infection and chronic diseases. Given the prevalence of sleep disturbances across populations, understanding their impact on immune health and overall wellness is essential.
Purpose of Work
This review aims to examine the relationship between sleep quality and immune function by synthesizing findings on how poor sleep contributes to immune suppression, heightened inflammation, and mental health disturbances, particularly in vulnerable populations. This review also explores possible interventions to mitigate these effects.
Material and Methods
A literature search was conducted on databases including PubMed and Google Scholar, focusing on studies from 2012 to 2023. Articles assessing sleep quality, immune markers, and the mediating roles of stress and depression were reviewed. Criteria included studies with both subjective and objective assessments of sleep, immune function, and relevant mental health markers.
Summary
Findings indicate that poor sleep quality negatively impacts immune health, primarily through increased systemic inflammation and decreased immune cell functionality. Depression and stress further exacerbate these effects, particularly in populations with chronic illnesses or high psychological distress. Targeted interventions that improve sleep quality and manage stress may bolster immune resilience and overall health. Future research should continue to address these interactions across diverse populations to develop targeted interventions.
References
Basner, M., Rao, H., Goel, N., & Dinges, D. F. (2013). Sleep deprivation and neurobehavioral dynamics. Current Opinion in Neurobiology, 23(5), 854–863. https://doi.org/10.1016/j.conb.2013.02.008
Cai, L., Wei, L., Yao, J., et al. (2022). Impact of depression on sleep quality and immune functions in patients with coronary artery disease. General Psychiatry, 35. https://doi.org/10.1136/gpsych-2022-100918
Chamberlin, N. L. (2013). Brain circuitry mediating arousal from obstructive sleep apnea. Current Opinion in Neurobiology, 23(6), 774–779. https://doi.org/10.1016/j.conb.2013.06.001
Cirelli, C. (2013). Sleep and synaptic changes. Current Opinion in Neurobiology, 23(6), 841–846. https://doi.org/10.1016/j.conb.2013.04.001
Donners, A. A. M. T., Tromp, M. D. P., Garssen, J., Roth, T., & Verster, J. C. (2015). Perceived immune status and sleep: A survey among Dutch students. Sleep Disorders, 2015, 721607. https://doi.org/10.1155/2015/721607
Frank, M. G. (2013). Astroglial regulation of sleep homeostasis. Current Opinion in Neurobiology, 23(6), 812–818. https://doi.org/10.1016/j.conb.2013.02.009
Franken, P. (2013). A role for clock genes in sleep homeostasis. Current Opinion in Neurobiology, 23(5), 864–872. https://doi.org/10.1016/j.conb.2013.05.002
Ganz, F. D. (2012). Sleep and immune function. Critical Care Nurse, 32(2). https://doi.org/10.4037/ccn2012689
Hastings, M. H., & Goedert, M. (2013). Circadian clocks and neurodegenerative diseases: Time to aggregate? Current Opinion in Neurobiology, 23(5), 880–887. https://doi.org/10.1016/j.conb.2013.05.004
Ingiosi, A. M., Opp, M. R., & Krueger, J. M. (2013). Sleep and immune function: Glial contributions and consequences of aging. Current Opinion in Neurobiology, 23(6), 806–811. https://doi.org/10.1016/j.conb.2013.02.003
Jagannath, A., Peirson, S. N., & Foster, R. G. (2013). Sleep and circadian rhythm disruption in neuropsychiatric illness. Current Opinion in Neurobiology, 23(5), 888–894. https://doi.org/10.1016/j.conb.2013.03.008
Kisiolek, J. N., Flores, V. A., Ramani, A., Butler, B., Haughian, J. M., & Stewart, L. K. (2023). Eight weeks of daily cannabidiol supplementation improves sleep quality and immune cell cytotoxicity. Nutrients, 15(4173). https://doi.org/10.3390/nu15194173
Kurien, P. A., Chong, S. Y. C., Ptáček, L. J., & Fu, Y.-H. (2013). Sick and tired: How molecular regulators of human sleep schedules and duration impact immune function. Current Opinion in Neurobiology, 23(5), 873–879. https://doi.org/10.1016/j.conb.2013.04.014
Lazarus, M., Chen, J. F., Urade, Y., & Huang, Z. L. (2013). Role of the basal ganglia in the control of sleep and wakefulness. Current Opinion in Neurobiology, 23(5), 780–785. https://doi.org/10.1016/j.conb.2013.02.001
Lueke, N. A., & Assar, A. (2022). Poor sleep quality and reduced immune function among college students: Perceived stress and depression as mediators. Journal of American College Health, 70(5), 506–514. https://doi.org/10.1080/07448481.2022.2068350
Luppi, P. H., Clément, O., & Fort, P. (2013). Paradoxical (REM) sleep genesis by the brainstem is under hypothalamic control. Current Opinion in Neurobiology, 23(6), 786–792. https://doi.org/10.1016/j.conb.2013.02.006
Mahlios, J., De la Herrán-Arita, A. K., & Mignot, E. (2013). The autoimmune basis of narcolepsy. Current Opinion in Neurobiology, 23(5), 767–773. https://doi.org/10.1016/j.conb.2013.04.013
Passos, G. S., Poyares, D., Santana, M. G., et al. (2014). Exercise improves immune function, antidepressive response, and sleep quality in patients with chronic primary insomnia. BioMed Research International, 2014, 498961. https://doi.org/10.1155/2014/498961
Porkka-Heiskanen, T. (2013). Sleep homeostasis. Current Opinion in Neurobiology, 23(5), 799–805. https://doi.org/10.1016/j.conb.2013.02.010
Stickgold, R. (2013). Parsing the role of sleep in memory processing. Current Opinion in Neurobiology, 23(6), 847–853. https://doi.org/10.1016/j.conb.2013.04.002
Wilder-Smith, A., Mustafa, F. B., Earnest, A., Gen, L., & MacAry, P. A. (2013). Impact of partial sleep deprivation on immune markers. Sleep Medicine, 14(9), 1031–1034. https://doi.org/10.1016/j.sleep.2013.07.001
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