Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

Ketogenic diet and metabolic health: A review of its impact on type 2 diabetes and obesity. Analysis of research on the ketogenic diet in the context of treating metabolic disorders
  • Home
  • /
  • Ketogenic diet and metabolic health: A review of its impact on type 2 diabetes and obesity. Analysis of research on the ketogenic diet in the context of treating metabolic disorders
  1. Home /
  2. Archives /
  3. Vol. 71 (2024) /
  4. Medical Sciences

Ketogenic diet and metabolic health: A review of its impact on type 2 diabetes and obesity. Analysis of research on the ketogenic diet in the context of treating metabolic disorders

Authors

  • Paweł Nojek Muncipal Hospital in Siemianowice Slaskie, ul. 1 maja 9, 41-100 Siemianowice Slaskie, Poland https://orcid.org/0009-0005-4460-3406
  • Monika Zawół Lower Silesian Center for Oncology, Pulmonology, and Hematology in Wrocław, plac Hirszfelda 12, 53-413 Wroclaw, Poland https://orcid.org/0009-0003-9854-5083
  • Mariusz Zimonczyk Muncipal Hospital in Zabrze, ul. Zamkowa 4, 41-803 Zabrze, Poland https://orcid.org/0009-0004-9256-3798
  • Wiktoria Pawlik Muncipal Hospital in Siemianowice Śląskie, ul. 1 maja 9, 41-100 Siemianowice Slaskie, Poland https://orcid.org/0009-0006-8756-5398
  • Agnieszka Nowotarska Katowice Oncology Center, ul. Raciborska 26, 40-074 Katowice, Poland https://orcid.org/0009-0009-2698-9519
  • Gustaw Błaszczyński Muncipal Hospital in Siemianowice Śląskie, ul. 1 maja 9, 41-100 Siemianowice Sląskie, Poland https://orcid.org/0009-0001-3017-3514

DOI:

https://doi.org/10.12775/JEHS.2024.71.55923

Keywords

Ketogenic diet, ketosis, ketone bodies, obesity, type 2 diabetes, metabolism, insulin sensitivity, glucose control, insulin resistance, biological mechanisms, metabolic processes, long-term use, inflammation, gut microbiota, neuroprotection, therapeutic effects, dietary changes, fat intake, carbohydrates, scientific research, lipid profile, side effects, supplementation, weight management, physical activity, dietary programs, patient education, dietary interventions

Abstract

This paper aims to review current research on the ketogenic diet as a potential therapeutic approach for obesity and type 2 diabetes. This diet is characterized by high fat intake, moderate protein, and minimal carbohydrates, leading to a state of ketosis in which the body utilizes ketone bodies as its primary energy source. Studies indicate that the ketogenic diet may positively influence blood glucose control, enhance insulin sensitivity, and facilitate weight reduction, particularly relevant in the context of insulin resistance. The paper discusses the biological mechanisms underlying these effects, as well as potential risks associated with long-term adherence to the diet. It underscores that, despite promising results, further research is necessary to better understand the long-term effects of the ketogenic diet and its applicability across various patient populations. Conclusions highlight the need for patient monitoring during the dietary regimen and the potential for integrating the ketogenic diet into a broader strategy for managing metabolic diseases

References

O'Neill, B., & Raggi, P. (2020). The ketogenic diet: Pros and cons. Atherosclerosis, 292, 119–126. https://doi.org/10.1016/j.atherosclerosis.2019.11.021

Di Raimondo, D., Buscemi, S., Musiari, G., Rizzo, G., Pirera, E., Corleo, D., Pinto, A., & Tuttolomondo, A. (2021). Ketogenic Diet, Physical Activity, and Hypertension-A Narrative Review. Nutrients, 13(8), 2567. https://doi.org/10.3390/nu13082567

Masino, S. A., & Rho, J. M. (2012). Mechanisms of Ketogenic Diet Action. In J. L. Noebels (Eds.) et. al., Jasper's Basic Mechanisms of the Epilepsies. (4th ed.). National Center for Biotechnology Information (US).

Nylen, K., Likhodii, S., & Burnham, W. M. (2009). The ketogenic diet: proposed mechanisms of action. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 6(2), 402–405. https://doi.org/10.1016/j.nurt.2009.01.021

Tiulganova, D. A., Nasaev, S. S., Chugreev, I. A., Rodionova, M. A., & Zavyalov, G. A. (2018). Mekhanizmy deĭstviia ketogennoĭ diety [Mechanisms of ketogenic diet action]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 118(10. Vyp. 2), 72–75. https://doi.org/10.17116/jnevro201811810272

Chandrasekaran, P., & Weiskirchen, R. (2024). The Role of Obesity in Type 2 Diabetes Mellitus-An Overview. International journal of molecular sciences, 25(3), 1882. https://doi.org/10.3390/ijms25031882

Ruze, R., Liu, T., Zou, X., Song, J., Chen, Y., Xu, R., Yin, X., & Xu, Q. (2023). Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments. Frontiers in endocrinology, 14, 1161521. https://doi.org/10.3389/fendo.2023.1161521

Tinajero, M. G., & Malik, V. S. (2021). An Update on the Epidemiology of Type 2 Diabetes: A Global Perspective. Endocrinology and metabolism clinics of North America, 50(3), 337–355. https://doi.org/10.1016/j.ecl.2021.05.013

Sandouk, Z., & Lansang, M. C. (2017). Diabetes with obesity--Is there an ideal diet?. Cleveland Clinic journal of medicine, 84(7 Suppl 1), S4–S14. https://doi.org/10.3949/ccjm.84.s1.02

Bales, C. W., & Porter Starr, K. N. (2018). Obesity Interventions for Older Adults: Diet as a Determinant of Physical Function. Advances in nutrition (Bethesda, Md.), 9(2), 151–159. https://doi.org/10.1093/advances/nmx016

Aaseth, J., Ellefsen, S., Alehagen, U., Sundfør, T. M., & Alexander, J. (2021). Diets and drugs for weight loss and health in obesity - An update. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 140, 111789. https://doi.org/10.1016/j.biopha.2021.111789

Martín-Peláez, S., Fito, M., & Castaner, O. (2020). Mediterranean Diet Effects on Type 2 Diabetes Prevention, Disease Progression, and Related Mechanisms. A Review. Nutrients, 12(8), 2236. https://doi.org/10.3390/nu12082236

Hemmingsen, B., Gimenez-Perez, G., Mauricio, D., Roqué I Figuls, M., Metzendorf, M. I., & Richter, B. (2017). Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus. The Cochrane database of systematic reviews, 12(12), CD003054. https://doi.org/10.1002/14651858.CD003054.pub4

Esposito, K., Maiorino, M. I., Bellastella, G., Chiodini, P., Panagiotakos, D., & Giugliano, D. (2015). A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses. BMJ open, 5(8), e008222. https://doi.org/10.1136/bmjopen-2015-008222

Zhou, C., Wang, M., Liang, J., He, G., & Chen, N. (2022). Ketogenic Diet Benefits to Weight Loss, Glycemic Control, and Lipid Profiles in Overweight Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trails. International journal of environmental research and public health, 19(16), 10429. https://doi.org/10.3390/ijerph191610429

Dashti, H. M., Mathew, T. C., & Al-Zaid, N. S. (2021). Efficacy of Low-Carbohydrate Ketogenic Diet in the Treatment of Type 2 Diabetes. Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 30(3), 223–235. https://doi.org/10.1159/000512142

Yuan, X., Wang, J., Yang, S., Gao, M., Cao, L., Li, X., Hong, D., Tian, S., & Sun, C. (2020). Effect of the ketogenic diet on glycemic control, insulin resistance, and lipid metabolism in patients with T2DM: a systematic review and meta-analysis. Nutrition & diabetes, 10(1), 38. https://doi.org/10.1038/s41387-020-00142-z

Paoli, A., Bianco, A., Moro, T., Mota, J. F., & Coelho-Ravagnani, C. F. (2023). The Effects of Ketogenic Diet on Insulin Sensitivity and Weight Loss, Which Came First: The Chicken or the Egg?. Nutrients, 15(14), 3120. https://doi.org/10.3390/nu15143120

Jing, T., Zhang, S., Bai, M., Chen, Z., Gao, S., Li, S., & Zhang, J. (2023). Effect of Dietary Approaches on Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review with Network Meta-Analysis of Randomized Trials. Nutrients, 15(14), 3156. https://doi.org/10.3390/nu15143156

Skow, S. L., & Jha, R. K. (2023). A Ketogenic Diet is Effective in Improving Insulin Sensitivity in Individuals with Type 2 Diabetes. Current diabetes reviews, 19(6), e250422203985. https://doi.org/10.2174/1573399818666220425093535

Cunha, G. M., Guzman, G., Correa De Mello, L. L., Trein, B., Spina, L., Bussade, I., Marques Prata, J., Sajoux, I., & Countinho, W. (2020). Efficacy of a 2-Month Very Low-Calorie Ketogenic Diet (VLCKD) Compared to a Standard Low-Calorie Diet in Reducing Visceral and Liver Fat Accumulation in Patients With Obesity. Frontiers in endocrinology, 11, 607. https://doi.org/10.3389/fendo.2020.00607

Choi, Y. J., Jeon, S. M., & Shin, S. (2020). Impact of a Ketogenic Diet on Metabolic Parameters in Patients with Obesity or Overweight and with or without Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials. Nutrients, 12(7), 2005. https://doi.org/10.3390/nu12072005

Murphy, E. A., & Jenkins, T. J. (2019). A ketogenic diet for reducing obesity and maintaining capacity for physical activity: hype or hope?. Current opinion in clinical nutrition and metabolic care, 22(4), 314–319. https://doi.org/10.1097/MCO.0000000000000572

Lambadiari, V., Katsimbri, P., Kountouri, A., Korakas, E., Papathanasi, A., Maratou, E., Pavlidis, G., Pliouta, L., Ikonomidis, I., Malisova, S., Vlachos, D., & Papadavid, E. (2024). The Effect of a Ketogenic Diet versus Mediterranean Diet on Clinical and Biochemical Markers of Inflammation in Patients with Obesity and Psoriatic Arthritis: A Randomized Crossover Trial. International journal of molecular sciences, 25(5), 2475. https://doi.org/10.3390/ijms25052475

Santangelo, A., Corsello, A., Spolidoro, G. C. I., Trovato, C. M., Agostoni, C., Orsini, A., Milani, G. P., & Peroni, D. G. (2023). The Influence of Ketogenic Diet on Gut Microbiota: Potential Benefits, Risks and Indications. Nutrients, 15(17), 3680. https://doi.org/10.3390/nu15173680

Batch, J. T., Lamsal, S. P., Adkins, M., Sultan, S., & Ramirez, M. N. (2020). Advantages and Disadvantages of the Ketogenic Diet: A Review Article. Cureus, 12(8), e9639. https://doi.org/10.7759/cureus.9639

Rafiullah, M., Musambil, M., & David, S. K. (2022). Effect of a very low-carbohydrate ketogenic diet vs recommended diets in patients with type 2 diabetes: a meta-analysis. Nutrition reviews, 80(3), 488–502. https://doi.org/10.1093/nutrit/nuab040

Merovci, A., Finley, B., Hansis-Diarte, A., Neppala, S., Abdul-Ghani, M. A., Cersosimo, E., Triplitt, C., & DeFronzo, R. A. (2024). Effect of weight-maintaining ketogenic diet on glycemic control and insulin sensitivity in obese T2D subjects. BMJ open diabetes research & care, 12(5), e004199. https://doi.org/10.1136/bmjdrc-2024-004199

Berk, K. A., van der Louw, E. J. T. M., Olieman, J. F., & van der Lely, A. J. (2021). Comment on Moriconi et al. Very-Low-Calorie Ketogenic Diet as a Safe and Valuable Tool for Long-Term Glycemic Management in Patients with Obesity and Type 2 Diabetes. Nutrients 2021, 13, 758. Nutrients, 13(10), 3613. https://doi.org/10.3390/nu13103613

Zhang, X., Qin, J., Zhao, Y., Shi, J., Lan, R., Gan, Y., Ren, H., Zhu, B., Qian, M., & Du, B. (2016). Long-term ketogenic diet contributes to glycemic control but promotes lipid accumulation and hepatic steatosis in type 2 diabetic mice. Nutrition research (New York, N.Y.), 36(4), 349–358. https://doi.org/10.1016/j.nutres.2015.12.002

Downloads

  • PDF

Published

2024-11-19

How to Cite

1.
NOJEK, Paweł, ZAWÓŁ, Monika, ZIMONCZYK, Mariusz, PAWLIK, Wiktoria, NOWOTARSKA, Agnieszka and BŁASZCZYŃSKI, Gustaw. Ketogenic diet and metabolic health: A review of its impact on type 2 diabetes and obesity. Analysis of research on the ketogenic diet in the context of treating metabolic disorders. Journal of Education, Health and Sport. Online. 19 November 2024. Vol. 71, p. 55923. [Accessed 28 June 2025]. DOI 10.12775/JEHS.2024.71.55923.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 71 (2024)

Section

Medical Sciences

License

Copyright (c) 2024 Paweł Nojek, Monika Zawół, Mariusz Zimonczyk, Wiktoria Pawlik, Agnieszka Nowotarska, Gustaw Błaszczyński

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 284
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

Ketogenic diet, ketosis, ketone bodies, obesity, type 2 diabetes, metabolism, insulin sensitivity, glucose control, insulin resistance, biological mechanisms, metabolic processes, long-term use, inflammation, gut microbiota, neuroprotection, therapeutic effects, dietary changes, fat intake, carbohydrates, scientific research, lipid profile, side effects, supplementation, weight management, physical activity, dietary programs, patient education, dietary interventions
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop